LOCUS       NM_021626               1921 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens serine carboxypeptidase 1 (SCPEP1), mRNA.
ACCESSION   NM_021626
VERSION     NM_021626.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1921)
  AUTHORS   Schreuder,H.A., Liesum,A., Kroll,K., Bohnisch,B., Buning,C., Ruf,S.
            and Sadowski,T.
  TITLE     Crystal structure of cathepsin A, a novel target for the treatment
            of cardiovascular diseases
  JOURNAL   Biochem Biophys Res Commun 445 (2), 451-456 (2014)
   PUBMED   24530914
  REMARK    GeneRIF: The structures of active lysosomal serine carboxypeptidase
            cathepsin A and the inactive precursor are very similar.
REFERENCE   2  (bases 1 to 1921)
  AUTHORS   Otsuka,M., Takata,A., Yoshikawa,T., Kojima,K., Kishikawa,T.,
            Shibata,C., Takekawa,M., Yoshida,H., Omata,M. and Koike,K.
  TITLE     Receptor for activated protein kinase C: requirement for efficient
            microRNA function and reduced expression in hepatocellular
            carcinoma
  JOURNAL   PLoS One 6 (9), e24359 (2011)
   PUBMED   21935400
  REMARK    GeneRIF: RACK1 binds to KH-type splicing regulatory protein (KSRP),
            a member of the Dicer complex, and is required for the recruitment
            of mature miRNAs to the RNA-induced silencing complex (RISC).
REFERENCE   3  (bases 1 to 1921)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   4  (bases 1 to 1921)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 1921)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   6  (bases 1 to 1921)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   7  (bases 1 to 1921)
  AUTHORS   Zhang,H., Li,X.J., Martin,D.B. and Aebersold,R.
  TITLE     Identification and quantification of N-linked glycoproteins using
            hydrazide chemistry, stable isotope labeling and mass spectrometry
  JOURNAL   Nat Biotechnol 21 (6), 660-666 (2003)
   PUBMED   12754519
REFERENCE   8  (bases 1 to 1921)
  AUTHORS   Chen,J., Streb,J.W., Maltby,K.M., Kitchen,C.M. and Miano,J.M.
  TITLE     Cloning of a novel retinoid-inducible serine carboxypeptidase from
            vascular smooth muscle cells
  JOURNAL   J Biol Chem 276 (36), 34175-34181 (2001)
   PUBMED   11447226
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY358559.1 and AF265441.1.
            
            On Jul 25, 2019 this sequence version replaced NM_021626.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF282618.1, AF113214.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262288.8/ ENSP00000262288.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1645              AY358559.1         5-1649
            1646-1921           AF265441.1         1139-1414
FEATURES             Location/Qualifiers
     source          1..1921
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q22"
     gene            1..1921
                     /gene="SCPEP1"
                     /gene_synonym="HSCP1; RISC"
                     /note="serine carboxypeptidase 1"
                     /db_xref="GeneID:59342"
                     /db_xref="HGNC:HGNC:29507"
                     /db_xref="MIM:619723"
     exon            1..105
                     /gene="SCPEP1"
                     /gene_synonym="HSCP1; RISC"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1388
                     /gene="SCPEP1"
                     /gene_synonym="HSCP1; RISC"
                     /note="serine carboxypeptidase 1 precursor protein;
                     retinoid-inducible serine carboxypeptidase"
                     /codon_start=1
                     /product="retinoid-inducible serine carboxypeptidase
                     precursor"
                     /protein_id="NP_067639.1"
                     /db_xref="CCDS:CCDS11593.1"
                     /db_xref="GeneID:59342"
                     /db_xref="HGNC:HGNC:29507"
                     /db_xref="MIM:619723"
                     /translation="MELALRRSPVPRWLLLLPLLLGLNAGAVIDWPTEEGKEVWDYVT
                     VRKDAYMFWWLYYATNSCKNFSELPLVMWLQGGPGGSSTGFGNFEEIGPLDSDLKPRK
                     TTWLQAASLLFVDNPVGTGFSYVNGSGAYAKDLAMVASDMMVLLKTFFSCHKEFQTVP
                     FYIFSESYGGKMAAGIGLELYKAIQRGTIKCNFAGVALGDSWISPVDSVLSWGPYLYS
                     MSLLEDKGLAEVSKVAEQVLNAVNKGLYREATELWGKAEMIIEQNTDGVNFYNILTKS
                     TPTSTMESSLEFTQSHLVCLCQRHVRHLQRDALSQLMNGPIRKKLKIIPEDQSWGGQA
                     TNVFVNMEEDFMKPVISIVDELLEAGINVTVYNGQLDLIVDTMGQEAWVRKLKWPELP
                     KFSQLKWKALYSDPKSLETSAFVKSYKNLAFYWILKAGHMVPSDQGDMALKMMRLVTQ
                     QE"
     exon            106..254
                     /gene="SCPEP1"
