LOCUS       NM_000334               7805 bp    mRNA    linear   PRI 06-OCT-2024
DEFINITION  Homo sapiens sodium voltage-gated channel alpha subunit 4 (SCN4A),
            mRNA.
ACCESSION   NM_000334
VERSION     NM_000334.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7805)
  AUTHORS   Talarico,M., Fortunato,F., Labalme,A., Januel,L., Chatron,N.,
            Sanlaville,D., Sammarra,I., Gagliardi,M., Procopio,R.,
            Valentino,P., Annesi,G., Lesca,G. and Gambardella,A.
  TITLE     Idiopathic generalized epilepsy in a family with SCN4A-related
            myotonia
  JOURNAL   Epilepsia Open 9 (3), 951-959 (2024)
   PUBMED   38544349
  REMARK    GeneRIF: Idiopathic generalized epilepsy in a family with
            SCN4A-related myotonia.
REFERENCE   2  (bases 1 to 7805)
  AUTHORS   Meng,F., Shi,Y., Ju,D., Wang,X., Dong,H., Li,X., Li,X. and Zhou,X.
  TITLE     [Prenatal diagnosis of a case with Congenital myasthenic syndrome
            due to compound heterozygous variants of SCN4A gene]
  JOURNAL   Zhonghua Yi Xue Yi Chuan Xue Za Zhi 41 (4), 450-455 (2024)
   PUBMED   38565511
  REMARK    GeneRIF: [Prenatal diagnosis of a case with Congenital myasthenic
            syndrome due to compound heterozygous variants of SCN4A gene].
REFERENCE   3  (bases 1 to 7805)
  AUTHORS   Campanale,C., Laghetti,P., Saltarella,I., Altamura,C., Canioni,E.,
            Iosa,E., Maggi,L., Brugnoni,R., Tacconi,P. and Desaphy,J.F.
  TITLE     A c.1775C > T Point Mutation of Sodium Channel Alfa Subunit Gene
            (SCN4A) in a Three-Generation Sardinian Family with Sodium Channel
            Myotonia
  JOURNAL   J Neuromuscul Dis 11 (3), 725-734 (2024)
   PUBMED   38427496
  REMARK    GeneRIF: A c.1775C > T Point Mutation of Sodium Channel Alfa
            Subunit Gene (SCN4A) in a Three-Generation Sardinian Family with
            Sodium Channel Myotonia.
REFERENCE   4  (bases 1 to 7805)
  AUTHORS   Zhang,Y.J., Dai,L.F., Ren,S.S. and Ding,C.H.
  TITLE     [Two cases of potassium-aggravated myotonia induced by SCN4A gene
            variation]
  JOURNAL   Zhonghua Er Ke Za Zhi 61 (11), 1043-1045 (2023)
   PUBMED   37899345
  REMARK    GeneRIF: [Two cases of potassium-aggravated myotonia induced by
            SCN4A gene variation].
REFERENCE   5  (bases 1 to 7805)
  AUTHORS   Weber,F.
  TITLE     Hyperkalemic Periodic Paralysis
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301669
REFERENCE   6  (bases 1 to 7805)
  AUTHORS   Weber,F. and Lehmann-Horn,F.
  TITLE     Hypokalemic Periodic Paralysis
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301512
REFERENCE   7  (bases 1 to 7805)
  AUTHORS   Abicht,A., Muller,J.S. and Lochmuller,H.
  TITLE     Congenital Myasthenic Syndromes Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301347
REFERENCE   8  (bases 1 to 7805)
  AUTHORS   McClatchey,A.I., Van den Bergh,P., Pericak-Vance,M.A., Raskind,W.,
            Verellen,C., McKenna-Yasek,D., Rao,K., Haines,J.L., Bird,T.,
            Brown,R.H. Jr. et al.
  TITLE     Temperature-sensitive mutations in the III-IV cytoplasmic loop
            region of the skeletal muscle sodium channel gene in paramyotonia
            congenita
  JOURNAL   Cell 68 (4), 769-774 (1992)
   PUBMED   1310898
REFERENCE   9  (bases 1 to 7805)
  AUTHORS   Ptacek,L.J., Tawil,R., Griggs,R.C., Storvick,D. and Leppert,M.
