LOCUS       NM_001153585            2009 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens short coiled-coil protein (SCOC), transcript variant
            5, mRNA.
ACCESSION   NM_001153585
VERSION     NM_001153585.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2009)
  AUTHORS   Wirth,M., Mouilleron,S., Zhang,W., Sjottem,E., Princely Abudu,Y.,
            Jain,A., Lauritz Olsvik,H., Bruun,J.A., Razi,M., Jefferies,H.B.J.,
            Lee,R., Joshi,D., O'Reilly,N., Johansen,T. and Tooze,S.A.
  TITLE     Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding
            Affinity and Specificity
  JOURNAL   J Mol Biol 433 (13), 166987 (2021)
   PUBMED   33845085
  REMARK    GeneRIF: Phosphorylation of the LIR Domain of SCOC Modulates ATG8
            Binding Affinity and Specificity.
            Erratum:[J Mol Biol. 2021 Jul 23;433(15):167049. doi:
            10.1016/j.jmb.2021.167049.. PMID: 34052024]
REFERENCE   2  (bases 1 to 2009)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2009)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2009)
  AUTHORS   Stringer,S., Minica,C.C., Verweij,K.J., Mbarek,H., Bernard,M.,
            Derringer,J., van Eijk,K.R., Isen,J.D., Loukola,A.,
            Maciejewski,D.F., Mihailov,E., van der Most,P.J., Sanchez-Mora,C.,
            Roos,L., Sherva,R., Walters,R., Ware,J.J., Abdellaoui,A.,
            Bigdeli,T.B., Branje,S.J., Brown,S.A., Bruinenberg,M., Casas,M.,
            Esko,T., Garcia-Martinez,I., Gordon,S.D., Harris,J.M.,
            Hartman,C.A., Henders,A.K., Heath,A.C., Hickie,I.B., Hickman,M.,
            Hopfer,C.J., Hottenga,J.J., Huizink,A.C., Irons,D.E., Kahn,R.S.,
            Korhonen,T., Kranzler,H.R., Krauter,K., van Lier,P.A., Lubke,G.H.,
            Madden,P.A., Magi,R., McGue,M.K., Medland,S.E., Meeus,W.H.,
            Miller,M.B., Montgomery,G.W., Nivard,M.G., Nolte,I.M.,
            Oldehinkel,A.J., Pausova,Z., Qaiser,B., Quaye,L.,
            Ramos-Quiroga,J.A., Richarte,V., Rose,R.J., Shin,J.,
            Stallings,M.C., Stiby,A.I., Wall,T.L., Wright,M.J., Koot,H.M.,
            Paus,T., Hewitt,J.K., Ribases,M., Kaprio,J., Boks,M.P., Snieder,H.,
            Spector,T., Munafo,M.R., Metspalu,A., Gelernter,J., Boomsma,D.I.,
            Iacono,W.G., Martin,N.G., Gillespie,N.A., Derks,E.M. and Vink,J.M.
  TITLE     Genome-wide association study of lifetime cannabis use based on a
            large meta-analytic sample of 32 330 subjects from the
            International Cannabis Consortium
  JOURNAL   Transl Psychiatry 6 (3), e769 (2016)
   PUBMED   27023175
  REMARK    GeneRIF: SCOC SNPs were associated with lifetime cannabis use, but
            the association did not reach genome-wide significance.
            [Meta-Analysis]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2009)
  AUTHORS   Alborghetti,M.R., Furlan Ada,S., da Silva,J.C., Sforca,M.L.,
            Honorato,R.V., Granato,D.C., dos Santos Migueleti,D.L., Neves,J.L.,
            de Oliveira,P.S., Paes-Leme,A.F., Zeri,A.C., de Torriani,I.C. and
            Kobarg,J.
  TITLE     Structural analysis of intermolecular interactions in the kinesin
            adaptor complex fasciculation and elongation protein zeta 1/ short
            coiled-coil protein (FEZ1/SCOCO)
  JOURNAL   PLoS One 8 (10), e76602 (2013)
   PUBMED   24116125
  REMARK    GeneRIF: Studies indicate that FEZ1 (fasciculation and elongation
            protein zeta 1), SCOCO (short coiled-coil protein) and kinesins
            (kinesin heavy chain) are involved in biological transport process.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2009)
  AUTHORS   Behrens,C., Binotti,B., Schmidt,C., Robinson,C.V., Chua,J.J. and
            Kuhnel,K.
