LOCUS       NM_004589               9577 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens synthesis of cytochrome C oxidase 1 (SCO1), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_004589
VERSION     NM_004589.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9577)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 9577)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 9577)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 9577)
  AUTHORS   Liu,X., Salokas,K., Tamene,F., Jiu,Y., Weldatsadik,R.G., Ohman,T.
            and Varjosalo,M.
  TITLE     An AP-MS- and BioID-compatible MAC-tag enables comprehensive
            mapping of protein interactions and subcellular localizations
  JOURNAL   Nat Commun 9 (1), 1188 (2018)
   PUBMED   29568061
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9577)
  AUTHORS   Aich,A., Wang,C., Chowdhury,A., Ronsor,C., Pacheu-Grau,D.,
            Richter-Dennerlein,R., Dennerlein,S. and Rehling,P.
  TITLE     COX16 promotes COX2 metallation and assembly during respiratory
            complex IV biogenesis
  JOURNAL   Elife 7, e32572 (2018)
   PUBMED   29381136
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9577)
  AUTHORS   Papadopoulou,L.C., Sue,C.M., Davidson,M.M., Tanji,K., Nishino,I.,
            Sadlock,J.E., Krishna,S., Walker,W., Selby,J., Glerum,D.M.,
            Coster,R.V., Lyon,G., Scalais,E., Lebel,R., Kaplan,P., Shanske,S.,
            De Vivo,D.C., Bonilla,E., Hirano,M., DiMauro,S. and Schon,E.A.
  TITLE     Fatal infantile cardioencephalomyopathy with COX deficiency and
            mutations in SCO2, a COX assembly gene
  JOURNAL   Nat Genet 23 (3), 333-337 (1999)
   PUBMED   10545952
REFERENCE   7  (bases 1 to 9577)
  AUTHORS   Paret,C., Ostermann,K., Krause-Buchholz,U., Rentzsch,A. and
            Rodel,G.
  TITLE     Human members of the SCO1 gene family: complementation analysis in
            yeast and intracellular localization
  JOURNAL   FEBS Lett 447 (1), 65-70 (1999)
   PUBMED   10218584
REFERENCE   8  (bases 1 to 9577)
  AUTHORS   Petruzzella,V., Tiranti,V., Fernandez,P., Ianna,P., Carrozzo,R. and
            Zeviani,M.
  TITLE     Identification and characterization of human cDNAs specific to
            BCS1, PET112, SCO1, COX15, and COX11, five genes involved in the
            formation and function of the mitochondrial respiratory chain
  JOURNAL   Genomics 54 (3), 494-504 (1998)
   PUBMED   9878253
REFERENCE   9  (bases 1 to 9577)
  AUTHORS   Schulze,M. and Rodel,G.
  TITLE     Accumulation of the cytochrome c oxidase subunits I and II in yeast
            requires a mitochondrial membrane-associated protein, encoded by
            the nuclear SCO1 gene
  JOURNAL   Mol Gen Genet 216 (1), 37-43 (1989)
   PUBMED   2543907
REFERENCE   10 (bases 1 to 9577)
  AUTHORS   Schulze,M. and Rodel,G.
  TITLE     SCO1, a yeast nuclear gene essential for accumulation of
            mitochondrial cytochrome c oxidase subunit II
  JOURNAL   Mol Gen Genet 211 (3), 492-498 (1988)
   PUBMED   2835635
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA571370.1, BC015504.2,
            KC877631.1, BM981070.1, BM994602.1 and AC002347.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004589.3.
            
            Summary: Mammalian cytochrome c oxidase (COX) catalyzes the
            transfer of reducing equivalents from cytochrome c to molecular
            oxygen and pumps protons across the inner mitochondrial membrane.