  TITLE     Linkage of atypical myotonia congenita to a sodium channel locus
  JOURNAL   Neurology 42 (2), 431-433 (1992)
   PUBMED   1310531
REFERENCE   10 (bases 1 to 7805)
  AUTHORS   Wang,J.Z., Rojas,C.V., Zhou,J.H., Schwartz,L.S., Nicholas,H. and
            Hoffman,E.P.
  TITLE     Sequence and genomic structure of the human adult skeletal muscle
            sodium channel alpha subunit gene on 17q
  JOURNAL   Biochem Biophys Res Commun 182 (2), 794-801 (1992)
   PUBMED   1310396
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from M81758.1, AY212253.1 and
            AC127029.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 26, 2006 this sequence version replaced NM_000334.3.
            
            Summary: Voltage-gated sodium channels are transmembrane
            glycoprotein complexes composed of a large alpha subunit with 24
            transmembrane domains and one or more regulatory beta subunits.
            They are responsible for the generation and propagation of action
            potentials in neurons and muscle. This gene encodes one member of
            the sodium channel alpha subunit gene family. It is expressed in
            skeletal muscle, and mutations in this gene have been linked to
            several myotonia and periodic paralysis disorders. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M81758.1, AY212253.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000435607.3/ ENSP00000396320.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               M81758.1           1-105
            106-1646            AY212253.1         29-1569
            1647-1647           AC127029.12        72837-72837         c
            1648-5630           AY212253.1         1571-5553
            5631-7344           AC127029.12        48144-49857         c
            7345-7805           M81758.1           7363-7823
FEATURES             Location/Qualifiers
     source          1..7805
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q23.3"
     gene            1..7805
                     /gene="SCN4A"
                     /gene_synonym="CMS16; CMYO22A; CMYP22A; HOKPP2; HYKPP;
                     HYPP; Na(V)1.4; NAC1A; Nav1.4; SkM1"
                     /note="sodium voltage-gated channel alpha subunit 4"
                     /db_xref="GeneID:6329"
                     /db_xref="HGNC:HGNC:10591"
                     /db_xref="MIM:603967"
     exon            1..350
                     /gene="SCN4A"
                     /gene_synonym="CMS16; CMYO22A; CMYP22A; HOKPP2; HYKPP;
                     HYPP; Na(V)1.4; NAC1A; Nav1.4; SkM1"
                     /inference="alignment:Splign:2.1.0"
     exon            351..469
                     /gene="SCN4A"
                     /gene_synonym="CMS16; CMYO22A; CMYP22A; HOKPP2; HYKPP;
                     HYPP; Na(V)1.4; NAC1A; Nav1.4; SkM1"
                     /inference="alignment:Splign:2.1.0"
     exon            470..559
                     /gene="SCN4A"
                     /gene_synonym="CMS16; CMYO22A; CMYP22A; HOKPP2; HYKPP;
                     HYPP; Na(V)1.4; NAC1A; Nav1.4; SkM1"
