LOCUS       NM_001193599            2687 bp    mRNA    linear   PRI 10-OCT-2024
DEFINITION  Homo sapiens sterol carrier protein 2 (SCP2), transcript variant 7,
            mRNA.
ACCESSION   NM_001193599
VERSION     NM_001193599.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2687)
  AUTHORS   Zou,J., Pei,X., Xing,D., Wu,X. and Chen,S.
  TITLE     LINC00261 elevation inhibits angiogenesis and cell cycle
            progression of pancreatic cancer cells by upregulating SCP2 via
            targeting FOXP3
  JOURNAL   J Cell Mol Med 25 (20), 9826-9836 (2021)
   PUBMED   34541823
  REMARK    GeneRIF: LINC00261 elevation inhibits angiogenesis and cell cycle
            progression of pancreatic cancer cells by upregulating SCP2 via
            targeting FOXP3.
REFERENCE   2  (bases 1 to 2687)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2687)
  AUTHORS   Bai,L., Li,J., Panagal,M., M,B. and Sekar,D.
  TITLE     Methylation dependent microRNA 1285-5p and sterol carrier proteins
            2 in type 2 diabetes mellitus
  JOURNAL   Artif Cells Nanomed Biotechnol 47 (1), 3417-3422 (2019)
   PUBMED   31407919
  REMARK    GeneRIF: Methylation dependent microRNA 1285-5p and sterol carrier
            proteins 2 in type 2 diabetes mellitus
REFERENCE   4  (bases 1 to 2687)
  AUTHORS   Dansen,T.B., Kops,G.J., Denis,S., Jelluma,N., Wanders,R.J.,
            Bos,J.L., Burgering,B.M. and Wirtz,K.W.
  TITLE     Regulation of sterol carrier protein gene expression by the
            forkhead transcription factor FOXO3a
  JOURNAL   J Lipid Res 45 (1), 81-88 (2004)
   PUBMED   14563822
  REMARK    GeneRIF: SCP2 in the cellular defense against oxidative damage and
            found that a fluorescent fatty acid analog bound to SCP2 is
            protected against H2O2/Cu2+-induced oxidative damage
REFERENCE   5  (bases 1 to 2687)
  AUTHORS   Ohba,T., Holt,J.A., Billheimer,J.T. and Strauss,J.F. 3rd.
  TITLE     Human sterol carrier protein x/sterol carrier protein 2 gene has
            two promoters
  JOURNAL   Biochemistry 34 (33), 10660-10668 (1995)
   PUBMED   7654720
REFERENCE   6  (bases 1 to 2687)
  AUTHORS   Ohba,T., Rennert,H., Pfeifer,S.M., He,Z., Yamamoto,R., Holt,J.A.,
            Billheimer,J.T. and Strauss,J.F. 3rd.
  TITLE     The structure of the human sterol carrier protein X/sterol carrier
            protein 2 gene (SCP2)
  JOURNAL   Genomics 24 (2), 370-374 (1994)
   PUBMED   7698762
REFERENCE   7  (bases 1 to 2687)
  AUTHORS   Seedorf,U., Brysch,P., Engel,T., Schrage,K. and Assmann,G.
  TITLE     Sterol carrier protein X is peroxisomal 3-oxoacyl coenzyme A
            thiolase with intrinsic sterol carrier and lipid transfer activity
  JOURNAL   J Biol Chem 269 (33), 21277-21283 (1994)
   PUBMED   8063752
REFERENCE   8  (bases 1 to 2687)
  AUTHORS   Vanderver,A., Tonduti,D., Schiffmann,R., Schmidt,J. and van der
            Knaap,M.S.
  TITLE     Leukodystrophy Overview - RETIRED CHAPTER, FOR HISTORICAL REFERENCE
            ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   24501781
REFERENCE   9  (bases 1 to 2687)
  AUTHORS   Heikoop,J.C., Ossendorp,B.C., Wanders,R.J., Wirtz,K.W. and
            Tager,J.M.
  TITLE     Subcellular localisation and processing of non-specific lipid
            transfer protein are not aberrant in Rhizomelic Chondrodysplasia
            Punctata fibroblasts
  JOURNAL   FEBS Lett 299 (2), 201-204 (1992)
   PUBMED   1347505
REFERENCE   10 (bases 1 to 2687)
  AUTHORS   Yamamoto,R., Kallen,C.B., Babalola,G.O., Rennert,H.,
            Billheimer,J.T. and Strauss,J.F. 3rd.
  TITLE     Cloning and expression of a cDNA encoding human sterol carrier
            protein 2
  JOURNAL   Proc Natl Acad Sci U S A 88 (2), 463-467 (1991)
   PUBMED   1703300
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC330171.1, AK294631.1,
            AL445183.19, AB208789.1 and AA664009.1.
            
            On May 31, 2019 this sequence version replaced NM_001193599.1.
