LOCUS       NM_001330587            2177 bp    mRNA    linear   PRI 13-OCT-2024
DEFINITION  Homo sapiens sterol carrier protein 2 (SCP2), transcript variant 9,
            mRNA.
ACCESSION   NM_001330587 XM_017002045
VERSION     NM_001330587.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2177)
  AUTHORS   Zou,J., Pei,X., Xing,D., Wu,X. and Chen,S.
  TITLE     LINC00261 elevation inhibits angiogenesis and cell cycle
            progression of pancreatic cancer cells by upregulating SCP2 via
            targeting FOXP3
  JOURNAL   J Cell Mol Med 25 (20), 9826-9836 (2021)
   PUBMED   34541823
  REMARK    GeneRIF: LINC00261 elevation inhibits angiogenesis and cell cycle
            progression of pancreatic cancer cells by upregulating SCP2 via
            targeting FOXP3.
REFERENCE   2  (bases 1 to 2177)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2177)
  AUTHORS   Bai,L., Li,J., Panagal,M., M,B. and Sekar,D.
  TITLE     Methylation dependent microRNA 1285-5p and sterol carrier proteins
            2 in type 2 diabetes mellitus
  JOURNAL   Artif Cells Nanomed Biotechnol 47 (1), 3417-3422 (2019)
   PUBMED   31407919
  REMARK    GeneRIF: Methylation dependent microRNA 1285-5p and sterol carrier
            proteins 2 in type 2 diabetes mellitus
REFERENCE   4  (bases 1 to 2177)
  AUTHORS   Dansen,T.B., Kops,G.J., Denis,S., Jelluma,N., Wanders,R.J.,
            Bos,J.L., Burgering,B.M. and Wirtz,K.W.
  TITLE     Regulation of sterol carrier protein gene expression by the
            forkhead transcription factor FOXO3a
  JOURNAL   J Lipid Res 45 (1), 81-88 (2004)
   PUBMED   14563822
  REMARK    GeneRIF: SCP2 in the cellular defense against oxidative damage and
            found that a fluorescent fatty acid analog bound to SCP2 is
            protected against H2O2/Cu2+-induced oxidative damage
REFERENCE   5  (bases 1 to 2177)
  AUTHORS   Ohba,T., Holt,J.A., Billheimer,J.T. and Strauss,J.F. 3rd.
  TITLE     Human sterol carrier protein x/sterol carrier protein 2 gene has
            two promoters
  JOURNAL   Biochemistry 34 (33), 10660-10668 (1995)
   PUBMED   7654720
REFERENCE   6  (bases 1 to 2177)
  AUTHORS   Ohba,T., Rennert,H., Pfeifer,S.M., He,Z., Yamamoto,R., Holt,J.A.,
            Billheimer,J.T. and Strauss,J.F. 3rd.
  TITLE     The structure of the human sterol carrier protein X/sterol carrier
            protein 2 gene (SCP2)
  JOURNAL   Genomics 24 (2), 370-374 (1994)
   PUBMED   7698762
REFERENCE   7  (bases 1 to 2177)
  AUTHORS   Seedorf,U., Brysch,P., Engel,T., Schrage,K. and Assmann,G.
  TITLE     Sterol carrier protein X is peroxisomal 3-oxoacyl coenzyme A
            thiolase with intrinsic sterol carrier and lipid transfer activity
  JOURNAL   J Biol Chem 269 (33), 21277-21283 (1994)
   PUBMED   8063752
REFERENCE   8  (bases 1 to 2177)
  AUTHORS   Vanderver,A., Tonduti,D., Schiffmann,R., Schmidt,J. and van der
            Knaap,M.S.
  TITLE     Leukodystrophy Overview - RETIRED CHAPTER, FOR HISTORICAL REFERENCE
            ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   24501781
REFERENCE   9  (bases 1 to 2177)
  AUTHORS   Heikoop,J.C., Ossendorp,B.C., Wanders,R.J., Wirtz,K.W. and
            Tager,J.M.
  TITLE     Subcellular localisation and processing of non-specific lipid
            transfer protein are not aberrant in Rhizomelic Chondrodysplasia
            Punctata fibroblasts
  JOURNAL   FEBS Lett 299 (2), 201-204 (1992)
   PUBMED   1347505
REFERENCE   10 (bases 1 to 2177)
  AUTHORS   Yamamoto,R., Kallen,C.B., Babalola,G.O., Rennert,H.,
            Billheimer,J.T. and Strauss,J.F. 3rd.
