LOCUS       NM_014766               5254 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens secernin 1 (SCRN1), transcript variant 2, mRNA.
ACCESSION   NM_014766
VERSION     NM_014766.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5254)
  AUTHORS   Weiner,S., Sauer,M., Brinkmalm,G., Constantinescu,J.,
            Constantinescu,R., Gomes,B.F., Becker,B., Nellgard,B., Dalla,K.,
            Galasko,D., Zetterberg,H., Blennow,K. and Gobom,J.
  TITLE     SCRN1: A cerebrospinal fluid biomarker correlating with tau in
            Alzheimer's disease
  JOURNAL   Alzheimers Dement 19 (10), 4609-4618 (2023)
   PUBMED   36946611
  REMARK    GeneRIF: SCRN1: A cerebrospinal fluid biomarker correlating with
            tau in Alzheimer's disease.
REFERENCE   2  (bases 1 to 5254)
  AUTHORS   Xiao,L., Zhang,T., Zheng,K., Xiao,Q., Zhang,W., Zhang,D., Wu,D.,
            He,C., Zhou,Y. and Liu,Y.
  TITLE     Knockdown of Secernin 1 inhibit cell invasion and migration by
            activating the TGF-beta/Smad3 pathway in oral squamous cell
            carcinomas
  JOURNAL   Sci Rep 13 (1), 14922 (2023)
   PUBMED   37691034
  REMARK    GeneRIF: Knockdown of Secernin 1 inhibit cell invasion and
            migration by activating the TGF-beta/Smad3 pathway in oral squamous
            cell carcinomas.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5254)
  AUTHORS   Tracy,T.E., Madero-Perez,J., Swaney,D.L., Chang,T.S., Moritz,M.,
            Konrad,C., Ward,M.E., Stevenson,E., Huttenhain,R., Kauwe,G.,
            Mercedes,M., Sweetland-Martin,L., Chen,X., Mok,S.A., Wong,M.Y.,
            Telpoukhovskaia,M., Min,S.W., Wang,C., Sohn,P.D., Martin,J.,
            Zhou,Y., Luo,W., Trojanowski,J.Q., Lee,V.M.Y., Gong,S.,
            Manfredi,G., Coppola,G., Krogan,N.J., Geschwind,D.H. and Gan,L.
  TITLE     Tau interactome maps synaptic and mitochondrial processes
            associated with neurodegeneration
  JOURNAL   Cell 185 (4), 712-728 (2022)
   PUBMED   35063084
REFERENCE   4  (bases 1 to 5254)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 5254)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 5254)
  AUTHORS   Suehara,Y., Tochigi,N., Kubota,D., Kikuta,K., Nakayama,R., Seki,K.,
            Yoshida,A., Ichikawa,H., Hasegawa,T., Kaneko,K., Chuman,H.,
            Beppu,Y., Kawai,A. and Kondo,T.
  TITLE     Secernin-1 as a novel prognostic biomarker candidate of synovial
            sarcoma revealed by proteomics
  JOURNAL   J Proteomics 74 (6), 829-842 (2011)
   PUBMED   21385630
  REMARK    GeneRIF: in synovial sarcoma, metastasis-free survival was
            significantly higher in the group with high secernin-1 expression
            compared to low expression; results indicate secernin-1 may be used
            as a biomarker to predict overall and metastasis-free survival
REFERENCE   7  (bases 1 to 5254)
  AUTHORS   Martins-de-Souza,D., Schmitt,A., Roder,R., Lebar,M.,
            Schneider-Axmann,T., Falkai,P. and Turck,C.W.
  TITLE     Sex-specific proteome differences in the anterior cingulate cortex
            of schizophrenia
  JOURNAL   J Psychiatr Res 44 (14), 989-991 (2010)
   PUBMED   20381070
  REMARK    GeneRIF: This protein has been found differentially expressed in
            the anterior cingulate cortex from patients with schizophrenia
REFERENCE   8  (bases 1 to 5254)
  AUTHORS   Miyoshi,N., Ishii,H., Mimori,K., Sekimoto,M., Doki,Y. and Mori,M.
  TITLE     SCRN1 is a novel marker for prognosis in colorectal cancer
  JOURNAL   J Surg Oncol 101 (2), 156-159 (2010)
   PUBMED   20039278
  REMARK    GeneRIF: SCRN1 expression is a prognostic factor in colorectal
            cancer patients
REFERENCE   9  (bases 1 to 5254)
  AUTHORS   Suda,T., Tsunoda,T., Uchida,N., Watanabe,T., Hasegawa,S., Satoh,S.,
            Ohgi,S., Furukawa,Y., Nakamura,Y. and Tahara,H.
