LOCUS       NM_024583               3052 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens secernin 3 (SCRN3), transcript variant 1, mRNA.
ACCESSION   NM_024583
VERSION     NM_024583.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3052)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 3052)
  AUTHORS   Way,G., Morrice,N., Smythe,C. and O'Sullivan,A.J.
  TITLE     Purification and identification of secernin, a novel cytosolic
            protein that regulates exocytosis in mast cells
  JOURNAL   Mol Biol Cell 13 (9), 3344-3354 (2002)
   PUBMED   12221138
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA760451.1, BC119684.1, BC031821.1, AA227619.1 and CK301138.1.
            
            On May 17, 2019 this sequence version replaced NM_024583.4.
            
            Transcript Variant: This variant (1) uses the same exon combination
            as variant 12 but represents the allele encoded by the GRCh38
            reference genome. The encoded isoform (1) has a frameshifted
            C-terminus compared to isoform 5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.111547.1,
                                           SRR1803611.134730.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000272732.11/ ENSP00000272732.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                DA760451.1         2-49
            49-1347             BC119684.1         1-1299
            1348-2346           BC031821.1         810-1808
            2347-2695           AA227619.1         114-462
            2696-3052           CK301138.1         19-375              c
FEATURES             Location/Qualifiers
     source          1..3052
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.1"
     gene            1..3052
                     /gene="SCRN3"
                     /gene_synonym="SES3"
                     /note="secernin 3"
                     /db_xref="GeneID:79634"
                     /db_xref="HGNC:HGNC:30382"
                     /db_xref="MIM:614967"
     exon            1..88
                     /gene="SCRN3"
                     /gene_synonym="SES3"
                     /inference="alignment:Splign:2.1.0"
     exon            89..256
                     /gene="SCRN3"
                     /gene_synonym="SES3"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1372
                     /gene="SCRN3"
                     /gene_synonym="SES3"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="secernin-3 isoform 1"
                     /protein_id="NP_078859.2"
                     /db_xref="CCDS:CCDS2258.1"
                     /db_xref="GeneID:79634"
                     /db_xref="HGNC:HGNC:30382"
                     /db_xref="MIM:614967"
                     /translation="MEPFSCDTFVALPPATVDNRIIFGKNSDRLYDEVQEVVYFPAVV
                     HDNLGERLKCTYIEIDQVPETYAVVLSRPAWLWGAEMGANEHGVCIGNEAVWGREEVC
                     DEEALLGMDLVRLGLERADTAEKALNVIVDLLEKYGQGGNCTEGRMVFSYHNSFLIAD
                     RNEAWILETAGKYWAAEKVQEGVRNISNQLSITTKIAREHPDMRNYAKRKGWWDGKKE
                     FDFAAAYSYLDTAKMMTSSGRYCEGYKLLNKHKGNITFETMMEILRDKPSGINMEGEF
                     LTTASMVSILPQDSSLPCIHFFTGTPDPERSVFKPFIFVPHISQLLDTSSPTFELEDL
                     VKKKSHFKPDRRHPLYQKHQQALEVVNNNEEKAKIMLDNMRKLEKELFREMESILQNK
                     HLDVEKIVNLFPQCTKDEIQIYQSNLSVKVSS"
     exon            257..438
                     /gene="SCRN3"
                     /gene_synonym="SES3"
                     /inference="alignment:Splign:2.1.0"
     exon            439..638
                     /gene="SCRN3"
                     /gene_synonym="SES3"
                     /inference="alignment:Splign:2.1.0"
     exon            639..851
                     /gene="SCRN3"
                     /gene_synonym="SES3"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1014
                     /gene="SCRN3"
                     /gene_synonym="SES3"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1189
                     /gene="SCRN3"
                     /gene_synonym="SES3"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..3052
                     /gene="SCRN3"
                     /gene_synonym="SES3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1674..1679
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCRN3"
                     /gene_synonym="SES3"
                     /note="hexamer: TATAAA"
     regulatory      1689..1694
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCRN3"
                     /gene_synonym="SES3"
                     /note="hexamer: ATTAAA"
     polyA_site      1695
                     /gene="SCRN3"
