LOCUS       XM_047445396            7725 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens sodium voltage-gated channel alpha subunit
            7 (SCN7A), transcript variant X3, mRNA.
ACCESSION   XM_047445396
VERSION     XM_047445396.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000002.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7725
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
     gene            1..7725
                     /gene="SCN7A"
                     /gene_synonym="NaG; Nav2.1; Nav2.2; SCN6A"
                     /note="sodium voltage-gated channel alpha subunit 7;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 2 mRNAs, 14 ESTs, 70 long SRA reads, 8
                     Proteins, and 100% coverage of the annotated genomic
                     feature by RNAseq alignments, including 9 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:6332"
                     /db_xref="HGNC:HGNC:10594"
                     /db_xref="MIM:182392"
     CDS             670..5718
                     /gene="SCN7A"
                     /gene_synonym="NaG; Nav2.1; Nav2.2; SCN6A"
                     /codon_start=1
                     /product="sodium channel protein type 7 subunit alpha
                     isoform X1"
                     /protein_id="XP_047301352.1"
                     /db_xref="GeneID:6332"
                     /db_xref="HGNC:HGNC:10594"
                     /db_xref="MIM:182392"
                     /translation="MLASPEPKGLVPFTKESFELIKQHIAKTHNEDHEEEDLKPTPDL
                     EVGKKLPFIYGNLSQGMVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLS
                     PFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEIL
                     VKLFARGVWAGSFSFLGDPWNWLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIP
                     LNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENEN
                     ETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFT
                     NFDSFGWALFALFRLMAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGI
                     LAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKKRSPISTDTSL
                     DVLEDATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTD
                     LFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQ
                     VGWNIFDSMIVFHGLIELCLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSW
                     VALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKDCQLPRWHMHDFFHSFLNVF
                     RILCGEWVETLWDCMEVAGQSWCIPFYLMVILIGNLLVLYLFLALVSSFSSCKDVTAE
                     ENNEAKNLQLAVARIKKGINYVLLKILCKTQNVPKDTMDHVNEVYVKEDISDHTLSEL
                     SNTQDFLKDKEKSSGTEKNATENESQSLIPSPSVSETVPIASGESDIENLDNKEIQSK
                     SGDGGSKEKIKQSSSSECSTVDIAISEEEEMFYGGERSKHLKNGCRRGSSLGQISGAS
                     KKGKIWQNIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYAD
                     MIFTYIFILEMLLKWMAYGFKAYFSNGWYRLDFVVVIVFCLSLIGKTREELKPLISMK
                     FLRPLRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECI
                     DPTSGERFPSSEVMNKSRCESLLFNESMLWENAKMNFDNVGNGFLSLLQVATFNGWIT
                     IMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLG
                     GSNIFITVKQRKQYRRLKKLMYEDSQRPVPRPLNKLQGFIFDVVTSQAFNVIVMVLIC
                     FQAIAMMIDTDVQSLQMSIALYWINSIFVMLYTMECILKLIAFRCFYFTIAWNIFDFM
