LOCUS       NM_031309               3980 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens scratch family transcriptional repressor 1 (SCRT1),
            mRNA.
ACCESSION   NM_031309 NM_032274 XM_001125687
VERSION     NM_031309.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3980)
  AUTHORS   Chen,Y., Wang,F., Li,J., Wang,W., Ge,L. and Ge,L.
  TITLE     Long non-coding RNA TCL6 induced by SCRT1 promotes proliferation
            and metastasis of non-small cell lung cancer through PDK1/AKT
            signaling
  JOURNAL   Pathol Res Pract 246, 154491 (2023)
   PUBMED   37141697
  REMARK    GeneRIF: Long non-coding RNA TCL6 induced by SCRT1 promotes
            proliferation and metastasis of non-small cell lung cancer through
            PDK1/AKT signaling.
REFERENCE   2  (bases 1 to 3980)
  AUTHORS   Sobel,J., Guay,C., Elhanani,O., Rodriguez-Trejo,A., Stoll,L.,
            Menoud,V., Jacovetti,C., Walker,M.D. and Regazzi,R.
  TITLE     Scrt1, a transcriptional regulator of beta-cell proliferation
            identified by differential chromatin accessibility during islet
            maturation
  JOURNAL   Sci Rep 11 (1), 8800 (2021)
   PUBMED   33888791
  REMARK    GeneRIF: Scrt1, a transcriptional regulator of beta-cell
            proliferation identified by differential chromatin accessibility
            during islet maturation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3980)
  AUTHORS   Chriett,S., Lindqvist,A., Shcherbina,L., Edlund,A., Abels,M.,
            Asplund,O., Martinez Lopez,J.A., Ottosson-Laakso,E., Hatem,G.,
            Prasad,R.B., Groop,L., Eliasson,L., Hansson,O. and Wierup,N.
  TITLE     SCRT1 is a novel beta cell transcription factor with insulin
            regulatory properties
  JOURNAL   Mol Cell Endocrinol 521, 111107 (2021)
   PUBMED   33309639
  REMARK    GeneRIF: SCRT1 is a novel beta cell transcription factor with
            insulin regulatory properties.
REFERENCE   4  (bases 1 to 3980)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   5  (bases 1 to 3980)
  AUTHORS   Rietveld,C.A., Esko,T., Davies,G., Pers,T.H., Turley,P.,
            Benyamin,B., Chabris,C.F., Emilsson,V., Johnson,A.D., Lee,J.J., de
            Leeuw,C., Marioni,R.E., Medland,S.E., Miller,M.B., Rostapshova,O.,
            van der Lee,S.J., Vinkhuyzen,A.A., Amin,N., Conley,D.,
            Derringer,J., van Duijn,C.M., Fehrmann,R., Franke,L., Glaeser,E.L.,
            Hansell,N.K., Hayward,C., Iacono,W.G., Ibrahim-Verbaas,C.,
            Jaddoe,V., Karjalainen,J., Laibson,D., Lichtenstein,P.,
            Liewald,D.C., Magnusson,P.K., Martin,N.G., McGue,M., McMahon,G.,
            Pedersen,N.L., Pinker,S., Porteous,D.J., Posthuma,D.,
            Rivadeneira,F., Smith,B.H., Starr,J.M., Tiemeier,H., Timpson,N.J.,
            Trzaskowski,M., Uitterlinden,A.G., Verhulst,F.C., Ward,M.E.,
            Wright,M.J., Davey Smith,G., Deary,I.J., Johannesson,M., Plomin,R.,
            Visscher,P.M., Benjamin,D.J., Cesarini,D. and Koellinger,P.D.
  TITLE     Common genetic variants associated with cognitive performance
            identified using the proxy-phenotype method
  JOURNAL   Proc Natl Acad Sci U S A 111 (38), 13790-13794 (2014)
   PUBMED   25201988
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):E380. doi:
            10.1073/pnas.1424631112.. PMID: 25572966]
REFERENCE   6  (bases 1 to 3980)
  AUTHORS   Jolma,A., Yan,J., Whitington,T., Toivonen,J., Nitta,K.R.,
            Rastas,P., Morgunova,E., Enge,M., Taipale,M., Wei,G., Palin,K.,
            Vaquerizas,J.M., Vincentelli,R., Luscombe,N.M., Hughes,T.R.,
            Lemaire,P., Ukkonen,E., Kivioja,T. and Taipale,J.