  TITLE     Crystal structure of the human short coiled coil protein and
            insights into SCOC-FEZ1 complex formation
  JOURNAL   PLoS One 8 (10), e76355 (2013)
   PUBMED   24098481
  REMARK    GeneRIF: SCOC forms a stable homogeneous complex with the coiled
            coil domain of FEZ1. SCOC dimerization and the SCOC surface residue
            R117 are important for this interaction.
            Erratum:[PLoS One. 2013;8(10).
            doi:10.1371/annotation/cb60d973-58aa-45e0-bbb3-1c7f5a42a8d2]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2009)
  AUTHORS   McKnight,N.C., Jefferies,H.B., Alemu,E.A., Saunders,R.E.,
            Howell,M., Johansen,T. and Tooze,S.A.
  TITLE     Genome-wide siRNA screen reveals amino acid starvation-induced
            autophagy requires SCOC and WAC
  JOURNAL   EMBO J 31 (8), 1931-1946 (2012)
   PUBMED   22354037
  REMARK    GeneRIF: The identification of SCOC and WAC as novel regulatory
            proteins with diverse functions in autophagy contributes towards a
            fuller understanding of autophagosome formation.
REFERENCE   8  (bases 1 to 2009)
  AUTHORS   Miyamoto-Sato,E., Fujimori,S., Ishizaka,M., Hirai,N., Masuoka,K.,
            Saito,R., Ozawa,Y., Hino,K., Washio,T., Tomita,M., Yamashita,T.,
            Oshikubo,T., Akasaka,H., Sugiyama,J., Matsumoto,Y. and Yanagawa,H.
  TITLE     A comprehensive resource of interacting protein regions for
            refining human transcription factor networks
  JOURNAL   PLoS One 5 (2), e9289 (2010)
   PUBMED   20195357
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2009)
  AUTHORS   Van Valkenburgh,H., Shern,J.F., Sharer,J.D., Zhu,X. and Kahn,R.A.
  TITLE     ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both
            specific and shared effectors: characterizing ARL1-binding proteins
  JOURNAL   J Biol Chem 276 (25), 22826-22837 (2001)
   PUBMED   11303027
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA625782.1, BC016511.1 and
            AA213765.1.
            
            Summary: This gene encodes a short coiled-coiled domain-containing
            protein that localizes to the Golgi apparatus. The encoded protein
            interacts with ADP-ribosylation factor-like proteins. Pseudogenes
            of this gene are found on chromosomes 1 and 14. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Apr 2009].
            
            Transcript Variant: This variant (5) differs in the 5' UTR and 5'
            coding region, compared to variant 1, resulting in an isoform (4)
            with a distinct and shorter N-terminus, compared to isoform 1.
            Variants 4, 5 and 6 encode the same isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA625782.1, SRR1660805.196764.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-548               DA625782.1         1-548
            549-1994            BC016511.1         351-1796
            1995-2009           AA213765.1         1-15                c
FEATURES             Location/Qualifiers
     source          1..2009
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.1"
     gene            1..2009
                     /gene="SCOC"
                     /gene_synonym="HRIHFB2072; SCOCO; UNC-69"
                     /note="short coiled-coil protein"
                     /db_xref="GeneID:60592"
                     /db_xref="HGNC:HGNC:20335"
     exon            1..248
                     /gene="SCOC"
                     /gene_synonym="HRIHFB2072; SCOCO; UNC-69"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..547
                     /gene="SCOC"
                     /gene_synonym="HRIHFB2072; SCOCO; UNC-69"
                     /note="isoform 4 is encoded by transcript variant 5"
                     /codon_start=1
                     /product="short coiled-coil protein isoform 4"
