LOCUS       NM_001153690            1925 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens short coiled-coil protein (SCOC), transcript variant
            8, mRNA.
ACCESSION   NM_001153690
VERSION     NM_001153690.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1925)
  AUTHORS   Wirth,M., Mouilleron,S., Zhang,W., Sjottem,E., Princely Abudu,Y.,
            Jain,A., Lauritz Olsvik,H., Bruun,J.A., Razi,M., Jefferies,H.B.J.,
            Lee,R., Joshi,D., O'Reilly,N., Johansen,T. and Tooze,S.A.
  TITLE     Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding
            Affinity and Specificity
  JOURNAL   J Mol Biol 433 (13), 166987 (2021)
   PUBMED   33845085
  REMARK    GeneRIF: Phosphorylation of the LIR Domain of SCOC Modulates ATG8
            Binding Affinity and Specificity.
            Erratum:[J Mol Biol. 2021 Jul 23;433(15):167049. doi:
            10.1016/j.jmb.2021.167049.. PMID: 34052024]
REFERENCE   2  (bases 1 to 1925)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1925)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1925)
  AUTHORS   Stringer,S., Minica,C.C., Verweij,K.J., Mbarek,H., Bernard,M.,
            Derringer,J., van Eijk,K.R., Isen,J.D., Loukola,A.,
            Maciejewski,D.F., Mihailov,E., van der Most,P.J., Sanchez-Mora,C.,
            Roos,L., Sherva,R., Walters,R., Ware,J.J., Abdellaoui,A.,
            Bigdeli,T.B., Branje,S.J., Brown,S.A., Bruinenberg,M., Casas,M.,
            Esko,T., Garcia-Martinez,I., Gordon,S.D., Harris,J.M.,
            Hartman,C.A., Henders,A.K., Heath,A.C., Hickie,I.B., Hickman,M.,
            Hopfer,C.J., Hottenga,J.J., Huizink,A.C., Irons,D.E., Kahn,R.S.,
            Korhonen,T., Kranzler,H.R., Krauter,K., van Lier,P.A., Lubke,G.H.,
            Madden,P.A., Magi,R., McGue,M.K., Medland,S.E., Meeus,W.H.,
            Miller,M.B., Montgomery,G.W., Nivard,M.G., Nolte,I.M.,
            Oldehinkel,A.J., Pausova,Z., Qaiser,B., Quaye,L.,
            Ramos-Quiroga,J.A., Richarte,V., Rose,R.J., Shin,J.,
            Stallings,M.C., Stiby,A.I., Wall,T.L., Wright,M.J., Koot,H.M.,
            Paus,T., Hewitt,J.K., Ribases,M., Kaprio,J., Boks,M.P., Snieder,H.,
            Spector,T., Munafo,M.R., Metspalu,A., Gelernter,J., Boomsma,D.I.,
            Iacono,W.G., Martin,N.G., Gillespie,N.A., Derks,E.M. and Vink,J.M.
  TITLE     Genome-wide association study of lifetime cannabis use based on a
            large meta-analytic sample of 32 330 subjects from the
            International Cannabis Consortium
  JOURNAL   Transl Psychiatry 6 (3), e769 (2016)
   PUBMED   27023175
  REMARK    GeneRIF: SCOC SNPs were associated with lifetime cannabis use, but
            the association did not reach genome-wide significance.
            [Meta-Analysis]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1925)
  AUTHORS   Alborghetti,M.R., Furlan Ada,S., da Silva,J.C., Sforca,M.L.,
            Honorato,R.V., Granato,D.C., dos Santos Migueleti,D.L., Neves,J.L.,
            de Oliveira,P.S., Paes-Leme,A.F., Zeri,A.C., de Torriani,I.C. and
            Kobarg,J.
  TITLE     Structural analysis of intermolecular interactions in the kinesin
            adaptor complex fasciculation and elongation protein zeta 1/ short
            coiled-coil protein (FEZ1/SCOCO)
  JOURNAL   PLoS One 8 (10), e76602 (2013)
   PUBMED   24116125
  REMARK    GeneRIF: Studies indicate that FEZ1 (fasciculation and elongation
            protein zeta 1), SCOCO (short coiled-coil protein) and kinesins
            (kinesin heavy chain) are involved in biological transport process.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1925)
  AUTHORS   Behrens,C., Binotti,B., Schmidt,C., Robinson,C.V., Chua,J.J. and
            Kuhnel,K.