            In yeast, 2 related COX assembly genes, SCO1 and SCO2 (synthesis of
            cytochrome c oxidase), enable subunits 1 and 2 to be incorporated
            into the holoprotein. This gene is the human homolog to the yeast
            SCO1 gene. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF026852.1, AK098826.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000255390.10/
                                                  ENSP00000255390.5
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                DA571370.1         36-46
            12-1251             BC015504.2         2-1241
            1252-1252           KC877631.1         37-37               c
            1253-1714           BM981070.1         18-479              c
            1715-1719           BM994602.1         15-19               c
            1720-9577           AC002347.3         64053-71910
FEATURES             Location/Qualifiers
     source          1..9577
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..9577
                     /gene="SCO1"
                     /gene_synonym="MC4DN4; SCOD1"
                     /note="synthesis of cytochrome C oxidase 1"
                     /db_xref="GeneID:6341"
                     /db_xref="HGNC:HGNC:10603"
                     /db_xref="MIM:603644"
     exon            1..299
                     /gene="SCO1"
                     /gene_synonym="MC4DN4; SCOD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..932
                     /gene="SCO1"
                     /gene_synonym="MC4DN4; SCOD1"
                     /note="SCO cytochrome oxidase deficient homolog 1; SCO1,
                     cytochrome c oxidase assembly protein; SCO cytochrome c
                     oxidase assembly protein 1"
                     /codon_start=1
                     /product="protein SCO1 homolog, mitochondrial"
                     /protein_id="NP_004580.1"
                     /db_xref="CCDS:CCDS11158.1"
                     /db_xref="GeneID:6341"
                     /db_xref="HGNC:HGNC:10603"
                     /db_xref="MIM:603644"
                     /translation="MAMLVLVPGRVMRPLGGQLWRFLPRGLEFWGPAEGTARVLLRQF
                     CARQAEAWRASGRPGYCLGTRPLSTARPPPPWSQKGPGDSTRPSKPGPVSWKSLAITF
                     AIGGALLAGMKHVKKEKAEKLEKERQRHIGKPLLGGPFSLTTHTGERKTDKDYLGQWL
                     LIYFGFTHCPDVCPEELEKMIQVVDEIDSITTLPDLTPLFISIDPERDTKEAIANYVK
                     EFSPKLVGLTGTREEVDQVARAYRVYYSPGPKDEDEDYIVDHTIIMYLIGPDGEFLDY
                     FGQNKRKGEIAASIATHMRPYRKKS"
     exon            300..390
                     /gene="SCO1"
                     /gene_synonym="MC4DN4; SCOD1"
                     /inference="alignment:Splign:2.1.0"
     exon            391..588
                     /gene="SCO1"
                     /gene_synonym="MC4DN4; SCOD1"
                     /inference="alignment:Splign:2.1.0"
     exon            589..681
                     /gene="SCO1"
                     /gene_synonym="MC4DN4; SCOD1"
                     /inference="alignment:Splign:2.1.0"
     exon            682..797
                     /gene="SCO1"
                     /gene_synonym="MC4DN4; SCOD1"
                     /inference="alignment:Splign:2.1.0"