  TITLE     DNA-binding specificities of human transcription factors
  JOURNAL   Cell 152 (1-2), 327-339 (2013)
   PUBMED   23332764
REFERENCE   7  (bases 1 to 3980)
  AUTHORS   Bastid,J., Bouchet,B.P., Ciancia,C., Pourchet,J., Audoynaud,C.,
            Grelier,G., Puisieux,A. and Ansieau,S.
  TITLE     The SNAIL family member SCRATCH1 is not expressed in human tumors
  JOURNAL   Oncol Rep 23 (2), 523-529 (2010)
   PUBMED   20043117
REFERENCE   8  (bases 1 to 3980)
  AUTHORS   Nakakura,E.K., Watkins,D.N., Sriuranpong,V., Borges,M.W.,
            Nelkin,B.D. and Ball,D.W.
  TITLE     Mammalian Scratch participates in neuronal differentiation in P19
            embryonal carcinoma cells
  JOURNAL   Brain Res Mol Brain Res 95 (1-2), 162-166 (2001)
   PUBMED   11687288
REFERENCE   9  (bases 1 to 3980)
  AUTHORS   Nakakura,E.K., Watkins,D.N., Schuebel,K.E., Sriuranpong,V.,
            Borges,M.W., Nelkin,B.D. and Ball,D.W.
  TITLE     Mammalian Scratch: a neural-specific Snail family transcriptional
            repressor
  JOURNAL   Proc Natl Acad Sci U S A 98 (7), 4010-4015 (2001)
   PUBMED   11274425
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC233992.5.
            
            On Nov 22, 2018 this sequence version replaced NM_031309.5.
            
            Summary: This gene encodes a C2H2-type zinc finger transcriptional
            repressor that binds to E-box motifs. The encoded protein may
            promote neural differention and may be involved in cancers with
            neuroendocrine features. [provided by RefSeq, Jul 2013].
            
            Sequence Note: The RefSeq transcript was derived from the reference
            genome assembly. The genomic coordinates were determined from
            alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY014996.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000569446.3/ ENSP00000455711.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-428               AC233992.5         98367-98794         c
            429-3980            AC233992.5         92877-96428         c
FEATURES             Location/Qualifiers
     source          1..3980
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..3980
                     /gene="SCRT1"
                     /gene_synonym="SCRT; ZNF898"
                     /note="scratch family transcriptional repressor 1"
                     /db_xref="GeneID:83482"
                     /db_xref="HGNC:HGNC:15950"
                     /db_xref="MIM:605858"
     exon            1..428
                     /gene="SCRT1"
                     /gene_synonym="SCRT; ZNF898"
                     /inference="alignment:Splign:2.1.0"
     CDS             314..1360
                     /gene="SCRT1"
                     /gene_synonym="SCRT; ZNF898"
                     /note="scratch homolog 1, zinc finger protein; scratch
                     family zinc finger 1"
                     /codon_start=1
                     /product="transcriptional repressor scratch 1"
                     /protein_id="NP_112599.2"
                     /db_xref="CCDS:CCDS6421.1"
