LOCUS       NM_006922               9102 bp    mRNA    linear   PRI 12-DEC-2024
DEFINITION  Homo sapiens sodium voltage-gated channel alpha subunit 3 (SCN3A),
            transcript variant 1, mRNA.
ACCESSION   NM_006922
VERSION     NM_006922.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9102)
  AUTHORS   M,K., M,R., J,B., A,B.I., K,I.P., R,W., E,O., A,Z.K., R,S. and R,P.
  TITLE     Neurodevelopmental disorder in a patient with HMBS and SCN3A
            variants-A possibly blended phenotype further delineating autosomal
            recessive HMBS related disease
  JOURNAL   Am J Med Genet A 194 (8), e63617 (2024)
   PUBMED   38568055
  REMARK    GeneRIF: Neurodevelopmental disorder in a patient with HMBS and
            SCN3A variants-A possibly blended phenotype further delineating
            autosomal recessive HMBS related disease.
REFERENCE   2  (bases 1 to 9102)
  AUTHORS   Qu,G., Merchant,J.P., Clatot,J., DeFlitch,L.M., Frederick,D.J.,
            Tang,S., Salvatore,M., Zhang,X., Li,J., Anderson,S.A. and
            Goldberg,E.M.
  TITLE     Targeted blockade of aberrant sodium current in a stem cell-derived
            neuron model of SCN3A encephalopathy
  JOURNAL   Brain 147 (4), 1247-1263 (2024)
   PUBMED   37935051
  REMARK    GeneRIF: Targeted blockade of aberrant sodium current in a stem
            cell-derived neuron model of SCN3A encephalopathy.
REFERENCE   3  (bases 1 to 9102)
  AUTHORS   Alghamdi,M.A., Al-Eitan,L.N., Asiri,A., Rababa'h,D.M.,
            Alqahtani,S.A., Aldarami,M.S., Alsaeedi,M.A., Almuidh,R.S.,
            Alzahrani,A.A., Sakah,A.H., El Nashar,E.M., Otaif,M.Y. and Abdel
            Ghaffar,N.F.
  TITLE     Association of sodium voltage-gated channel genes polymorphisms
            with epilepsy risk and prognosis in the Saudi population
  JOURNAL   Ann Med 54 (1), 1938-1951 (2022)
   PUBMED   35801810
  REMARK    GeneRIF: Association of sodium voltage-gated channel genes
            polymorphisms with epilepsy risk and prognosis in the Saudi
            population.
REFERENCE   4  (bases 1 to 9102)
  AUTHORS   Li,X., Xu,F., Xu,H., Zhang,S., Gao,Y., Zhang,H., Dong,Y., Zheng,Y.,
            Yang,B., Sun,J., Zhang,X.C., Zhao,Y. and Jiang,D.
  TITLE     Structural basis for modulation of human NaV1.3 by clinical drug
            and selective antagonist
  JOURNAL   Nat Commun 13 (1), 1286 (2022)
   PUBMED   35277491
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9102)
  AUTHORS   Ma,H., Guo,Y., Chen,Z., Wang,L., Tang,Z., Zhang,J., Miao,Q. and
            Zhai,Q.
  TITLE     Mutations in the sodium channel genes SCN1A, SCN3A, and SCN9A in
            children with epilepsy with febrile seizures plus(EFS+)
  JOURNAL   Seizure 88, 146-152 (2021)
   PUBMED   33895391
  REMARK    GeneRIF: Mutations in the sodium channel genes SCN1A, SCN3A, and
            SCN9A in children with epilepsy with febrile seizures plus(EFS+).
REFERENCE   6  (bases 1 to 9102)
  AUTHORS   Chen,Y.H., Dale,T.J., Romanos,M.A., Whitaker,W.R., Xie,X.M. and
            Clare,J.J.
  TITLE     Cloning, distribution and functional analysis of the type III
            sodium channel from human brain
  JOURNAL   Eur J Neurosci 12 (12), 4281-4289 (2000)
   PUBMED   11122339
REFERENCE   7  (bases 1 to 9102)
  AUTHORS   Gotthardt,M., Trommsdorff,M., Nevitt,M.F., Shelton,J.,
            Richardson,J.A., Stockinger,W., Nimpf,J. and Herz,J.