            
            Summary: This gene encodes two proteins: sterol carrier protein X
            (SCPx) and sterol carrier protein 2 (SCP2), as a result of
            transcription initiation from 2 independently regulated promoters.
            The transcript initiated from the proximal promoter encodes the
            longer SCPx protein, and the transcript initiated from the distal
            promoter encodes the shorter SCP2 protein, with the 2 proteins
            sharing a common C-terminus. Evidence suggests that the SCPx
            protein is a peroxisome-associated thiolase that is involved in the
            oxidation of branched chain fatty acids, while the SCP2 protein is
            thought to be an intracellular lipid transfer protein. This gene is
            highly expressed in organs involved in lipid metabolism, and may
            play a role in Zellweger syndrome, in which cells are deficient in
            peroxisomes and have impaired bile acid synthesis. Alternative
            splicing of this gene produces multiple transcript variants, some
            encoding different isoforms.[provided by RefSeq, Aug 2010].
            
            Transcript Variant: This variant (7) lacks an in-frame exon in the
            coding region, compared to variant 1. The encoded isoform (7) is
            shorter than isoform 1. It is unknown whether this isoform (7) is
            proteolytically processed like isoforms 1 and 5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK294631.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                DC330171.1         32-41
            11-1069             AK294631.1         1-1059
            1070-1070           AL445183.19        34690-34690
            1071-2014           AK294631.1         1061-2004
            2015-2390           AB208789.1         4829-5204
            2391-2606           AA664009.1         1-216               c
            2607-2687           AL445183.19        98232-98312
FEATURES             Location/Qualifiers
     source          1..2687
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..2687
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /note="sterol carrier protein 2"
                     /db_xref="GeneID:6342"
                     /db_xref="HGNC:HGNC:10606"
                     /db_xref="MIM:184755"
     exon            1..190
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1693
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /EC_number="2.3.1.16"
                     /EC_number="2.3.1.176"
                     /EC_number="2.3.1.155"
                     /note="isoform 7 is encoded by transcript variant 7;
                     sterol carrier protein X; non-specific lipid-transfer
                     protein; propanoyl-CoA C-acyltransferase; epididymis
                     secretory sperm binding protein; SCP-2/thiolase;
                     SCP-2/3-oxoacyl-CoA thiolase; straight-chain acyl-CoA
                     oxidase; acetyl-CoA C-myristoyltransferase"
                     /codon_start=1
                     /product="sterol carrier protein 2 isoform 7"
                     /protein_id="NP_001180528.1"
                     /db_xref="CCDS:CCDS53318.1"
                     /db_xref="GeneID:6342"
                     /db_xref="HGNC:HGNC:10606"
                     /db_xref="MIM:184755"
                     /translation="MSSSPWEPATLRRVFVVGVGMTKFVKPGAENSRDYPDLAEEAGD
                     STCGQRAIYHSLGMTGIPIINVNNNCATGSTALFMARQLIQGGVAECVLALGFEKMSK
                     GSLGIKFSDRTIPTDKHVDLLINKYGLSAHPVAPQMFGYAGKEHMEKYGTKIEHFAKI
                     GWKNHKHSVNNPYSQFQDEYSLDEVMASKEVFDFLTILQCCPTSDGAAAAILASEAFV
                     QKYGLQSKAVEILAQEMMTDLPSSFEEKSIIKMVGFDMSKEAARKCYEKSGLTPNDID
                     VIELHDCFSTNELLTYEALGLCPEGQGATLVDRGDNTYGGKWVINPSGGLISKGHPLG
                     ATGLAQCAELCWQLRGEAGKRQVPGAKVALQHNLGIGGAVVVTLYKMGFPEAASSFRT
                     HQIEAVPTSSASDGFKANLVFKEIEKKLEEEGEQFVKKIGGIFAFKVKDGPGGKEATW
                     VVDVKNGKGSVLPNSDKKADCTITMADSDFLALMTGKMNPQSAFFQGKLKITGNMGLA
                     MKLQNLQLQPGNAKL"
     exon            191..248
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            249..380
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            381..445
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            446..572
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            573..636
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            637..723