                     /db_xref="GeneID:83482"
                     /db_xref="HGNC:HGNC:15950"
                     /db_xref="MIM:605858"
                     /translation="MPRSFLVKKVKLDAFSSADLESAYGRARSDLGAPLHDKGYLSDY
                     VGPSSVYDGDAEAALLKGPSPEPMYAAAVRGELGPAAAGSAPPPTPRPELATAAGGYI
                     NGDAAVSEGYAADAFFITDGRSRRKASNAGAAAAPSTASAAAPDGDAGGGGGAGGRSL
                     GSGPGGRGGTRAGAGTEARAGPGAAGAGGRHACGECGKTYATSSNLSRHKQTHRSLDS
                     QLARRCPTCGKVYVSMPAMAMHLLTHDLRHKCGVCGKAFSRPWLLQGHMRSHTGEKPF
                     GCAHCGKAFADRSNLRAHMQTHSAFKHFQCKRCKKSFALKSYLNKHYESACFKGGAGG
                     PAAPAPPQLSPVQA"
     exon            429..3980
                     /gene="SCRT1"
                     /gene_synonym="SCRT; ZNF898"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3958..3963
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCRT1"
                     /gene_synonym="SCRT; ZNF898"
                     /note="hexamer: AATAAA"
     polyA_site      3980
                     /gene="SCRT1"
                     /gene_synonym="SCRT; ZNF898"
                     /note="major polyA site"
ORIGIN      
        1 actgcgggct gggaagccgg gaccagagga gggaaggaag gaagaggaga ggagagaaga
       61 ggagagaagg aaggaaggat tgaaggaagg aaggaaggat tgaaggaagg aggaagaaga
      121 gggatccgga ggggcaacgg aggagacgca gggcagcaag gagagaggac accactcgcg
      181 cggcagcatc caaaggccag agtggggacc cgcgctgcct ccgccgctcc tcggatggtg
      241 acggggccct gccgccgcag cccccccaag ccccggctcc gcaggcccac agcgccggag
      301 ccccgcagga atcatgccca ggtccttcct ggtcaagaag gtcaaacttg acgcgttctc
      361 ttcggccgac ctggagagcg cctacggacg cgcccgcagc gacctcggcg cgccactgca
      421 cgataaaggg tacctcagcg actacgtggg gccctcgtcc gtctacgatg gcgacgccga
      481 ggctgcgctg ctcaaagggc cgtcgccgga gcccatgtac gcagcagctg tgcgtggaga
      541 gctgggtccg gcggctgcag ggtctgcgcc gccgcccacc ccgcgcccgg agctggccac
      601 cgctgcgggc ggctacatca acggcgacgc ggccgtcagc gagggctacg cggcggacgc
      661 cttcttcatc accgacgggc gctcgcggcg taaggcttcc aatgccggcg ctgccgccgc
      721 tccctccaca gcctcggcgg cggcccccga cggcgacgcc ggaggcgggg gcggggcggg
      781 cgggcgcagc ttgggatccg ggccgggggg ccggggcggc acgcgcgcgg gggcaggcac
      841 cgaggcgcgc gcggggccag gggccgcagg tgctggcggc cggcacgcgt gcggcgagtg
      901 cggcaaaaca tacgccacgt cgtcgaacct gagccgccac aagcagacgc accgcagcct
      961 ggacagccag ctggcgcggc gctgcccgac gtgcggcaag gtgtacgtgt ccatgccggc
     1021 catggccatg cacctgctca cgcacgacct gcgccacaag tgcggcgtgt gcggcaaagc
     1081 cttctcgcgg ccctggctgc tgcagggcca catgcgctcg cacaccggcg agaaaccctt
     1141 cggctgcgcg cactgcggca aggccttcgc cgaccgctcc aacctgcgcg cgcacatgca
     1201 gacgcattcg gccttcaagc acttccagtg caagcgctgc aagaagagct tcgcgctcaa
     1261 gtcctatctc aacaagcact acgagtcggc ctgcttcaag ggcggcgccg gaggccccgc
     1321 ggctcctgcg ccgccacagc tcagccctgt gcaggcctag ggcggcgggg cctcccccag
     1381 ccaggtcggc tctcagcaat acggcccccc agggaagtct tcgctggcgt ccgggtggag
     1441 gggccggagg gcgggcccct cctcacagca atagggggag gggggcccgg tcccaccccg
     1501 ccccgcccgc caggggcctt gccggcccct tcaagcaata gggtcccgag gggagaccca