                     /gene_synonym="SES3"
                     /note="major polyA site"
     polyA_site      1722
                     /gene="SCRN3"
                     /gene_synonym="SES3"
     regulatory      2456..2461
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCRN3"
                     /gene_synonym="SES3"
                     /note="hexamer: AATAAA"
     polyA_site      2483
                     /gene="SCRN3"
                     /gene_synonym="SES3"
     regulatory      2576..2581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCRN3"
                     /gene_synonym="SES3"
                     /note="hexamer: AAGAAA"
     polyA_site      2599
                     /gene="SCRN3"
                     /gene_synonym="SES3"
ORIGIN      
        1 atcaaaggtg acagcttccg gcaactgatg cctccactgg ccactcctcc ctccgtccac
       61 ctgtcacttc gggtagctgg gaggccagtt aaaaaaaatg gaaccttttt cctgtgacac
      121 tttcgtggca ttacctccag caacagtcga taacaggatt atttttggaa aaaattcaga
      181 tagactctat gatgaagtac aagaggtggt ttattttcct gctgtagttc atgataacct
      241 gggagaacgt cttaagtgta catatataga aattgatcaa gttcctgaaa catatgctgt
      301 tgtcctgagt cgcccagcgt ggttgtgggg ggcagaaatg ggagccaatg agcatggagt
      361 ttgcattggg aatgaagctg tatggggaag agaagaagtt tgtgatgaag aagcactatt
      421 aggaatggac cttgtcagac ttggccttga aagagctgat acagctgaaa aagccctcaa
      481 tgtcattgtt gacttactag aaaaatatgg ccagggtgga aattgcacag agggtagaat
      541 ggtatttagc tatcacaaca gtttcctgat agctgatagg aatgaagcct ggattctgga
      601 gactgcaggg aagtactggg cagcagaaaa agtacaagag ggagttcgta atatttctaa
      661 tcaactttcc ataacaacca agattgcccg ggaacaccca gacatgagaa actatgctaa
      721 gcggaaaggt tggtgggatg gtaaaaagga gtttgatttt gctgcagcat attcctatct
      781 tgacacagcc aagatgatga cttcatcagg cagatactgt gagggctaca agcttctaaa
      841 taagcacaaa ggaaatataa cttttgaaac aatgatggaa attcttcgag ataaaccaag
      901 tggcattaat atggagggag aattcctgac cactgcaagc atggtttcta ttttacctca
      961 agactccagc cttccttgca ttcacttctt tacagggact cctgatcctg agagatctgt
     1021 ttttaagcct ttcatatttg tgccacatat ttcacaacta ttggatacca gttcaccaac
     1081 atttgaactt gaagatctag ttaaaaagaa atcacatttt aagcctgaca gaagacaccc
     1141 actctaccaa aaacatcaac aggcattgga agtagtaaat aataatgagg aaaaagccaa
     1201 aataatgttg gacaacatga ggaaactgga gaaagaacta ttcagagaga tggaatcaat
     1261 ccttcaaaac aagcatcttg atgtggagaa aattgttaat ctctttcctc agtgtacaaa
     1321 agatgaaatt caaatttatc agtcaaattt atcagtcaaa gttagttctt agtgatcata
     1381 tggtcagcta atattagttc ttagtgatca gtggtcagta atcttcaaag tcagaatcta
     1441 tcaccttggt aaattatata aacctaactt gagcagatct gattattctt ggatagtatt
     1501 caagtggtat cttgactatt aaactacgta tagtgttgct gaaatagaaa gaaaacagca
     1561 ttggaattgg attcatgtat cgtgggatac aggtgttatt tcaggtgatg tacttgcatt
     1621 attttcttta gccatagtaa ctttttgtca caataactaa gtattcaatt atatataaag
     1681 agtgaaacat taaaatgacg catggattta tatttattat aattatgtag taccctcaaa
     1741 tcattttgtc agttacatca agaaagcaga tttttcttta gtcatgaaaa atatctcaag
     1801 tggtaagttg tttgtgcttt aggcaaacat taaccagctc taacaagaaa aatgtctaga
     1861 tttacacatt gtcaatacag tatattagtt ctgcaaatgc acttttgtta aactcaaaca
     1921 tgctctttgt caagacttgg ctaaccagtg agcttgtagc tctgattatc tagcattttt
     1981 agggtcattc tccttaatag gcttttatgt taataagata tatttttaga agagcttgtt
     2041 tgggagatta gagaataaga taaaagaacc aaaaccttag gatatactgt ttctgggtct
     2101 gaaatctctc tcattgttta cttctgttca ctcagtgaaa acagaaacaa gaatgaggta
     2161 gtggcaatga aatagaatta ttagtatatt atgaacatta taacattttg aacactataa
     2221 tgcattatat attatgaact tttatgaact ttatacatga gtaatagctt cctaaagttt
     2281 ataaaacatt gtttaggtta cataaagatt accaagtaag actcaaaatt gcaaatataa
     2341 acaaaagaaa aatccaactg aaaataacac taagtatttt tgagttccta gaatgtccat
     2401 tttggtattt ggttacatta tcatatttac tagtcactat cagcacaatt aggttaataa
     2461 agaagtgggt cattatattc aaagagtgct caggaagtta tgtgttcaaa gttctctcat
     2521 aaataccatc gtctgcctga tactgctctt gtctaataga gggttgacat tacaaaagaa
     2581 aagatgtctg actcaagaac tcagttgatt ctgtttgcct taagtttggt tcagtgatag
     2641 gctgtcttct aacccctata ctcctcttct ctcctttaat agatgaggaa actaagggca
     2701 aacagttcgt tacacttacg ggaatcttat ttccctctct aggggcagca tgttttcacc
     2761 ttctcctttg ctgccacctt ggcctaaact agcaccgtct tttagctaga ccattgcgtt
     2821 aactgttctc ctacacccat ttttgttctt tatttccacc cacatgagtc actgcagcca
     2881 atctattaca aatttaaatc tgattatgaa ttcccctcct aaaactcttt tttaaaagag
     2941 actttatttt ttggagcagt tttaggttca cagcaaaatt gaacagaaag tacagagttc
     3001 caatacagcc cctatcagca tacatgcata gcctccccca ctatcaacat cc
//
