LOCUS       NM_001040151            5683 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens sodium voltage-gated channel beta subunit 3 (SCN3B),
            transcript variant 2, mRNA.
ACCESSION   NM_001040151
VERSION     NM_001040151.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5683)
  AUTHORS   Noland,C.L., Chua,H.C., Kschonsak,M., Heusser,S.A., Braun,N.,
            Chang,T., Tam,C., Tang,J., Arthur,C.P., Ciferri,C., Pless,S.A. and
            Payandeh,J.
  TITLE     Structure-guided unlocking of NaX reveals a non-selective
            tetrodotoxin-sensitive cation channel
  JOURNAL   Nat Commun 13 (1), 1416 (2022)
   PUBMED   35301303
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5683)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 5683)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5683)
  AUTHORS   Li,S., Han,J., Guo,G., Sun,Y., Zhang,T., Zhao,M., Xu,Y., Cui,Y.,
            Liu,Y. and Zhang,J.
  TITLE     Voltage-gated sodium channels beta3 subunit promotes tumorigenesis
            in hepatocellular carcinoma by facilitating p53 degradation
  JOURNAL   FEBS Lett 594 (3), 497-508 (2020)
   PUBMED   31626714
  REMARK    GeneRIF: Voltage-gated sodium channels beta3 subunit promotes
            tumorigenesis in hepatocellular carcinoma by facilitating p53
            degradation.
REFERENCE   5  (bases 1 to 5683)
  AUTHORS   Pawlak-Osinska,K., Linkowska,K., Holub,K., Winiarska,K.,
            Stankiewicz,B., Kazmierczak,H., Osinski,S., Marzec,M. and
            Grzybowski,T.
  TITLE     An Analysis of the Association between Epilepsy-Related Genes and
            Vertigo in the Polish Population
  JOURNAL   Audiol Neurootol 23 (3), 135-144 (2018)
   PUBMED   30300896
  REMARK    GeneRIF: rs1783901 may play a potential role of gene regulation
            and/or epistasis in a complex etiology of vertigo.
REFERENCE   6  (bases 1 to 5683)
  AUTHORS   Ratcliffe,C.F., Westenbroek,R.E., Curtis,R. and Catterall,W.A.
  TITLE     Sodium channel beta1 and beta3 subunits associate with neurofascin
            through their extracellular immunoglobulin-like domain
  JOURNAL   J Cell Biol 154 (2), 427-434 (2001)
   PUBMED   11470829
REFERENCE   7  (bases 1 to 5683)
  AUTHORS   Stevens,E.B., Cox,P.J., Shah,B.S., Dixon,A.K., Richardson,P.J.,
            Pinnock,R.D. and Lee,K.
  TITLE     Tissue distribution and functional expression of the human
            voltage-gated sodium channel beta3 subunit
  JOURNAL   Pflugers Arch 441 (4), 481-488 (2001)
   PUBMED   11212211
REFERENCE   8  (bases 1 to 5683)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   9  (bases 1 to 5683)
  AUTHORS   Morgan,K., Stevens,E.B., Shah,B., Cox,P.J., Dixon,A.K., Lee,K.,
            Pinnock,R.D., Hughes,J., Richardson,P.J., Mizuguchi,K. and
            Jackson,A.P.
  TITLE     beta 3: an additional auxiliary subunit of the voltage-sensitive
            sodium channel that modulates channel gating with distinct kinetics
  JOURNAL   Proc Natl Acad Sci U S A 97 (5), 2308-2313 (2000)
   PUBMED   10688874
REFERENCE   10 (bases 1 to 5683)
  AUTHORS   Brugada,R., Campuzano,O., Sarquella-Brugada,G., Brugada,P.,
            Brugada,J. and Hong,K.
  TITLE     Brugada Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301690
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP002765.3.
            
            On Jun 1, 2020 this sequence version replaced NM_001040151.1.