  TITLE     Interactions of the low density lipoprotein receptor gene family
            with cytosolic adaptor and scaffold proteins suggest diverse
            biological functions in cellular communication and signal
            transduction
  JOURNAL   J Biol Chem 275 (33), 25616-25624 (2000)
   PUBMED   10827173
REFERENCE   8  (bases 1 to 9102)
  AUTHORS   Lu,C.M. and Brown,G.B.
  TITLE     Isolation of a human-brain sodium-channel gene encoding two
            isoforms of the subtype III alpha-subunit
  JOURNAL   J Mol Neurosci 10 (1), 67-70 (1998)
   PUBMED   9589372
REFERENCE   9  (bases 1 to 9102)
  AUTHORS   Malo,M.S., Srivastava,K., Andresen,J.M., Chen,X.N., Korenberg,J.R.
            and Ingram,V.M.
  TITLE     Targeted gene walking by low stringency polymerase chain reaction:
            assignment of a putative human brain sodium channel gene (SCN3A) to
            chromosome 2q24-31
  JOURNAL   Proc Natl Acad Sci U S A 91 (8), 2975-2979 (1994)
   PUBMED   8159690
REFERENCE   10 (bases 1 to 9102)
  AUTHORS   Helbig,K.L. and Goldberg,E.M.
  TITLE     SCN3A-Related Neurodevelopmental Disorder
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   34081427
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL079365.1, DA796981.1,
            AF225987.1, AJ251507.1, AF035686.1, AC013463.7 and BM681920.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_006922.3.
            
            Summary: Voltage-gated sodium channels are transmembrane
            glycoprotein complexes composed of a large alpha subunit with 24
            transmembrane domains and one or more regulatory beta subunits.
            They are responsible for the generation and propagation of action
            potentials in neurons and muscle. This gene encodes one member of
            the sodium channel alpha subunit gene family, and is found in a
            cluster of five alpha subunit genes on chromosome 2. Multiple
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1), also known as 12v4,
            represents the longest transcript and encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF225987.1, SRR1660809.151366.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000283254.12/ ENSP00000283254.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               AL079365.1         18-151
            135-160             DA796981.1         135-160
            161-1626            AF225987.1         157-1622
            1627-2285           AJ251507.1         1463-2121
            2286-2505           AF225987.1         2282-2501
            2506-2514           AF035686.1         1938-1946
            2515-5727           AJ251507.1         2204-5416
            5728-8528           AC013463.7         47145-49945         c
            8529-9102           BM681920.1         23-596              c
FEATURES             Location/Qualifiers
     source          1..9102
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q24.3"
     gene            1..9102
                     /gene="SCN3A"
                     /gene_synonym="DEE62; EIEE62; FFEVF4; NAC3; Nav1.3"
                     /note="sodium voltage-gated channel alpha subunit 3"
                     /db_xref="GeneID:6328"
                     /db_xref="HGNC:HGNC:10590"
                     /db_xref="MIM:182391"
     exon            1..228
                     /gene="SCN3A"
                     /gene_synonym="DEE62; EIEE62; FFEVF4; NAC3; Nav1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            229..425
                     /gene="SCN3A"
                     /gene_synonym="DEE62; EIEE62; FFEVF4; NAC3; Nav1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            426..739
                     /gene="SCN3A"
