LOCUS       NM_007281               4000 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens stimulator of chondrogenesis 1 (SCRG1), transcript
            variant 2, mRNA.
ACCESSION   NM_007281
VERSION     NM_007281.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4000)
  AUTHORS   Yuan,R., Xin,Q., Ma,X., Yu,M., Miao,Y., Chen,K. and Cong,W.
  TITLE     Identification of a Novel Angiogenesis Signalling
            circSCRG1/miR-1268b/NR4A1 Pathway in Atherosclerosis and the
            Regulatory Effects of TMP-PF In Vitro
  JOURNAL   Molecules 28 (3), 1271 (2023)
   PUBMED   36770940
  REMARK    GeneRIF: Identification of a Novel Angiogenesis Signalling
            circSCRG1/miR-1268b/NR4A1 Pathway in Atherosclerosis and the
            Regulatory Effects of TMP-PF In Vitro.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4000)
  AUTHORS   Liu,G., He,G., Zhang,J., Zhang,Z. and Wang,L.
  TITLE     Identification of SCRG1 as a Potential Therapeutic Target for Human
            Synovial Inflammation
  JOURNAL   Front Immunol 13, 893301 (2022)
   PUBMED   35720295
  REMARK    GeneRIF: Identification of SCRG1 as a Potential Therapeutic Target
            for Human Synovial Inflammation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4000)
  AUTHORS   Cohen,A.S.A., Simotas,C., Webb,B.D., Shi,H., Khan,W.A.,
            Edelmann,L., Scott,S.A. and Singh,R.
  TITLE     Haploinsufficiency of the basic helix-loop-helix transcription
            factor HAND2 causes congenital heart defects
  JOURNAL   Am J Med Genet A 182 (5), 1263-1267 (2020)
   PUBMED   32134193
  REMARK    GeneRIF: Haploinsufficiency of the basic helix-loop-helix
            transcription factor HAND2 causes congenital heart defects.
REFERENCE   4  (bases 1 to 4000)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4000)
  AUTHORS   Wu,J.C., Luo,S.Z., Liu,T., Lu,L.G. and Xu,M.Y.
  TITLE     linc-SCRG1 accelerates liver fibrosis by decreasing RNA-binding
            protein tristetraprolin
  JOURNAL   FASEB J 33 (2), 2105-2115 (2019)
   PUBMED   30226813
  REMARK    GeneRIF: High lncRNA in SCRG1 gene expression is associated with
            liver fibrosis.
REFERENCE   6  (bases 1 to 4000)
  AUTHORS   Aomatsu,E., Takahashi,N., Sawada,S., Okubo,N., Hasegawa,T.,
            Taira,M., Miura,H., Ishisaki,A. and Chosa,N.
  TITLE     Novel SCRG1/BST1 axis regulates self-renewal, migration, and
            osteogenic differentiation potential in mesenchymal stem cells
  JOURNAL   Sci Rep 4, 3652 (2014)
   PUBMED   24413464
  REMARK    GeneRIF: Novel SCRG1/BST1 axis regulates self-renewal, migration,
            and osteogenic differentiation potential in mesenchymal stem cells.
            GeneRIF: Aomatsu et al. identified a novel SCRG1/BST1 (CD157)
            ligand-receptor combination that maintains human mesenchymal stem
            cells expressions of stem cell markers Oct-4 and CD271 (LNGFR), as
            well as self-renewal, migration, and osteogenic differentiation
            potentials during ex vivo expansion.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4000)
  AUTHORS   Ochi,K., Derfoul,A. and Tuan,R.S.
  TITLE     A predominantly articular cartilage-associated gene, SCRG1, is
            induced by glucocorticoid and stimulates chondrogenesis in vitro
  JOURNAL   Osteoarthritis Cartilage 14 (1), 30-38 (2006)
   PUBMED   16188469
REFERENCE   8  (bases 1 to 4000)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   9  (bases 1 to 4000)
  AUTHORS   Dron,M., Dandoy-Dron,F., Guillo,F., Benboudjema,L., Hauw,J.J.,
            Lebon,P., Dormont,D. and Tovey,M.G.
