LOCUS       NM_002979               2759 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens sterol carrier protein 2 (SCP2), transcript variant 1,
            mRNA.
ACCESSION   NM_002979
VERSION     NM_002979.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2759)
  AUTHORS   Zou,J., Pei,X., Xing,D., Wu,X. and Chen,S.
  TITLE     LINC00261 elevation inhibits angiogenesis and cell cycle
            progression of pancreatic cancer cells by upregulating SCP2 via
            targeting FOXP3
  JOURNAL   J Cell Mol Med 25 (20), 9826-9836 (2021)
   PUBMED   34541823
  REMARK    GeneRIF: LINC00261 elevation inhibits angiogenesis and cell cycle
            progression of pancreatic cancer cells by upregulating SCP2 via
            targeting FOXP3.
REFERENCE   2  (bases 1 to 2759)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2759)
  AUTHORS   Bai,L., Li,J., Panagal,M., M,B. and Sekar,D.
  TITLE     Methylation dependent microRNA 1285-5p and sterol carrier proteins
            2 in type 2 diabetes mellitus
  JOURNAL   Artif Cells Nanomed Biotechnol 47 (1), 3417-3422 (2019)
   PUBMED   31407919
  REMARK    GeneRIF: Methylation dependent microRNA 1285-5p and sterol carrier
            proteins 2 in type 2 diabetes mellitus
REFERENCE   4  (bases 1 to 2759)
  AUTHORS   Dansen,T.B., Kops,G.J., Denis,S., Jelluma,N., Wanders,R.J.,
            Bos,J.L., Burgering,B.M. and Wirtz,K.W.
  TITLE     Regulation of sterol carrier protein gene expression by the
            forkhead transcription factor FOXO3a
  JOURNAL   J Lipid Res 45 (1), 81-88 (2004)
   PUBMED   14563822
  REMARK    GeneRIF: SCP2 in the cellular defense against oxidative damage and
            found that a fluorescent fatty acid analog bound to SCP2 is
            protected against H2O2/Cu2+-induced oxidative damage
REFERENCE   5  (bases 1 to 2759)
  AUTHORS   Ohba,T., Holt,J.A., Billheimer,J.T. and Strauss,J.F. 3rd.
  TITLE     Human sterol carrier protein x/sterol carrier protein 2 gene has
            two promoters
  JOURNAL   Biochemistry 34 (33), 10660-10668 (1995)
   PUBMED   7654720
REFERENCE   6  (bases 1 to 2759)
  AUTHORS   Ohba,T., Rennert,H., Pfeifer,S.M., He,Z., Yamamoto,R., Holt,J.A.,
            Billheimer,J.T. and Strauss,J.F. 3rd.
  TITLE     The structure of the human sterol carrier protein X/sterol carrier
            protein 2 gene (SCP2)
  JOURNAL   Genomics 24 (2), 370-374 (1994)
   PUBMED   7698762
REFERENCE   7  (bases 1 to 2759)
  AUTHORS   Seedorf,U., Brysch,P., Engel,T., Schrage,K. and Assmann,G.
  TITLE     Sterol carrier protein X is peroxisomal 3-oxoacyl coenzyme A
            thiolase with intrinsic sterol carrier and lipid transfer activity
  JOURNAL   J Biol Chem 269 (33), 21277-21283 (1994)
   PUBMED   8063752
REFERENCE   8  (bases 1 to 2759)
  AUTHORS   Vanderver,A., Tonduti,D., Schiffmann,R., Schmidt,J. and van der
            Knaap,M.S.
  TITLE     Leukodystrophy Overview - RETIRED CHAPTER, FOR HISTORICAL REFERENCE
            ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   24501781
REFERENCE   9  (bases 1 to 2759)
  AUTHORS   Heikoop,J.C., Ossendorp,B.C., Wanders,R.J., Wirtz,K.W. and
            Tager,J.M.
  TITLE     Subcellular localisation and processing of non-specific lipid
            transfer protein are not aberrant in Rhizomelic Chondrodysplasia
            Punctata fibroblasts
  JOURNAL   FEBS Lett 299 (2), 201-204 (1992)
   PUBMED   1347505
REFERENCE   10 (bases 1 to 2759)
  AUTHORS   Yamamoto,R., Kallen,C.B., Babalola,G.O., Rennert,H.,
            Billheimer,J.T. and Strauss,J.F. 3rd.
  TITLE     Cloning and expression of a cDNA encoding human sterol carrier
            protein 2
  JOURNAL   Proc Natl Acad Sci U S A 88 (2), 463-467 (1991)
   PUBMED   1703300
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC330171.1, AK312856.1,
            AL445183.19, AB208789.1 and AA664009.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002979.4.