                     /gene_synonym="DEE62; EIEE62; FFEVF4; NAC3; Nav1.3"
                     /inference="alignment:Splign:2.1.0"
     CDS             476..6478
                     /gene="SCN3A"
                     /gene_synonym="DEE62; EIEE62; FFEVF4; NAC3; Nav1.3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sodium channel, voltage-gated, type III, alpha
                     polypeptide; sodium channel protein type 3 subunit alpha;
                     brain III voltage-gated sodium channel; voltage-gated
                     sodium channel subtype III; sodium channel protein type
                     III subunit alpha; sodium channel, voltage gated, type III
                     alpha subunit; sodium channel protein brain III subunit
                     alpha; voltage-gated sodium channel subunit alpha Nav1.3"
                     /codon_start=1
                     /product="sodium channel protein type 3 subunit alpha
                     isoform 1"
                     /protein_id="NP_008853.3"
                     /db_xref="CCDS:CCDS33312.1"
                     /db_xref="GeneID:6328"
                     /db_xref="HGNC:HGNC:10590"
                     /db_xref="MIM:182391"
                     /translation="MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDND
                     DENKPKPNSDLEAGKNLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRF
                     SATSALYILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYT
                     FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTF
                     RVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNK
                     CLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDP
                     LLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLT
                     LRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLE
                     QLKKQQEEAQAVAAASAASRDFSGIGGLGELLESSSEASKLSSKSAKEWRNRRKKRRQ
                     REHLEGNNKGERDSFPKSESEDSVKRSSFLFSMDGNRLTSDKKFCSPHQSLLSIRGSL
                     FSPRRNSKTSIFSFRGRAKDVGSENDFADDEHSTFEDSESRRDSLFVPHRHGERRNSN
                     VSQASMSSRMVPGLPANGKMHSTVDCNGVVSLVGGPSALTSPTGQLPPEGTTTETEVR
                     KRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEELEESRQKCPPCWYRFANVFLIW
                     DCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLV
                     FTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLL
                     RVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCK
                     INDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIVFMLVMVIGN
                     LVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNKMRECFQKAF
                     FRKPKVIEIHEGNKIDSCMSNNTGIEISKELNYLRDGNGTTSGVGTGSSVEKYVIDEN
                     DYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLNATSSSEGSTVDV
                     VLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVE
                     HNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAY
                     GFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEG
                     MRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDV
                     NNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQP
                     VYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYN
                     AMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGK
                     YMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMI
                     EKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFI
                     YAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDC
                     DPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEP
