LOCUS       NP_002970                547 aa            linear   PRI 08-OCT-2024
DEFINITION  sterol carrier protein 2 isoform 1 precursor [Homo sapiens].
ACCESSION   NP_002970
VERSION     NP_002970.2
DBSOURCE    REFSEQ: accession NM_002979.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 547)
  AUTHORS   Zou,J., Pei,X., Xing,D., Wu,X. and Chen,S.
  TITLE     LINC00261 elevation inhibits angiogenesis and cell cycle
            progression of pancreatic cancer cells by upregulating SCP2 via
            targeting FOXP3
  JOURNAL   J Cell Mol Med 25 (20), 9826-9836 (2021)
   PUBMED   34541823
  REMARK    GeneRIF: LINC00261 elevation inhibits angiogenesis and cell cycle
            progression of pancreatic cancer cells by upregulating SCP2 via
            targeting FOXP3.
REFERENCE   2  (residues 1 to 547)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (residues 1 to 547)
  AUTHORS   Bai,L., Li,J., Panagal,M., M,B. and Sekar,D.
  TITLE     Methylation dependent microRNA 1285-5p and sterol carrier proteins
            2 in type 2 diabetes mellitus
  JOURNAL   Artif Cells Nanomed Biotechnol 47 (1), 3417-3422 (2019)
   PUBMED   31407919
  REMARK    GeneRIF: Methylation dependent microRNA 1285-5p and sterol carrier
            proteins 2 in type 2 diabetes mellitus
REFERENCE   4  (residues 1 to 547)
  AUTHORS   Dansen,T.B., Kops,G.J., Denis,S., Jelluma,N., Wanders,R.J.,
            Bos,J.L., Burgering,B.M. and Wirtz,K.W.
  TITLE     Regulation of sterol carrier protein gene expression by the
            forkhead transcription factor FOXO3a
  JOURNAL   J Lipid Res 45 (1), 81-88 (2004)
   PUBMED   14563822
  REMARK    GeneRIF: SCP2 in the cellular defense against oxidative damage and
            found that a fluorescent fatty acid analog bound to SCP2 is
            protected against H2O2/Cu2+-induced oxidative damage
REFERENCE   5  (residues 1 to 547)
  AUTHORS   Ohba,T., Holt,J.A., Billheimer,J.T. and Strauss,J.F. 3rd.
  TITLE     Human sterol carrier protein x/sterol carrier protein 2 gene has
            two promoters
  JOURNAL   Biochemistry 34 (33), 10660-10668 (1995)
   PUBMED   7654720
REFERENCE   6  (residues 1 to 547)
  AUTHORS   Ohba,T., Rennert,H., Pfeifer,S.M., He,Z., Yamamoto,R., Holt,J.A.,
            Billheimer,J.T. and Strauss,J.F. 3rd.
  TITLE     The structure of the human sterol carrier protein X/sterol carrier
            protein 2 gene (SCP2)
  JOURNAL   Genomics 24 (2), 370-374 (1994)
   PUBMED   7698762
REFERENCE   7  (residues 1 to 547)
  AUTHORS   Seedorf,U., Brysch,P., Engel,T., Schrage,K. and Assmann,G.
  TITLE     Sterol carrier protein X is peroxisomal 3-oxoacyl coenzyme A
            thiolase with intrinsic sterol carrier and lipid transfer activity
  JOURNAL   J Biol Chem 269 (33), 21277-21283 (1994)
   PUBMED   8063752
REFERENCE   8  (residues 1 to 547)
  AUTHORS   Vanderver,A., Tonduti,D., Schiffmann,R., Schmidt,J. and van der
            Knaap,M.S.
  TITLE     Leukodystrophy Overview - RETIRED CHAPTER, FOR HISTORICAL REFERENCE
            ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   24501781
REFERENCE   9  (residues 1 to 547)
  AUTHORS   Heikoop,J.C., Ossendorp,B.C., Wanders,R.J., Wirtz,K.W. and
            Tager,J.M.
  TITLE     Subcellular localisation and processing of non-specific lipid
            transfer protein are not aberrant in Rhizomelic Chondrodysplasia
            Punctata fibroblasts
  JOURNAL   FEBS Lett 299 (2), 201-204 (1992)
   PUBMED   1347505
REFERENCE   10 (residues 1 to 547)
  AUTHORS   Yamamoto,R., Kallen,C.B., Babalola,G.O., Rennert,H.,
            Billheimer,J.T. and Strauss,J.F. 3rd.
  TITLE     Cloning and expression of a cDNA encoding human sterol carrier
            protein 2
  JOURNAL   Proc Natl Acad Sci U S A 88 (2), 463-467 (1991)
   PUBMED   1703300
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC330171.1, AK312856.1,
            AL445183.19, AB208789.1 and AA664009.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 4, 2002 this sequence version replaced NP_002970.1.
            
            Summary: This gene encodes two proteins: sterol carrier protein X
            (SCPx) and sterol carrier protein 2 (SCP2), as a result of
            transcription initiation from 2 independently regulated promoters.