                     VVIFSITGLCLPMTVGSYLVPPSLVQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLP
                     ALLNIILLIFLVMFIYAVFGMYNFAYVKKEAGINDVSNFETFGNSMLCLFQVAIFAGW
                     DGMLDAIFNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSYILISWLIIVNMYIVV
                     VMEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYIDSSKLSDFAAALDPPLFMA
                     KPNKGQLIALDLPMAVGDRIHCLDILLAFTKRVMGQDVRMEKVVSEIESGFLLANPFK
                     ITCEPITTTLKRKQEAVSATIIQRAYKNYRLRRNDKNTSDIHMIDGDRDVHATKEGAY
                     FDKAKEKSPIQSQI"
ORIGIN      
        1 ggctccactg gacatctggg taggaggggt ctctgggtca gtggctggag agtcgcccca
       61 gtgagtcggt gtctaactgg ccatttagtg gggcccattt actgcagagc cacagctggt
      121 gaggacagac gccagcctaa cagcagcttc tgtacaacta gagctcagaa aacccgagag
      181 atccgtggag aaagagaagc ccaggaggag gaaagggctc caaggagccc tgctcctgaa
      241 gggtccctca ggcactggtg gagacctgtc gcttcgtagc aaggtcccca gcaggaggac
      301 agagatttga aattgtggac gtgcattagg agagttactt caagagtata cttcaagagc
      361 agccgtggtc tgtgggtgtt tgcatggcat gtgccgtcag ttttctaatt ccatcaggat
      421 caactccagt ttctcagaaa gcacagagat tgattcttta ggtgctgtat tttcaattcc
      481 ctaagatggg aataaatgga aatgaagagg ctgtgactgg cctgggcagt catctcctac
      541 aggtcctcca ccatgtgaat gccaacatgg ccaggtcatt agagctgagg gaaaactagt
      601 gcccaaagat atgaaaagag tgtggatctt ctggagaagt gctgttgttc aacaggtaca
      661 aaattggaaa tgttggcttc accagaacct aagggccttg ttcccttcac taaagagtct
      721 tttgaactta taaaacagca tattgctaaa acacataatg aagaccatga agaagaagac
      781 ttaaagccaa ctcctgattt ggaagttggc aaaaagcttc catttattta tggaaacctt
      841 tctcaaggaa tggtgtcaga gcccttggaa gatgtggacc catattacta caagaaaaaa
      901 aatactttca tagtattaaa taaaaataga acaatcttca gattcaatgc ggcttccatc
      961 ttgtgtacat tgtctccttt caattgtatt agaagaacaa ctatcaaggt tttggtacat
     1021 ccctttttcc aactgtttat tctaattagt gtcctgattg attgcgtatt catgtccctg
     1081 actaatttgc caaaatggag accagtatta gagaatactt tgcttggaat ttacacattt
     1141 gaaatacttg taaaactctt tgcaagaggt gtctgggcag gatcattttc cttcctcggt
     1201 gatccatgga actggctcga tttcagcgta actgtgtttg aggttattat aagatactca
     1261 cctctggact tcattccaac gcttcaaact gcaagaactt tgagaatttt aaaaattatt
     1321 cctttaaatc aaggtctgaa atcccttgta ggggtcctga tccactgctt gaagcagctt
     1381 attggtgtca ttatcctaac tctgtttttt ctgagcatat tttctctaat tgggatgggg
     1441 ctcttcatgg gcaacttgaa acataaatgt tttcgatggc cccaagagaa tgaaaatgaa
     1501 accctgcaca acagaactgg aaacccatat tatattcgag aaacagaaaa cttttattat
     1561 ttggaaggag aaagatatgc tctcctttgt ggcaacagga cagatgctgg tcagtgtcct
     1621 gaaggatatg tgtgtgtaaa agctggcata aatcctgatc aaggcttcac aaattttgac
     1681 agttttggct gggccttatt tgccctattt cggttaatgg ctcaggatta ccctgaagta
     1741 ctttatcacc agatacttta tgcttctggg aaggtctaca tgatattttt tgtggtggta
     1801 agttttttgt tttcctttta tatggcaagt ttgttcttag gcatacttgc catggcctat
     1861 gaagaagaaa agcagagagt tggtgaaata tctaagaaga ttgaaccaaa atttcaacag
     1921 actggaaaag aacttcaaga aggaaatgaa acagatgagg ccaagaccat acaaatagaa
     1981 atgaagaaaa ggtcaccaat ttccacagac acatcattgg atgtgttgga agatgctact
     2041 ctcagacata aggaagaact tgaaaaatcc aagaagatat gcccattata ctggtataag
     2101 tttgctaaaa ctttcttgat ctggaattgt tctccctgtt ggttaaaatt gaaagagttt
     2161 gtccatagga ttataatggc accatttact gatcttttcc ttatcatatg cataatttta
     2221 aacgtatgtt ttctgacctt ggagcattat ccaatgagta aacaaactaa cactcttctc