  TITLE     Crystal structure of the human short coiled coil protein and
            insights into SCOC-FEZ1 complex formation
  JOURNAL   PLoS One 8 (10), e76355 (2013)
   PUBMED   24098481
  REMARK    GeneRIF: SCOC forms a stable homogeneous complex with the coiled
            coil domain of FEZ1. SCOC dimerization and the SCOC surface residue
            R117 are important for this interaction.
            Erratum:[PLoS One. 2013;8(10).
            doi:10.1371/annotation/cb60d973-58aa-45e0-bbb3-1c7f5a42a8d2]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1925)
  AUTHORS   McKnight,N.C., Jefferies,H.B., Alemu,E.A., Saunders,R.E.,
            Howell,M., Johansen,T. and Tooze,S.A.
  TITLE     Genome-wide siRNA screen reveals amino acid starvation-induced
            autophagy requires SCOC and WAC
  JOURNAL   EMBO J 31 (8), 1931-1946 (2012)
   PUBMED   22354037
  REMARK    GeneRIF: The identification of SCOC and WAC as novel regulatory
            proteins with diverse functions in autophagy contributes towards a
            fuller understanding of autophagosome formation.
REFERENCE   8  (bases 1 to 1925)
  AUTHORS   Miyamoto-Sato,E., Fujimori,S., Ishizaka,M., Hirai,N., Masuoka,K.,
            Saito,R., Ozawa,Y., Hino,K., Washio,T., Tomita,M., Yamashita,T.,
            Oshikubo,T., Akasaka,H., Sugiyama,J., Matsumoto,Y. and Yanagawa,H.
  TITLE     A comprehensive resource of interacting protein regions for
            refining human transcription factor networks
  JOURNAL   PLoS One 5 (2), e9289 (2010)
   PUBMED   20195357
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1925)
  AUTHORS   Van Valkenburgh,H., Shern,J.F., Sharer,J.D., Zhu,X. and Kahn,R.A.
  TITLE     ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both
            specific and shared effectors: characterizing ARL1-binding proteins
  JOURNAL   J Biol Chem 276 (25), 22826-22837 (2001)
   PUBMED   11303027
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA625782.1, BU070009.1,
            BC016511.1 and AA213765.1.
            
            Summary: This gene encodes a short coiled-coiled domain-containing
            protein that localizes to the Golgi apparatus. The encoded protein
            interacts with ADP-ribosylation factor-like proteins. Pseudogenes
            of this gene are found on chromosomes 1 and 14. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Apr 2009].
            
            Transcript Variant: This variant (8) differs in the 5' UTR, has
            multiple differences in the coding region, and initiates
            translation at an alternate start codon, compared to variant 1. The
            encoded isoform (6) has a distinct N-terminus and is shorter than
            isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU070009.1, DA046444.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                DA625782.1         1-68
            69-650              BU070009.1         8-589
            651-1660            BC016511.1         537-1546
            1661-1925           AA213765.1         1-265               c
FEATURES             Location/Qualifiers
     source          1..1925
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.1"
     gene            1..1925
                     /gene="SCOC"
                     /gene_synonym="HRIHFB2072; SCOCO; UNC-69"
                     /note="short coiled-coil protein"
                     /db_xref="GeneID:60592"
                     /db_xref="HGNC:HGNC:20335"
     exon            1..248
                     /gene="SCOC"
                     /gene_synonym="HRIHFB2072; SCOCO; UNC-69"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..463
                     /gene="SCOC"