            The transcript initiated from the proximal promoter encodes the
            longer SCPx protein, and the transcript initiated from the distal
            promoter encodes the shorter SCP2 protein, with the 2 proteins
            sharing a common C-terminus. Evidence suggests that the SCPx
            protein is a peroxisome-associated thiolase that is involved in the
            oxidation of branched chain fatty acids, while the SCP2 protein is
            thought to be an intracellular lipid transfer protein. This gene is
            highly expressed in organs involved in lipid metabolism, and may
            play a role in Zellweger syndrome, in which cells are deficient in
            peroxisomes and have impaired bile acid synthesis. Alternative
            splicing of this gene produces multiple transcript variants, some
            encoding different isoforms.[provided by RefSeq, Aug 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1, also known as SCPx).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.18490.1,
                                           SRR3476690.1001248.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371514.8/ ENSP00000360569.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..547
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     Protein         1..547
                     /product="sterol carrier protein 2 isoform 1 precursor"
                     /EC_number="2.3.1.16"
                     /EC_number="2.3.1.176"
                     /EC_number="2.3.1.155"
                     /note="sterol carrier protein X; non-specific
                     lipid-transfer protein; propanoyl-CoA C-acyltransferase;
                     epididymis secretory sperm binding protein;
                     SCP-2/thiolase; SCP-2/3-oxoacyl-CoA thiolase;
                     straight-chain acyl-CoA oxidase; acetyl-CoA
                     C-myristoyltransferase"
                     /calculated_mol_wt=58863
     mat_peptide     1..404
                     /product="sterol carrier protein 2 isoform 1"
                     /experiment="EXISTENCE:western blot[PMID:14563822]"
                     /calculated_mol_wt=43611
     Site            3
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P11915; propagated from
                     UniProtKB/Swiss-Prot (P22307.2)"
     Region          12..404
                     /region_name="PRK08256"
                     /note="lipid-transfer protein; Provisional"
                     /db_xref="CDD:181327"
     Site            20..21
                     /site_type="cleavage"
                     /note="Cleavage. /evidence=ECO:0000305; propagated from
                     UniProtKB/Swiss-Prot (P22307.2)"
     Site            132
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P32020; propagated from
                     UniProtKB/Swiss-Prot (P22307.2)"
     Site            173
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P32020; propagated from
                     UniProtKB/Swiss-Prot (P22307.2)"
     Site            177
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P32020; propagated from
                     UniProtKB/Swiss-Prot (P22307.2)"
     Site            183
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:19608861; propagated from
                     UniProtKB/Swiss-Prot (P22307.2)"
     Site            341
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P32020; propagated from
                     UniProtKB/Swiss-Prot (P22307.2)"
     Site            432
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P32020; propagated from
                     UniProtKB/Swiss-Prot (P22307.2)"
     Site            438
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:19608861; propagated from
                     UniProtKB/Swiss-Prot (P22307.2)"
     Site            443
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P32020; propagated from
                     UniProtKB/Swiss-Prot (P22307.2)"
     Region          452..538
                     /region_name="SCP2"
                     /note="SCP-2 sterol transfer family; pfam02036"
                     /db_xref="CDD:460423"
     Site            453
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P32020; propagated from
                     UniProtKB/Swiss-Prot (P22307.2)"
     Site            470
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:19608861; propagated from
                     UniProtKB/Swiss-Prot (P22307.2)"
     Site            491
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P32020; propagated from
                     UniProtKB/Swiss-Prot (P22307.2)"
     Site            516
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P32020; propagated from
                     UniProtKB/Swiss-Prot (P22307.2)"
     Region          545..547
                     /region_name="Microbody targeting signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (P22307.2)"
     CDS             1..547
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /coded_by="NM_002979.5:122..1765"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS572.1"
                     /db_xref="GeneID:6342"
                     /db_xref="HGNC:HGNC:10606"
                     /db_xref="MIM:184755"
ORIGIN      
        1 mssspwepat lrrvfvvgvg mtkfvkpgae nsrdypdlae eagkkalada qipysavdqa
       61 cvgyvfgdst cgqraiyhsl gmtgipiinv nnncatgsta lfmarqliqg gvaecvlalg
      121 fekmskgslg ikfsdrtipt dkhvdllink yglsahpvap qmfgyagkeh mekygtkieh
      181 fakigwknhk hsvnnpysqf qdeysldevm askevfdflt ilqccptsdg aaaailasea
      241 fvqkyglqsk aveilaqemm tdlpssfeek siikmvgfdm skeaarkcye ksgltpndid
      301 vielhdcfst nelltyealg lcpegqgatl vdrgdntygg kwvinpsggl iskghplgat
      361 glaqcaelcw qlrgeagkrq vpgakvalqh nlgiggavvv tlykmgfpea assfrthqie
      421 avptssasdg fkanlvfkei ekkleeegeq fvkkiggifa fkvkdgpggk eatwvvdvkn
      481 gkgsvlpnsd kkadctitma dsdflalmtg kmnpqsaffq gklkitgnmg lamklqnlql
      541 qpgnakl
//