                     LSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMV
                     SGDRIHCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQE
                     EVSAAIIQRNFRCYLLKQRLKNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKT
                     DGSSSTTSPPSYDSVTKPDKEKFEKDKPEKESKGKEVRENQK"
     exon            740..858
                     /gene="SCN3A"
                     /gene_synonym="DEE62; EIEE62; FFEVF4; NAC3; Nav1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            859..948
                     /gene="SCN3A"
                     /gene_synonym="DEE62; EIEE62; FFEVF4; NAC3; Nav1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1077
                     /gene="SCN3A"
                     /gene_synonym="DEE62; EIEE62; FFEVF4; NAC3; Nav1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1169
                     /gene="SCN3A"
                     /gene_synonym="DEE62; EIEE62; FFEVF4; NAC3; Nav1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1442
                     /gene="SCN3A"
                     /gene_synonym="DEE62; EIEE62; FFEVF4; NAC3; Nav1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1506
                     /gene="SCN3A"
                     /gene_synonym="DEE62; EIEE62; FFEVF4; NAC3; Nav1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1648
                     /gene="SCN3A"
                     /gene_synonym="DEE62; EIEE62; FFEVF4; NAC3; Nav1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1855
                     /gene="SCN3A"
                     /gene_synonym="DEE62; EIEE62; FFEVF4; NAC3; Nav1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..2146
                     /gene="SCN3A"
                     /gene_synonym="DEE62; EIEE62; FFEVF4; NAC3; Nav1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2494
                     /gene="SCN3A"
                     /gene_synonym="DEE62; EIEE62; FFEVF4; NAC3; Nav1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            2495..2627
                     /gene="SCN3A"
                     /gene_synonym="DEE62; EIEE62; FFEVF4; NAC3; Nav1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2866
                     /gene="SCN3A"
                     /gene_synonym="DEE62; EIEE62; FFEVF4; NAC3; Nav1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            2867..3040
                     /gene="SCN3A"
                     /gene_synonym="DEE62; EIEE62; FFEVF4; NAC3; Nav1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            3041..3397
                     /gene="SCN3A"
                     /gene_synonym="DEE62; EIEE62; FFEVF4; NAC3; Nav1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            3398..3868
                     /gene="SCN3A"
                     /gene_synonym="DEE62; EIEE62; FFEVF4; NAC3; Nav1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            3869..3989
                     /gene="SCN3A"
                     /gene_synonym="DEE62; EIEE62; FFEVF4; NAC3; Nav1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            3990..4144
                     /gene="SCN3A"
                     /gene_synonym="DEE62; EIEE62; FFEVF4; NAC3; Nav1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            4145..4318
                     /gene="SCN3A"
                     /gene_synonym="DEE62; EIEE62; FFEVF4; NAC3; Nav1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            4319..4441
                     /gene="SCN3A"
                     /gene_synonym="DEE62; EIEE62; FFEVF4; NAC3; Nav1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            4442..4714
                     /gene="SCN3A"
                     /gene_synonym="DEE62; EIEE62; FFEVF4; NAC3; Nav1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            4715..4768