     2281 aacattggaa acctggtttt cattggaatt ttcacagcag aaatgatttt taaaataatt
     2341 gcaatgcatc catatgggta tttccaagta ggttggaaca tttttgatag catgatagtg
     2401 ttccatggtt taatagaact ttgtctagca aatgttgcag gaatggctct tcttcgatta
     2461 ttcaggatgt taagaatttt caagttggga aagtattggc caacattcca gattttgatg
     2521 tggtctctta gtaactcatg ggtggccctg aaagacttgg tcctgttgtt gttcacattc
     2581 atcttctttt ctgctgcatt cggcatgaag ctgtttggta agaattatga agaatttgtc
     2641 tgccacatag acaaagactg tcaactccca cgctggcaca tgcatgactt tttccactcc
     2701 ttcctgaatg tgttccgaat tctctgtgga gagtgggtag agaccttgtg ggactgtatg
     2761 gaggttgcag gccaatcctg gtgtattcct ttttacctga tggtcatttt aattggaaat
     2821 ttactggtac tttacctgtt tctggcattg gtgagctcat ttagttcatg caaggatgta
     2881 acagctgaag agaataatga agcaaaaaat ctccagcttg cagtggcaag aattaaaaaa
     2941 ggaataaact atgtgcttct taaaatacta tgcaaaacac aaaatgtccc aaaggacaca
     3001 atggaccatg taaatgaggt atatgttaaa gaagatattt ctgaccatac cctttctgaa
     3061 ttgagcaaca cccaagattt tctcaaagat aaggaaaaaa gcagtggcac agagaaaaac
     3121 gctactgaaa atgagagcca atcacttatc cccagtccta gtgtctcaga aactgtacca
     3181 attgcttcag gagaatctga tatagaaaat ctggataata aggagattca gagtaagtct
     3241 ggtgatggag gcagcaaaga gaaaataaag caatctagct catctgaatg cagtactgtt
     3301 gatattgcta tctctgaaga agaagaaatg ttctatggag gtgaaagatc aaagcatctg
     3361 aaaaatggtt gcagacgcgg atcttcactt ggtcaaatca gtggagcatc caagaaagga
     3421 aaaatctggc agaacatcag gaaaacctgc tgcaagattg tagagaacaa ttggtttaag
     3481 tgttttattg ggcttgttac tctgctcagc actggcactc tggcttttga agatatatat
     3541 atggatcaga gaaagacaat taaaatttta ttagaatatg ctgacatgat ctttacttat
     3601 atcttcattc tggaaatgct tctaaaatgg atggcatatg gttttaaggc ctatttctct
     3661 aatggctggt acaggctgga cttcgtggtt gttattgtgt tttgtcttag cttaataggc
     3721 aaaactcggg aagaactaaa acctcttatt tccatgaaat tccttcggcc cctcagagtt
     3781 ctatctcaat ttgaaagaat gaaggtggtt gtgagagctt tgatcaaaac aaccttaccc
     3841 actttgaatg tgtttcttgt ctgcctgatg atctggctga tttttagtat catgggagta
     3901 gacttatttg ctggcagatt ctatgaatgc attgacccaa caagtggaga aaggtttcct
     3961 tcatctgaag tcatgaataa gagtcggtgt gaaagccttc tgtttaacga atccatgcta
     4021 tgggaaaatg caaaaatgaa ctttgataat gttggaaatg gtttcctttc tctgcttcaa
     4081 gtagcaacat ttaatggatg gatcactatt atgaattcag caattgattc tgttgctgtt
     4141 aatatacagc ctcattttga agtcaacatc tacatgtatt gttactttat caactttatt
     4201 atatttggag tatttctccc tctgagtatg ctgattactg ttattattga taatttcaac
     4261 aagcataaaa taaagctggg aggctcaaat atctttataa cggttaaaca gagaaaacag
     4321 taccgcaggc tgaagaagct aatgtatgag gattctcaaa gaccagtacc tcgcccatta
     4381 aacaagctcc aaggattcat ctttgatgtg gtaacaagcc aagcttttaa tgtcattgtt
     4441 atggttctta tatgtttcca agcaatagcc atgatgatag acactgatgt tcagagtcta
     4501 caaatgtcca ttgctctcta ctggattaac tcaatttttg ttatgctata tactatggaa
     4561 tgtatactga agctcatcgc tttccgttgt ttttatttca ccattgcgtg gaacattttt
     4621 gattttatgg tggttatttt ctccatcaca ggactatgtc tgcctatgac agtaggatcc
     4681 taccttgtgc ctccttcact tgtgcaactg atacttctct cacggatcat tcacatgctg
     4741 cgtcttggaa aaggaccaaa ggtgtttcat aatctgatgc ttcctttgat gctgtccctc
     4801 ccagcattat tgaacatcat tcttctcatc ttcctggtca tgttcatcta tgccgtattt
     4861 ggaatgtata attttgccta tgttaaaaaa gaagctggaa ttaatgatgt gtctaatttt
     4921 gaaacctttg gcaacagtat gctctgtctt tttcaagttg caatatttgc tggttgggat