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            724..874
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1022
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1130
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1284
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1387
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1517
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1597
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..2687
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2579..2584
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /note="hexamer: ATTAAA"
     polyA_site      2600
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /note="major polyA site"
     regulatory      2653..2658
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
                     /note="hexamer: AATAAA"
     polyA_site      2687
                     /gene="SCP2"
                     /gene_synonym="NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X;
                     SCPX"
ORIGIN      
        1 acgcgcctgt gttgccgccc gcggccctgg cttcgggctt cagggagctc tggtgcagtc
       61 tccgcctgtc agtgccggca gtcgtccgcg gcgcccgccc cggtcccgca ctggtgcagc
      121 catgtcctct tccccgtggg agcctgcgac cctgcgccgg gtgttcgtgg tgggggttgg
      181 catgaccaag tttgtgaagc ctggagctga gaattcaaga gactaccctg acttggcaga
      241 agaagcaggt gactctacct gtgggcagag ggctatctat cacagtttgg gaatgactgg
      301 aattcctata atcaatgtca acaataactg tgctactggt tctactgctt tgtttatggc
      361 ccgccagctg attcagggtg gtgtggcaga atgtgtcttg gctcttgggt ttgagaagat
      421 gagtaaggga agccttggaa taaaattttc agatagaacc attcccactg ataagcatgt
      481 tgacctcctg atcaataagt atggattgtc tgctcaccca gttgctcctc agatgtttgg
      541 gtatgctgga aaagaacata tggaaaaata tggaacaaaa attgaacact ttgcaaaaat
      601 tggatggaaa aatcataaac attcagttaa taacccgtat tcccagttcc aagatgaata
      661 cagtttagat gaagtgatgg catctaaaga agtttttgat tttttgacta tcttacaatg
      721 ttgtcccact tcagatggtg ctgcagcagc aattttggcc agtgaagcat ttgtacagaa
      781 gtatggcctg caatccaaag ctgtggaaat tttggcacaa gaaatgatga ctgatttgcc
      841 aagctcgttt gaagaaaaaa gcattattaa aatggttggc tttgatatga gtaaagaagc
      901 tgcaagaaaa tgctatgaga aatctggcct gacaccaaat gatattgacg taatagaact
      961 tcacgattgc ttttctacca acgaactcct tacttatgaa gcactgggac tctgtccaga
     1021 aggacaaggt gcaacgctgg ttgatagagg agataataca tatggaggaa agtgggtcat
     1081 aaatcctagt ggtggactga tttcaaaggg acacccacta ggcgctacag gtcttgctca
     1141 gtgtgcagaa ctctgctggc agctgagagg ggaagccgga aagaggcaag ttcctggtgc
     1201 aaaggtggct ctgcagcata atttaggcat tggaggagct gtggttgtaa cactctacaa
     1261 gatgggtttt ccggaagccg ccagttcttt tagaactcat caaattgaag ctgttccaac
     1321 cagctctgca agtgatggat ttaaggcaaa tcttgttttt aaggagattg agaagaaact
     1381 tgaagaggaa ggggaacagt ttgtgaagaa aatcggtggt atttttgcct tcaaggtgaa
     1441 agatggccct gggggtaaag aggccacctg ggtggtggat gtgaagaatg gcaaaggatc
     1501 agtgcttcct aactcagata agaaggctga ctgcacaatc acaatggctg actcagactt
     1561 cctggcttta atgactggta aaatgaatcc tcagtcggcc ttctttcaag gcaaattgaa
     1621 aatcactggc aacatgggtc tcgctatgaa gttacaaaat cttcagcttc agccaggcaa
     1681 cgctaagctc tgaagaactc cctttggcta cttttgaaaa tcaagatgag atatatagat
     1741 atatatccat acattttatt gtcagaattt agactgaaac tacacattgg caaatagcgt
     1801 gggatagatt tgtttcttaa tgggtgtgac caatcctgtt tttcctatgc tctgggtgaa
     1861 tagagcctga tggtatacta ctgctttgcg gaattgcata caactgtgca ttacaaagtt
     1921 aatatggtaa ttatggtctg gggtaaaatt gagtttcaga ataaaattag gaacagtaaa
     1981 atccaaagaa ctatgtaaac aaaaaagctt ttgttttgct tacaaagtat atttaaggat
     2041 tattctgctg aagattcagt ttaagagttt tccttgggag aactaagtaa gaaacacaat
     2101 gccaacagct ggccagtaat tagtgttgtg cacttcatgt cattaatcaa tttctcaata
     2161 gttcttaaaa ttagtgagat taaaaatcta aaaattttgc atttcatgct atcagaaaca
     2221 gtattttctt cccaaatcaa aataaaagaa atatgatcag agcttgaaca caggcttatt
     2281 tttaaaataa aaatattttt aacatgggtt tccttattga aaaatcagtg tattagtcat
     2341 aaaacaccat cattaagaat aattgaacaa taaagtttgc tttcagatgc agttttcaaa
     2401 ttataatctc atttcaattt ataacgttct cagtcctttg ttataatttt cctttttcat
     2461 gtaagtttaa ttatctgcat ttatcttttt tcctagtttt tctaatacta atgttatttc
     2521 ttaaaattca gtgagatata ggataaaata atgctttgag aagaatgttt aatagaaaat
     2581 taaaataact ttttctggcc tctcttgttt ttactgtgta tgttcttgct cagggctctc
     2641 tagataatgc agaataaaga gaaacgttgg gggatttata aactgaa
//