                     /gene="SCN3A"
                     /gene_synonym="DEE62; EIEE62; FFEVF4; NAC3; Nav1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            4769..4906
                     /gene="SCN3A"
                     /gene_synonym="DEE62; EIEE62; FFEVF4; NAC3; Nav1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            4907..5011
                     /gene="SCN3A"
                     /gene_synonym="DEE62; EIEE62; FFEVF4; NAC3; Nav1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            5012..5282
                     /gene="SCN3A"
                     /gene_synonym="DEE62; EIEE62; FFEVF4; NAC3; Nav1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            5283..9102
                     /gene="SCN3A"
                     /gene_synonym="DEE62; EIEE62; FFEVF4; NAC3; Nav1.3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9085..9090
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCN3A"
                     /gene_synonym="DEE62; EIEE62; FFEVF4; NAC3; Nav1.3"
                     /note="hexamer: ATTATA"
     polyA_site      9102
                     /gene="SCN3A"
                     /gene_synonym="DEE62; EIEE62; FFEVF4; NAC3; Nav1.3"
                     /note="major polyA site"
ORIGIN      
        1 agaacaggaa gcggaggcat aagcagagag gattctggaa aggtctcttt gttttcttat
       61 ccacagagaa agaaagaaaa aaaattgtaa ctaatttgta aacctctgtg gtcaaaaaaa
      121 aaaaaaaaaa aaaaagctga acagctgcag aggaagacac gttataccct aaccatcttg
      181 gatgctgggc tttgttatgc tgtaattcat aaggctctgt tttatcagag attatggagc
      241 aagaaaactg aagccaagcc acatcaaggt ttgacaggga tgagatacct gtcaaggatt
      301 catagtagag tggcttactg ggaaaggagc aaagaatctc ttctagggat attgtaagaa
      361 taaatgagat aattcacaga agggacctgg agcttttccg gaaaaaggtg ctgtgactat
      421 ctaaggtaat tcgtatgcaa gaagctacac gtaattaaat gtgcaggatg aaaagatggc
      481 acaggcactg ttggtacccc caggacctga aagcttccgc ctttttacta gagaatctct
      541 tgctgctatc gaaaaacgtg ctgcagaaga gaaagccaag aagcccaaaa aggaacaaga
      601 taatgatgat gagaacaaac caaagccaaa tagtgacttg gaagctggaa agaaccttcc
      661 atttatttat ggagacattc ctccagagat ggtgtcagag cccctggagg acctggatcc
      721 ctactatatc aataagaaaa cttttatagt aatgaataaa ggaaaggcaa ttttccgatt
      781 cagtgccacc tctgccttgt atattttaac tccactaaac cctgttagga aaattgctat
      841 caagattttg gtacattctt tattcagcat gcttatcatg tgcactattt tgaccaactg
      901 tgtatttatg accttgagca accctcctga ctggacaaag aatgtagagt acacattcac
      961 tggaatctat acctttgagt cacttataaa aatcttggca agagggtttt gcttagaaga
     1021 ttttacgttt cttcgtgatc catggaactg gctggatttc agtgtcattg tgatggcata
     1081 tgtgacagag tttgtggacc tgggcaatgt ctcagcgttg agaacattca gagttctccg
     1141 agcactgaaa acaatttcag tcattccagg tttaaagacc attgtggggg ccctgatcca
     1201 gtcggtaaag aagctttctg atgtgatgat cctgactgtg ttctgtctga gcgtgtttgc
     1261 tctcattggg ctgcagctgt tcatgggcaa tctgaggaat aaatgtttgc agtggccccc
     1321 aagcgattct gcttttgaaa ccaacaccac ttcctacttt aatggcacaa tggattcaaa
     1381 tgggacattt gttaatgtaa caatgagcac atttaactgg aaggattaca ttggagatga
     1441 cagtcacttt tatgttttgg atgggcaaaa agacccttta ctctgtggaa atggctcaga
     1501 tgcaggccag tgtccagaag gatacatctg tgtgaaggct ggtcgaaacc ccaactatgg
     1561 ctacacaagc tttgacacct ttagctgggc tttcctgtct ctatttcgac tcatgactca
     1621 agactactgg gaaaatcttt accagttgac attacgtgct gctgggaaaa catacatgat
     1681 attttttgtc ctggtcattt tcttgggctc attttatttg gtgaatttga tcctggctgt
     1741 ggtggccatg gcctatgagg agcagaatca ggccaccttg gaagaagcag aacaaaaaga
     1801 ggccgaattt cagcagatgc tcgaacagct taaaaagcaa caggaagaag ctcaggcagt
     1861 tgcggcagca tcagctgctt caagagattt cagtggaata ggtgggttag gagagctgtt
