LOCUS       NM_001153484            4995 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens short coiled-coil protein (SCOC), transcript variant
            1, mRNA.
ACCESSION   NM_001153484
VERSION     NM_001153484.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4995)
  AUTHORS   Wirth,M., Mouilleron,S., Zhang,W., Sjottem,E., Princely Abudu,Y.,
            Jain,A., Lauritz Olsvik,H., Bruun,J.A., Razi,M., Jefferies,H.B.J.,
            Lee,R., Joshi,D., O'Reilly,N., Johansen,T. and Tooze,S.A.
  TITLE     Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding
            Affinity and Specificity
  JOURNAL   J Mol Biol 433 (13), 166987 (2021)
   PUBMED   33845085
  REMARK    GeneRIF: Phosphorylation of the LIR Domain of SCOC Modulates ATG8
            Binding Affinity and Specificity.
            Erratum:[J Mol Biol. 2021 Jul 23;433(15):167049. doi:
            10.1016/j.jmb.2021.167049.. PMID: 34052024]
REFERENCE   2  (bases 1 to 4995)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4995)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4995)
  AUTHORS   Stringer,S., Minica,C.C., Verweij,K.J., Mbarek,H., Bernard,M.,
            Derringer,J., van Eijk,K.R., Isen,J.D., Loukola,A.,
            Maciejewski,D.F., Mihailov,E., van der Most,P.J., Sanchez-Mora,C.,
            Roos,L., Sherva,R., Walters,R., Ware,J.J., Abdellaoui,A.,
            Bigdeli,T.B., Branje,S.J., Brown,S.A., Bruinenberg,M., Casas,M.,
            Esko,T., Garcia-Martinez,I., Gordon,S.D., Harris,J.M.,
            Hartman,C.A., Henders,A.K., Heath,A.C., Hickie,I.B., Hickman,M.,
            Hopfer,C.J., Hottenga,J.J., Huizink,A.C., Irons,D.E., Kahn,R.S.,
            Korhonen,T., Kranzler,H.R., Krauter,K., van Lier,P.A., Lubke,G.H.,
            Madden,P.A., Magi,R., McGue,M.K., Medland,S.E., Meeus,W.H.,
            Miller,M.B., Montgomery,G.W., Nivard,M.G., Nolte,I.M.,
            Oldehinkel,A.J., Pausova,Z., Qaiser,B., Quaye,L.,
            Ramos-Quiroga,J.A., Richarte,V., Rose,R.J., Shin,J.,
            Stallings,M.C., Stiby,A.I., Wall,T.L., Wright,M.J., Koot,H.M.,
            Paus,T., Hewitt,J.K., Ribases,M., Kaprio,J., Boks,M.P., Snieder,H.,
            Spector,T., Munafo,M.R., Metspalu,A., Gelernter,J., Boomsma,D.I.,
            Iacono,W.G., Martin,N.G., Gillespie,N.A., Derks,E.M. and Vink,J.M.
  TITLE     Genome-wide association study of lifetime cannabis use based on a
            large meta-analytic sample of 32 330 subjects from the
            International Cannabis Consortium
  JOURNAL   Transl Psychiatry 6 (3), e769 (2016)
   PUBMED   27023175
  REMARK    GeneRIF: SCOC SNPs were associated with lifetime cannabis use, but
            the association did not reach genome-wide significance.
            [Meta-Analysis]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4995)
  AUTHORS   Alborghetti,M.R., Furlan Ada,S., da Silva,J.C., Sforca,M.L.,
            Honorato,R.V., Granato,D.C., dos Santos Migueleti,D.L., Neves,J.L.,
            de Oliveira,P.S., Paes-Leme,A.F., Zeri,A.C., de Torriani,I.C. and
            Kobarg,J.
  TITLE     Structural analysis of intermolecular interactions in the kinesin
            adaptor complex fasciculation and elongation protein zeta 1/ short
            coiled-coil protein (FEZ1/SCOCO)
  JOURNAL   PLoS One 8 (10), e76602 (2013)
   PUBMED   24116125
  REMARK    GeneRIF: Studies indicate that FEZ1 (fasciculation and elongation
            protein zeta 1), SCOCO (short coiled-coil protein) and kinesins
            (kinesin heavy chain) are involved in biological transport process.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4995)
  AUTHORS   Behrens,C., Binotti,B., Schmidt,C., Robinson,C.V., Chua,J.J. and
            Kuhnel,K.
  TITLE     Crystal structure of the human short coiled coil protein and
            insights into SCOC-FEZ1 complex formation
  JOURNAL   PLoS One 8 (10), e76355 (2013)
   PUBMED   24098481
  REMARK    GeneRIF: SCOC forms a stable homogeneous complex with the coiled
            coil domain of FEZ1. SCOC dimerization and the SCOC surface residue
            R117 are important for this interaction.