                     /inference="alignment:Splign:2.1.0"
     exon            560..688
                     /gene="SCN4A"
                     /gene_synonym="CMS16; CMYO22A; CMYP22A; HOKPP2; HYKPP;
                     HYPP; Na(V)1.4; NAC1A; Nav1.4; SkM1"
                     /inference="alignment:Splign:2.1.0"
     exon            689..780
                     /gene="SCN4A"
                     /gene_synonym="CMS16; CMYO22A; CMYP22A; HOKPP2; HYKPP;
                     HYPP; Na(V)1.4; NAC1A; Nav1.4; SkM1"
                     /inference="alignment:Splign:2.1.0"
     exon            781..1113
                     /gene="SCN4A"
                     /gene_synonym="CMS16; CMYO22A; CMYP22A; HOKPP2; HYKPP;
                     HYPP; Na(V)1.4; NAC1A; Nav1.4; SkM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1177
                     /gene="SCN4A"
                     /gene_synonym="CMS16; CMYO22A; CMYP22A; HOKPP2; HYKPP;
                     HYPP; Na(V)1.4; NAC1A; Nav1.4; SkM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1319
                     /gene="SCN4A"
                     /gene_synonym="CMS16; CMYO22A; CMYP22A; HOKPP2; HYKPP;
                     HYPP; Na(V)1.4; NAC1A; Nav1.4; SkM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1529
                     /gene="SCN4A"
                     /gene_synonym="CMS16; CMYO22A; CMYP22A; HOKPP2; HYKPP;
                     HYPP; Na(V)1.4; NAC1A; Nav1.4; SkM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1683
                     /gene="SCN4A"
                     /gene_synonym="CMS16; CMYO22A; CMYP22A; HOKPP2; HYKPP;
                     HYPP; Na(V)1.4; NAC1A; Nav1.4; SkM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1922
                     /gene="SCN4A"
                     /gene_synonym="CMS16; CMYO22A; CMYP22A; HOKPP2; HYKPP;
                     HYPP; Na(V)1.4; NAC1A; Nav1.4; SkM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..2096
                     /gene="SCN4A"
                     /gene_synonym="CMS16; CMYO22A; CMYP22A; HOKPP2; HYKPP;
                     HYPP; Na(V)1.4; NAC1A; Nav1.4; SkM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2453
                     /gene="SCN4A"
                     /gene_synonym="CMS16; CMYO22A; CMYP22A; HOKPP2; HYKPP;
                     HYPP; Na(V)1.4; NAC1A; Nav1.4; SkM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2454..2930
                     /gene="SCN4A"
                     /gene_synonym="CMS16; CMYO22A; CMYP22A; HOKPP2; HYKPP;
                     HYPP; Na(V)1.4; NAC1A; Nav1.4; SkM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2931..3066
                     /gene="SCN4A"
                     /gene_synonym="CMS16; CMYO22A; CMYP22A; HOKPP2; HYKPP;
                     HYPP; Na(V)1.4; NAC1A; Nav1.4; SkM1"
                     /inference="alignment:Splign:2.1.0"
     exon            3067..3221
                     /gene="SCN4A"
                     /gene_synonym="CMS16; CMYO22A; CMYP22A; HOKPP2; HYKPP;
                     HYPP; Na(V)1.4; NAC1A; Nav1.4; SkM1"
                     /inference="alignment:Splign:2.1.0"
