LOCUS       NP_001146956              82 aa            linear   PRI 12-FEB-2025
DEFINITION  short coiled-coil protein isoform 1 [Homo sapiens].
ACCESSION   NP_001146956
VERSION     NP_001146956.2
DBSOURCE    REFSEQ: accession NM_001153484.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 82)
  AUTHORS   Wirth,M., Mouilleron,S., Zhang,W., Sjottem,E., Princely Abudu,Y.,
            Jain,A., Lauritz Olsvik,H., Bruun,J.A., Razi,M., Jefferies,H.B.J.,
            Lee,R., Joshi,D., O'Reilly,N., Johansen,T. and Tooze,S.A.
  TITLE     Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding
            Affinity and Specificity
  JOURNAL   J Mol Biol 433 (13), 166987 (2021)
   PUBMED   33845085
  REMARK    GeneRIF: Phosphorylation of the LIR Domain of SCOC Modulates ATG8
            Binding Affinity and Specificity.
            Erratum:[J Mol Biol. 2021 Jul 23;433(15):167049. doi:
            10.1016/j.jmb.2021.167049.. PMID: 34052024]
REFERENCE   2  (residues 1 to 82)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (residues 1 to 82)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (residues 1 to 82)
  AUTHORS   Stringer,S., Minica,C.C., Verweij,K.J., Mbarek,H., Bernard,M.,
            Derringer,J., van Eijk,K.R., Isen,J.D., Loukola,A.,
            Maciejewski,D.F., Mihailov,E., van der Most,P.J., Sanchez-Mora,C.,
            Roos,L., Sherva,R., Walters,R., Ware,J.J., Abdellaoui,A.,
            Bigdeli,T.B., Branje,S.J., Brown,S.A., Bruinenberg,M., Casas,M.,
            Esko,T., Garcia-Martinez,I., Gordon,S.D., Harris,J.M.,
            Hartman,C.A., Henders,A.K., Heath,A.C., Hickie,I.B., Hickman,M.,
            Hopfer,C.J., Hottenga,J.J., Huizink,A.C., Irons,D.E., Kahn,R.S.,
            Korhonen,T., Kranzler,H.R., Krauter,K., van Lier,P.A., Lubke,G.H.,
            Madden,P.A., Magi,R., McGue,M.K., Medland,S.E., Meeus,W.H.,
            Miller,M.B., Montgomery,G.W., Nivard,M.G., Nolte,I.M.,
            Oldehinkel,A.J., Pausova,Z., Qaiser,B., Quaye,L.,
            Ramos-Quiroga,J.A., Richarte,V., Rose,R.J., Shin,J.,
            Stallings,M.C., Stiby,A.I., Wall,T.L., Wright,M.J., Koot,H.M.,
            Paus,T., Hewitt,J.K., Ribases,M., Kaprio,J., Boks,M.P., Snieder,H.,
            Spector,T., Munafo,M.R., Metspalu,A., Gelernter,J., Boomsma,D.I.,
            Iacono,W.G., Martin,N.G., Gillespie,N.A., Derks,E.M. and Vink,J.M.
  TITLE     Genome-wide association study of lifetime cannabis use based on a
            large meta-analytic sample of 32 330 subjects from the
            International Cannabis Consortium
  JOURNAL   Transl Psychiatry 6 (3), e769 (2016)
   PUBMED   27023175
  REMARK    GeneRIF: SCOC SNPs were associated with lifetime cannabis use, but
            the association did not reach genome-wide significance.
            [Meta-Analysis]
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 82)
  AUTHORS   Alborghetti,M.R., Furlan Ada,S., da Silva,J.C., Sforca,M.L.,
            Honorato,R.V., Granato,D.C., dos Santos Migueleti,D.L., Neves,J.L.,
            de Oliveira,P.S., Paes-Leme,A.F., Zeri,A.C., de Torriani,I.C. and
            Kobarg,J.
