LOCUS       XM_017004662            8964 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens sodium voltage-gated channel alpha subunit
            3 (SCN3A), transcript variant X5, mRNA.
ACCESSION   XM_017004662
VERSION     XM_017004662.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000002.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_017004662.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8964
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
     gene            1..8964
                     /gene="SCN3A"
                     /gene_synonym="DEE62; EIEE62; FFEVF4; NAC3; Nav1.3"
                     /note="sodium voltage-gated channel alpha subunit 3;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 4 mRNAs, 4 ESTs, 253 long SRA reads, 43
                     Proteins, and 100% coverage of the annotated genomic
                     feature by RNAseq alignments, including 11 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:6328"
                     /db_xref="HGNC:HGNC:10590"
                     /db_xref="MIM:182391"
     CDS             476..6340
                     /gene="SCN3A"
                     /gene_synonym="DEE62; EIEE62; FFEVF4; NAC3; Nav1.3"
                     /codon_start=1
                     /product="sodium channel protein type 3 subunit alpha
                     isoform X5"
                     /protein_id="XP_016860151.1"
                     /db_xref="GeneID:6328"
                     /db_xref="HGNC:HGNC:10590"
                     /db_xref="MIM:182391"
                     /translation="MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDND
                     DENKPKPNSDLEAGKNLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRF
                     SATSALYILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYT
                     FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTF
                     RVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNK
                     CLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDP
                     LLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLT
                     LRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLE
                     QLKKQQEEAQAVAAASAASRDFSGIGGLGELLESSSEASKLSSKSAKEWRNRRKKRRQ
                     REHLEGNNKGERDSFPKSESEDSVKRSSFLFSMDGNRLTSDKKFCSPHQSLLSIRGSL
                     FSPRRNSKTSIFSFRGRAKDVGSENDFADDEHSTFEDSESRRDSLFVPHRHGERRNSN
                     VSQGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEELEESRQKCPP
                     CWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTE
                     QFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNV
                     EGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQ
                     LFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMC
                     LIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYV
                     KNKMRECFQKAFFRKPKVIEIHEGNKIDSCMSNNTGIEISKELNYLRDGNGTTSGVGT
                     GSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLN
                     ATSSSEGSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIW
                     WNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYI
                     FILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRA
                     LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVN
                     MTTGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMY
                     AAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQD
                     IFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNM
                     VTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVI
                     LSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALF
                     NIGLLLFLVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGL
                     LAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILE
                     NFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPN
                     KVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSY
                     EPITTTLKRKQEEVSAAIIQRNFRCYLLKQRLKNISSNYNKEAIKGRIDLPIKQDMII
                     DKLNGNSTPEKTDGSSSTTSPPSYDSVTKPDKEKFEKDKPEKESKGKEVRENQK"
ORIGIN      
        1 agaacaggaa gcggaggcat aagcagagag gattctggaa aggtctcttt gttttcttat
       61 ccacagagaa agaaagaaaa aaaattgtaa ctaatttgta aacctctgtg gtcaaaaaaa
      121 aaaaaaaaaa aaaaagctga acagctgcag aggaagacac gttataccct aaccatcttg
      181 gatgctgggc tttgttatgc tgtaattcat aaggctctgt tttatcagag attatggagc
      241 aagaaaactg aagccaagcc acatcaaggt ttgacaggga tgagatacct gtcaaggatt
      301 catagtagag tggcttactg ggaaaggagc aaagaatctc ttctagggat attgtaagaa
      361 taaatgagat aattcacaga agggacctgg agcttttccg gaaaaaggtg ctgtgactat
      421 ctaaggtaat tcgtatgcaa gaagctacac gtaattaaat gtgcaggatg aaaagatggc
      481 acaggcactg ttggtacccc caggacctga aagcttccgc ctttttacta gagaatctct
      541 tgctgctatc gaaaaacgtg ctgcagaaga gaaagccaag aagcccaaaa aggaacaaga
      601 taatgatgat gagaacaaac caaagccaaa tagtgacttg gaagctggaa agaaccttcc
      661 atttatttat ggagacattc ctccagagat ggtgtcagag cccctggagg acctggatcc
      721 ctactatatc aataagaaaa cttttatagt aatgaataaa ggaaaggcaa ttttccgatt
      781 cagtgccacc tctgccttgt atattttaac tccactaaac cctgttagga aaattgctat
      841 caagattttg gtacattctt tattcagcat gcttatcatg tgcactattt tgaccaactg
      901 tgtatttatg accttgagca accctcctga ctggacaaag aatgtagagt acacattcac
      961 tggaatctat acctttgagt cacttataaa aatcttggca agagggtttt gcttagaaga
     1021 ttttacgttt cttcgtgatc catggaactg gctggatttc agtgtcattg tgatggcata
     1081 tgtgacagag tttgtggacc tgggcaatgt ctcagcgttg agaacattca gagttctccg
     1141 agcactgaaa acaatttcag tcattccagg tttaaagacc attgtggggg ccctgatcca
     1201 gtcggtaaag aagctttctg atgtgatgat cctgactgtg ttctgtctga gcgtgtttgc
     1261 tctcattggg ctgcagctgt tcatgggcaa tctgaggaat aaatgtttgc agtggccccc
     1321 aagcgattct gcttttgaaa ccaacaccac ttcctacttt aatggcacaa tggattcaaa
     1381 tgggacattt gttaatgtaa caatgagcac atttaactgg aaggattaca ttggagatga
     1441 cagtcacttt tatgttttgg atgggcaaaa agacccttta ctctgtggaa atggctcaga
     1501 tgcaggccag tgtccagaag gatacatctg tgtgaaggct ggtcgaaacc ccaactatgg
