LOCUS       NM_174934               4487 bp    mRNA    linear   PRI 15-DEC-2024
DEFINITION  Homo sapiens sodium voltage-gated channel beta subunit 4 (SCN4B),
            transcript variant 1, mRNA.
ACCESSION   NM_174934
VERSION     NM_174934.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4487)
  AUTHORS   Yang,X., Liu,Q. and Li,G.
  TITLE     Anti-NSCLC role of SCN4B by negative regulation of the cGMP-PKG
            pathway: Integrated utilization of bioinformatics analysis and in
            vitro assay validation
  JOURNAL   Drug Dev Res 85 (3), e22192 (2024)
   PUBMED   38678552
  REMARK    GeneRIF: Anti-NSCLC role of SCN4B by negative regulation of the
            cGMP-PKG pathway: Integrated utilization of bioinformatics analysis
            and in vitro assay validation.
REFERENCE   2  (bases 1 to 4487)
  AUTHORS   Ma,M., Guo,B., Lu,H. and Hong,L.
  TITLE     SCN4B inhibits the progression of lung adenocarcinoma and is
            associated with better prognosis
  JOURNAL   Clin Respir J 17 (12), 1233-1245 (2023)
   PUBMED   37826914
  REMARK    GeneRIF: SCN4B inhibits the progression of lung adenocarcinoma and
            is associated with better prognosis.
REFERENCE   3  (bases 1 to 4487)
  AUTHORS   Doray,A., Lemoine,R., Severin,M., Chadet,S., Lopez-Charcas,O.,
            Heraud,A., Baron,C., Besson,P., Monteil,A., Pedersen,S.F. and
            Roger,S.
  TITLE     The Voltage-Gated Sodium Channel Beta4 Subunit Maintains Epithelial
            Phenotype in Mammary Cells
  JOURNAL   Cells 10 (7), 1624 (2021)
   PUBMED   34209614
  REMARK    GeneRIF: The Voltage-Gated Sodium Channel Beta4 Subunit Maintains
            Epithelial Phenotype in Mammary Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4487)
  AUTHORS   Huang,H., Qing,X.Y., Zhou,Q., Li,H.D. and Hu,Z.Y.
  TITLE     Silencing of microRNA-3175 represses cell proliferation and
            invasion in prostate cancer by targeting the potential
            tumor-suppressor SCN4B
  JOURNAL   Kaohsiung J Med Sci 37 (1), 20-26 (2021)
   PUBMED   32833340
  REMARK    GeneRIF: Silencing of microRNA-3175 represses cell proliferation
            and invasion in prostate cancer by targeting the potential
            tumor-suppressor SCN4B.
REFERENCE   5  (bases 1 to 4487)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4487)
  AUTHORS   Watanabe,H., Darbar,D., Kaiser,D.W., Jiramongkolchai,K., Chopra,S.,
            Donahue,B.S., Kannankeril,P.J. and Roden,D.M.
  TITLE     Mutations in sodium channel beta1- and beta2-subunits associated
            with atrial fibrillation
  JOURNAL   Circ Arrhythm Electrophysiol 2 (3), 268-275 (2009)
   PUBMED   19808477
  REMARK    GeneRIF: Loss of function mutations in sodium channel beta-subunits
            were identified in patients with atrial fibrillation and were
            associated with a distinctive ECG phenotype
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 4487)
  AUTHORS   Webb,J., Wu,F.F. and Cannon,S.C.
  TITLE     Slow inactivation of the NaV1.4 sodium channel in mammalian cells
            is impeded by co-expression of the beta1 subunit
  JOURNAL   Pflugers Arch 457 (6), 1253-1263 (2009)
   PUBMED   18941776
  REMARK    GeneRIF: Co-expression of the beta1 subunit impeded slow
            inactivation elicited by a 30-s depolarization, such that the
            voltage dependence was right shifted (depolarized) and recovery was
            hastened.
REFERENCE   8  (bases 1 to 4487)
  AUTHORS   Medeiros-Domingo,A., Kaku,T., Tester,D.J., Iturralde-Torres,P.,
            Itty,A., Ye,B., Valdivia,C., Ueda,K., Canizales-Quinteros,S.,
            Tusie-Luna,M.T., Makielski,J.C. and Ackerman,M.J.
  TITLE     SCN4B-encoded sodium channel beta4 subunit in congenital long-QT
            syndrome
  JOURNAL   Circulation 116 (2), 134-142 (2007)
   PUBMED   17592081
  REMARK    GeneRIF: SCN4B is a long QT syndrome susceptibility gene.