  TITLE     Identification of secernin 1 as a novel immunotherapy target for
            gastric cancer using the expression profiles of cDNA microarray
  JOURNAL   Cancer Sci 97 (5), 411-419 (2006)
   PUBMED   16630140
REFERENCE   10 (bases 1 to 5254)
  AUTHORS   Way,G., Morrice,N., Smythe,C. and O'Sullivan,A.J.
  TITLE     Purification and identification of secernin, a novel cytosolic
            protein that regulates exocytosis in mast cells
  JOURNAL   Mol Biol Cell 13 (9), 3344-3354 (2002)
   PUBMED   12221138
  REMARK    GeneRIF: Purified and identified bovine secernin, in addition to
            bioinformatics analysis of similar proteins in mouse, rat and
            human.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC370097.1, AB071705.1 and
            AA910381.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_014766.4.
            
            Summary: This gene likely encodes a member of the secernin family
            of proteins. A similar protein in rat functions in regulation of
            exocytosis in mast cells. Alternatively spliced transcript variants
            have been described. [provided by RefSeq, Mar 2009].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein
            (isoform a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.49661.1,
                                           SRR1803615.120058.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000242059.10/ ENSP00000242059.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               DC370097.1         9-110
            103-5089            AB071705.1         1-4987
            5090-5254           AA910381.1         29-193              c
FEATURES             Location/Qualifiers
     source          1..5254
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p14.3"
     gene            1..5254
                     /gene="SCRN1"
                     /gene_synonym="SES1"
                     /note="secernin 1"
                     /db_xref="GeneID:9805"
                     /db_xref="HGNC:HGNC:22192"
                     /db_xref="MIM:614965"
     exon            1..160
                     /gene="SCRN1"
                     /gene_synonym="SES1"
                     /inference="alignment:Splign:2.1.0"
     exon            161..320
                     /gene="SCRN1"
                     /gene_synonym="SES1"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..1406
                     /gene="SCRN1"
                     /gene_synonym="SES1"
                     /note="isoform a is encoded by transcript variant 2"
                     /codon_start=1
                     /product="secernin-1 isoform a"
                     /protein_id="NP_055581.3"
                     /db_xref="CCDS:CCDS5422.1"
                     /db_xref="GeneID:9805"
                     /db_xref="HGNC:HGNC:22192"
                     /db_xref="MIM:614965"
                     /translation="MAAAPPSYCFVAFPPRAKDGLVVFGKNSARPRDEVQEVVYFSAA
                     DHEPESKVECTYISIDQVPRTYAIMISRPAWLWGAEMGANEHGVCIANEAINTREPAA
                     EIEALLGMDLVRLGLERGETAKEALDVIVSLLEEHGQGGNYFEDANSCHSFQSAYLIV
                     DRDEAWVLETIGKYWAAEKVTEGVRCICSQLSLTTKMDAEHPELRSYAQSQGWWTGEG
                     EFNFSEVFSPVEDHLDCGAGKDSLEKQEESITVQTMMNTLRDKASGVCIDSEFFLTTA
                     SGVSVLPQNRSSPCIHYFTGTPDPSRSIFKPFIFVDDVKLVPKTQSPCFGDDDPAKKE
                     PRFQEKPDRRHELYKAHEWARAIIESDQEQGRKLRSTMLELEKQGLEAMEEILTSSEP
                     LDPAEVGDLFYDCVDTEIKFFK"
     exon            321..502
                     /gene="SCRN1"
                     /gene_synonym="SES1"
                     /inference="alignment:Splign:2.1.0"
     exon            503..705
                     /gene="SCRN1"
                     /gene_synonym="SES1"