     exon            798..9577
                     /gene="SCO1"
                     /gene_synonym="MC4DN4; SCOD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1688..1693
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCO1"
                     /gene_synonym="MC4DN4; SCOD1"
                     /note="hexamer: AGTAAA"
     polyA_site      1714
                     /gene="SCO1"
                     /gene_synonym="MC4DN4; SCOD1"
                     /note="major polyA site"
     regulatory      9556..9561
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCO1"
                     /gene_synonym="MC4DN4; SCOD1"
                     /note="hexamer: AATAAA"
     polyA_site      9577
                     /gene="SCO1"
                     /gene_synonym="MC4DN4; SCOD1"
ORIGIN      
        1 caaaggagac ccggtctccg aggctcatgg cgatgctggt cctagtaccc ggacgagtta
       61 tgcggcctct gggtggccaa ctttggcgct tcttgcctcg cggactcgag ttttggggcc
      121 cagccgaggg gactgcgaga gtcttgctga ggcagttctg cgcgcggcaa gcggaggcgt
      181 ggcgtgcctc ggggcgccct ggctattgcc tgggaacccg gcccctcagc actgcgaggc
      241 cgccaccccc gtggtcgcag aagggccccg gagactccac gcgcccctcg aagcccgggc
      301 ctgtttcctg gaagtcttta gcaatcacat ttgctattgg aggagcttta ctggctggaa
      361 tgaagcacgt caagaaagaa aaggcagaga agttagagaa ggaacggcag cgacacatcg
      421 gcaagccttt acttggggga ccgttttccc tcacaactca tactggggag cgtaaaactg
      481 acaaggacta cttgggtcag tggttattga tttattttgg cttcactcat tgccctgatg
      541 tctgtccaga agaactagaa aagatgattc aagtcgtgga tgaaatagat agcattacaa
      601 ctctgccaga tctaactcca cttttcatca gcattgaccc agagagggac acaaaagaag
      661 ccatcgcaaa ttatgtgaaa gaattttctc ccaaactggt tggcttgact ggcacgagag
      721 aagaggtcga tcaagtggcc agagcataca gagtgtatta cagccctggc cccaaggacg
      781 aagatgaaga ctacatagtg gatcacacaa taataatgta cttgattgga ccagatggtg
      841 agtttctaga ttattttggc cagaacaaga ggaagggaga aatagctgct tcaattgcca
      901 cacacatgag gccatacaga aaaaagagct agccaaagca gtgttgctgg atgcagtatt
      961 ctcttgctaa gaggaaggaa actgtctcgc ataggagcct atataaatat aaacatatat
     1021 acgtgcactc tacagaatgg ccttcatacc atgagaacat ttctgttttg gatggggatg
     1081 ttacccttgc gttcaaccaa aattgattct tggaactgta aagattacaa cccaaagtct
     1141 cccaggaagc tgtggggaga ccagaggatc aagctgaagt gaagccagtg aagagcccac
     1201 ctgtggaagg acatggcggg gcgaggcaca gccagtgcat tcctgcctgc gaacaggccc
     1261 tcccagcagc tttgccgcct ctccatcgtc ttgggccctt gctcaaatag ctgtgggact
     1321 gaatttcaca gaaaagaata taatttccat agtgctcttg cttgcctctt cttgagttct
     1381 ttgctcttct gagttcttgg tggctaataa cagtcagatt agggtctctg ccattcagag
     1441 ttgatgcttg aaaactttag ttttccttat taatgaatat cactatcaga tttgactaat
     1501 gaagaggaaa tctattgttt gggggaaaaa aaacatcagt ttgatttctc taggggttct
     1561 tttatgtgat ttttagctaa gtggtgtgcc aggttttcag tgacatacca aatggaaata
     1621 agaggatatt gatcacgagt gtgatgctga gtacctttct gcatatactg gattgtactt
     1681 tgtgtaaagt aaacatactc agttttgctg ttcagacaag cgtgatcttt ttcatgggtg
     1741 atgagtgggt acatagatgg ctgcacacag ttctcaggaa agagacccac aggctccagc
     1801 gggcaggtgg gtgggacgct tgctgaagtg cagttcccca gacccagagc tgaattcact
     1861 gaatctgcag tatgatgcag agacctgctt ccatgacaga taccccaggt gactcggatg