     4981 gggatgcttg atgcaatttt caacagtaaa tggtctgact gtgatcctga taaaattaac
     5041 cctgggactc aagttagagg agattgtggg aacccctctg ttgggatttt ttattttgtc
     5101 agttatatcc tcatatcatg gctgatcatt gtaaatatgt acattgttgt tgtcatggag
     5161 tttttaaata ttgcttctaa gaagaaaaac aagaccttga gtgaagatga ttttaggaaa
     5221 ttctttcagg tatggaaaag gtttgatcct gataggaccc agtacataga ctctagcaag
     5281 ctttcagatt ttgcagctgc tcttgatcct cctcttttca tggcaaaacc aaacaagggc
     5341 cagctcattg ctttggacct ccccatggct gttggggaca gaattcattg cctcgatatc
     5401 ttacttgctt ttacaaagag agttatgggt caagatgtga ggatggagaa agttgtttca
     5461 gaaatagaat cagggttttt gttagccaac ccttttaaga tcacatgtga gccaattacg
     5521 actactttga aacgaaaaca agaggcagtt tcagcaacca tcattcaacg tgcttataaa
     5581 aattaccgct tgaggcgaaa tgacaaaaat acatcagata ttcatatgat agatggtgac
     5641 agagatgttc atgctactaa agaaggtgcc tattttgaca aagctaagga aaagtcacct
     5701 attcaaagcc agatctaata ccacttacca cctcttttca tatttcttca catatctgaa
     5761 aaatgttgaa agcctaagcc aggaataaaa gaaaagtaga gataataatc agttctttac
     5821 aaccgatggt aattaagctt gtattcacaa gacttcatgc caaattcact ttttagcatt
     5881 atatctaaca aatcaagaga atccttaata ttgctgcagt gagtttaaag tgggttaaag
     5941 tggccatttg acaatctcat atttgttttc tctacatggc ttatatgatg tgtgccttct
     6001 agggaatgaa gggaagtggt gatagagatc agcagcagca ggggctttct tttatatttt
     6061 atgtataatt taatgggctt taagtcacca ctattaagac ttacaaataa gcaaatactt
     6121 tcctgatgtg ggatggtgaa atgctaatgg ccattaaatc ataaacttgc ctagacaaaa
     6181 gccaattgga agaagggaga gagcagttct ttagaaagtg cctttgagat caacctcaga
     6241 gattcttggg ctgattaaaa ctgcatttga aaaagattgg ttgaagctct gtgtttattt
     6301 ttgtatgttc ttgttttcat ttggaactgg gaatgaatag gatttcattg tgctcaagct
     6361 cctggtttct catctctgga tagtttcacc taagctctgg ctcttaagca ggacagattc
     6421 gtaaaacaag aagcataaag gagaggtata gccttttttt tttttttttt tttcattttc
     6481 ttctcattta cacctatttt tttaaaaagt atacatttac taaaatgatg taataaataa
     6541 catgttaata gactcaagct ttaccttatg aaattgatgt atttttacca gttatttcta
     6601 atgtaacatt gaatatataa gatctgacaa atgtatgttt aaacatgaat tagaagagtt
     6661 gagaactacc attatgtata gggattctca tagtgtcttg gcccttaatt ggaaagttgt
     6721 ggcaacttta aagtactttt tactgtatgt tataattctt tataacttag agagagacaa
     6781 tggtcactca aactatgaga actatgaatt aggagataaa agtttaaatt tgttgttgtt
     6841 ttataacagt atgtacaagt tagttttccc ttatatattt acgttttcaa gttttttaat
     6901 ctcatcatat acatccatac tctataaaat gttttatatt caaagaactg taaaatccta
     6961 aacattagtt ttcactattg aaattgtttt ttaaagatag gcataaatag ttgtccttag
     7021 acttattcat acaaatatag tcatttactt ctatgtagtt tgagattctg agagttattc
     7081 caactttatg aagattgatt tcaatgtgcc tgctaagtcc taaaagattc agaaagaaaa
     7141 tttatatatt attgatttaa atatcatcct ttaaatatgt tgtataacat tcaatatagt
     7201 ttatgtatca gtgattgtat tttattctga atgcatgatc tcaagcctta actactataa
     7261 tctttttctg cccctcagaa attgaataac ctaaccaaga tgcctttagg ggatgcccta
     7321 agtaaatgta atttcagatt tcagggtttt ttttttttcc tctctaagtg ttccttccct
     7381 ttcttctcct gctctccatc atgttatgga gaccagtgag gaaccagtgt taacttggtg
     7441 acaatgtgac agctggtgct ttatctaagc tccgttttct atttcttggg aatgctttat
     7501 tgtggaaact gcttcagata cttaaattga atcataactt gcttctgtaa attgcgtaaa
     7561 gacaacaaac tgattttagt ttgaaaagtt tatcttttac ttgtaaacct tgtttgccag
     7621 ttaccttccg aaagctgtgt aaagagttat ttttaacaaa gtcttaacaa tatatgttac
     7681 tttttagata ctatagaaaa taataaatat aacctgtaaa ccaca
//