                     /inference="alignment:Splign:2.1.0"
     exon            706..900
                     /gene="SCRN1"
                     /gene_synonym="SES1"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1066
                     /gene="SCRN1"
                     /gene_synonym="SES1"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1247
                     /gene="SCRN1"
                     /gene_synonym="SES1"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..5254
                     /gene="SCRN1"
                     /gene_synonym="SES1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5234..5239
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCRN1"
                     /gene_synonym="SES1"
                     /note="hexamer: AATAAA"
     polyA_site      5254
                     /gene="SCRN1"
                     /gene_synonym="SES1"
                     /note="major polyA site"
ORIGIN      
        1 gagtctgggt agggggaagc gcccggcggc cgcctccgcc actgcagctg cagcccccga
       61 ggtcgccgca gtaatccgga cccggcagca cccgcaccct cggcggccgc agcctcagca
      121 ccgcagagcg gagagcggag cccggagccc gccgccccag gatggctgca gctcctccaa
      181 gttactgttt tgttgccttc cctccacgtg ctaaggatgg tctggtggta tttgggaaaa
      241 attcagcccg gcccagagat gaagtgcaag aggttgtgta tttctcggct gctgatcacg
      301 aaccggagag caaggttgag tgcacttaca tttcaatcga ccaagttcca aggacctatg
      361 ccataatgat aagcagaccc gcctggctct ggggagcaga aatgggagcc aatgaacatg
      421 gagtgtgcat agccaatgaa gccatcaaca ccagagagcc agctgccgag atagaagcct
      481 tgctggggat ggatctggtc aggcttggtt tagaaagagg ggaaacagct aaagaagcct
      541 tagatgtcat tgtctccttg ttggaagaac atggacaagg tgggaattac tttgaagatg
      601 caaactcctg ccacagcttc caaagtgcat atctgattgt ggatcgtgat gaagcctggg
      661 tgctcgagac catagggaag tactgggctg ccgagaaagt cacagaggga gtgaggtgca
      721 tttgcagtca gctttcgctc accactaaga tggatgcaga gcatccggaa ctcaggagtt
      781 acgctcagag ccaaggttgg tggacgggag agggcgagtt caatttttcc gaagtctttt
      841 ctccagttga ggatcatcta gactgcggtg ctggcaaaga cagcttagaa aaacaagaag
      901 aaagcatcac agtgcagact atgatgaaca ccttacggga caaagccagc ggagtgtgca
      961 tagactctga gtttttcctc accacagcca gtggagtgtc tgtcctgccg cagaatagaa
     1021 gctctccgtg cattcactac ttcactggaa cccctgatcc ttccaggtcc atattcaagc
     1081 ctttcatctt tgttgatgac gtaaaacttg tccccaaaac acagtctccc tgttttgggg
     1141 atgacgaccc tgccaaaaag gagcctcggt tccaggagaa accagaccgc cggcatgagc
     1201 tgtacaaagc ccacgagtgg gcacgtgcca tcatcgaaag tgaccaggag caaggtcgca
     1261 agctgaggag caccatgctg gagctggaga agcaaggcct ggaagccatg gaagaaatcc
     1321 tgaccagctc cgagccactg gaccctgcgg aagtggggga ccttttctat gactgtgttg
     1381 acacggagat taagttcttt aagtgaagta agcgttccct ttccccttct tatttaagac
     1441 ttcccacctt actaaattac cagcaaaaca aaccactctc ctgtttgagt aaaatgagaa
     1501 agttaatatg tggcctcctt ttctgaagcc agatcaaact gttaccttgt gttccacctt
     1561 gaatctcaca gcgtcccctt ctgcaatgta ggtctccttc ctgtgcagtg taacatgtat
     1621 cccgttgcct gttgttcggt tgtgtgacta attgtggatt ttaagctgct attattgtat
     1681 ttcagtggca atggacacat tagcctttta caagaggact agagttcatc aagccttgaa
     1741 aggcaggctt cacagtgccg agttggcggg aaaagcaaat tcttttgaag tcttagtctt
     1801 tccctcagta gcggtttctt tcaggttaac aagaggcatt tgtgcacaca cacagggctc
     1861 ttgtgtgtgt tgtcaagggg accctccgtg gcctcccgtg agtgcatgcc tgtagtgcac
     1921 agtgtctcta caggtgtctt ctggggggca gaaccaattg gaaggaagaa agggacccct
     1981 ctccagtcct ggctccttcc tacatcctgg gctcctgaag aagctgtctt cccattttcc
     2041 atgcgctgtg cttatgtgtg gtggactgca gagctgcttc cacttacagg agagctgata
     2101 atttgttagc tggaacctat tcacttccga gattcagaca tagccatgct ggtggccttc
     2161 tgaatcactg catggatgtc ccaggaggca gctctcccca cacagcagca cagccatcac
     2221 aggattcctt gtgtagaaat gattcccagt ctagttacca acagctagtc taggagtaat