     exon            3222..3395
                     /gene="SCN4A"
                     /gene_synonym="CMS16; CMYO22A; CMYP22A; HOKPP2; HYKPP;
                     HYPP; Na(V)1.4; NAC1A; Nav1.4; SkM1"
                     /inference="alignment:Splign:2.1.0"
     exon            3396..3518
                     /gene="SCN4A"
                     /gene_synonym="CMS16; CMYO22A; CMYP22A; HOKPP2; HYKPP;
                     HYPP; Na(V)1.4; NAC1A; Nav1.4; SkM1"
                     /inference="alignment:Splign:2.1.0"
     exon            3519..3797
                     /gene="SCN4A"
                     /gene_synonym="CMS16; CMYO22A; CMYP22A; HOKPP2; HYKPP;
                     HYPP; Na(V)1.4; NAC1A; Nav1.4; SkM1"
                     /inference="alignment:Splign:2.1.0"
     exon            3798..3851
                     /gene="SCN4A"
                     /gene_synonym="CMS16; CMYO22A; CMYP22A; HOKPP2; HYKPP;
                     HYPP; Na(V)1.4; NAC1A; Nav1.4; SkM1"
                     /inference="alignment:Splign:2.1.0"
     exon            3852..3989
                     /gene="SCN4A"
                     /gene_synonym="CMS16; CMYO22A; CMYP22A; HOKPP2; HYKPP;
                     HYPP; Na(V)1.4; NAC1A; Nav1.4; SkM1"
                     /inference="alignment:Splign:2.1.0"
     exon            3990..4094
                     /gene="SCN4A"
                     /gene_synonym="CMS16; CMYO22A; CMYP22A; HOKPP2; HYKPP;
                     HYPP; Na(V)1.4; NAC1A; Nav1.4; SkM1"
                     /inference="alignment:Splign:2.1.0"
     exon            4095..4365
                     /gene="SCN4A"
                     /gene_synonym="CMS16; CMYO22A; CMYP22A; HOKPP2; HYKPP;
                     HYPP; Na(V)1.4; NAC1A; Nav1.4; SkM1"
                     /inference="alignment:Splign:2.1.0"
     exon            4366..7805
                     /gene="SCN4A"
                     /gene_synonym="CMS16; CMYO22A; CMYP22A; HOKPP2; HYKPP;
                     HYPP; Na(V)1.4; NAC1A; Nav1.4; SkM1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7781..7786
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCN4A"
                     /gene_synonym="CMS16; CMYO22A; CMYP22A; HOKPP2; HYKPP;
                     HYPP; Na(V)1.4; NAC1A; Nav1.4; SkM1"
                     /note="hexamer: AATAAA"
     polyA_site      7805
                     /gene="SCN4A"
                     /gene_synonym="CMS16; CMYO22A; CMYP22A; HOKPP2; HYKPP;
                     HYPP; Na(V)1.4; NAC1A; Nav1.4; SkM1"
                     /note="major polyA site"
ORIGIN      
        1 ccagcacccc ggggctgcgc actgcagctc cccaggccac ccaccaccct tctggtctct
       61 gagcccagga tgcgaggatg gccagaccat ctctgtgcac cctggtgcct ctgggccctg
      121 agtgcttgcg ccccttcacc cgggagtcac tggcagccat agaacagcgg gcggtggagg
      181 aggaggcccg gctgcagcgg aataagcaga tggagattga ggagcccgaa cggaagccac
      241 gaagtgactt ggaggctggc aagaacctac ccatgatcta cggagacccc ccgccggagg
      301 tcatcggcat ccccctggag gacctggatc cctactacag caataagaag accttcatcg
      361 tactcaacaa gggcaaggcc atcttccgct tctccgccac acctgctctc tacctgctga