            
            Summary: Voltage-gated sodium channels are transmembrane
            glycoprotein complexes composed of a large alpha subunit and one or
            more regulatory beta subunits. They are responsible for the
            generation and propagation of action potentials in neurons and
            muscle. This gene encodes one member of the sodium channel beta
            subunit gene family, and influences the inactivation kinetics of
            the sodium channel. Two alternatively spliced variants, encoding
            the same protein, have been identified. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same isoform.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB032984.1, SRR1660809.251090.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2162841 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299333.8/ ENSP00000299333.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-399               AP002765.3         107585-107983       c
            400-479             AP002765.3         107106-107185       c
            480-643             AP002765.3         98946-99109         c
            644-869             AP002765.3         95805-96030         c
            870-1008            AP002765.3         91545-91683         c
            1009-1094           AP002765.3         87480-87565         c
            1095-5683           AP002765.3         82547-87135         c
FEATURES             Location/Qualifiers
     source          1..5683
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.1"
     gene            1..5683
                     /gene="SCN3B"
                     /gene_synonym="ATFB16; BRGDA7; HSA243396; SCNB3"
                     /note="sodium voltage-gated channel beta subunit 3"
                     /db_xref="GeneID:55800"
                     /db_xref="HGNC:HGNC:20665"
                     /db_xref="MIM:608214"
     exon            1..399
                     /gene="SCN3B"
                     /gene_synonym="ATFB16; BRGDA7; HSA243396; SCNB3"
                     /inference="alignment:Splign:2.1.0"
     exon            400..479
                     /gene="SCN3B"
                     /gene_synonym="ATFB16; BRGDA7; HSA243396; SCNB3"
                     /inference="alignment:Splign:2.1.0"
     CDS             425..1072
                     /gene="SCN3B"
                     /gene_synonym="ATFB16; BRGDA7; HSA243396; SCNB3"
                     /note="voltage-gated sodium channel beta-3 subunit; sodium
                     channel subunit beta-3; sodium channel, voltage-gated,
                     type III, beta subunit; sodium channel regulatory subunit
                     beta-3"
                     /codon_start=1
                     /product="sodium channel regulatory subunit beta-3
                     precursor"
                     /protein_id="NP_001035241.1"
                     /db_xref="CCDS:CCDS8442.1"
                     /db_xref="GeneID:55800"
                     /db_xref="HGNC:HGNC:20665"
                     /db_xref="MIM:608214"
                     /translation="MPAFNRLFPLASLVLIYWVSVCFPVCVEVPSETEAVQGNPMKLR
                     CISCMKREEVEATTVVEWFYRPEGGKDFLIYEYRNGHQEVESPFQGRLQWNGSKDLQD
                     VSITVLNVTLNDSGLYTCNVSREFEFEAHRPFVKTTRLIPLRVTEEAGEDFTSVVSEI
                     MMYILLVFLTLWLLIEMIYCYRKVSKAEEAAQENASDYLAIPSENKENSAVPVEE"
     exon            480..643
                     /gene="SCN3B"
                     /gene_synonym="ATFB16; BRGDA7; HSA243396; SCNB3"
                     /inference="alignment:Splign:2.1.0"
     exon            644..869
                     /gene="SCN3B"
                     /gene_synonym="ATFB16; BRGDA7; HSA243396; SCNB3"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1008
                     /gene="SCN3B"
                     /gene_synonym="ATFB16; BRGDA7; HSA243396; SCNB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1094
                     /gene="SCN3B"