     2281 tgaatggccc tatggcacag ttccacccac agagtagtga atctctcagc caaggaggga
     2341 aagaaaagga agaactcttg actatttaga ttctagttaa atatctggaa tcctagcagt
     2401 cactacatta tctcagcaga gagactttaa ttaaactgat ttgtttccaa tgtcgggttc
     2461 acttaaagga tttgacttac caccagagca tagaaaagca tgcaaggaag accagatggg
     2521 cttagcattg ggaagacaga gggcaaggag gtgatagatg gatatagaag catttctctg
     2581 caggatacca gttcaggccc caccattcct gccaaggcca ttacatccca caaacccaaa
     2641 tacaaagcag ctgacttccc tggatcttcc ccccactcct cacacctcac atgtcccagg
     2701 agctgccttc attcaggcgg gtagctgcac tgggcatggg gtggtggtgg gagcttaccg
     2761 ccacctattc aagctctcag ctactcctga aacgggcaga gatgatgaac agaagtgtat
     2821 gtaaatacag cagctagtgg gagagcacca gttgggccta atcctgcctc atcattcttg
     2881 gcaggaatct gcaaatggaa acattgtgag tatcagcaat ctgggaagtg acagggttaa
     2941 taactccttc ccagaagctg tatcatgaga ttttgagggg accgagccct gttacatgga
     3001 tgtgaacagt gaggatcaga ggttttatca gaacacattc tttttttcta ccaactctcc
     3061 agagcgtgag tataggagtg ccatgagctt tttagtcagc agttttgtaa actctgtata
     3121 taaaatcatt aaccacacat tgtgggtgat gggaagacga tttcagctga cagagttaat
     3181 ggcaaccaat aatggtggcc tgtagctgct aagagcttca cgcaggtttg gcctgggctt
     3241 tcactgttgg tgaatttaga gtgtcctttt aggtggggcg gctattctaa aagtgtcttt
     3301 ctatcactgt taaggggggg ggaaagtgag gttcgaggat gacgtaggta actctcccct
     3361 cccaagtcca tgttccaagt ggctatgtaa agcaagatga tacagaaagc tgctctaaaa
     3421 tctcactgag tgatttcacc ttcgcctact atgaaatgtc tcatcagacc tgacatgtct
     3481 gagataacca aggtgattca ggatttgatc aaaagaagtc tagtaagaat taattacaca
     3541 gaagcctcct ttcatttcta tgggccaaac aaaggccatg gataacccta cccgctttat
     3601 gtcattaccc attgggaaac acaatggcta cttctgttag ggtacattga ccttggtcaa
     3661 gcatcttaaa gaaggcaacc ctaattgaga gctgtcttgg ctaatactct gcaccacaat
     3721 tgtgatgtcc tagtcctacc actagagggc atggtacagc ctggcaaaag ttaaaagggg
     3781 tgtggcagct cccatcaggt ctggaggtgg tctataagca cagttgacag ttgtgcattg
     3841 ggatgggtgg agaaagacga caagagagca gagaatctgc tgatgtggct gcgcttactt
     3901 ttagtgactt tatgtactta tattaacagc tggaaatagg ttgttgggtt ttgagcaggc
     3961 tgttatagtg aggaatgttc atttttaaat gttcctaaca gattttgctt ttgaaaaatg
     4021 cttgttacat gaataatttg tggaccaggg attgcttttc tgaaggcagt atagggaaca
     4081 tgaatattca agatgaaata caaaaattat gtttaagggt catagtgtat aagtagcttc
     4141 ctaggaaacc ctttgtgtat cttttcagac tggggtgggg gctgagcatg cttgtgcaga
     4201 aagaagccat agccagaaag gacagaatct ctcccccact cccttgcccc ataaccaaac
     4261 ataagctagc tagtcttgtc taatagatgg gatttactat aggtgaagat agccctcata
     4321 ttcaaggaca gaagctctgg caggagtaaa ttagcaaagc agaaatagta ccctttcatt
     4381 cttggaggtg ctttgaaatt ttaggtagaa tataatcgaa attatggagg ttccttagtg
     4441 ctcaataata taagacctgg tgttattaga acgagtcttt cttataaact aacagagcag
     4501 gtatatgcct gttagacctt agctgtgggg ttcctttact attgggtgaa tcattaggta
     4561 taaaaaataa tcatcaacca ggcaaattac tttgcttcct agctgatgtc atcccacatt
     4621 ggtacaggtg ttattcagta ctgggtggtt cagcagggaa gccgggtggg accagtgtgt
     4681 ctgtcatgaa accactaact gcattcctga ctgaagagcc atctgtcatt tattggggaa
     4741 ggtcttcagt tgagctctca gccttaggaa ggaagcacgt ggaggaggga cggaggaggt
     4801 tcccttgctg ggcatgcttc gtagagggcc aggagcagca ggtcatgtgc acatgccgtt
     4861 gcagcacaag cttatgcttc ccgtagccgt ggcttttcat tctgcacagt cccaggtccc
     4921 agctcccctc ttatggtttc tgtcataatg tgctttatct gattgactcc aaacatcccg
     4981 aaatgtcacc tgcagatttc tcgtgggaac caatatgtac atgtttgcaa ttatgctgtg
     5041 agaatttaaa tgtgttagat ggaaaatgct attggcaggg aataataata aaaaaaaaag
     5101 aaaatcattc tgtttcctgc agtgggaact ggccatgtag tcttaacagt cttttgtaca
     5161 aatatctaca aagcagataa tatccctatc cagtgcttgc ccttggaatt gtctctaaat
     5221 gcatcaagca tacaataaaa aaaactgaaa ttaa
//