REFERENCE   9  (bases 1 to 4487)
  AUTHORS   Yu,F.H., Westenbroek,R.E., Silos-Santiago,I., McCormick,K.A.,
            Lawson,D., Ge,P., Ferriera,H., Lilly,J., DiStefano,P.S.,
            Catterall,W.A., Scheuer,T. and Curtis,R.
  TITLE     Sodium channel beta4, a new disulfide-linked auxiliary subunit with
            similarity to beta2
  JOURNAL   J Neurosci 23 (20), 7577-7585 (2003)
   PUBMED   12930796
  REMARK    GeneRIF: molecular cloning and characterization of sodium channel
            beta4
REFERENCE   10 (bases 1 to 4487)
  AUTHORS   Groffen,A.J., Bikker,H. and Christiaans,I.
  TITLE     Long QT Syndrome Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301308
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB237478.1, AY149967.1,
            DB101246.1 and BC035017.2.
            
            On Feb 27, 2020 this sequence version replaced NM_174934.3.
            
            Summary: The protein encoded by this gene is one of several sodium
            channel beta subunits. These subunits interact with voltage-gated
            alpha subunits to change sodium channel kinetics. The encoded
            transmembrane protein forms interchain disulfide bonds with SCN2A.
            Defects in this gene are a cause of long QT syndrome type 10
            (LQT10). Three protein-coding and one non-coding transcript variant
            have been found for this gene.[provided by RefSeq, Mar 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY149967.1, SRR14038194.2534091.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2157437 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000324727.9/ ENSP00000322460.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               DB237478.1         158-339
            183-1621            AY149967.1         186-1624
            1622-1771           DB101246.1         165-314
            1772-2006           DB101246.1         326-560
            2007-3890           BC035017.2         2000-3883
            3891-4487           AY149967.1         3893-4489
FEATURES             Location/Qualifiers
     source          1..4487
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
     gene            1..4487
                     /gene="SCN4B"
                     /gene_synonym="ATFB17; LQT10; Navbeta4"
                     /note="sodium voltage-gated channel beta subunit 4"
                     /db_xref="GeneID:6330"
                     /db_xref="HGNC:HGNC:10592"
                     /db_xref="MIM:608256"
     exon            1..211
                     /gene="SCN4B"
                     /gene_synonym="ATFB17; LQT10; Navbeta4"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..837
                     /gene="SCN4B"
                     /gene_synonym="ATFB17; LQT10; Navbeta4"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; sodium channel subunit beta-4; sodium channel,
                     voltage-gated, type IV, beta subunit; sodium channel
                     regulatory subunit beta-4"
                     /codon_start=1
                     /product="sodium channel regulatory subunit beta-4 isoform
                     1 precursor"
                     /protein_id="NP_777594.1"
                     /db_xref="CCDS:CCDS8389.1"
                     /db_xref="GeneID:6330"
                     /db_xref="HGNC:HGNC:10592"
                     /db_xref="MIM:608256"
                     /translation="MPGAGDGGKAPARWLGTGLLGLFLLPVTLSLEVSVGKATDIYAV