            Erratum:[PLoS One. 2013;8(10).
            doi:10.1371/annotation/cb60d973-58aa-45e0-bbb3-1c7f5a42a8d2]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4995)
  AUTHORS   McKnight,N.C., Jefferies,H.B., Alemu,E.A., Saunders,R.E.,
            Howell,M., Johansen,T. and Tooze,S.A.
  TITLE     Genome-wide siRNA screen reveals amino acid starvation-induced
            autophagy requires SCOC and WAC
  JOURNAL   EMBO J 31 (8), 1931-1946 (2012)
   PUBMED   22354037
  REMARK    GeneRIF: The identification of SCOC and WAC as novel regulatory
            proteins with diverse functions in autophagy contributes towards a
            fuller understanding of autophagosome formation.
REFERENCE   8  (bases 1 to 4995)
  AUTHORS   Miyamoto-Sato,E., Fujimori,S., Ishizaka,M., Hirai,N., Masuoka,K.,
            Saito,R., Ozawa,Y., Hino,K., Washio,T., Tomita,M., Yamashita,T.,
            Oshikubo,T., Akasaka,H., Sugiyama,J., Matsumoto,Y. and Yanagawa,H.
  TITLE     A comprehensive resource of interacting protein regions for
            refining human transcription factor networks
  JOURNAL   PLoS One 5 (2), e9289 (2010)
   PUBMED   20195357
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 4995)
  AUTHORS   Van Valkenburgh,H., Shern,J.F., Sharer,J.D., Zhu,X. and Kahn,R.A.
  TITLE     ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both
            specific and shared effectors: characterizing ARL1-binding proteins
  JOURNAL   J Biol Chem 276 (25), 22826-22837 (2001)
   PUBMED   11303027
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093671.3.
            
            On Jun 5, 2020 this sequence version replaced NM_001153484.1.
            
            Summary: This gene encodes a short coiled-coiled domain-containing
            protein that localizes to the Golgi apparatus. The encoded protein
            interacts with ADP-ribosylation factor-like proteins. Pseudogenes
            of this gene are found on chromosomes 1 and 14. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Apr 2009].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.4033318.1,
                                           SRR14038192.2435441.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000608372.6/ ENSP00000477352.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                AC093671.3         2758-2829
            73-144              AC093671.3         8233-8304
            145-228             AC093671.3         8681-8764
            229-4995            AC093671.3         10074-14840
FEATURES             Location/Qualifiers
     source          1..4995
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.1"
     gene            1..4995
                     /gene="SCOC"
                     /gene_synonym="HRIHFB2072; SCOCO; UNC-69"
                     /note="short coiled-coil protein"
                     /db_xref="GeneID:60592"
                     /db_xref="HGNC:HGNC:20335"
     exon            1..72
                     /gene="SCOC"
                     /gene_synonym="HRIHFB2072; SCOCO; UNC-69"
                     /inference="alignment:Splign:2.1.0"
     exon            73..144
                     /gene="SCOC"
                     /gene_synonym="HRIHFB2072; SCOCO; UNC-69"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..371
                     /gene="SCOC"
                     /gene_synonym="HRIHFB2072; SCOCO; UNC-69"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="short coiled-coil protein isoform 1"
                     /protein_id="NP_001146956.2"
                     /db_xref="CCDS:CCDS54806.2"
                     /db_xref="GeneID:60592"
                     /db_xref="HGNC:HGNC:20335"
                     /translation="MMNADMDAVDAENQVELEEKTRLINQVLELQHTLEDLSARVDAV