      421 gccccttcag cgtagtcagg cgcggggcca tcaaggtgct catccatgcg ctgttcagca
      481 tgttcatcat gatcaccatc ttgaccaact gcgtattcat gaccatgagt gacccgcctc
      541 cctggtccaa gaatgtggag tacaccttca cagggatcta cacctttgag tccctcatca
      601 agatactggc ccgaggcttc tgtgtcgacg acttcacatt cctccgggac ccctggaact
      661 ggctggactt cagtgtcatc atgatggcgt acctgacaga gtttgtggac ttgggcaaca
      721 tctcagccct gaggaccttc cgggtgctgc gggccctcaa aaccatcacg gtcatcccag
      781 ggctgaagac gatcgtgggg gccctgatcc agtcggtgaa aaagctgtcg gatgtgatga
      841 tcctcactgt cttctgcctg agcgtctttg cgctggtagg actgcagctc ttcatgggaa
      901 acctgaggca gaagtgtgtg cgctggcccc cgccgttcaa cgacaccaac accacgtggt
      961 acagcaatga cacgtggtac ggcaatgaca catggtatgg caatgagatg tggtacggca
     1021 atgactcatg gtatgccaac gacacgtgga acagccatgc aagctgggcc accaacgata
     1081 cctttgattg ggacgcctac atcagtgatg aagggaactt ctacttcctg gagggctcca
     1141 acgatgccct gctctgtggg aacagcagtg atgctgggca ctgccctgag ggttatgagt
     1201 gcatcaagac cgggcggaac cccaactatg gctacaccag ctatgacacc ttcagctggg
     1261 ccttcttggc tctcttccgc ctcatgacac aggactattg ggagaacctc ttccagctga
     1321 cccttcgagc agctggcaag acctacatga tcttcttcgt ggtcatcatc ttcctgggct
     1381 ctttctacct catcaatctg atcctggccg tggtggccat ggcatatgcc gagcagaatg
     1441 aggccaccct ggccgaggat aaggagaaag aggaggagtt tcagcagatg cttgagaagt
     1501 tcaaaaagca ccaggaggag ctggagaagg ccaaggccgc ccaagctctg gaaggtgggg
     1561 aggcagatgg ggacccagcc catggcaaag actgcaatgg cagcctggac acatcgcaag
     1621 gggagaaggg agccccgagg cagagcagca gcggagacag cggcatctcc gacgccatgg
     1681 aagaactgga agaggcccac caaaagtgcc caccatggtg gtacaagtgc gcccacaaag
     1741 tgctcatatg gaactgctgc gccccgtggc tgaagttcaa gaacatcatc cacctgatcg
     1801 tcatggaccc gttcgtggac ctgggcatca ccatctgcat cgtgctcaac accctcttca
     1861 tggccatgga acattacccc atgacggagc actttgacaa cgtgctcact gtgggcaacc
     1921 tggtcttcac aggcatcttc acagcagaga tggttctgaa gctgattgcc atggacccct
     1981 acgagtattt ccagcagggt tggaatatct tcgacagcat catcgtcacc ctcagcctgg
     2041 tagagctagg cctggccaac gtacagggac tgtctgtgct acgctccttc cgtctgctgc
     2101 gggtcttcaa gctggccaag tcgtggccaa cgctgaacat gctcatcaag atcattggca
     2161 attcagtggg ggcgctgggt aacctgacgc tggtgctggc tatcatcgtg ttcatcttcg
     2221 ccgtggtggg catgcagctg tttggcaaga gctacaagga gtgcgtgtgc aagattgcct
     2281 tggactgcaa cctgccgcgc tggcacatgc atgatttctt ccactccttc ctcatcgtct
     2341 tccgcatcct gtgcggggag tggatcgaga ccatgtggga ctgcatggag gtggccggcc
     2401 aagccatgtg cctcaccgtc ttcctcatgg tcatggtcat cggcaatctt gtggtcctga
     2461 acctgttcct ggctctgctg ctgagctcct tcagcgccga cagtctggca gcctcggatg
     2521 aggatggcga gatgaacaac ctgcagattg ccatcgggcg catcaagttg ggcatcggct
     2581 ttgccaaggc cttcctcctg gggctgctgc atggcaagat cctgagcccc aaggacatca
     2641 tgctcagcct cggggaggct gacggggccg gggaggctgg agaggcgggg gagactgccc
     2701 ccgaggatga gaagaaggag ccgcccgagg aggacctgaa gaaggacaat cacatcctga
     2761 accacatggg cctggctgac ggccccccat ccagcctcga gctggaccac cttaacttca
     2821 tcaacaaccc ctacctgacc atacaggtgc ccatcgcctc cgaggagtcc gacctggaga