     1921 ctggcggact gggaccatcc cttaagaaag tgttttttgg ggaaataact tgcctggcac
     1981 aatggctaat gcctataatc ccaaaacttt gggaggccag ggcctgagga ttgctagagg
     2041 ttaggtattc aagacaagcc tgggcaacat agtgagaccc cccccccccg cccccatctc
     2101 tacagaagat ttttttggca tggtggcaca tgcctgtagt cctggctact caggagactg
     2161 aaatggagta tcacttgagc ccaggaattc aaggcttcag tgagctataa tcacaccact
     2221 gcattccagc ctgggcaaca gagtgagacc ctctagatat atctatgtag agatacagaa
     2281 attaaaatga atttaaaaat aaataaattt gacccttctt ttggtgtgtc agccattgaa
     2341 gaaaatgatt attgagtgat agaatgaatc ttggcttttg tttctaaatt taactgccct
     2401 agaatcctgg gtttggcctt tttctgccag aagctgctgc cctaggggca aagttctcca
     2461 aaagtttttc agtaaatcct aagatgcaac aaatataatg cctagataga caacagattc
     2521 tttttacatg atatgtttct acacgcacat gatagaggtc ttttggtttt taaattctca
     2581 atacttaaac ctaaatatat caaagtaaaa gtatgtgaaa aaaaactatg ctagttatag
     2641 gttgaataat gtcccccaaa atttatacat tgaagcccta atctcagtac ttcagaatgt
     2701 gactgtaatt ggagataggg tctttagaga gatagttaaa ttaaaatgag gctgctaggt
     2761 tggccctaat tctatatgac tggtgttctt aaaataatag attagctggg cacagtggct
     2821 tatgcctgta atcccagcac tttgggaggc cgaggcgtgc agatcaccta aggtcaggag
     2881 ttcgagacca gcctggccaa catggtgaaa cgtcgtctct ctcctaaaaa tacaaaaatt
     2941 agccgggcat ggtagcgggt gcctgtaatc tcagttactc cggaggctga ggcaggagaa
     3001 tcgcttgaac ccaggaggca gaggtggcag tgaggcaaga ttgcgccatc gtactccagc
     3061 ctgggcgaca gagcaagact ccgtctcaaa aagaatagga gacacagtga gacgaccatg
     3121 agaagccaga gagaaaacag ccatcttaca agccaagaga gaagttgtga gaaaaaaaaa
     3181 aaaaaacaaa ccctgctgac tccttgattt ttgccttcca agctccagaa ctgtgaggaa
     3241 ataaatgtct gttgttttag ccaccaaacc tggtaaggca gtcctagcaa gctaatacaa
     3301 tagcctgttc cttaataaac aactgcaaga tttagtttat agaaaccagc tcggaagcag
     3361 ttggtttaga atgactttcc taggaatctg gtcaagaaag gaacttacta aaagactatt
     3421 ctcatttaac aaaagagata ttaagtatct caaaggccaa atctttaaaa agattatctg
     3481 ttttaagcca caaaacattt gtgtggatcc ctttgcagca agtttgctct tagataagat
     3541 tcagtcttcg ttctcagctg ttgcaggtta aggcttgtga aatgatccaa aaagggaaca
     3601 gcagcttttg gagaaaactt ttatttgttc ttcattctag tgtcaagttt aaaggcttga
     3661 agtcagaatg ttagaagtgg ggaaggggac cttagaggtg acgtcttcca gatgttcctg
     3721 tttatgcaca aggggacagt ctcggagaat taaggcgcaa aactcgggtc ccaatttcta
     3781 ggtaggttcc tgtttgttct gctgctatcg tgcgcttatg gtgactgtgt gaatccaacc
     3841 aaaacggagg ttccgtatgc cagtggggca acgtttttca gctgcaaatc ttgggaaatc
     3901 aaaagcaagg ctgttttttt tttcttttct tttttgagac agagtttcac tcttgttgcc
     3961 caggctggag tgcaatggcg caatctcagc tcactgcaac ctccacctcc caggttcaag
     4021 caattctcct gcctcagcct cccaagtagc tgggattaca agcatgtgcc accacacccg
     4081 gctaattttg tatttttagt agagactggg tttctctatg ttggtcagac tggtctcaaa
     4141 ctcccgacct caggtgatcc gccgcctcgg cctcccaaag tgctgggatt acaggtgtga
     4201 gccaccacgc ccggcctcaa ggctgtgttt cagtgaaata tcccttgcaa atctttacct
     4261 gggtgggtta cagtgttttc actagactct tcaatagaat taatatttta agaaatgcca
     4321 cttgtttatt tgaaaagtat aagaatccta tcaatgcagt aggcatgaat gtattcatgt
     4381 gtctggctgt tcatgaagca gctgatatct taagtgtaag aggtgagatt tactgactac
     4441 cagtaaaata tgcgagttgg gaggctaatg attttaaatt gtaaatgcgt ctgcataaga