  TITLE     Characterization of the human analogue of a Scrapie-responsive gene
  JOURNAL   J Biol Chem 273 (29), 18015-18018 (1998)
   PUBMED   9660755
REFERENCE   10 (bases 1 to 4000)
  AUTHORS   Dandoy-Dron,F., Guillo,F., Benboudjema,L., Deslys,J.P.,
            Lasmezas,C., Dormont,D., Tovey,M.G. and Dron,M.
  TITLE     Gene expression in scrapie. Cloning of a new scrapie-responsive
            gene and the identification of increased levels of seven other mRNA
            transcripts
  JOURNAL   J Biol Chem 273 (13), 7691-7697 (1998)
   PUBMED   9516475
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AJ224677.1 and AC097534.3.
            
            On Nov 22, 2018 this sequence version replaced NM_007281.3.
            
            Summary: Scrapie-responsive gene 1 is associated with
            neurodegenerative changes observed in transmissible spongiform
            encephalopathies. It may play a role in host response to
            prion-associated infections. The scrapie responsive protein 1 may
            be partly included in the membrane or secreted by the cells due to
            its hydrophobic N-terminus. In addition, the encoded protein can
            interact with bone marrow stromal cell antigen 1 (BST1) to enhance
            the differentiation potentials of human mesenchymal stem cells
            during tissue and bone regeneration. [provided by RefSeq, Jul
            2016].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP369081.1, SRR1660807.169193.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874, SAMEA2158188
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296506.8/ ENSP00000296506.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-553               AJ224677.1         351-903
            554-4000            AC097534.3         130678-134124       c
FEATURES             Location/Qualifiers
     source          1..4000
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q34.1"
     gene            1..4000
                     /gene="SCRG1"
                     /gene_synonym="lincSCRG1; SCRG-1"
                     /note="stimulator of chondrogenesis 1"
                     /db_xref="GeneID:11341"
                     /db_xref="HGNC:HGNC:17036"
                     /db_xref="MIM:603163"
     exon            1..49
                     /gene="SCRG1"
                     /gene_synonym="lincSCRG1; SCRG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            50..305
                     /gene="SCRG1"
                     /gene_synonym="lincSCRG1; SCRG-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..360
                     /gene="SCRG1"
                     /gene_synonym="lincSCRG1; SCRG-1"
                     /note="scrapie responsive gene 1; scrapie-responsive
                     protein 1; scrapie-responsive gene 1 protein"
                     /codon_start=1
                     /product="scrapie-responsive protein 1 precursor"
                     /protein_id="NP_009212.1"
                     /db_xref="CCDS:CCDS3818.1"
                     /db_xref="GeneID:11341"
                     /db_xref="HGNC:HGNC:17036"
                     /db_xref="MIM:603163"