  TITLE     Structural analysis of intermolecular interactions in the kinesin
            adaptor complex fasciculation and elongation protein zeta 1/ short
            coiled-coil protein (FEZ1/SCOCO)
  JOURNAL   PLoS One 8 (10), e76602 (2013)
   PUBMED   24116125
  REMARK    GeneRIF: Studies indicate that FEZ1 (fasciculation and elongation
            protein zeta 1), SCOCO (short coiled-coil protein) and kinesins
            (kinesin heavy chain) are involved in biological transport process.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 82)
  AUTHORS   Behrens,C., Binotti,B., Schmidt,C., Robinson,C.V., Chua,J.J. and
            Kuhnel,K.
  TITLE     Crystal structure of the human short coiled coil protein and
            insights into SCOC-FEZ1 complex formation
  JOURNAL   PLoS One 8 (10), e76355 (2013)
   PUBMED   24098481
  REMARK    GeneRIF: SCOC forms a stable homogeneous complex with the coiled
            coil domain of FEZ1. SCOC dimerization and the SCOC surface residue
            R117 are important for this interaction.
            Erratum:[PLoS One. 2013;8(10).
            doi:10.1371/annotation/cb60d973-58aa-45e0-bbb3-1c7f5a42a8d2]
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 82)
  AUTHORS   McKnight,N.C., Jefferies,H.B., Alemu,E.A., Saunders,R.E.,
            Howell,M., Johansen,T. and Tooze,S.A.
  TITLE     Genome-wide siRNA screen reveals amino acid starvation-induced
            autophagy requires SCOC and WAC
  JOURNAL   EMBO J 31 (8), 1931-1946 (2012)
   PUBMED   22354037
  REMARK    GeneRIF: The identification of SCOC and WAC as novel regulatory
            proteins with diverse functions in autophagy contributes towards a
            fuller understanding of autophagosome formation.
REFERENCE   8  (residues 1 to 82)
  AUTHORS   Miyamoto-Sato,E., Fujimori,S., Ishizaka,M., Hirai,N., Masuoka,K.,
            Saito,R., Ozawa,Y., Hino,K., Washio,T., Tomita,M., Yamashita,T.,
            Oshikubo,T., Akasaka,H., Sugiyama,J., Matsumoto,Y. and Yanagawa,H.
  TITLE     A comprehensive resource of interacting protein regions for
            refining human transcription factor networks
  JOURNAL   PLoS One 5 (2), e9289 (2010)
   PUBMED   20195357
  REMARK    Publication Status: Online-Only
REFERENCE   9  (residues 1 to 82)
  AUTHORS   Van Valkenburgh,H., Shern,J.F., Sharer,J.D., Zhu,X. and Kahn,R.A.
  TITLE     ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both
            specific and shared effectors: characterizing ARL1-binding proteins
  JOURNAL   J Biol Chem 276 (25), 22826-22837 (2001)
   PUBMED   11303027
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093671.3.
            
            On Jun 5, 2020 this sequence version replaced NP_001146956.1.
            
            Summary: This gene encodes a short coiled-coiled domain-containing
            protein that localizes to the Golgi apparatus. The encoded protein
            interacts with ADP-ribosylation factor-like proteins. Pseudogenes
            of this gene are found on chromosomes 1 and 14. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Apr 2009].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.4033318.1,
                                           SRR14038192.2435441.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000608372.6/ ENSP00000477352.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..82
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.1"
     Protein         1..82
                     /product="short coiled-coil protein isoform 1"
                     /calculated_mol_wt=9223
     Region          13..73
                     /region_name="DUF2205"
                     /note="Short coiled-coil protein; pfam10224"
                     /db_xref="CDD:431150"
     CDS             1..82
                     /gene="SCOC"
                     /gene_synonym="HRIHFB2072; SCOCO; UNC-69"
                     /coded_by="NM_001153484.2:123..371"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS54806.2"
                     /db_xref="GeneID:60592"
                     /db_xref="HGNC:HGNC:20335"
ORIGIN      
        1 mmnadmdavd aenqveleek trlinqvlel qhtledlsar vdavkeenlk lksenqvlgq
       61 yienlmsass vfqttdtksk rk
//