                     /gene_synonym="HSCP1; RISC"
                     /inference="alignment:Splign:2.1.0"
     exon            255..344
                     /gene="SCPEP1"
                     /gene_synonym="HSCP1; RISC"
                     /inference="alignment:Splign:2.1.0"
     exon            345..500
                     /gene="SCPEP1"
                     /gene_synonym="HSCP1; RISC"
                     /inference="alignment:Splign:2.1.0"
     exon            501..575
                     /gene="SCPEP1"
                     /gene_synonym="HSCP1; RISC"
                     /inference="alignment:Splign:2.1.0"
     exon            576..648
                     /gene="SCPEP1"
                     /gene_synonym="HSCP1; RISC"
                     /inference="alignment:Splign:2.1.0"
     exon            649..686
                     /gene="SCPEP1"
                     /gene_synonym="HSCP1; RISC"
                     /inference="alignment:Splign:2.1.0"
     exon            687..815
                     /gene="SCPEP1"
                     /gene_synonym="HSCP1; RISC"
                     /inference="alignment:Splign:2.1.0"
     exon            816..909
                     /gene="SCPEP1"
                     /gene_synonym="HSCP1; RISC"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1023
                     /gene="SCPEP1"
                     /gene_synonym="HSCP1; RISC"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1161
                     /gene="SCPEP1"
                     /gene_synonym="HSCP1; RISC"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1325
                     /gene="SCPEP1"
                     /gene_synonym="HSCP1; RISC"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1921
                     /gene="SCPEP1"
                     /gene_synonym="HSCP1; RISC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1894..1899
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCPEP1"
                     /gene_synonym="HSCP1; RISC"
                     /note="hexamer: AATAAA"
     polyA_site      1921
                     /gene="SCPEP1"
                     /gene_synonym="HSCP1; RISC"
                     /note="major polyA site"
ORIGIN      
        1 gttgctgatg ctgccgtgcg gtacttgtca tggagctggc actgcggcgc tctcccgtcc
       61 cgcggtggtt gctgctgctg ccgctgctgc tgggcctgaa cgcaggagct gtcattgact
      121 ggcccacaga ggagggcaag gaagtatggg attatgtgac ggtccgcaag gatgcctaca
      181 tgttctggtg gctctattat gccaccaact cctgcaagaa cttctcagaa ctgcccctgg
      241 tcatgtggct tcagggcggt ccaggcggtt ctagcactgg atttggaaac tttgaggaaa
      301 ttgggcccct tgacagtgat ctcaaaccac ggaaaaccac ctggctccag gctgccagtc
      361 tcctatttgt ggataatccc gtgggcactg ggttcagtta tgtgaatggt agtggtgcct
      421 atgccaagga cctggctatg gtggcttcag acatgatggt tctcctgaag accttcttca
      481 gttgccacaa agaattccag acagttccat tctacatttt ctcagagtcc tatggaggaa
      541 aaatggcagc tggcattggt ctagagcttt ataaggccat tcagcgaggg accatcaagt
      601 gcaactttgc gggggttgcc ttgggtgatt cctggatctc ccctgttgat tcggtgctct
      661 cctggggacc ttacctgtac agcatgtctc ttctcgaaga caaaggtctg gcagaggtgt
      721 ctaaggttgc agagcaagta ctgaatgccg taaataaggg gctctacaga gaggccacag
      781 agctgtgggg gaaagcagaa atgatcattg aacagaacac agatggggtg aacttctata
      841 acatcttaac taaaagcact cccacgtcta caatggagtc gagtctagaa ttcacacaga
      901 gccacctagt ttgtctttgt cagcgccacg tgagacacct acaacgagat gccttaagcc
      961 agctcatgaa tggccccatc agaaagaagc tcaaaattat tcctgaggat caatcctggg
     1021 gaggccaggc taccaacgtc tttgtgaaca tggaggagga cttcatgaag ccagtcatta
     1081 gcattgtgga cgagttgctg gaggcaggga tcaacgtgac ggtgtataat ggacagctgg
     1141 atctcatcgt agataccatg ggtcaggagg cctgggtgcg gaaactgaag tggccagaac
     1201 tgcctaaatt cagtcagctg aagtggaagg ccctgtacag tgaccctaaa tctttggaaa
     1261 catctgcttt tgtcaagtcc tacaagaacc ttgctttcta ctggattctg aaagctggtc
     1321 atatggttcc ttctgaccaa ggggacatgg ctctgaagat gatgagactg gtgactcagc
     1381 aagaatagga tggatggggc tggagatgag ctggtttggc cttggggcac agagctgagc
     1441 tgaggccgct gaagctgtag gaagcgccat tcttccctgt atctaactgg ggctgtgatc
     1501 aagaaggttc tgaccagctt ctgcagagga taaaatcatt gtctctggag gcaatttgga
     1561 aattatttct gcttcttaaa aaaacctaag attttttaaa aaattgattt gttttgatca
     1621 aaataaagga tgataataga tattattttt tcttatgaca gaagcaaatg atgtgattta
     1681 tagaaaaact gggaaataca ggtacccaaa gagtaaatca acatctgtat acccccttcc
     1741 caggggtaag cactgttacc aatttagcat atgtccttgc agaatttttt tttctatata
     1801 tacatatata ttttttacca aaatgaatca ttactctatg ttgttttact atttgtttga
     1861 catatcagta tatctgaaac accttttcat gtcaataaat gttcttctct aacattttta
     1921 a
//