     1921 ggaaagttct tcagaagcat caaagttgag ttccaaaagt gctaaagaat ggaggaaccg
     1981 aaggaagaaa agaagacaga gagagcacct tgaaggaaac aacaaaggag agagagacag
     2041 ctttcccaaa tccgaatctg aagacagcgt caaaagaagc agcttccttt tctccatgga
     2101 tggaaacaga ctgaccagtg acaaaaaatt ctgctcccct catcagtctc tcttgagtat
     2161 ccgtggctcc ctgttttccc caagacgcaa tagcaaaaca agcattttca gtttcagagg
     2221 tcgggcaaag gatgttggat ctgaaaatga ctttgctgat gatgaacaca gcacatttga
     2281 agacagcgaa agcaggagag actcactgtt tgtgccgcac agacatggag agcgacgcaa
     2341 cagtaacgtt agtcaggcca gtatgtcatc caggatggtg ccagggcttc cagcaaatgg
     2401 gaagatgcac agcactgtgg attgcaatgg tgtggtttcc ttggtgggtg gaccttcagc
     2461 tctaacgtca cctactggac aacttccccc agagggcacc accacagaaa cggaagtcag
     2521 aaagagaagg ttaagctctt accagatttc aatggagatg ctggaggatt cctctggaag
     2581 gcaaagagcc gtgagcatag ccagcattct gaccaacaca atggaagaac ttgaagaatc
     2641 tagacagaaa tgtccgccat gctggtatag atttgccaat gtgttcttga tctgggactg
     2701 ctgtgatgca tggttaaaag taaaacatct tgtgaattta attgttatgg atccatttgt
     2761 tgatcttgcc atcactattt gcattgtctt aaataccctc tttatggcca tggagcacta
     2821 ccccatgact gagcaattca gtagtgtgtt gactgtagga aacctggtct ttactgggat
     2881 tttcacagca gaaatggttc tcaagatcat tgccatggat ccttattact atttccaaga
     2941 aggctggaat atctttgatg gaattattgt cagcctcagt ttaatggagc ttggtctgtc
     3001 aaatgtggag ggattgtctg tactgcgatc attcagactg cttagagttt tcaagttggc
     3061 aaaatcctgg cccacactaa atatgctaat taagatcatt ggcaattctg tgggggctct
     3121 aggaaacctc accttggtgt tggccatcat cgtcttcatt tttgctgtgg tcggcatgca
     3181 gctctttggt aagagctaca aagaatgtgt ctgcaagatc aatgatgact gtacgctccc
     3241 acggtggcac atgaacgact tcttccactc cttcctgatt gtgttccgcg tgctgtgtgg
     3301 agagtggata gagaccatgt gggactgtat ggaggtcgct ggccaaacca tgtgccttat
     3361 tgttttcatg ttggtcatgg tcattggaaa ccttgtggtt ctgaacctct ttctggcctt
     3421 attgttgagt tcatttagct cagacaacct tgctgctact gatgatgaca atgaaatgaa
     3481 taatctgcag attgcagtag gaagaatgca aaagggaatt gattatgtga aaaataagat
     3541 gcgggagtgt ttccaaaaag ccttttttag aaagccaaaa gttatagaaa tccatgaagg
     3601 caataagata gacagctgca tgtccaataa tactggaatt gaaataagca aagagcttaa
     3661 ttatcttaga gatgggaatg gaaccaccag tggtgtaggt actggaagca gtgttgaaaa
     3721 atacgtaatc gatgaaaatg attatatgtc attcataaac aaccccagcc tcaccgtcac
     3781 agtgccaatt gctgttggag agtctgactt tgaaaactta aatactgaag agttcagcag
     3841 tgagtcagaa ctagaagaaa gcaaagagaa attaaatgca accagctcat ctgaaggaag
     3901 cacagttgat gttgttctac cccgagaagg tgaacaagct gaaactgaac ccgaagaaga
     3961 ccttaaaccg gaagcttgtt ttactgaagg atgtattaaa aagtttccat tctgtcaagt
     4021 aagtacagaa gaaggcaaag ggaagatctg gtggaatctt cgaaaaacct gctacagtat
     4081 tgttgagcac aactggtttg agactttcat tgtgttcatg atccttctca gtagtggtgc
     4141 attggccttt gaagatatat acattgaaca gcgaaagact atcaaaacca tgctagaata
     4201 tgctgacaaa gtctttacct atatattcat tctggaaatg cttctcaaat gggttgctta
     4261 tggatttcaa acatatttca ctaatgcctg gtgctggcta gatttcttga tcgttgatgt
     4321 ttctttggtt agcctggtag ccaatgctct tggctactca gaactcggtg ccatcaaatc
     4381 attacggaca ttaagagctt taagacctct aagagcctta tcccggtttg aaggcatgag
     4441 ggtggttgtg aatgctcttg ttggagcaat tccctctatc atgaatgtgc tgttggtctg
     4501 tctcatcttc tggttgatct ttagcatcat gggtgtgaat ttgtttgctg gcaagttcta
     4561 ccactgtgtt aacatgacaa cgggtaacat gtttgacatt agtgatgtta acaatttgag
     4621 tgactgtcag gctcttggca agcaagctcg gtggaaaaac gtgaaagtaa actttgataa
     4681 tgttggcgct ggctatcttg cactgcttca agtggccaca tttaaaggct ggatggatat
     4741 tatgtatgca gctgttgatt cacgagatgt taaacttcag cctgtatatg aagaaaatct
     4801 gtacatgtat ttatactttg tcatctttat catctttggg tcattcttca ctctgaatct