     4501 tcctttaaaa tagcttttat tgttcttaaa tttatgttta aaagaaattg acattaatat
     4561 tttcaaatca tccataatct cccaaacctt ttttggtttt ctgtttagta ccatttaaat
     4621 ctttgtgtat gtgtatatga gctaccttta aaagagcagt cacccatgcg agcatttgtt
     4681 acccaattag tttgtacttt tttttggttt ttattttgtt gttgttattt gtttcttttt
     4741 gagatggagt ctcgctcttc tcacgcaggc tggaatgcaa taatggcata atcttggctc
     4801 actgcaacct ccgcctccca ggttcaagcg attctccagc ctgagtctcc cgagtagctg
     4861 ggattacagg cgcccaccag cacacccagc taaatttttg tatttttagt agagacgggt
     4921 ttctccatgt tggtcaggct ggtctcgaac tctcaacctc aggtgatccg cccgccttgg
     4981 cctcccaaag tgctgggatt acacgcgtga gccactgcgc ccggcctagt ttgtgctttt
     5041 tacttaccag ttaggggtta tattactgtg taacaaaatg gacggttatt tctattcatt
     5101 aacaagattc aagtaatagc ctctttagcc acatattcct taataacacc tttagacctt
     5161 ataggggtaa ttattttcta tatacttttc caatgtattt gaaagtttgt tggctcttct
     5221 tccgtaatta tactatatcc tcagtaaaga aagtttggca tacagaaaag ttgaaggaag
     5281 aaaattttca atcactgttg ttccactacc aagaaataat acttggaggt atttcctttc
     5341 aatcttcaac atgaggatgc taatgtcccc ctcataaggg gccttaaagt cactgactct
     5401 gtgcactatt tcatgagaac attgatgtgg gtatttaacc gaaagaaaac ttgagttttc
     5461 tttttttcct ttttattgtg aaaatttgga aacttattca aaaagtagaa tagttaacta
     5521 attgatgtac ccatcagcaa gcttcagtga ttaccaccat ttaattttgt ctgcaccccc
     5581 ccacccactg ccaccccagc ccattcccag catgtgcctc tgaaagagac caactttgtc
     5641 ctttaaaaac aaccacagtt ggctgggcac ggtggctcat gcctgtaatc ccagtacttt
     5701 gggaagcaaa ggcgggtgga tcacctgagg ttgagagttc gagactggcc tgaccaacat
     5761 ggagaaaccc gtctctacta aaaataccaa agttagccgg gcgtggtggc gggtgcctgt
     5821 aatcccagct actcgggagg ctgaggtagg agaatcgtgt gaatctggga ggcggaggtt
     5881 gcagtgagcc gagatcacgc cactgcactc cagcctgggc aacaagagtt gtctcaaaaa
     5941 acaaaaaaga aagaaagaaa aaaacaacca cagtttcatc agcacagcaa aaaggttttt
     6001 gtttttgctc ttggattttg tcgtttggtt tttgcttaat atcaaatatc cagtcagtgt
     6061 aaactcgttt ataatttggt cctttgattt caaggagcta tgatgcagtt cgttgtgggg
     6121 atgtgttgtc tccatgtcat acatgtgact ttgtccatgt ttgcacccag ttcaaggaag
     6181 acacaaccct agggaaagac aaccctcccc gccaagcctc tcttcccatt cttaaacata
     6241 gggtggcgtt attcaggttg gaccagttta aaaagactaa cgcatttgtc ctcgttgttg
     6301 ggtgtttttt ttctttaaat ttgtaaaaca ggaataattg tgttaggatg aagtatgata
     6361 ctaggagaac agggaaaact aacccatcgt gttaaaagtc agaatagtgc ttaactctgg
     6421 caggaggtga gatggttagt aattcagaag ggggtgccag gagagcttcc agagccattg
     6481 aaatgttcag tagcttgatc tgggtgatga tttacataca taaaaacata ttaaactttg
     6541 aacttaagat ttatgccttt tactgtttgc accctataac tccaaaagaa aagtagaggg
     6601 gaaaaagagt ccctgcaaaa ggcagtcttg aaagaaagca agtctgtgat gtggagaatg
     6661 cattggacag ctctcagcaa tttgctgtag cttgggcaga gagataaaag ctaatgccag
     6721 catcaggttg cccaggcgag agaaggcctg aaagaagaca gcgtggagaa agtgtcagca
     6781 agcttcagca acagcaggag gcagatggta ggagagtggg cctcaggtgt ggtgtggcag
     6841 agcagagtag ccacacttag gccccagaga cagtgtcttc tcaccctcag ttgaaggggc
     6901 aggaaatcaa tcgctctagt cacccctaag ctggaggacg gacctaaagt tgccacagct
     6961 ttgagaggca aagaagtttg ctcagtggct tttagagact tctagggccc tgggaccctg