                     /gene_synonym="ATFB16; BRGDA7; HSA243396; SCNB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..5683
                     /gene="SCN3B"
                     /gene_synonym="ATFB16; BRGDA7; HSA243396; SCNB3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5662..5667
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCN3B"
                     /gene_synonym="ATFB16; BRGDA7; HSA243396; SCNB3"
                     /note="hexamer: AATAAA"
     polyA_site      5683
                     /gene="SCN3B"
                     /gene_synonym="ATFB16; BRGDA7; HSA243396; SCNB3"
                     /note="major polyA site"
ORIGIN      
        1 ggagagccgc ctgcgcatgt cagggctgac agcacacacg gcctgggggc ctagagaagg
       61 gttgctgatc acctgccacc cagggtcggg gccccgcacc atccgggggc gagctcccgg
      121 gaaggggctc cgcctctaca cccacccccc aacctctgac atcgccggcc gaacgggagc
      181 tgccgcttcc ttcccggccc cgctgcacct ccccagggag ccgagggcgg gcgtggacgg
      241 gaccgacgtg gaacgcattc tgtagcccag acgggcggcc ccggcggctt cgggagtggg
      301 gtcacgccca gctggagaag cagttagggc ggacgaagca ggagccgcgg ggctgggagg
      361 attccagtcg gaacgcaacc gatcctgggg aggcgagagc cttggaagcc gccagcccca
      421 gaagatgcct gccttcaata gattgtttcc cctggcttct ctcgtgctta tctactgggt
      481 cagtgtctgc ttccctgtgt gtgtggaagt gccctcggag acggaggccg tgcagggcaa
      541 ccccatgaag ctgcgctgca tctcctgcat gaagagagag gaggtggagg ccaccacggt
      601 ggtggaatgg ttctacaggc ccgagggcgg taaagatttc cttatttacg agtatcggaa
      661 tggccaccag gaggtggaga gcccctttca ggggcgcctg cagtggaatg gcagcaagga
      721 cctgcaggac gtgtccatca ctgtgctcaa cgtcactctg aacgactctg gcctctacac
      781 ctgcaatgtg tcccgggagt ttgagtttga ggcgcatcgg ccctttgtga agacgacgcg
      841 gctgatcccc ctaagagtca ccgaggaggc tggagaggac ttcacctctg tggtctcaga
      901 aatcatgatg tacatccttc tggtcttcct caccttgtgg ctgctcatcg agatgatata
      961 ttgctacaga aaggtctcaa aagccgaaga ggcagcccaa gaaaacgcgt ctgactacct
     1021 tgccatccca tctgagaaca aggagaactc tgcggtacca gtggaggaat agaacaggag
     1081 cagtgtgaca tgaggtggcc tgaacacctg agggactgga catcccatgt tcagcaatgt
     1141 caatggcatc aggagggcgc cccaagggcc ccatcgcttc ccttcatgca tccattgttc
     1201 tgttcattca ttcatccata catccacctg cctctgagct ttcacctctg actccctaac
     1261 tccatcagac ctctacgcac cataagactc tgccagaact gagaagccaa catttctaca
     1321 tagactcaac ctcaccctct cctagttttc caacaagaca ctccaaagcc aactggattt
     1381 ctcccctgtg ctccaaatga ctttgtacaa gtgctggagt tagcacctcc ctctgccctt
     1441 aactggctgg aactggttca ttctccatta ctgcaagaga atggaagtct taatagaagg
     1501 aagcaggagt gattagttcg ggttaaagca aaagtgtgtc atgaacttgg attccctgaa
     1561 gtcagttttg tcaggttcat ggcccacttt gctacagcat cagagtgaag cacgcctgtc
     1621 taggttctcc agtgacagaa agatcctgaa gcatggacta acatgctctc tggagcttag
     1681 tactccagag ctagatcctg atgggtctct aaggttccct ccaagaagac aaggacagga
     1741 gacttgggaa ggaccaatgg taatttaagt ggctcttaaa aagtcatgca acatgtttct
     1801 ggacacgttc ctgatcctat tgcgataatg tatgtgtgcc ctccctgtgg gcacaccacc
     1861 tgggcattag gactgaaatt cctgagttct tcctctcaaa atttctgtgc accagtatta
     1921 ttcctcattt tacatacagg aggcaactaa gactcataca gggctcaact gaataagagg
     1981 cttaagagga taaactggag cagaaataag ccttaggtgc tgcccagttt acacttcctg
     2041 ggatggatgt ttttgtttgt tttgtttttt gttttttttg tttgagatgg agtctcactc
     2101 tgtcacctag gctagagtgc agtggtgtga tctcggctca ctgcaacctc tgcctcttgg
     2161 gttcaagcaa ttctcatgcc tcggcctctc cagtagctgg gattacaggt gtgcaccacc
     2221 acgcctggct aaattttgta tttttagtac agacagggtt tgactatgtt ggccaggcta
     2281 gtcttgaact cctgacctca aatgacccac ccacctcagc ctcccaaagt gctgagatta
     2341 caggcgtgag gcactgcgcc cggtggataa ctttgtttct gaaaagactg acattgaact
     2401 tgtctatggc aatgcttctt tcacaagcac ggactgggct gaggtcaact ctgatagatt
     2461 cagatgacta gaaattggcc aaaaaagcag ggagaagaac atgaggtaga cttaaagaac
     2521 ttcctttatg taaagatctg tgactctgaa atatcctcca aaaggagagt gcatctgaga