                     /translation="MKLMVLVFTIGLTLLLGVQAMPANRLSCYRKILKDHNCHNLPEG
                     VADLTQIDVNVQDHFWDGKGCEMICYCNFSELLCCPKDVFFGPKISFVIPCNNQ"
     exon            306..4000
                     /gene="SCRG1"
                     /gene_synonym="lincSCRG1; SCRG-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      518..523
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCRG1"
                     /gene_synonym="lincSCRG1; SCRG-1"
                     /note="hexamer: AATAAA"
     polyA_site      539
                     /gene="SCRG1"
                     /gene_synonym="lincSCRG1; SCRG-1"
                     /note="major polyA site"
     regulatory      1837..1842
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCRG1"
                     /gene_synonym="lincSCRG1; SCRG-1"
                     /note="hexamer: AATAAA"
     polyA_site      1862
                     /gene="SCRG1"
                     /gene_synonym="lincSCRG1; SCRG-1"
     regulatory      3973..3978
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCRG1"
                     /gene_synonym="lincSCRG1; SCRG-1"
                     /note="hexamer: ATTAAA"
     polyA_site      4000
                     /gene="SCRG1"
                     /gene_synonym="lincSCRG1; SCRG-1"
ORIGIN      
        1 agcatttaag aagcatcctc tgccaagacc aaaaggaaag aagaaaaagg gccaaaagcc
       61 aaaatgaaac tgatggtact tgttttcacc attgggctaa ctttgctgct aggagttcaa
      121 gccatgcctg caaatcgcct ctcttgctac agaaagatac taaaagatca caactgtcac
      181 aaccttccgg aaggagtagc tgacctgaca cagattgatg tcaatgtcca ggatcatttc
      241 tgggatggga agggatgtga gatgatctgt tactgcaact tcagcgaatt gctctgctgc
      301 ccaaaagacg ttttctttgg accaaagatc tctttcgtga ttccttgcaa caatcaatga
      361 gaatcttcat gtattctgga gaacaccatt cctgatttcc cacaaactgc actacatcag
      421 tataactgca tttctagttt ctatatagtg caatagagca tagattctat aaattcttac
      481 ttgtctaaga caagtaaatc tgtgttaaac aagtagtaat aaaagttaat tcaatctaat
      541 ttttctctgt ggacattgtt ggcattggtt aaaaattttg cctagaaaat gtaatctatg
      601 aggtgttcat tatactcagt taaagagttc tgtcccccag atgaagagcc ataggcatgg
      661 ctcaaggatt gaaaatactt tcagtcctta gttgacagtt attaaccaca tattgaaaga
      721 accaggtata agctgagatt cttggaaggg agctagaaat tttctagtaa gaaggaaaaa
      781 gggaccagcc tgggcaacat agtgagaccc cctctttaca aaaaaattaa aaaattagca
      841 ggttgtgggt gcccacatct gtagttctag ttactcaaga gggtcatttg aatctagaat
      901 ttcgagtctg cagtgagcta tgattgcact actgcactct agcctgggtg acagagcaag
      961 accctgtctc gaaaaaaaaa aaaaaaaaaa aaaaaggaaa agggaacaat atttgagggt
     1021 atattatgta tgctaataac tttaagtaca tttcaggctg ggactggtga ctaatgcctg
     1081 taatcctagc attttgggag gccaaggcgg gaagatcact tgagtccagg agtttgagac
     1141 cagcctgggc aacatagtga gatcctgtct ttacaaaaaa aatttaaaaa ttagctgcat
     1201 ggcggcatgc acctgtagtc ccagctattt gggaggctga ggtaggagga tcactcgagc
     1261 ccagaaattc aaggctgcag tgagctaaga tgatgccact gaactccacc atggaaccac
     1321 agagtgagac tctgtctcaa acaaacaaac aaaaaccaag aactttaagc acatttcatt
     1381 ttactctctt aaaaaacaac aacaaaagcc ttcaaggtaa atattctcag ccccattttt
     1441 cagctgctaa ctcaagttta agatatttgc taaaaatcaa ggcagatttt caagagttcc