     7021 acactgagga ggagcaaact gaaggggaga gtgggcacat tccttgttgg ctgctgtggt
     7081 gagcagcagc tggtcgttgt cagtcaagct ccggaccact ctgatgatgc tcactgcatt
     7141 ttgatggagt aagccaggga cattaccact gtgtttgagc catctgaagt attcctgggt
     7201 gggtctgcag ttggcagccc gtgatccttt ttccattcaa ggatgatgca aaggtaaggg
     7261 gccaaggctg agctctgtag atgcctgtga gagcctcctg gtctcaagag gtcataccaa
     7321 gggccttggc caccaaggtt tcgtgaggac cttgaggtgg tttcgccatc acaatgtcag
     7381 acgtgtcaca caccatctgg tatgtcctca ctgtatagag gaagaagggc ccaagtggtg
     7441 aattatctac aagtttgtag caaagctaat actcagactc cctctacagc cttgctactc
     7501 agtgtagtct gtggtccggc agtgtcacac cactggggta cttagcagaa atgcagcttc
     7561 tcaggctcca ctccagctct cctcaatcac agtctgtttt tttgtttgtt tgtttgtttg
     7621 ttttgagatg gagtttcgct cttgttgcct aggctggaga gcagtggtgc gatcttggct
     7681 cactgcaacc tccacctccc tggttcaagt gattctgctg cctcagcctc ccaagtagct
     7741 gggattacag gcgcccgcca ccatgcccgg tggcgtgcat ggtaattttt gtatttttag
     7801 tagaaacagg atctcgccat gttggccagg ctggtcttga actcctgacc tcaggtgatc
     7861 cacccgcctt ggcctcccaa agtactgggg attacagatg tgagccacca cgcctggccc
     7921 acagtctgta ttttaacaag atccccacct cagtcttagg cacatggatt ctcctcaacc
     7981 cccaatacca cagagtctat taatttttac ccaataggga aggggaaaaa gtcaagaaag
     8041 aataatgaat taagtaatct ttccccctcc aggaagctct ttatttaatt tcgctcccat
     8101 gaaacacaat ttgaagagtc tctcaaataa acaaattcca ttttctgata attatttaat
     8161 tgccccactt ttgaaatttt tgtcaaagac gactgtcact ccctgtcaga acttctattc
     8221 agcacagtat accaagcgtt tctccatcga gttgttataa tatgatcaaa aagcagggag
     8281 agatgctgct tggttaccct gtggggcctt atcggggctc agtgcagtct ttccatgtag
     8341 gcattctcaa atactcaatt gaaacctgat tgaggatcat ttgatctctg ttggccctag
     8401 tgcagtaggc tgctgagaac cactgatgca atagactgag agactaactg cctgcttccc
     8461 tgtcagccca ggctctgcta aggccgtctt agttacagaa gaaagtgggg cagagagccc
     8521 tgcaaggatt acattccatt cctaacggag acaggcaagc gttcagtgcc cgaagcaggg
     8581 caggcctttg tatggctcac ttttccctgt accagcctca gccccgtaca ttcagaaagc
     8641 cctgtcggga acgtgcggga tcacagcaca agacagtcat tcactgattg attgacgacg
     8701 tcaacattgc ggaataccta tgttaagctg agtacgaggg atataaaaag taggccctgg
     8761 agagtgcctc tgggatgcac ataaccagac aagataaaga aaaggcagat cacgagatca
     8821 agagatcgag atcatcctgg ccaacatggt gaaaccccat ctctactaaa attacaaaaa
     8881 tcagctagac gtggtggcgg gcgcctgtag tcccagctac tcaggaggct gaggcaggag
     8941 aatcgcttga acccgggagg cagagattgc actgagctga ggtcatgcca ctgcactcca
     9001 gcctggcaac agggcaagac tccatctcaa aaaaaaaaaa aaagaaaaaa aagaaaaatt
     9061 agggcagctt ttagacatga ggccccaaag tgccaactag tgcacctaaa cttcaactct
     9121 cttttgagtg ttttatgtat ctactcagca tccagttgta aatatgcaaa aatcaatgcc
     9181 tactgtattt aaaaattact aaattcacaa taaccacaca gaatctataa taaatagaat
     9241 caatgtaata atgactcaga tccaggggaa gaaaattata aaattttgga aaaaatgatg
     9301 agctattaat taagaaaata gtttgttcct tggtgagaag actcaatgta aatatgtcag
     9361 ttttctcctg acttaagtct tcaacacagg cctaataata ttgcagtggc aaatgattgc
     9421 caggggcagg aggggatttg gggaagtggt aaaaatgatc tgtgtcttgg tagtggtcgc
     9481 tgcacaactg catacatctg tgaaaactca ctgaactgcg cactttaaaa gggtgaattg
     9541 taatatacat acctcaataa accttactta aaaatta
//