     1561 ctacacaagc tttgacacct ttagctgggc tttcctgtct ctatttcgac tcatgactca
     1621 agactactgg gaaaatcttt accagttgac attacgtgct gctgggaaaa catacatgat
     1681 attttttgtc ctggtcattt tcttgggctc attttatttg gtgaatttga tcctggctgt
     1741 ggtggccatg gcctatgagg agcagaatca ggccaccttg gaagaagcag aacaaaaaga
     1801 ggccgaattt cagcagatgc tcgaacagct taaaaagcaa caggaagaag ctcaggcagt
     1861 tgcggcagca tcagctgctt caagagattt cagtggaata ggtgggttag gagagctgtt
     1921 ggaaagttct tcagaagcat caaagttgag ttccaaaagt gctaaagaat ggaggaaccg
     1981 aaggaagaaa agaagacaga gagagcacct tgaaggaaac aacaaaggag agagagacag
     2041 ctttcccaaa tccgaatctg aagacagcgt caaaagaagc agcttccttt tctccatgga
     2101 tggaaacaga ctgaccagtg acaaaaaatt ctgctcccct catcagtctc tcttgagtat
     2161 ccgtggctcc ctgttttccc caagacgcaa tagcaaaaca agcattttca gtttcagagg
     2221 tcgggcaaag gatgttggat ctgaaaatga ctttgctgat gatgaacaca gcacatttga
     2281 agacagcgaa agcaggagag actcactgtt tgtgccgcac agacatggag agcgacgcaa
     2341 cagtaacgtt agtcagggca ccaccacaga aacggaagtc agaaagagaa ggttaagctc
     2401 ttaccagatt tcaatggaga tgctggagga ttcctctgga aggcaaagag ccgtgagcat
     2461 agccagcatt ctgaccaaca caatggaaga acttgaagaa tctagacaga aatgtccgcc
     2521 atgctggtat agatttgcca atgtgttctt gatctgggac tgctgtgatg catggttaaa
     2581 agtaaaacat cttgtgaatt taattgttat ggatccattt gttgatcttg ccatcactat
     2641 ttgcattgtc ttaaataccc tctttatggc catggagcac taccccatga ctgagcaatt
     2701 cagtagtgtg ttgactgtag gaaacctggt ctttactggg attttcacag cagaaatggt
     2761 tctcaagatc attgccatgg atccttatta ctatttccaa gaaggctgga atatctttga
     2821 tggaattatt gtcagcctca gtttaatgga gcttggtctg tcaaatgtgg agggattgtc
     2881 tgtactgcga tcattcagac tgcttagagt tttcaagttg gcaaaatcct ggcccacact
     2941 aaatatgcta attaagatca ttggcaattc tgtgggggct ctaggaaacc tcaccttggt
     3001 gttggccatc atcgtcttca tttttgctgt ggtcggcatg cagctctttg gtaagagcta
     3061 caaagaatgt gtctgcaaga tcaatgatga ctgtacgctc ccacggtggc acatgaacga
     3121 cttcttccac tccttcctga ttgtgttccg cgtgctgtgt ggagagtgga tagagaccat
     3181 gtgggactgt atggaggtcg ctggccaaac catgtgcctt attgttttca tgttggtcat
     3241 ggtcattgga aaccttgtgg ttctgaacct ctttctggcc ttattgttga gttcatttag
     3301 ctcagacaac cttgctgcta ctgatgatga caatgaaatg aataatctgc agattgcagt
     3361 aggaagaatg caaaagggaa ttgattatgt gaaaaataag atgcgggagt gtttccaaaa
     3421 agcctttttt agaaagccaa aagttataga aatccatgaa ggcaataaga tagacagctg
     3481 catgtccaat aatactggaa ttgaaataag caaagagctt aattatctta gagatgggaa
     3541 tggaaccacc agtggtgtag gtactggaag cagtgttgaa aaatacgtaa tcgatgaaaa
     3601 tgattatatg tcattcataa acaaccccag cctcaccgtc acagtgccaa ttgctgttgg
     3661 agagtctgac tttgaaaact taaatactga agagttcagc agtgagtcag aactagaaga
     3721 aagcaaagag aaattaaatg caaccagctc atctgaagga agcacagttg atgttgttct
     3781 accccgagaa ggtgaacaag ctgaaactga acccgaagaa gaccttaaac cggaagcttg
     3841 ttttactgaa ggatgtatta aaaagtttcc attctgtcaa gtaagtacag aagaaggcaa
     3901 agggaagatc tggtggaatc ttcgaaaaac ctgctacagt attgttgagc acaactggtt
     3961 tgagactttc attgtgttca tgatccttct cagtagtggt gcattggcct ttgaagatat