  TITLE     Cloning and expression of a cDNA encoding human sterol carrier
            protein 2
  JOURNAL   Proc Natl Acad Sci U S A 88 (2), 463-467 (1991)
   PUBMED   1703300
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC099677.2 and AL445183.19.
            
            On Aug 14, 2020 this sequence version replaced NM_001330587.1.
            
            Summary: This gene encodes two proteins: sterol carrier protein X
            (SCPx) and sterol carrier protein 2 (SCP2), as a result of
            transcription initiation from 2 independently regulated promoters.
            The transcript initiated from the proximal promoter encodes the
            longer SCPx protein, and the transcript initiated from the distal
            promoter encodes the shorter SCP2 protein, with the 2 proteins
            sharing a common C-terminus. Evidence suggests that the SCPx
            protein is a peroxisome-associated thiolase that is involved in the
            oxidation of branched chain fatty acids, while the SCP2 protein is
            thought to be an intracellular lipid transfer protein. This gene is
            highly expressed in organs involved in lipid metabolism, and may
            play a role in Zellweger syndrome, in which cells are deficient in
            peroxisomes and have impaired bile acid synthesis. Alternative
            splicing of this gene produces multiple transcript variants, some
            encoding different isoforms.[provided by RefSeq, Aug 2010].
            
            Transcript Variant: This variant (9) differs in the 3' UTR and
            coding sequence compared to variant 1. The resulting isoform (9)
            has a shorter and distinct C-terminus compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.334818.1,
                                           SRR14038196.635276.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-190               AC099677.2         88126-88315
            191-248             AC099677.2         102646-102703
            249-320             AC099677.2         108859-108930
            321-452             AC099677.2         111605-111736
            453-517             AC099677.2         115590-115654
            518-644             AL445183.19        8117-8243
            645-708             AL445183.19        21383-21446
            709-795             AL445183.19        23297-23383
            796-946             AL445183.19        24831-24981
            947-1094            AL445183.19        27010-27157
            1095-1202           AL445183.19        34643-34750
            1203-2177           AL445183.19        39872-40846
FEATURES             Location/Qualifiers
     source          1..2177
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..2177
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /note="sterol carrier protein 2"
                     /db_xref="GeneID:6342"
                     /db_xref="HGNC:HGNC:10606"
                     /db_xref="MIM:184755"
     exon            1..190
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1222
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /EC_number="2.3.1.16"
                     /EC_number="2.3.1.176"
                     /EC_number="2.3.1.155"
                     /note="isoform 9 is encoded by transcript variant 9;
                     sterol carrier protein X; non-specific lipid-transfer
                     protein; propanoyl-CoA C-acyltransferase; epididymis
                     secretory sperm binding protein; SCP-2/thiolase;
                     SCP-2/3-oxoacyl-CoA thiolase; straight-chain acyl-CoA
                     oxidase; acetyl-CoA C-myristoyltransferase"
                     /codon_start=1
                     /product="sterol carrier protein 2 isoform 9"
                     /protein_id="NP_001317516.1"
                     /db_xref="CCDS:CCDS81325.1"
                     /db_xref="GeneID:6342"
                     /db_xref="HGNC:HGNC:10606"
                     /db_xref="MIM:184755"
                     /translation="MSSSPWEPATLRRVFVVGVGMTKFVKPGAENSRDYPDLAEEAGK
                     KALADAQIPYSAVDQACVGYVFGDSTCGQRAIYHSLGMTGIPIINVNNNCATGSTALF
