LOCUS       NP_067639                452 aa            linear   PRI 29-APR-2025
DEFINITION  retinoid-inducible serine carboxypeptidase precursor [Homo
            sapiens].
ACCESSION   NP_067639
VERSION     NP_067639.1
DBSOURCE    REFSEQ: accession NM_021626.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 452)
  AUTHORS   Schreuder,H.A., Liesum,A., Kroll,K., Bohnisch,B., Buning,C., Ruf,S.
            and Sadowski,T.
  TITLE     Crystal structure of cathepsin A, a novel target for the treatment
            of cardiovascular diseases
  JOURNAL   Biochem Biophys Res Commun 445 (2), 451-456 (2014)
   PUBMED   24530914
  REMARK    GeneRIF: The structures of active lysosomal serine carboxypeptidase
            cathepsin A and the inactive precursor are very similar.
REFERENCE   2  (residues 1 to 452)
  AUTHORS   Otsuka,M., Takata,A., Yoshikawa,T., Kojima,K., Kishikawa,T.,
            Shibata,C., Takekawa,M., Yoshida,H., Omata,M. and Koike,K.
  TITLE     Receptor for activated protein kinase C: requirement for efficient
            microRNA function and reduced expression in hepatocellular
            carcinoma
  JOURNAL   PLoS One 6 (9), e24359 (2011)
   PUBMED   21935400
  REMARK    GeneRIF: RACK1 binds to KH-type splicing regulatory protein (KSRP),
            a member of the Dicer complex, and is required for the recruitment
            of mature miRNAs to the RNA-induced silencing complex (RISC).
REFERENCE   3  (residues 1 to 452)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   4  (residues 1 to 452)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (residues 1 to 452)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   6  (residues 1 to 452)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   7  (residues 1 to 452)
  AUTHORS   Zhang,H., Li,X.J., Martin,D.B. and Aebersold,R.
  TITLE     Identification and quantification of N-linked glycoproteins using
            hydrazide chemistry, stable isotope labeling and mass spectrometry
  JOURNAL   Nat Biotechnol 21 (6), 660-666 (2003)
   PUBMED   12754519
REFERENCE   8  (residues 1 to 452)
  AUTHORS   Chen,J., Streb,J.W., Maltby,K.M., Kitchen,C.M. and Miano,J.M.
  TITLE     Cloning of a novel retinoid-inducible serine carboxypeptidase from
            vascular smooth muscle cells
  JOURNAL   J Biol Chem 276 (36), 34175-34181 (2001)
   PUBMED   11447226
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY358559.1 and AF265441.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF282618.1, AF113214.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262288.8/ ENSP00000262288.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q22"
     Protein         1..452
                     /product="retinoid-inducible serine carboxypeptidase
                     precursor"
                     /note="serine carboxypeptidase 1 precursor protein;
                     retinoid-inducible serine carboxypeptidase"
                     /calculated_mol_wt=47936
     sig_peptide     1..26
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2913
     mat_peptide     27..452
                     /product="Retinoid-inducible serine carboxypeptidase.
                     /id=PRO_0000004284"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9HB40.1)"
                     /calculated_mol_wt=47936
     Region          37..446
                     /region_name="Peptidase_S10"
                     /note="Serine carboxypeptidase; pfam00450"
                     /db_xref="CDD:459815"
     Site            64
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9HB40.1)"
     Site            126
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:12754519; propagated from
                     UniProtKB/Swiss-Prot (Q9HB40.1)"
     Site            362
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9HB40.1)"
     CDS             1..452
                     /gene="SCPEP1"
                     /gene_synonym="HSCP1; RISC"
                     /coded_by="NM_021626.3:30..1388"
                     /db_xref="CCDS:CCDS11593.1"
                     /db_xref="GeneID:59342"
                     /db_xref="HGNC:HGNC:29507"
                     /db_xref="MIM:619723"
ORIGIN      
        1 melalrrspv prwllllpll lglnagavid wpteegkevw dyvtvrkday mfwwlyyatn
       61 scknfselpl vmwlqggpgg sstgfgnfee igpldsdlkp rkttwlqaas llfvdnpvgt
      121 gfsyvngsga yakdlamvas dmmvllktff schkefqtvp fyifsesygg kmaagiglel
      181 ykaiqrgtik cnfagvalgd swispvdsvl swgpylysms lledkglaev skvaeqvlna
      241 vnkglyreat elwgkaemii eqntdgvnfy niltkstpts tmessleftq shlvclcqrh
      301 vrhlqrdals qlmngpirkk lkiipedqsw ggqatnvfvn meedfmkpvi sivdelleag
      361 invtvyngql dlivdtmgqe awvrklkwpe lpkfsqlkwk alysdpksle tsafvksykn
      421 lafywilkag hmvpsdqgdm alkmmrlvtq qe
//