                     /protein_id="NP_001147057.1"
                     /db_xref="CCDS:CCDS3750.1"
                     /db_xref="GeneID:60592"
                     /db_xref="HGNC:HGNC:20335"
                     /translation="MDGSRKEEEEDSTFTNISLADDIDHSSRILYPRPKSLLPKMMNA
                     DMDAVDAENQVELEEKTRLINQVLELQHTLEDLSARVDAVKEENLKLKSENQVLGQYI
                     ENLMSASSVFQTTDTKSKRK"
     exon            249..320
                     /gene="SCOC"
                     /gene_synonym="HRIHFB2072; SCOCO; UNC-69"
                     /inference="alignment:Splign:2.1.0"
     exon            321..404
                     /gene="SCOC"
                     /gene_synonym="HRIHFB2072; SCOCO; UNC-69"
                     /inference="alignment:Splign:2.1.0"
     exon            405..1999
                     /gene="SCOC"
                     /gene_synonym="HRIHFB2072; SCOCO; UNC-69"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1976..1981
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCOC"
                     /gene_synonym="HRIHFB2072; SCOCO; UNC-69"
                     /note="hexamer: AATAAA"
     polyA_site      1997
                     /gene="SCOC"
                     /gene_synonym="HRIHFB2072; SCOCO; UNC-69"
                     /note="major polyA site"
ORIGIN      
        1 aacactcagg tgagaacttc tcaggtggaa agcaggaaga gggtggctag tgcaaggatc
       61 agatagcacc tgcttggaag ttcactgatt aatgatttaa caagggcggt cacatgggac
      121 aactgctgct tttctctgcc ctcatttttc ttactaacag gtctgaaaat tgaacaagat
      181 ggacgggtcc aggaaagagg aggaggaaga cagcacattc accaacattt ctcttgcaga
      241 tgacatagac cattcctcaa gaattttgta tccaaggccc aaaagtttgt tacccaagat
      301 gatgaatgct gacatggatg cagttgatgc tgaaaatcaa gtggaactgg aggaaaaaac
      361 aagacttatt aatcaagtgt tggaactcca acacacactt gaagatctct ctgcaagagt
      421 agatgcagtt aaggaagaaa atctgaagct aaaatcagaa aaccaagttc ttggacaata
      481 tatagaaaat ctcatgtcag cttctagtgt ttttcaaaca actgacacaa aaagcaaaag
      541 aaagtaaggg attgacaccc ttctgtttta tggaattgct gctgatcatt ttttctttaa
      601 aacttggata gattccaaaa gttacagtac ctttgtggct tcattgaata tttatgaaga
      661 taatgtcaga tgtagacaaa aataacacaa taacaggaga cttccataag tttgtgtatt
      721 atgttagtct atgaaaacgt gcaaatgtat tgtagagact ttatgattag aattgcatat
      781 atttatgaaa cttaaagatg aatgttttat tgaatttgta ggtttagcac tgtcttttat
      841 tataggatta gtaagatata caagaaaata accaccgtgt tgtgaaaaag tgaccaaaat
      901 catgtactaa atgcacagct ttatgtaccc tgtccaccat cttgtgcctc ttctccattt
      961 gcctcttcct tcctatttcc cttccgctaa ggaaaaaaat tggtgtcaca tttgtaaaag
     1021 taattttaat agttaatcat ctctgagagt aacctgtatt ttaattgttg aaacttaacc
     1081 aaaataagat actgtctcag ctagggcttg tcatttgtgt atttagtgtt aagataggaa
     1141 tgctagtgtc tctttaatta attggaaata gatggaggct aaaaatgaag gtttttcttt
     1201 gaaactgaat taacttggga atatttgttg ttaaaaactt ctttttgccc aaaataactc
     1261 attttgtatt atctgaaaat atataatttc tggtcatgtg tatgttaaaa tagaaaattt
     1321 tgaggaaaaa tggaaatagg gtggaaaagt actcggtaaa cagtagtaac caaatatttt
     1381 cactccagat ttgtgttttc tctggcacag agtagatctt ttgggaaata tatatgaaag
     1441 tggattaagt ttgactaccc ttatgttagc cacatctgga tgagaacagt tacaaagagt
     1501 ttggtctcta agttgatttg tacccagtgg gtcaacttct gcaaaattcc gtaatggtgt
     1561 attagtatta gaatagtgaa taaaatggga aagttataca tgtatactta ttatcttgct
     1621 cagtatttta tctcacttgt tctagaattt tctgtaaacc ctgctactgg gtttgaagag
     1681 ttttagtcat cctttaacaa tttttaaaaa tttagcttct agattccatt tggtaaggaa
     1741 atcaatattg gaagtattgc taaaatctta taatatgaaa agagatccac taatgtagct
     1801 taaggttatt agatttgggc ttttaatcat ggaataatct tatgtattgg tgtaagagtt
     1861 gatgaatgac tttagctgtg tgaatatata atagtcaaac tgcaaacatt ttgcatccct
     1921 tttgtgacct aatttacaga catttaaatt gtgttgcagt tctgctttgc cgtttaataa
     1981 aaagctattt cagaggttga aaaaaaaaa
//
