LOCUS       NM_138355               1496 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens secernin 2 (SCRN2), transcript variant 1, mRNA.
ACCESSION   NM_138355
VERSION     NM_138355.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1496)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1496)
  AUTHORS   Lee,O.H., Kim,H., He,Q., Baek,H.J., Yang,D., Chen,L.Y., Liang,J.,
            Chae,H.K., Safari,A., Liu,D. and Songyang,Z.
  TITLE     Genome-wide YFP fluorescence complementation screen identifies new
            regulators for telomere signaling in human cells
  JOURNAL   Mol Cell Proteomics 10 (2), M110.001628 (2011)
   PUBMED   21044950
REFERENCE   3  (bases 1 to 1496)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 1496)
  AUTHORS   Way,G., Morrice,N., Smythe,C. and O'Sullivan,A.J.
  TITLE     Purification and identification of secernin, a novel cytosolic
            protein that regulates exocytosis in mast cells
  JOURNAL   Mol Biol Cell 13 (9), 3344-3354 (2002)
   PUBMED   12221138
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC003665.1, BC010408.2, CN480733.1 and AW452880.1.
            
            On Nov 22, 2018 this sequence version replaced NM_138355.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.158153.1,
                                           SRR3476690.206279.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2155751
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000290216.14/ ENSP00000290216.9
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AC003665.1         14534-14559
            27-1032             BC010408.2         1-1006
            1033-1454           CN480733.1         61-482              c
            1455-1496           AW452880.1         27-68               c
FEATURES             Location/Qualifiers
     source          1..1496
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.32"
     gene            1..1496
                     /gene="SCRN2"
                     /gene_synonym="Ses2"
                     /note="secernin 2"
                     /db_xref="GeneID:90507"
                     /db_xref="HGNC:HGNC:30381"
                     /db_xref="MIM:614966"
     exon            1..66
                     /gene="SCRN2"
                     /gene_synonym="Ses2"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1344
                     /gene="SCRN2"
                     /gene_synonym="Ses2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="secernin-2 isoform 1"
                     /protein_id="NP_612364.2"
                     /db_xref="CCDS:CCDS11519.1"
                     /db_xref="GeneID:90507"
                     /db_xref="HGNC:HGNC:30381"
                     /db_xref="MIM:614966"
                     /translation="MASSSPDSPCSCDCFVSVPPASAIPAVIFAKNSDRPRDEVQEVV
                     FVPAGTHTPGSRLQCTYIEVEQVSKTHAVILSRPSWLWGAEMGANEHGVCIGNEAVWT
                     KEPVGEGEALLGMDLLRLALERSSSAQEALHVITGLLEHYGQGGNCLEDAAPFSYHST
                     FLLADRTEAWVLETAGRLWAAQRIQEGARNISNQLSIGTDISAQHPELRTHAQAKGWW
                     DGQGAFDFAQIFSLTQQPVRMEAAKARFQAGRELLRQRQGGITAEVMMGILRDKESGI
                     CMDSGGFRTTASMVSVLPQDPTQPCVHFLTATPDPSRSVFKPFIFGMGVAQAPQVLSP
                     TFGAQDPVRTLPRFQTQVDRRHTLYRGHQAALGLMERDQDRGQQLQQKQQDLEQEGLE
                     ATQGLLAGEWAPPLWELGSLFQAFVKRESQAYA"
     exon            67..240
                     /gene="SCRN2"
                     /gene_synonym="Ses2"
                     /inference="alignment:Splign:2.1.0"
     exon            241..422
                     /gene="SCRN2"
                     /gene_synonym="Ses2"
                     /inference="alignment:Splign:2.1.0"
     exon            423..622
                     /gene="SCRN2"
                     /gene_synonym="Ses2"
                     /inference="alignment:Splign:2.1.0"
     exon            623..838
                     /gene="SCRN2"
                     /gene_synonym="Ses2"
                     /inference="alignment:Splign:2.1.0"
     exon            839..1004
                     /gene="SCRN2"
                     /gene_synonym="Ses2"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1185
                     /gene="SCRN2"
                     /gene_synonym="Ses2"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1496
                     /gene="SCRN2"
                     /gene_synonym="Ses2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1477..1482
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCRN2"
                     /gene_synonym="Ses2"
                     /note="hexamer: AATAAA"
     polyA_site      1496
                     /gene="SCRN2"
                     /gene_synonym="Ses2"
                     /note="major polyA site"
ORIGIN      
        1 gcggccctgg ccagaagcgg aggaggtggc acccgggacc gagctggggt cttggaggaa
       61 gagaggatgg cgtcgtcgag ccctgactcc ccatgttcct gcgactgctt tgtctccgtg
      121 cccccggcct cagccatccc ggctgtgatc tttgccaaga actcggaccg accccgggac
      181 gaggtgcagg aggtggtgtt tgtccccgca ggcactcaca ctcctgggag ccggctccag
      241 tgcacctaca ttgaagtgga acaggtgtcg aagacgcacg ctgtgattct gagccgtcct
      301 tcttggctat ggggggctga gatgggcgcc aacgagcatg gtgtctgcat tggcaacgag
      361 gctgtgtgga cgaaggagcc agttggggag ggggaagccc tgctgggcat ggacctactc
      421 aggctggctt tggaacggag cagctctgcc caggaggcct tgcatgtgat cacagggtta
      481 ctggagcact atgggcaggg gggcaactgc ctggaggatg ctgcgccatt ctcctaccat
      541 agcaccttcc tgctggctga ccgcactgag gcgtgggtgc tggagacagc tgggaggctc
      601 tgggctgcac agaggatcca ggagggggcc cgcaacatct ccaaccagct gagcattggc
      661 acggacatct cggcccaaca cccggagctg cggactcatg cccaggccaa gggctggtgg
      721 gatgggcagg gtgcctttga ctttgctcag atcttctccc tgacccagca gcctgtgcgc
      781 atggaggctg ccaaggcccg cttccaggca gggcgggagc tgctgcggca acggcaaggg
      841 ggcatcacgg cagaggtgat gatgggcatc ctcagagaca aggagagtgg tatctgtatg
      901 gactcgggag gctttcgcac cacggccagc atggtgtctg tcctgcccca ggatcccacg
      961 cagccctgcg tgcactttct taccgccacg ccagacccat ccaggtctgt gttcaaacct
     1021 ttcatcttcg ggatgggggt ggcccaggcc ccccaggtgc tgtcccccac ttttggagca
     1081 caagaccctg ttcggaccct gccccgattc cagactcagg tagatcgtcg gcataccctc
     1141 taccgtggac accaggcagc cctggggctg atggagagag atcaggatcg ggggcagcag
     1201 ctccagcaga aacagcagga tctggagcag gaaggcctcg aggccacaca ggggctgctg
     1261 gccggcgagt gggccccacc cctctgggag ctgggcagcc tcttccaggc cttcgtgaag
     1321 agggagagcc aggcttatgc gtaagcttca tagcttctgc tggcctgggg tggacccagg
     1381 acccctgggg cctgggtgcc ctgagtggtg gtaaagtgga gcaatccctt cacgctcctt
     1441 ggccatgttc tgagcggcca gcttggcctt tgccttaata aatgtgcttt attttc
//