                     KEENLKLKSENQVLGQYIENLMSASSVFQTTDTKSKRK"
     exon            145..228
                     /gene="SCOC"
                     /gene_synonym="HRIHFB2072; SCOCO; UNC-69"
                     /inference="alignment:Splign:2.1.0"
     exon            229..4995
                     /gene="SCOC"
                     /gene_synonym="HRIHFB2072; SCOCO; UNC-69"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1800..1805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCOC"
                     /gene_synonym="HRIHFB2072; SCOCO; UNC-69"
                     /note="hexamer: AATAAA"
     polyA_site      1821
                     /gene="SCOC"
                     /gene_synonym="HRIHFB2072; SCOCO; UNC-69"
                     /note="major polyA site"
     regulatory      4971..4976
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCOC"
                     /gene_synonym="HRIHFB2072; SCOCO; UNC-69"
                     /note="hexamer: AATAAA"
     polyA_site      4995
                     /gene="SCOC"
                     /gene_synonym="HRIHFB2072; SCOCO; UNC-69"
ORIGIN      
        1 gtcagttggt ccaagtgtcc cggcctgagg tgtcggccgg atccctcctt ctcccggcgc
       61 ctcaagcgga agaccattcc tcaagaattt tgtatccaag gcccaaaagt ttgttaccca
      121 agatgatgaa tgctgacatg gatgcagttg atgctgaaaa tcaagtggaa ctggaggaaa
      181 aaacaagact tattaatcaa gtgttggaac tccaacacac acttgaagat ctctctgcaa
      241 gagtagatgc agttaaggaa gaaaatctga agctaaaatc agaaaaccaa gttcttggac
      301 aatatataga aaatctcatg tcagcttcta gtgtttttca aacaactgac acaaaaagca
      361 aaagaaagta agggattgac acccttctgt tttatggaat tgctgctgat cattttttct
      421 ttaaaacttg gatagattcc aaaagttaca gtacctttgt ggcttcattg aatatttatg
      481 aagataatgt cagatgtaga caaaaataac acaataacag gagacttcca taagtttgtg
      541 tattatgtta gtctatgaaa acgtgcaaat gtattgtaga gactttatga ttagaattgc
      601 atatatttat gaaacttaaa gatgaatgtt ttattgaatt tgtaggttta gcactgtctt
      661 ttattatagg attagtaaga tatacaagaa aataaccacc gtgttgtgaa aaagtgacca
      721 aaatcatgta ctaaatgcac agctttatgt accctgtcca ccatcttgtg cctcttctcc
      781 atttgcctct tccttcctat ttcccttccg ctaaggaaaa aaattggtgt cacatttgta
      841 aaagtaattt taatagttaa tcatctctga gagtaacctg tattttaatt gttgaaactt
      901 aaccaaaata agatactgtc tcagctaggg cttgtcattt gtgtatttag tgttaagata
      961 ggaatgctag tgtctcttta attaattgga aatagatgga ggctaaaaat gaaggttttt
     1021 ctttgaaact gaattaactt gggaatattt gttgttaaaa acttcttttt gcccaaaata
     1081 actcattttg tattatctga aaatatataa tttctggtca tgtgtatgtt aaaatagaaa
     1141 attttgagga aaaatggaaa tagggtggaa aagtactcgg taaacagtag taaccaaata
     1201 ttttcactcc agatttgtgt tttctctggc acagagtaga tcttttggga aatatatatg
     1261 aaagtggatt aagtttgact acccttatgt tagccacatc tggatgagaa cagttacaaa
     1321 gagtttggtc tctaagttga tttgtaccca gtgggtcaac ttctgcaaaa ttccgtaatg
     1381 gtgtattagt attagaatag tgaataaaat gggaaagtta tacatgtata cttattatct
     1441 tgctcagtat tttatctcac ttgttctaga attttctgta aaccctgcta ctgggtttga
     1501 agagttttag tcatccttta acaattttta aaaatttagc ttctagattc catttggtaa
     1561 ggaaatcaat attggaagta ttgctaaaat cttataatat gaaaagagat ccactaatgt
     1621 agcttaaggt tattagattt gggcttttaa tcatggaata atcttatgta ttggtgtaag
     1681 agttgatgaa tgactttagc tgtgtgaata tataatagtc aaactgcaaa cattttgcat
     1741 cccttttgtg acctaattta cagacattta aattgtgttg cagttctgct ttgccgttta
     1801 ataaaaagct atttcagagg ttgtgtgtgt tttgatatag ttgcctaagt aaatggggta
     1861 tttaggtata gtggtgtatc cagggttatt caatgccaca gaatagtgta tcttatttaa
     1921 gtacccagtt actgattatt taggggaata atatttttat taatacaact ataactggtt
     1981 atcaatataa atatcatagg ctattataca ttaatttgga aaacaaaagc aaagcactca