                     NGTEILLPCTFSSCFGFEDLHFRWTYNSSDAFKILIEGTVKNEKSDPKVTLKDDDRIT
                     LVGSTKEKMNNISIVLRDLEFSDTGKYTCHVKNPKENNLQHHATIFLQVVDRLEEVDN
                     TVTLIILAVVGGVIGLLILILLIKKLIIFILKKTREKKKECLVSSSGNDNTENGLPGS
                     KAEEKPPSKV"
     exon            212..384
                     /gene="SCN4B"
                     /gene_synonym="ATFB17; LQT10; Navbeta4"
                     /inference="alignment:Splign:2.1.0"
     exon            385..613
                     /gene="SCN4B"
                     /gene_synonym="ATFB17; LQT10; Navbeta4"
                     /inference="alignment:Splign:2.1.0"
     exon            614..743
                     /gene="SCN4B"
                     /gene_synonym="ATFB17; LQT10; Navbeta4"
                     /inference="alignment:Splign:2.1.0"
     exon            744..4487
                     /gene="SCN4B"
                     /gene_synonym="ATFB17; LQT10; Navbeta4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4467..4472
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCN4B"
                     /gene_synonym="ATFB17; LQT10; Navbeta4"
                     /note="hexamer: AATAAA"
     polyA_site      4487
                     /gene="SCN4B"
                     /gene_synonym="ATFB17; LQT10; Navbeta4"
                     /note="major polyA site"
ORIGIN      
        1 gctctctgcc cgctaacttt cccgagcccc gaccggcggc gcagagctcc ggggtagctt
       61 tgtggccgaa cgccgacctc gggcggagag cgcggctgtg cccagtatcc catccccgcg
      121 acccccgcgc gctccggaga gaacaggact atgcccgggg ctggggacgg aggcaaagcc
      181 ccggcgagat ggctgggcac tgggcttttg ggcctcttcc tgctccccgt aaccctgtcg
      241 ctggaggtgt ctgtgggaaa ggccaccgac atctacgctg tcaatggcac ggagatcctg
      301 ctgccctgca ccttctccag ctgctttggc ttcgaggacc tccacttccg gtggacctac
      361 aacagcagtg acgcattcaa gattctcata gaggggactg tgaagaatga gaagtctgac
      421 cccaaggtga cgttgaaaga cgatgaccgc atcactctgg taggctctac taaggagaag
      481 atgaacaaca tttccattgt gctgagggac ctggagttca gcgacacggg caaatacacc
      541 tgccatgtga agaaccccaa ggagaataat ctccagcacc acgccaccat cttcctccaa
      601 gtcgttgata gactggaaga agtggacaac acagtgacac tcatcatcct ggctgtcgtg
      661 ggcggggtca tcgggctcct catcctcatc ctgctgatca agaaactcat catcttcatc
      721 ctgaagaaga ctcgggagaa gaagaaggag tgtctcgtga gctcctcggg gaatgacaac
      781 acggagaacg gcttgcctgg ctccaaggca gaggagaaac caccttcaaa agtgtgagcc
      841 ctgcttcggg ctgagcagct gcagggagcc ccctttctga tgatgaaact gatgcttgag
      901 ccccgaccgt agaacccacg tgcctgagac atctgctgct tggctcaaac tgtagtcttt
      961 ccgggcacaa gaaaccagag tcctgcccag cctgcccatc cccttcccag tcagggctcc
     1021 ccagggacaa gggatggcca ggggaggggg tctgtggaag attcaggaga aagaaaggag
     1081 aggctagggt ggtgtggagg ggctggtccc ctgacacctg ggcagatggg gtctccttca
     1141 gtctccctac cctgcacaag cagggccttg attttcctcc aggcttctct tcacaagaga
     1201 ctgggaggat ccgtaaggga tgtcctaaga gctgcaccct ggagatgggg tgtaggaaga
     1261 agtggcttcc tttggaggtg ggagtgggct ggaggcctct ggagaagacc tggggtgggg
     1321 gctgatgggg gcaggcccac agtgagagac tgcctctgct tcataggata ccagatcccc
     1381 cacagtcttc caagtaggaa acttcctttc ccctgccccg ggaccctatc tgcctatccc
     1441 ctcccctgct cagagttttt aagccctctc aaccagggct ggccaccctg gtcttgaggg
     1501 ttcctggcca cctagcctgc tcctctgctc tctgggttac tgaggggctc aggaaggggc
     1561 ccctcgagcc ttcctggagt acccgagtgc tccctatgcc tttccaagca tttctacttg
     1621 gggaattggg ccacagaggt agtgagccag tgtcctgggc ctctgggatg cccgccccat
     1681 tgctgccaat gctggcagcc cctcccctgg catggcagga ccatcgccac tctgggcact