                     MARQLIQGGVAECVLALGFEKMSKGSLGIKFSDRTIPTDKHVDLLINKYGLSAHPVAP
                     QMFGYAGKEHMEKYGTKIEHFAKIGWKNHKHSVNNPYSQFQDEYSLDEVMASKEVFDF
                     LTILQCCPTSDGAAAAILASEAFVQKYGLQSKAVEILAQEMMTDLPSSFEEKSIIKMV
                     GFDMSKEAARKCYEKSGLTPNDIDVIELHDCFSTNELLTYEALGLCPEGQGATLVDRG
                     DNTYGGKWVINPSGGLISKGHPLGATGGHSCS"
     exon            191..248
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            249..320
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            321..452
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            453..517
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            518..644
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            645..708
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            709..795
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            796..946
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1094
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1202
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..2177
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2148..2153
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /note="hexamer: AATAAA"
     polyA_site      2177
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /note="major polyA site"
ORIGIN      
        1 acgcgcctgt gttgccgccc gcggccctgg cttcgggctt cagggagctc tggtgcagtc
       61 tccgcctgtc agtgccggca gtcgtccgcg gcgcccgccc cggtcccgca ctggtgcagc
      121 catgtcctct tccccgtggg agcctgcgac cctgcgccgg gtgttcgtgg tgggggttgg
      181 catgaccaag tttgtgaagc ctggagctga gaattcaaga gactaccctg acttggcaga
      241 agaagcaggc aagaaggctt tagctgatgc acagatccct tattcagcag tggaccaggc
      301 atgtgttggc tatgtttttg gtgactctac ctgtgggcag agggctatct atcacagttt
      361 gggaatgact ggaattccta taatcaatgt caacaataac tgtgctactg gttctactgc
      421 tttgtttatg gcccgccagc tgattcaggg tggtgtggca gaatgtgtct tggctcttgg
      481 gtttgagaag atgagtaagg gaagccttgg aataaaattt tcagatagaa ccattcccac
      541 tgataagcat gttgacctcc tgatcaataa gtatggattg tctgctcacc cagttgctcc
      601 tcagatgttt gggtatgctg gaaaagaaca tatggaaaaa tatggaacaa aaattgaaca
      661 ctttgcaaaa attggatgga aaaatcataa acattcagtt aataacccgt attcccagtt
      721 ccaagatgaa tacagtttag atgaagtgat ggcatctaaa gaagtttttg attttttgac
      781 tatcttacaa tgttgtccca cttcagatgg tgctgcagca gcaattttgg ccagtgaagc
      841 atttgtacag aagtatggcc tgcaatccaa agctgtggaa attttggcac aagaaatgat
      901 gactgatttg ccaagctcgt ttgaagaaaa aagcattatt aaaatggttg gctttgatat
      961 gagtaaagaa gctgcaagaa aatgctatga gaaatctggc ctgacaccaa atgatattga
     1021 cgtaatagaa cttcacgatt gcttttctac caacgaactc cttacttatg aagcactggg
     1081 actctgtcca gaaggacaag gtgcaacgct ggttgataga ggagataata catatggagg
     1141 aaagtgggtc ataaatccta gtggtggact gatttcaaag ggacacccac taggcgctac
     1201 aggaggacat tcctgctctt gaaatttcct gataacccgg acaagttcat ggaaagcttg
     1261 atctacattc atcctaatct ttgctgatgc ctccatgtat gttaccttaa gttgccgtgc
     1321 taactgccgt ccttcttcct gtgttacctg tctttgatga tccagatctg ctttattacc
     1381 aattaaaatc attgggaact catcacgatc ctttactctg agaatctgtc tttgaaactt
     1441 atagatttct tcaaaactgc ctctatctgt gactgaaaag accaacagga agccctcgcc
     1501 agtcctcata tactgttctc tcatggctcc aagctcttct tgtcctgctg tatccaaaat
     1561 atctagccgg gctgctctgt catctatcac acactgcttt gtgtaagaat cttcattggt
     1621 tggatcataa tccgttacaa aataggactc ccaacttagg aaacaaaaca tttgtaatat
     1681 gattgaagac tcctgcatgc ctcctcaata atattcccct ctctcctccc ccagcaccaa
     1741 gaggtaatca atatcctgaa tttggtatct gtcattctca tgcatttata caacattagt
     1801 aatcatatga tagtattcct aagctatgtt ttggagagga caccactgca aatcttcagc
     1861 cctatactag cttttatcgg tagccatcaa ttgcagtttt aatagaaata caaatacatc
     1921 aagtgtctgt tctttaattt gtaaagaaaa tttgttttct agcgtgacac cctcaaggta
     1981 ccgtatctgt atgtaaatgt tgtgcccaat gctacacaga cattatttta aaactatttt
     2041 ctgcctttgg taaatagact aaactgtttt ctttattcct caaaagaatt agatcatact
     2101 tcagtgttga ttttgttgct aatgggacat ggagatgtct ggatgataat aaatattcct
     2161 gtggtatggt cactgaa
//