     4021 atacattgaa cagcgaaaga ctatcaaaac catgctagaa tatgctgaca aagtctttac
     4081 ctatatattc attctggaaa tgcttctcaa atgggttgct tatggatttc aaacatattt
     4141 cactaatgcc tggtgctggc tagatttctt gatcgttgat gtttctttgg ttagcctggt
     4201 agccaatgct cttggctact cagaactcgg tgccatcaaa tcattacgga cattaagagc
     4261 tttaagacct ctaagagcct tatcccggtt tgaaggcatg agggtggttg tgaatgctct
     4321 tgttggagca attccctcta tcatgaatgt gctgttggtc tgtctcatct tctggttgat
     4381 ctttagcatc atgggtgtga atttgtttgc tggcaagttc taccactgtg ttaacatgac
     4441 aacgggtaac atgtttgaca ttagtgatgt taacaatttg agtgactgtc aggctcttgg
     4501 caagcaagct cggtggaaaa acgtgaaagt aaactttgat aatgttggcg ctggctatct
     4561 tgcactgctt caagtggcca catttaaagg ctggatggat attatgtatg cagctgttga
     4621 ttcacgagat gttaaacttc agcctgtata tgaagaaaat ctgtacatgt atttatactt
     4681 tgtcatcttt atcatctttg ggtcattctt cactctgaat ctattcattg gtgtcatcat
     4741 agataacttc aaccagcaga aaaagaagtt tggaggtcaa gacatcttta tgacagagga
     4801 acagaaaaaa tattacaatg caatgaagaa acttggatcc aagaaacctc agaaacccat
     4861 acctcgccca gcaaacaaat tccaaggaat ggtctttgat tttgtaacca gacaagtctt
     4921 tgatatcagc atcatgatcc tcatctgcct caacatggtc accatgatgg tggaaacgga
     4981 tgaccagggc aaatacatga ccctagtttt gtcccggatc aacctagtgt tcattgttct
     5041 gttcactgga gaatttgtgc tgaagctcgt ctccctcaga cactactact tcactatagg
     5101 ctggaacatc tttgactttg tggtggtgat tctctccatt gtaggtatgt ttctggctga
     5161 gatgatagaa aagtattttg tgtcccctac cttgttccga gtgatccgtc ttgccaggat
     5221 tggccgaatc ctacgtctga tcaaaggagc aaaggggatc cgcacgctgc tctttgcttt
     5281 gatgatgtcc cttcctgcgt tgtttaacat cggcctcctg ctcttcctgg tcatgtttat
     5341 ctatgccatc tttgggatgt ccaactttgc ctatgttaaa aaggaagctg gaattgatga
     5401 catgttcaac tttgagacct ttggcaacag catgatctgc ttgttccaaa ttacaacctc
     5461 tgctggctgg gatggattgc tagcacctat tcttaatagt gcaccacccg actgtgaccc
     5521 tgacacaatt caccctggca gctcagttaa gggagactgt gggaacccat ctgttgggat
     5581 tttctttttt gtcagttaca tcatcatatc cttcctggtt gtggtgaaca tgtacatcgc
     5641 ggtcatcctg gagaacttca gtgttgctac tgaagaaagt gcagagcccc tgagtgagga
     5701 tgactttgag atgttctatg aggtttggga aaagtttgat cccgatgcga cccagtttat
     5761 agagttctct aaactctctg attttgcagc tgccctggat cctcctcttc tcatagcaaa
     5821 acccaacaaa gtccagctta ttgccatgga tctgcccatg gtcagtggtg accggatcca
     5881 ctgtcttgat attttatttg cctttacaaa gcgtgttttg ggtgagagtg gagagatgga
     5941 tgcccttcga atacagatgg aagacaggtt tatggcatca aacccctcca aagtctctta
     6001 tgagcctatt acaaccactt tgaaacgtaa acaagaggag gtgtctgccg ctatcattca
     6061 gcgtaatttc agatgttatc ttttaaagca aaggttaaaa aatatatcaa gtaactataa
     6121 caaagaggca attaaaggga ggattgactt acctataaaa caagacatga ttattgacaa
     6181 actaaatggg aactccactc cagaaaaaac agatgggagt tcctctacca cctctcctcc
     6241 ttcctatgat agtgtaacaa aaccagacaa ggaaaagttt gagaaagaca aaccagaaaa
     6301 agaaagcaaa ggaaaagagg tcagagaaaa tcaaaagtaa aaagaaacaa agaattatct
     6361 ttgtgatcaa ttgtttacag cctatgaagg taaagtatat gtgtcaactg gacttcaaga
     6421 ggaggtccat gccaaactga ctgttttaac aaatactcat agtcagtgcc tatacaagac