     2041 aaggatccag tatctccagg gaaaaaggaa gttgtatttt ttagggtagg ctaagctact
     2101 ttagcaagag acccagtgat aaagaatata aatatagaag tttctctccc aaccagtggt
     2161 tccaaggtca gcattgcagg ctagcagccc ttgttcaaac agttattcag ggactttggc
     2221 tgaggatggt gctgccattt taaatcatgg ctttcaagtc actctagtta ttcttctaat
     2281 ttgcagaaaa agaacatgga agtgtacata tgcaaggtgt tatgggctgt gcctggaaat
     2341 ggctcatata tcttctcata ttccagtggt gtggagactt agttacatct agatacaaga
     2401 ggagctgaga aatgtagtcc ctggctggga agccatcttc cagctataaa tacaagattt
     2461 tggtggctgc tagcagcctc agccacagct cttcttgtgc taccaagtat cttcccttac
     2521 acagaaagta atccctcttc atccagctag tgattcagct cacaatctag gatctctatt
     2581 aaaggtccat ccctttacat gtggcttcta atagtctgac aatctctaaa ctgataggca
     2641 aattatttgc tctcaccctt gctgctgccc atttataatg tagttgggac aggatggcca
     2701 aataaaaagt ctcaatttgg aaaatggaat aaagggaaac gtaaaaattg tggaatgctc
     2761 ctgggagatg tatgaagatt ttgtccctag cagtggagaa gttccttgat tcaactatga
     2821 ttctgatctc tggcagggga ctcccttgtt cattgaactc catggtttcc cctctggaaa
     2881 gttactcctt atccattttc ttccatggct acctcagaag tagagattgg gtgttcactc
     2941 catgggaatt gtgaagacag tccacttcct gctggtgtga atttggtgcc catcatttta
     3001 aggccaagct catgtttctg tggaatacga ttctctcaaa aactcaagcc tttttatcag
     3061 tgtgcttctg attgcatatg ccgaggaacc acaaccaagc ttttgaccaa attctcaaag
     3121 tatgtattat ttttgccttt ctttaatgga ggctatcttg agatcaacta aaaataagat
     3181 tacactggga atgttacatg cagatcatca ctgcaaagct gggttccttt ggcttaacga
     3241 ttggtagaga agtcttcatg ggcttccccc caatctcccc cacctcaaaa ataattttga
     3301 acctttgctg ctattcagac ttcagaaaca attggcttaa tttcatgagg ttccttgtat
     3361 caaaactttg tctattccct tctatctttg cttgaaaatg tcaatttttt tgataccttg
     3421 ctgaaagcaa ggaatagcca attcacttaa cattctggct ttttccagct agagctatca
     3481 gattagtagg tgtcaaaata tatccccact gcttgtcatg ttaatggtaa gctaatgcta
     3541 tatacttagt ttttgctatg caatacttca ggataatttc ttcattagaa atataggtgg
     3601 tacacagtgt gcacagggac tgtgtccagc ttctggaaaa gactcgacca aattttagac
     3661 aggcacctct gagccctgtt tttgactagt ccagttttag caaaaatcct gctaaatgag
     3721 tttagagata atcccatcct caataactga tgatcgtcaa cctggcctgt ctttggcaag
     3781 aatcacccta ctcttgatgt ctccagttag tagttttcca tccactgacc tcatcactgc
     3841 tcattgacta taaatcctca gttgtatttg ctgtgttagt tgagcccagt ttctttccct
     3901 tattgggtga tggtcttaac atatacagtc ctgagtaaag tcttctttac tgctttaaca
     3961 agtgtcagaa tggtttttcc tttaatactt cctagtttac atgctggtag aataatgttt
     4021 ggtagggaaa aatcagcata ctccttgtta tggactgaat gtgtcctccc aaaattctta
     4081 ggttgaaatc ctaaccccaa tgtgatgctt ttaggaggtg gggcttttgg gagataatta
     4141 ggtaatgagg gtgaaaccct catgaatggg attgtgtcat taaaagaaac cccagagagc
     4201 tctctttctg ccacatagaa gacagcagtc tgcatcttgg aagagggccc tcaacactga
     4261 tctctcagac ttccagcttc caaaactgag aaataaattt gtttataagc cacccagtct
     4321 atattttgtt atagcatccc aaatagttta aggcacccat tttccccact gtttcccaat
     4381 acaaatttcc ccagtattga cactgccatt ctatgcaaaa tgtgtcctct ttatagtccc
     4441 tttggactca cagcaggtta ctacacatca cagatcctcg tctgaaactt gtagggccag
     4501 atgtcttaga atttggagtt ttccagattt tataaaatat tatgactcag acaccaatat
     4561 ggtttggggc aacacctata atcaagtata ttaacatttc tgtagcaaaa tgagtattaa
     4621 agtaggataa agaaagacta catatgtaca taaaaccttg ccggggaagt caggctcagc
     4681 taccaggtga gttttgttgc caaaatgcta ggaaaatctt taacttttca gagatttttg
     4741 gtcatggaat tgtagcaaca aaaccttttg tagaagagta accaaaatca tgtatgcatt
     4801 tagttccaac tagttaatgt cacatctcta ttcctgtcac ccttccctgt gatctagtcc
     4861 cttttgtaag agaaatatgg tagttgaatt ataaaatcta aaattaattt tgtggtccaa
     4921 agaaaagcaa aatagatctt tagaatgtaa agccattctt tactttgccc aataaaaatt
     4981 ttgttattcc ctgaa
//