     1741 cctgagccca gctctcccct gcttctcccc ctcctacctg agaggctgca ccctccaacc
     1801 tcccattggc tcgctccccc ccccccaccg tgccctccat cacgccctgc ccccagggtg
     1861 gttcatttcc cagccctggg tcaagggcct gccttcgcct cagggactct cttcctttgg
     1921 atgagggggt ccttgggttt cccagctgct tcctgctcag ctgggccacc ccctcccacc
     1981 ctggggttgg ggaggagcag ggagtgggtg cccacagttt tcctttgctt ctcccagagc
     2041 tggtttgcac agcccttgtg tgtggggcta gaatgtgcct tagtcctgaa tcctagccct
     2101 tacccccatc ctctctagac ggtatgtcct gacataacag cagagtctgg tgtggtgctg
     2161 gtgagggttc gccagccctc ccctccccag ggtcatagag ggggccatga ggctggaatt
     2221 ggccagtgac tgaatcttgg agatgtcggc caggtgctcc cattggggtt tctagcctgc
     2281 cctaggggga ggtggtgatg ttgggagtgg gatctcctga gtccttgttg ggcagaattg
     2341 gtgaggccag ggatggcagg gaaaagtggt aacaagcctc tctgcccatc tacttccaat
     2401 ccctctctcc cttactgatt ttttgatgcc ctgtcttctg ggcccctagg agggatgaga
     2461 gaggagtagc cccctttttc agagagtttg gggtctacct cagagctctc cctgtcaaaa
     2521 agcagctgca agcctcgcaa gggtggagtg gggggagact gaggaccagt agtacctgca
     2581 gggtgcccgt ggctgtggcc agtgtccctt agccaacctg ctgggctcac cagttccccg
     2641 tctgatctgc ctgtgcgcct cccattcttc tctacccaga acctgtcatg ggctggggct
     2701 cagattttcc tggctttggg agcagacaga ccagagccac cagccattca gaaaacttct
     2761 tatagctacc ttcatgcaaa actgttttct tcttccttct caatggtgac atttgaagag
     2821 gcagagcacc ttggggctcc tccttctgtc ttaagagaaa gccaaggcac gtagagtagg
     2881 gagaagaagg gcaccatcct ctctttcctc cccagggtct actgctgatt tctagatgga
     2941 tcatgcagct tctctcagct cagctctttc catctaccaa atgggtgtaa taatacttac
     3001 ctacctcaca ggactgttgt gaggcttggc aagttttgtc taaaaacatc tttttggctt
     3061 ggaaagggat ctgggaagcc aggtattaat tgcagggata gttccaagtc tgtcctgtct
     3121 tcatctctgt gtcccatctc tacaacccac atacagacac acacactctc tctctctttc
     3181 tttccatccc accccccttg gaattattta gtctttgcaa tattagaaac cttgactctg
     3241 atgcttaaag cttcttgtcc atggcttttg tttgatggtt ttcaatagag gtgactgaga
     3301 ttgtaggggg ggcatttttg gttgccccca tgcgtggggg cactactaag aatgctaaac
     3361 ttagtcccca caacaaagaa tcatcctgtc ccatgtcaac attataccca tggagaaaca
     3421 ctggcatgga tttgcactag gatgtatatg ggcaaagcta tcttccccaa gtggaacctc
     3481 agtgcatgca aatctctgat ggtggcttcc agggcttgtg ggctagagag agccacttac
     3541 aaagtcgatc ttgagagacc tggccacatg cagctgggct gagtgatgtc agcgagacta
     3601 aagacaaagt tctgagctcc tcatcaacta caaaatatga aatcagcatt ccaggttctg
     3661 ggcttctccc catgtcgtaa ttgaacagaa ggcagcccga ataaacccct gatgttagag
     3721 aggcctgggg agagcagccg atggggctca gactacatat ggcaggccga tcagagctct
     3781 tgtggagcga gggcttgaga gcatgcttgt gagatggcag gaggtggggt gtgcttgtgt
     3841 ggagtgtgcg tgtgcaggca gtgtgggtgc atggcagcgt aactgtggag tggatgggct
     3901 ctgcatgtaa ggggtgatgc atgatgggca gatgctggac atttgaggag ccgtctttct
     3961 tggcctgagc tatgcctgtt gaggcatctg gagactgaga aagaatcaaa ggcagagaag
     4021 accagccgtg ctcctgcatt ccgtcactcc atgacttcat ctcagtgtca cagacagctg
     4081 ccatcagagg gctggcagta gggagttcca ggagcgggga cttctcggga aaatcctata
     4141 acttgcttta ctttactttg tcccaggttg gagtccctac cctcccacct cccacctgat
     4201 atgcagtgct tttgactatc ttatgcatgg tttattcctc tggcttggat gacaacaata
     4261 cccatagtca attttcctat gtaactatag atcaaatgat gcaacaacag gccttgggag
     4321 gcctcaggtg tgcgagtgcc tctgggaggc gcagatgccc acacagccag cactgacttg
     4381 tgttcgagca cagaacggat ataatcagtc tggcctctac aacaagtttt gcattgtaga
     4441 attgtattta gctttgcctt ggatgaaata aaaattatgt ttaataa
//