     6481 agtgaagtga cctctctgtc actgcaactc tgtgaagcag ggtatcaaca ttgacaagag
     6541 gttgctgttt ttattaccag ctgacactgc tgaggagaaa cccaatggct acctagacta
     6601 tagggatagt tgtgcaaagt gaacattgta actacaccaa acacctttag tacagtcctt
     6661 gcatccattc tatttttaac ttccatatct gccatatttt tacaaaattt gttctagtgc
     6721 atttccatgg tccccaattc atagtttatt cataatgcta tgtcactatt tttgtaaatg
     6781 aggtttacgt tgaagaaaca gtatacaaga accctgtctc tcaaatgatc agacaaaggt
     6841 gttttgccag agagataaaa tttttgctca aaaccagaaa aagaattgta atggctacag
     6901 tttcagttac ttccattttc tagatggctt taattttgaa agtattttag tctgttatgt
     6961 ttgtttctat ctgaacagtt atgtgcctgt aaagtctcct ctaatattta aaggattatt
     7021 tttatgcaaa gtattctgtt tcagcaagtg caaattttat tctaagtttc agagctctat
     7081 atttaattta ggtcaaatgc tttccaaaaa gtaatctaat aaatccattc tagaaaaata
     7141 tatctaaagt attgctttag aatagttgtt ccactttctg ctgcagtatt gctttgccat
     7201 cttctgctct cagcaaagct gatagtctat gtcaattaaa taccctatgt tatgtaaata
     7261 gttattttat cctgtggtgc atgtttgggc aaatatatat atagcctgat aaacaacttc
     7321 tattaaatca aatatgtacc acagtgtatg tgtcttttgc aagcttccaa cagggatgta
     7381 tcctgtatca ttcattaaac atagtttaaa ggctatcact aatgcatgtt aatattgcct
     7441 atgctgctct attttactca atccattctt cacaagtctt ggttaaagaa tgtcacatat
     7501 tggtgataga atgaattcaa cctgctctgt ccattatgtc aagcagaata atttgaagct
     7561 atttacaaac acctttactt ttgcactttt aattcaacat gagtatcata tggtatctct
     7621 ctagatttca aggaaacaca ctggatactg cctactgaca aaacctattc ttcatatttt
     7681 gctaaaaata tgtctaaaac ttgtttaaat ataaataatg taaaaatata atcaacttta
     7741 tttgtcagca ttttgtacat aagaaaatta ttttcaggtt gatgacatca caatttattt
     7801 tactttatgc ttttgctttt gatttttaat cacaattcca aacttttgaa tccataagat
     7861 ttttcaatgg ataatttcct aaaataaaag ttagataatg ggttttatgg atttctttgt
     7921 tataatatat tttctaccat tccaatagga gatacattgg tcaaacactc aaacctagat
     7981 cattttctac caactatggt tgcctcaata taacctttta ttcatagatg ttttttttta
     8041 ttcaactttt gtagtattta cgtatgcaga ctagtcttat ttttttaatt cctgctgcac
     8101 taaagctatt acaaatataa catggacttt gttcttttta gccatgaaca aagtggcaaa
     8161 gttgtgcaat tacctaacat gatataaatt tttgtttttt gcacaaacca aaagtttaat
     8221 gttaattctt tttacaaaac tatttactgt agtgtattga agaactgcat gcagggaatt
     8281 gctattgcta aaaagaatgg tgagctacgt cattattgag ccaaaagaat aaatttcatt
     8341 ttttattgca tttcacttat tggcctctgg ggttttttgt ttttgttttt tgctgttggc
     8401 agtttaaaat atatataatt aataaaacct gtgcttgatc tgacatttgt atacataaaa
     8461 gtttacatga attttacaac aaactagtgc atgattcacc aagcagtact acagaacaaa
     8521 ggcaaattaa aagcagcttt gtgaactttt atgtgtgcaa aggatcaagt tcacatgttc
     8581 caactttcag gtttgataat aatagtagta accacctaca atagctttca atttcaatta
     8641 actcccttgg ctataagcat ctaaactcat cttctttcaa tataattgat gctatctcct
     8701 aattacttgg tggctaataa atgttacatt ctttgttact taaatgcatt atataaactc
     8761 ctatgtatac ataaggtatt aatgatatag ttattgagaa tttatattaa cttttttttc
     8821 aagaaccctt ggatttatgt gaggtcaaaa ccaaactctt attctcagtg gaaaactcca
     8881 gttgtaatgc atatttttaa agacaatttg gatctaaata tgtatttcat aattctccca
     8941 taataaatta tataaggtgg ctaa
//