     1501 aattccaaag cccatatgcc acacacagat gtatccttaa aaccatgata catttcctaa
     1561 agtatccatt tttaagaata acaaaacaca cattaaaaga aacataatgg atgagaattt
     1621 aaaagtatca tacattttaa aagtaaataa aacagggaac ttcaaaggta ttttctgatt
     1681 gttagaggag acagctttgg attatgcccc ataacttaag aggtatgtga ctcatattgc
     1741 catcagaggt aatgtcagaa agtctttcat gttataaaaa tgtattcaaa gcctgctaag
     1801 tgccagccat tattaagatc tgggcataca gtaatgaata aaatggactt atcttcttgg
     1861 aacttgtgct ctaacaaagg tgtgattgct ataaacaagt aattatttat aaatgtgaag
     1921 cctgctacag agaagtatag ggtgccatac aaagtattgt ggggaaatgt ttgagagaca
     1981 ccataccaca caggcaatct gggagatatc attttatgaa taaaagtgac attatttcat
     2041 taaaatatat ccttggaggt ccctgatctg tttctggaga ccacacccag aacagtatct
     2101 ggtatctaat ctgtgtttag taagtgttac tgggctgaaa gaccacaccc aaaacagtgt
     2161 ctggtatcta atctgtgtaa ataagtgtta ctgggctgga ccaaacaatt ttgaggtagt
     2221 cacaattcag tgtcttaaag tgtatataaa cacggctggg tgcggtggct cacgcctgta
     2281 atcccagcac tttgggaggc ggaggcgggc ttatcacgag gtcaggagat caagaccatc
     2341 ctggctaata cggtgaaacc tcgtctctac taaaaataca aaaaaaaaaa aaaaaaaaat
     2401 tagctgggcg tggtggcagg cgcctctagt cccagctatt tgggaggctg aggcaggaga
     2461 atggcgtgaa cccaggaggt ggagcttgca gtgagctgag atcgtgccac tgcactccag
     2521 cctgggcgac agagtgagac tccgtccccc caaaaaaaaa gtgtatataa acacaagtca
     2581 gaacatgttt tcgaacagtg taagctccta taaaatacat gaagtgaaat tgtaaaataa
     2641 tatagatagg taggtagatg gataatatta gttgttttat caagatagca tgtgatttga
     2701 ttggcctttc tttcttcact gaattgactg gtaatgaaat cagcctaact caataatgaa
     2761 agtttcatat ccattctgga acaatgcata gaataggtaa atttaaaaaa actatcagca
     2821 aaccagtttt attttctact tggtaggaac tctccttgag ggggaaaaag cattaaagat
     2881 ccagtgtctc catttacaaa tgacacatca gcataaggac atatgtgaga caacaacggc
     2941 tttttagtaa acgttccctt actactgcaa tcaaagcctg gtaagaaaaa ttgtatctaa
     3001 caaagctaaa tatttaataa ataaaatttt ataaattatt catcataatg tctttctgaa
     3061 aatatgaaat tcagttattt cttttagaaa tgaatgcatt atacaagtac acagccttct
     3121 ttatattaca aaataaatgt aaaaacatac attcacacaa cttaccttat ataactattt
     3181 ctctaacttg gtcaatgcat ttttaaaaac aatagatttt tttttttttt tgaaactgag
     3241 tctcactctg tcacccaggc cagagtacag tggcacaatc ttgactcact gcaacctctg
     3301 cctcccaggt tcaagtgata cttgtgcttc aacctcctga gtagctggga ctacaggcac
     3361 ttgtcaccat gctcagctaa tttttgtatt ttttagtaga aatgaggttt tgccatgttg
     3421 gacaggctgg tctccaactc ctggcctcaa atgatctgcc tgccttggcc tcccaaagtg
     3481 ttaggattac aggcatgagt ttttccaata gattttagtt ataagacaac taagctttta
     3541 ttaaaatttt attattcttc taaacaccat cttgcagcaa ctgaatgaga taggtactga
     3601 tattatcctt gttctatgga caaaaaagct aaggtttaaa gatattaagt agtttgtcta
     3661 agtttacatt atcagtgagc aattgagcca gattttgaat atggccagtc ttacactagc
     3721 atctagagtc ttaaccacta tgttgtttaa cagcattacc taatgcatta tttcctttac
     3781 agaaaggcaa acttttacat ggataggaca cacaattgta catttcagat agctcatata
     3841 tgctaaaagc ttactgaaca agtatttctg tattgttatc tttgactttc tatatcattg
     3901 ttcttactgt gaatcccacg ttactgagca caaagttgac agtaatacat attaatagct
     3961 cacctctttt taattaaaat tcatcttttc ttcatcgtaa
//