                     /gene_synonym="HRIHFB2072; SCOCO; UNC-69"
                     /note="isoform 6 is encoded by transcript variant 8"
                     /codon_start=1
                     /product="short coiled-coil protein isoform 6"
                     /protein_id="NP_001147162.1"
                     /db_xref="GeneID:60592"
                     /db_xref="HGNC:HGNC:20335"
                     /translation="MDGSRKEEEEDSTFTNISLADDIDHSSRILYPRPKSLLPKMMNA
                     DMDDLSARVDAVKEENLKLKSENQVLGQYIENLMSASSVFQTTDTKSKRK"
     exon            249..320
                     /gene="SCOC"
                     /gene_synonym="HRIHFB2072; SCOCO; UNC-69"
                     /inference="alignment:Splign:2.1.0"
     exon            321..1915
                     /gene="SCOC"
                     /gene_synonym="HRIHFB2072; SCOCO; UNC-69"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1892..1897
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCOC"
                     /gene_synonym="HRIHFB2072; SCOCO; UNC-69"
                     /note="hexamer: AATAAA"
     polyA_site      1913
                     /gene="SCOC"
                     /gene_synonym="HRIHFB2072; SCOCO; UNC-69"
                     /note="major polyA site"
ORIGIN      
        1 aacactcagg tgagaacttc tcaggtggaa agcaggaaga gggtggctag tgcaaggatc
       61 agatagcacc tgcttggaag ttcactgatt aatgatttaa caagggcggt cacatgggac
      121 aactgctgct tttctctgcc ctcatttttc ttactaacag gtctgaaaat tgaacaagat
      181 ggacgggtcc aggaaagagg aggaggaaga cagcacattc accaacattt ctcttgcaga
      241 tgacatagac cattcctcaa gaattttgta tccaaggccc aaaagtttgt tacccaagat
      301 gatgaatgct gacatggatg atctctctgc aagagtagat gcagttaagg aagaaaatct
      361 gaagctaaaa tcagaaaacc aagttcttgg acaatatata gaaaatctca tgtcagcttc
      421 tagtgttttt caaacaactg acacaaaaag caaaagaaag taagggattg acacccttct
      481 gttttatgga attgctgctg atcatttttt ctttaaaact tggatagatt ccaaaagtta
      541 cagtaccttt gtggcttcat tgaatattta tgaagataat gtcagatgta gacaaaaata
      601 acacaataac aggagacttc cataagtttg tgtattatgt tagtctatga aaacgtgcaa
      661 atgtattgta gagactttat gattagaatt gcatatattt atgaaactta aagatgaatg
      721 ttttattgaa tttgtaggtt tagcactgtc ttttattata ggattagtaa gatatacaag
      781 aaaataacca ccgtgttgtg aaaaagtgac caaaatcatg tactaaatgc acagctttat
      841 gtaccctgtc caccatcttg tgcctcttct ccatttgcct cttccttcct atttcccttc
      901 cgctaaggaa aaaaattggt gtcacatttg taaaagtaat tttaatagtt aatcatctct
      961 gagagtaacc tgtattttaa ttgttgaaac ttaaccaaaa taagatactg tctcagctag
     1021 ggcttgtcat ttgtgtattt agtgttaaga taggaatgct agtgtctctt taattaattg
     1081 gaaatagatg gaggctaaaa atgaaggttt ttctttgaaa ctgaattaac ttgggaatat
     1141 ttgttgttaa aaacttcttt ttgcccaaaa taactcattt tgtattatct gaaaatatat
     1201 aatttctggt catgtgtatg ttaaaataga aaattttgag gaaaaatgga aatagggtgg
     1261 aaaagtactc ggtaaacagt agtaaccaaa tattttcact ccagatttgt gttttctctg
     1321 gcacagagta gatcttttgg gaaatatata tgaaagtgga ttaagtttga ctacccttat
     1381 gttagccaca tctggatgag aacagttaca aagagtttgg tctctaagtt gatttgtacc
     1441 cagtgggtca acttctgcaa aattccgtaa tggtgtatta gtattagaat agtgaataaa
     1501 atgggaaagt tatacatgta tacttattat cttgctcagt attttatctc acttgttcta
     1561 gaattttctg taaaccctgc tactgggttt gaagagtttt agtcatcctt taacaatttt
     1621 taaaaattta gcttctagat tccatttggt aaggaaatca atattggaag tattgctaaa
     1681 atcttataat atgaaaagag atccactaat gtagcttaag gttattagat ttgggctttt
     1741 aatcatggaa taatcttatg tattggtgta agagttgatg aatgacttta gctgtgtgaa
     1801 tatataatag tcaaactgca aacattttgc atcccttttg tgacctaatt tacagacatt
     1861 taaattgtgt tgcagttctg ctttgccgtt taataaaaag ctatttcaga ggttgaaaaa
     1921 aaaaa
//