            
            Summary: This gene encodes two proteins: sterol carrier protein X
            (SCPx) and sterol carrier protein 2 (SCP2), as a result of
            transcription initiation from 2 independently regulated promoters.
            The transcript initiated from the proximal promoter encodes the
            longer SCPx protein, and the transcript initiated from the distal
            promoter encodes the shorter SCP2 protein, with the 2 proteins
            sharing a common C-terminus. Evidence suggests that the SCPx
            protein is a peroxisome-associated thiolase that is involved in the
            oxidation of branched chain fatty acids, while the SCP2 protein is
            thought to be an intracellular lipid transfer protein. This gene is
            highly expressed in organs involved in lipid metabolism, and may
            play a role in Zellweger syndrome, in which cells are deficient in
            peroxisomes and have impaired bile acid synthesis. Alternative
            splicing of this gene produces multiple transcript variants, some
            encoding different isoforms.[provided by RefSeq, Aug 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1, also known as SCPx).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.18490.1,
                                           SRR3476690.1001248.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371514.8/ ENSP00000360569.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-542               DC330171.1         32-573
            543-788             AK312856.1         541-786
            789-789             AL445183.19        23377-23377
            790-1765            AK312856.1         788-1763
            1766-2462           AB208789.1         4508-5204
            2463-2678           AA664009.1         1-216               c
            2679-2759           AL445183.19        98232-98312
FEATURES             Location/Qualifiers
     source          1..2759
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..2759
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /note="sterol carrier protein 2"
                     /db_xref="GeneID:6342"
                     /db_xref="HGNC:HGNC:10606"
                     /db_xref="MIM:184755"
     exon            1..190
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1765
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /EC_number="2.3.1.16"
                     /EC_number="2.3.1.176"
                     /EC_number="2.3.1.155"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; sterol carrier protein X; non-specific
                     lipid-transfer protein; propanoyl-CoA C-acyltransferase;
                     epididymis secretory sperm binding protein;
                     SCP-2/thiolase; SCP-2/3-oxoacyl-CoA thiolase;
                     straight-chain acyl-CoA oxidase; acetyl-CoA
                     C-myristoyltransferase"
                     /codon_start=1
                     /product="sterol carrier protein 2 isoform 1 precursor"
                     /protein_id="NP_002970.2"
                     /db_xref="CCDS:CCDS572.1"
                     /db_xref="GeneID:6342"
                     /db_xref="HGNC:HGNC:10606"
                     /db_xref="MIM:184755"
                     /translation="MSSSPWEPATLRRVFVVGVGMTKFVKPGAENSRDYPDLAEEAGK
                     KALADAQIPYSAVDQACVGYVFGDSTCGQRAIYHSLGMTGIPIINVNNNCATGSTALF
                     MARQLIQGGVAECVLALGFEKMSKGSLGIKFSDRTIPTDKHVDLLINKYGLSAHPVAP
                     QMFGYAGKEHMEKYGTKIEHFAKIGWKNHKHSVNNPYSQFQDEYSLDEVMASKEVFDF
                     LTILQCCPTSDGAAAAILASEAFVQKYGLQSKAVEILAQEMMTDLPSSFEEKSIIKMV
                     GFDMSKEAARKCYEKSGLTPNDIDVIELHDCFSTNELLTYEALGLCPEGQGATLVDRG
                     DNTYGGKWVINPSGGLISKGHPLGATGLAQCAELCWQLRGEAGKRQVPGAKVALQHNL
                     GIGGAVVVTLYKMGFPEAASSFRTHQIEAVPTSSASDGFKANLVFKEIEKKLEEEGEQ
                     FVKKIGGIFAFKVKDGPGGKEATWVVDVKNGKGSVLPNSDKKADCTITMADSDFLALM
                     TGKMNPQSAFFQGKLKITGNMGLAMKLQNLQLQPGNAKL"
     exon            191..248
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            249..320
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            321..452
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            453..517
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            518..644
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            645..708