     2581 ctgatattta aactaagaaa aatgtttagt ctgagatgga tcataagtaa atgagcagtg
     2641 tgagagggga gggatgggta ggtgctttcc aaatacttcg cctatgaatg cataattttc
     2701 agattttttt cccctagatt ttgagggagc agagaaactg gaaaaaactt tagtcaatat
     2761 ctcgtgtttc attttaatta agtgacaggt ccaagtgtga catccttcag cacccaggga
     2821 caagagaggg gaaagatgct ttatggaatg taagaagatg aaggtgactg ggattcagcg
     2881 agagagaggt ccctcagacc tgggacctcc ctttataggg aaagaccata ttccataggt
     2941 ttagggcttt accttaaaag ctcatttttt tcattcttcc atccctagga aagtacttaa
     3001 aaccagactt ttaaattttt atttatttat tattattttt ttgagacaga ttctcactct
     3061 gtctcccagg ctagagtgca gtggtgcaat ctcagctcac tgcagcctca actgccccag
     3121 gtttaagcaa tcctcccacc tcagccccca ggtaactggg actacaggca tgcaccacca
     3181 tgcctggcta atttttgtat tttatgtaga gacaggggtc ttgccatgtc gcccaggctg
     3241 atcttgaact cctgggctca agcaatctgc cagcctcagc ctctcaaagt gctgggatta
     3301 caggcctgag caactgtgcc tggcccaaaa ccagaccgtt aacacattaa agagtctgat
     3361 tttgttgaag aaaatatttg caataaattc aagactcttc ttattggtaa ttttccacac
     3421 aatccctctg aaataaggga gaggatatag acctttttaa ctttatagtt agaaaaattg
     3481 gcctcagtgt gaaatttttc cagtcccata gctcatggat gccaccagct tgcggtagta
     3541 gcaagatgct tactaccaca ccgttttcct cggtggccca atagctcgtg tatctaagtt
     3601 gaacccggca gtatgcatga ttgccttttt ctcttctttt taaaaaaacc caactcagat
     3661 gctgcttgcg tggcttttaa tgaagctgaa tggtatctat cacttattta tccttgacag
     3721 gttatcttcc ccactcttcc tttttctaac ttctccattc ttctcattct tgacactttc
     3781 attagaacta tatggtttac gaagtatttt cacttaacta ttttatttct tctctataac
     3841 tggtcctgtg aggtcacatt acaaaagaag aaactgaggg tctctgaggt taagtagctt
     3901 tactaaatta taaggaaacc tagctggtag gtagacagca agaatccagg tcttctgact
     3961 cctctttcag ttctctttcc acttagacca tagctgcttc cttttcttat tttttagctt
     4021 ccatctaacc attgcctatc ttgcctgtcc taatgttctc catcttctct cacccctaat
     4081 cccactcact gcttctctac cactttgctt tttggtggat gctagcaatg tgctttgaga
     4141 gtcagtccta ttttggttct ctttctagtt ggtttgtaca tcattatttc tcctgaattg
     4201 caattaaact ccttcctggg agatttgata atgactgtaa atcaataagg tactgtgatc
     4261 accagcctac ttccaatctc cacccacctc cctgtctctt cccataatcc tacgaaagac
     4321 ccagactaga tgtctgtttc tctggaagct ttatctggca tgatgttgct tattaaaggg
     4381 cttagaagag ttctcaaggg ctattaatat cactttagaa accccatctg ttgtcttggt
     4441 gctggatatt tcccatgtct gatcctcaat aacacaattc actaaaggcc aagcttggct
     4501 caatctgatt ttcccattct tactacttca cagccatgaa tgtgattgct caatccagtt
     4561 ggccctgaga gcaccttgcc ctgctgacct tcactgtcac ctcggtcttg aatcagagcc
     4621 ccaacccaaa cactccctgc ctgtccctac cccagccttt attctcacca cttgtttaac
     4681 ggcatgacct tttagtttct ccattcccag acacccacac acccagactt ccttctgagt
     4741 tgcaggtttc tccttagatg tccaactaga aatattacta ggaaagttac ttttcaaagc
     4801 aggaatgtgc tgggaagtag gagacagcaa ctccctcctc tctccccaaa attattggat
     4861 caaaaaagaa attccatcca tctcagaatc tgtgagtcct cctcacataa atctgaggga
     4921 aaaggctgtg tcactgcatc tttgcaggaa gaaagagaag caagagctag acacacttca
     4981 gaatatatct tagtttcccc tttcccagtt taacatgaaa atgaaaaaag aaaaaaatga
     5041 aaaacaaaaa caaaagaagc cttcctctca cctcattttg taaatgaaaa atccctaatt
     5101 cagtgaattc acctagtcac tgcaaatgta tctgaatagt gcttggtgtg cttgccagtc
     5161 tgatcatcca ctcattctac taacatcttt ttgcacccac tctgtcaagc tctagcctag
     5221 acctttagtg tgccatgcag tcacaggtct gaaaagcagc atcatccaaa ccttacttaa
     5281 tctctaaaat ctcagctggt ggacagctca tgattagttc agcccacttc ctccccctta
     5341 gttgagtttg cagcaggacg caggagataa gcacttccaa gcaagtctga tttatatatc
     5401 aaactcggtc tccatcccag gccagctgac cctcagagcc agcaatgctc tgtgcttcct
     5461 ccctgcgtca cggcttggca agagctgcct ctgctgagca gtgtgtgtga tggagacgga
     5521 ggccgctgaa ggccgagtgc ttgcaggctt gtgaactgcc atcgaacaca atccaaactc
     5581 tggaaatgtt cctgaccacc taagccctca acaacgtaat gcctgtatgt gctgtttttc
     5641 agtaaactcc ttgttcatgt caataaagta tccctgaaaa cca
//