     2881 tgcccaccga ggaggaaacc gacactttct cagagcctga ggatagcaag aagccgccgc
     2941 agcctctcta tgatgggaac tcgtccgtct gcagcacagc tgactacaag ccccccgagg
     3001 aggaccctga ggagcaggca gaggagaacc ccgaggggga gcagcctgag gagtgcttca
     3061 ctgaggcctg cgtgcagcgc tggccctgcc tctacgtgga catctcccag ggccgtggga
     3121 agaagtggtg gactctgcgc agggcctgct tcaagattgt cgagcacaac tggttcgaga
     3181 ccttcattgt cttcatgatc ctgctcagca gtggggctct ggccttcgag gacatctaca
     3241 ttgagcagcg gcgagtcatt cgcaccatcc tagaatatgc cgacaaggtc ttcacctaca
     3301 tcttcatcat ggagatgctg ctcaaatggg tggcctacgg ctttaaggtg tacttcacca
     3361 acgcctggtg ctggctcgac ttcctcatcg tggatgtctc catcatcagc ttggtggcca
     3421 actggctggg ctactcggag ctgggaccca tcaaatccct gcggacactg cgggccctgc
     3481 gtcccctgag ggcactgtcc cgattcgagg gcatgagggt ggtggtgaac gccctcctag
     3541 gcgccatccc ctccatcatg aatgtgctgc ttgtctgcct catcttctgg ctgatcttca
     3601 gcatcatggg tgtcaacctg tttgccggca agttctacta ctgcatcaac accaccacct
     3661 ctgagaggtt cgacatctcc gaggtcaaca acaagtctga gtgcgagagc ctcatgcaca
     3721 caggccaggt ccgctggctc aatgtcaagg tcaactacga caacgtgggt ctgggctacc
     3781 tctccctcct gcaggtggcc accttcaagg gttggatgga catcatgtat gcagccgtgg
     3841 actcccggga gaaggaggag cagccgcagt acgaggtgaa cctctacatg tacctctact
     3901 ttgtcatctt catcatcttt ggctccttct tcaccctcaa cctcttcatt ggcgtcatca
     3961 ttgacaactt caaccagcag aagaagaagt taggggggaa agacatcttt atgacggagg
     4021 aacagaagaa atactataac gccatgaaga agcttggctc caagaagcct cagaagccaa
     4081 ttccccggcc ccagaacaag atccagggca tggtgtatga cctcgtgacg aagcaggcct
     4141 tcgacatcac catcatgatc ctcatctgcc tcaacatggt caccatgatg gtggagacag
     4201 acaaccagag ccagctcaag gtggacatcc tgtacaacat caacatgatc ttcatcatca
     4261 tcttcacagg ggagtgcgtg ctcaagatgc tcgccctgcg ccagtactac ttcaccgttg
     4321 gctggaacat ctttgacttc gtggtcgtca tcctgtccat tgtgggcctt gccctctctg
     4381 acctgatcca gaagtacttc gtgtcaccca cgctgttccg tgtgatccgc ctggcgcgga
     4441 ttgggcgtgt cctgcggctg atccgcgggg ccaagggcat ccggacgctg ctgttcgccc
     4501 tcatgatgtc gctgcctgcc ctcttcaaca tcggcctcct cctcttcctg gtcatgttca
     4561 tctactccat cttcggcatg tccaactttg cctacgtcaa gaaggagtcg ggcatcgatg
     4621 atatgttcaa cttcgagacc ttcggcaaca gcatcatctg cctgttcgag atcaccacgt
     4681 cggccggctg ggacgggctc ctcaacccca tcctcaacag cgggccccca gactgtgacc
     4741 ccaacctgga gaacccgggc accagtgtca agggtgactg cggcaacccc tccatcggca
     4801 tctgcttctt ctgcagctat atcatcatct ccttcctcat cgtggtcaac atgtacatcg
     4861 ccatcatcct ggagaacttc aatgtggcca cagaggagag cagcgagccc cttggtgaag
     4921 atgactttga gatgttctac gagacatggg agaagttcga ccccgacgcc acccagttca
     4981 tcgcctacag ccgcctctca gacttcgtgg acaccctgca ggaaccgctg aggattgcca
     5041 agcccaacaa gatcaagctc atcacactgg acttgcccat ggtgccaggg gacaagatcc
     5101 actgcctgga catcctcttt gccctgacca aagaggtcct gggtgactct ggggaaatgg
     5161 acgccctcaa gcagaccatg gaggagaagt tcatggcagc caacccctcc aaggtgtcct
     5221 acgagcccat caccaccacc ctcaagagga agcacgagga ggtgtgcgcc atcaagatcc
     5281 agagggccta ccgccggcac ctgctacagc gctccatgaa gcaggcatcc tacatgtacc