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            709..795
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            796..946
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1094
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1202
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1356
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1459
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1589
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1669
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..2759
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2651..2656
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /note="hexamer: ATTAAA"
     polyA_site      2672
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /note="major polyA site"
     regulatory      2725..2730
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /note="hexamer: AATAAA"
     polyA_site      2759
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
ORIGIN      
        1 acgcgcctgt gttgccgccc gcggccctgg cttcgggctt cagggagctc tggtgcagtc
       61 tccgcctgtc agtgccggca gtcgtccgcg gcgcccgccc cggtcccgca ctggtgcagc
      121 catgtcctct tccccgtggg agcctgcgac cctgcgccgg gtgttcgtgg tgggggttgg
      181 catgaccaag tttgtgaagc ctggagctga gaattcaaga gactaccctg acttggcaga
      241 agaagcaggc aagaaggctt tagctgatgc acagatccct tattcagcag tggaccaggc
      301 atgtgttggc tatgtttttg gtgactctac ctgtgggcag agggctatct atcacagttt
      361 gggaatgact ggaattccta taatcaatgt caacaataac tgtgctactg gttctactgc
      421 tttgtttatg gcccgccagc tgattcaggg tggtgtggca gaatgtgtct tggctcttgg
      481 gtttgagaag atgagtaagg gaagccttgg aataaaattt tcagatagaa ccattcccac
      541 tgataagcat gttgacctcc tgatcaataa gtatggattg tctgctcacc cagttgctcc
      601 tcagatgttt gggtatgctg gaaaagaaca tatggaaaaa tatggaacaa aaattgaaca
      661 ctttgcaaaa attggatgga aaaatcataa acattcagtt aataacccgt attcccagtt
      721 ccaagatgaa tacagtttag atgaagtgat ggcatctaaa gaagtttttg attttttgac
      781 tatcttacaa tgttgtccca cttcagatgg tgctgcagca gcaattttgg ccagtgaagc
      841 atttgtacag aagtatggcc tgcaatccaa agctgtggaa attttggcac aagaaatgat
      901 gactgatttg ccaagctcgt ttgaagaaaa aagcattatt aaaatggttg gctttgatat
      961 gagtaaagaa gctgcaagaa aatgctatga gaaatctggc ctgacaccaa atgatattga
     1021 cgtaatagaa cttcacgatt gcttttctac caacgaactc cttacttatg aagcactggg
     1081 actctgtcca gaaggacaag gtgcaacgct ggttgataga ggagataata catatggagg
     1141 aaagtgggtc ataaatccta gtggtggact gatttcaaag ggacacccac taggcgctac
     1201 aggtcttgct cagtgtgcag aactctgctg gcagctgaga ggggaagccg gaaagaggca
     1261 agttcctggt gcaaaggtgg ctctgcagca taatttaggc attggaggag ctgtggttgt
     1321 aacactctac aagatgggtt ttccggaagc cgccagttct tttagaactc atcaaattga
     1381 agctgttcca accagctctg caagtgatgg atttaaggca aatcttgttt ttaaggagat
     1441 tgagaagaaa cttgaagagg aaggggaaca gtttgtgaag aaaatcggtg gtatttttgc
     1501 cttcaaggtg aaagatggcc ctgggggtaa agaggccacc tgggtggtgg atgtgaagaa
     1561 tggcaaagga tcagtgcttc ctaactcaga taagaaggct gactgcacaa tcacaatggc
     1621 tgactcagac ttcctggctt taatgactgg taaaatgaat cctcagtcgg ccttctttca
     1681 aggcaaattg aaaatcactg gcaacatggg tctcgctatg aagttacaaa atcttcagct
     1741 tcagccaggc aacgctaagc tctgaagaac tccctttggc tacttttgaa aatcaagatg
     1801 agatatatag atatatatcc atacatttta ttgtcagaat ttagactgaa actacacatt
     1861 ggcaaatagc gtgggataga tttgtttctt aatgggtgtg accaatcctg tttttcctat
     1921 gctctgggtg aatagagcct gatggtatac tactgctttg cggaattgca tacaactgtg
     1981 cattacaaag ttaatatggt aattatggtc tggggtaaaa ttgagtttca gaataaaatt
     2041 aggaacagta aaatccaaag aactatgtaa acaaaaaagc ttttgttttg cttacaaagt
     2101 atatttaagg attattctgc tgaagattca gtttaagagt tttccttggg agaactaagt
     2161 aagaaacaca atgccaacag ctggccagta attagtgttg tgcacttcat gtcattaatc
     2221 aatttctcaa tagttcttaa aattagtgag attaaaaatc taaaaatttt gcatttcatg
     2281 ctatcagaaa cagtattttc ttcccaaatc aaaataaaag aaatatgatc agagcttgaa
     2341 cacaggctta tttttaaaat aaaaatattt ttaacatggg tttccttatt gaaaaatcag
     2401 tgtattagtc ataaaacacc atcattaaga ataattgaac aataaagttt gctttcagat
     2461 gcagttttca aattataatc tcatttcaat ttataacgtt ctcagtcctt tgttataatt
     2521 ttcctttttc atgtaagttt aattatctgc atttatcttt tttcctagtt tttctaatac
     2581 taatgttatt tcttaaaatt cagtgagata taggataaaa taatgctttg agaagaatgt
     2641 ttaatagaaa attaaaataa ctttttctgg cctctcttgt ttttactgtg tatgttcttg
     2701 ctcagggctc tctagataat gcagaataaa gagaaacgtt gggggattta taaactgaa
//