     1561 ccccgagccc cctcccctcc cctccagggt gcccccggct ttctcccagc aatagggtcg
     1621 acgagaccta gaaccgaacc tcatctccga gttgggtctc tgaagacggg ggtgaggtga
     1681 ggtagggagc gccctccttc tcccgcctct gcgcccctgg atcgcgtcgc agggactcag
     1741 gtcttcccca ccccttccca agccttctag cgcagggcct gcggcccaga cgtccaggga
     1801 gccggcccct ccccggcagc aggccggggc ggagcaggag cgggcgggcc tgcagggacg
     1861 cccctgccta gcagccttcg cggaactccc ggcagtgtta gacgcgttgt gggtcgggga
     1921 gaggggcgga cggcggcacc ccctccctcg ggttgcttct ggggcctcag tcggagccgc
     1981 cctcctaccc tcgcctcgca tcctctgcca aatccgaatt cttccagccc agcttcccgg
     2041 gctctgtcct ccatatcgaa taataatgac acatatcgaa tcgcatggac ttatccgacc
     2101 tcctcagacc ccgcttccgc cctgccccgg gcccccaccc cccacccccg taccccaggc
     2161 attcgtgttg gaggacggat tcccggggcc ggcaggcagg cctgggcgct gccctctaca
     2221 cacctctgtc ttcgctttgc gggtaaagcc ccctgggggg gttgcggacg cgtcgggttt
     2281 ctttttctgt atttgtacgt tttatttatg aacggattgc actcgggtca gggagggggc
     2341 gctgaacccc catcttgccc gccgacgccg ggggcctggg atgtccggga ttactttcca
     2401 cgccccgagg cccgccccta gctgggagcc tctagggagc ctcaggcccc gcctctccga
     2461 ggcaggcccc tcccctgaga cccaggcccc gcccctgaga cccaggcccc gcccccactc
     2521 ggttgccaac tttcgcccgt ctatgccaaa gcctcggcgg cgaccccgcc ccaagggccc
     2581 gccccattgg ccgccgcctt tgtgacgtca ctgcatgcag ccccacccct cctcccgatc
     2641 ctacccgggg ctgcccgctc cccctccctc ttaggtagtc cgaagccgac tatagagcaa
     2701 taatgcgcac tgcatgcgaa gctgccgccg cctctagagt tactgagaat caggtatccc
     2761 ctcgccctac ccaccccata ggcccctaga tcagggacgc tgcgcggggc cggccgcgca
     2821 gactttctcc ccacccctcc ccgaccccca cggcagagcc cggcggctgt aatggttcca
     2881 tgggcggggg tggggtggtt gcccccaaga cccctccttc aggcattaat cattcactga
     2941 ccgttcattg agcacctact atgtgccagg ccaattgctg agtccgccag gagcgcagcc
     3001 acctgctggg aggtgtgttt gcaggacagg ggtccaaccg gcttgggtgg gccagggaag
     3061 aacggcagat gcagagagac caggtcccta ggttcacatg ccccctacac tcctccccac
     3121 ctcaaccagt ccctgctggg cacaactggg ctctaccttt gagttaggcc ttttgactcc
     3181 agctgagggg gacagatcca gggctcctgg gcccccacac aggtggccac ttctctgatc
     3241 ctctggccaa cacacatctg ccatgtccag ccaggggcag agccatggct ggagaagaag
     3301 gtgccagctg tagcctatgg tgtggccagc ctcaccccca gcagcaagcg tggctgcccc
     3361 cacaaggatg acccaccgct ctgcacagca gtgcccacat ccaaacaccc tacacaacca
     3421 ggtgtggtgc ctgcacagct cccaagctgg ggcctgccca cctgtgccgc atgcacacgc
     3481 acacacaggc gcccccacct caccccaccc catactcctg tctacctacc taaggagaaa
     3541 gctggagggc tgtgggcccg tcagggtctc ctgcttcccc ctacaccccg ccgccgtgga
     3601 aagccatggg ccccctcccg cccccataac taagcagcac aataaccgac ttagcgaatt
     3661 caggtagaag gaacgtttag gtagcaccta ttttgtactg attctacaag tagggcccga
     3721 ggtgcggggg ccctcgggtg ggggctgcgg ccgccggccc gcccgccccc acccccgcct
     3781 gtgccccgcc gccttgtaca tattcccacc cggaataggc cgggattttt actcgggccg
     3841 tgcccctctt ccgcccccat ttggggccag gccggccgga cagacggacg gacggacaga
     3901 cctccttcct aagcacaata gcaccagctc cccggagcac cgcacctcca caaggagaat
     3961 aaatgccact cttgatagaa
//
