LOCUS       NM_001405228             552 bp    mRNA    linear   PRI 27-MAY-2024
DEFINITION  Homo sapiens secretory calcium-binding phosphoprotein
            proline-glutamine rich 1 (SCPPPQ1), mRNA.
ACCESSION   NM_001405228
VERSION     NM_001405228.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 552)
  AUTHORS   Moffatt,P., Wazen,R.M., Dos Santos Neves,J. and Nanci,A.
  TITLE     Characterisation of secretory calcium-binding
            phosphoprotein-proline-glutamine-rich 1: a novel basal lamina
            component expressed at cell-tooth interfaces
  JOURNAL   Cell Tissue Res 358 (3), 843-855 (2014)
   PUBMED   25193156
REFERENCE   2  (bases 1 to 552)
  AUTHORS   Kawasaki,K.
  TITLE     The SCPP gene repertoire in bony vertebrates and graded differences
            in mineralized tissues
  JOURNAL   Dev Genes Evol 219 (3), 147-157 (2009)
   PUBMED   19255778
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC112250.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: MK322956.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1968189,
                                           SAMEA1968540 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000715253.1/ ENSP00000520428.1
            NMD candidate          :: translation inferred
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AC112250.4         62825-62858         c
            35-64               AC112250.4         62436-62465         c
            65-135              AC112250.4         61400-61470         c
            136-168             AC112250.4         59787-59819         c
            169-246             AC112250.4         59617-59694         c
            247-273             AC112250.4         55985-56011         c
            274-303             AC112250.4         55222-55251         c
            304-332             AC112250.4         55072-55100         c
            333-370             AC112250.4         53775-53812         c
            371-552             AC112250.4         52610-52791         c
FEATURES             Location/Qualifiers
     source          1..552
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q22.1"
     gene            1..552
                     /gene="SCPPPQ1"
                     /note="secretory calcium-binding phosphoprotein
                     proline-glutamine rich 1"
                     /db_xref="GeneID:105377321"
                     /db_xref="HGNC:HGNC:56851"
     exon            1..34
                     /gene="SCPPPQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            35..64
                     /gene="SCPPPQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            65..135
                     /gene="SCPPPQ1"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..318
                     /gene="SCPPPQ1"
                     /codon_start=1
                     /product="secretory calcium-binding phosphoprotein
                     proline-glutamine rich 1 precursor"
                     /protein_id="NP_001392157.1"
                     /db_xref="GeneID:105377321"
                     /db_xref="HGNC:HGNC:56851"
                     /translation="MKFLILAGLLSTATALPIPLEQYAESSSEQRFIFYPPQVPPFFP
                     QVLFPLPPQPPLVLTPNDLIALLIAILNQLGILFP"
     exon            136..168
                     /gene="SCPPPQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            169..246
                     /gene="SCPPPQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            247..273
                     /gene="SCPPPQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            274..303
                     /gene="SCPPPQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            304..332
                     /gene="SCPPPQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            333..370
                     /gene="SCPPPQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            371..552
                     /gene="SCPPPQ1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      530..535
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCPPPQ1"
                     /note="hexamer: AATAAA"
     polyA_site      552
                     /gene="SCPPPQ1"
                     /note="major polyA site"
ORIGIN      
        1 tgaatttgtt gctccaaggg ccactgaagc aaagaataca gtgatttggt ttgaaactca
       61 caaggctcga cctttagaat gaaatttctc atcttggctg gccttttgag cactgccact
      121 gctctgccca tccccctcga acaatatgct gaaagttcca gtgaacagag atttatcttt
      181 tacccaccac aagtaccacc atttttccct caggtcctct ttcccctacc tccgcaaccg
      241 cccctggtcc tcacacctaa tgatcttatc gcgttactca ttgctatttt gaaccaacta
      301 gggattttat ttccatgact aaattgataa agaaataatt ctcccactac tatgccagaa
      361 gttacgtatg atggtgctgg atatttacag ttatcagaag agtatctact tctatcttaa
      421 ctatagttga tggtagtttt ataattttgc atactttgtg catgttccag tgaaaactcc
      481 aaaaaaccat aaagaatgta tctagaccat gggctttagt catactttaa ataaaccttt
      541 aatataacca aa
//