     5341 gccacagcca cgacggcagc ggggatgacg cccctgagaa ggaggggctg cttgccaaca
     5401 ccatgagcaa gatgtatggc cacgagaatg ggaacagcag ctcgccaagc ccggaggaga
     5461 agggcgaggc aggggacgcc ggacccacta tggggctgat gcccatcagc ccctcagaca
     5521 ctgcctggcc tcccgcccct cccccagggc agactgtgcg cccaggtgtc aaggagtctc
     5581 ttgtctagca ggcagcatcg gggtggccca ctgagtctcg gcatagtccc cagagctccc
     5641 ccgtggtgcc tgcacacaga gtgagggagg agggctttga atctgggact gtgcctggct
     5701 ccctgatggg ggacaggatt tggccacact ggggctgaca cccaggcccg agcgcctgcg
     5761 ttcccagacc atgggaaatg ggaattgcgc tcaggggctc catgctgggt ctgaggcccc
     5821 tgcctccaag atttaacctg caagttgctc tgacctcctc tgggccctgt cgcccctcct
     5881 tttggcctgg gggaggtcag aacattcgaa tctctgcccc tcacttgagg aggagctggc
     5941 ctgcggtgga gggatcagtt gccccccatc accagagtct taagggtcac tggcctctcc
     6001 ccaggaagtg gctcagaccc ctcagcccca gcccagacaa agatgtctta acctcaggga
     6061 gtgcagacac ctaaccccag ggcactgcca gcccaccccc tttgactctg gggtgcagct
     6121 tcacccacca ggccagctca ggaattccct ggaaaaggga aatgtgactg gttcagaaat
     6181 agctcctcaa agcctcaaaa cctgattggc cactggatcc tgctgctttg ggctgggatg
     6241 gtgactcctg aaacctcttc ctaggccacg tccaggtccg tagctcccct ggctggctcc
     6301 taggggaaga gcagaaggaa ggatgccact tgggaatgaa ttgtcctttt ctaggaagca
     6361 cgggggagtg agacaggctg ggtcctgcca gctggatcgc tgcacatggc ctgagcatcc
     6421 agacctgagc gggagtcagg gacctgctgc tcagtaagaa gattctcgcc ccttccctct
     6481 ctccctgcct cactcctccg tgagcaccac cagggctcca ggagcctcat ccagcctcag
     6541 agatctccct tctcatctcc ccacgcccgt ctctttctca cctttcccac ctctctcccc
     6601 aaagtgatcc taagaatgta cagttgagct caggttagat atttcgaccc tggggcgtgc
     6661 agcagggaag gcccaactgg ttcaggctca accttccaac ttcctgtggc ctgaagaagc
     6721 acttctgctg catcgctgtt ctgggcatgg cagggccagg cctctgctgg ctcaggagga
     6781 ggggtgagag acctgctcag gcgtcgctgg atttattcac ttgtgtgtgt acctgtggct
     6841 gtgtgtctgc ttgtatgctt ttataggcct gtgtgtatag ctgtgtgtgt gttcaagtgc
     6901 gtgactgtat gtgtgtgtgt gaaccactgt gtactggagc ctgcattatg cacgtgtctg
     6961 ggtatctttg tatatatgtg tatatatgtg tgccctggac tgtttcaagg tccatggagt
     7021 acggctggtg tgtcatactg tgcaggcctg tccctgggag tgttcccgtg cctgggagag
     7081 tggacctgtg ctgtgagtgt gtggatgcgt gtgaacgcat gtggtaaggt gtgtactcag
     7141 ggcattctgt tggcctaagt gcctcttctt tttcttcttg tttctcatga aaagtttgat
     7201 taaaattcag gaagcagcaa aaccttcaaa acaagacatg tatgtgtgct tgagtgtgtg
     7261 aacacgtgtg tgtgtgtgca catctacatg ccatgcctat gggccagagt tgtctttatt
     7321 gtccaccatg ctctctcacc tgctcccagt cctgcctgaa cagccctctc tctcactccc
     7381 ctctcctccc cttcctgttt ctcgttgtca cacccatggc ctcagccctg ctccctgcct
     7441 cctgcctatg tctcctctat ggaaggaggc ctccactcct tccatctctt ccttcagaag
     7501 tttcgtctaa tgggggcagt ctccccttcc tggcacattg cccctctgcc ttgccctcct
     7561 gggccctggg ctggcacagc ccctggagcc tcagaaatct gtttgattgg atattctcct
     7621 cggactgtgt gcaggttgca gaggaagagt agatgagccg ggtccggcct ctccctgcct
     7681 gtggcccctc ccctgcagac ggatgcccat tcctgcctgg tccagtgggg aacaggtccc
     7741 acgccaggcc agcaggcggg ctcctttgta cagttcttac aataaaccct ccttggtgcc
     7801 tctgg
//