     4861 attcattggt gtcatcatag ataacttcaa ccagcagaaa aagaagtttg gaggtcaaga
     4921 catctttatg acagaggaac agaaaaaata ttacaatgca atgaagaaac ttggatccaa
     4981 gaaacctcag aaacccatac ctcgcccagc aaacaaattc caaggaatgg tctttgattt
     5041 tgtaaccaga caagtctttg atatcagcat catgatcctc atctgcctca acatggtcac
     5101 catgatggtg gaaacggatg accagggcaa atacatgacc ctagttttgt cccggatcaa
     5161 cctagtgttc attgttctgt tcactggaga atttgtgctg aagctcgtct ccctcagaca
     5221 ctactacttc actataggct ggaacatctt tgactttgtg gtggtgattc tctccattgt
     5281 aggtatgttt ctggctgaga tgatagaaaa gtattttgtg tcccctacct tgttccgagt
     5341 gatccgtctt gccaggattg gccgaatcct acgtctgatc aaaggagcaa aggggatccg
     5401 cacgctgctc tttgctttga tgatgtccct tcctgcgttg tttaacatcg gcctcctgct
     5461 cttcctggtc atgtttatct atgccatctt tgggatgtcc aactttgcct atgttaaaaa
     5521 ggaagctgga attgatgaca tgttcaactt tgagaccttt ggcaacagca tgatctgctt
     5581 gttccaaatt acaacctctg ctggctggga tggattgcta gcacctattc ttaatagtgc
     5641 accacccgac tgtgaccctg acacaattca ccctggcagc tcagttaagg gagactgtgg
     5701 gaacccatct gttgggattt tcttttttgt cagttacatc atcatatcct tcctggttgt
     5761 ggtgaacatg tacatcgcgg tcatcctgga gaacttcagt gttgctactg aagaaagtgc
     5821 agagcccctg agtgaggatg actttgagat gttctatgag gtttgggaaa agtttgatcc
     5881 cgatgcgacc cagtttatag agttctctaa actctctgat tttgcagctg ccctggatcc
     5941 tcctcttctc atagcaaaac ccaacaaagt ccagcttatt gccatggatc tgcccatggt
     6001 cagtggtgac cggatccact gtcttgatat tttatttgcc tttacaaagc gtgttttggg
     6061 tgagagtgga gagatggatg cccttcgaat acagatggaa gacaggttta tggcatcaaa
     6121 cccctccaaa gtctcttatg agcctattac aaccactttg aaacgtaaac aagaggaggt
     6181 gtctgccgct atcattcagc gtaatttcag atgttatctt ttaaagcaaa ggttaaaaaa
     6241 tatatcaagt aactataaca aagaggcaat taaagggagg attgacttac ctataaaaca
     6301 agacatgatt attgacaaac taaatgggaa ctccactcca gaaaaaacag atgggagttc
     6361 ctctaccacc tctcctcctt cctatgatag tgtaacaaaa ccagacaagg aaaagtttga
     6421 gaaagacaaa ccagaaaaag aaagcaaagg aaaagaggtc agagaaaatc aaaagtaaaa
     6481 agaaacaaag aattatcttt gtgatcaatt gtttacagcc tatgaaggta aagtatatgt
     6541 gtcaactgga cttcaagagg aggtccatgc caaactgact gttttaacaa atactcatag
     6601 tcagtgccta tacaagacag tgaagtgacc tctctgtcac tgcaactctg tgaagcaggg
     6661 tatcaacatt gacaagaggt tgctgttttt attaccagct gacactgctg aggagaaacc
     6721 caatggctac ctagactata gggatagttg tgcaaagtga acattgtaac tacaccaaac
     6781 acctttagta cagtccttgc atccattcta tttttaactt ccatatctgc catattttta
     6841 caaaatttgt tctagtgcat ttccatggtc cccaattcat agtttattca taatgctatg
     6901 tcactatttt tgtaaatgag gtttacgttg aagaaacagt atacaagaac cctgtctctc
     6961 aaatgatcag acaaaggtgt tttgccagag agataaaatt tttgctcaaa accagaaaaa
     7021 gaattgtaat ggctacagtt tcagttactt ccattttcta gatggcttta attttgaaag
     7081 tattttagtc tgttatgttt gtttctatct gaacagttat gtgcctgtaa agtctcctct
     7141 aatatttaaa ggattatttt tatgcaaagt attctgtttc agcaagtgca aattttattc
     7201 taagtttcag agctctatat ttaatttagg tcaaatgctt tccaaaaagt aatctaataa
     7261 atccattcta gaaaaatata tctaaagtat tgctttagaa tagttgttcc actttctgct
     7321 gcagtattgc tttgccatct tctgctctca gcaaagctga tagtctatgt caattaaata
     7381 ccctatgtta tgtaaatagt tattttatcc tgtggtgcat gtttgggcaa atatatatat
     7441 agcctgataa acaacttcta ttaaatcaaa tatgtaccac agtgtatgtg tcttttgcaa
     7501 gcttccaaca gggatgtatc ctgtatcatt cattaaacat agtttaaagg ctatcactaa
     7561 tgcatgttaa tattgcctat gctgctctat tttactcaat ccattcttca caagtcttgg
     7621 ttaaagaatg tcacatattg gtgatagaat gaattcaacc tgctctgtcc attatgtcaa
     7681 gcagaataat ttgaagctat ttacaaacac ctttactttt gcacttttaa ttcaacatga
     7741 gtatcatatg gtatctctct agatttcaag gaaacacact ggatactgcc tactgacaaa
     7801 acctattctt catattttgc taaaaatatg tctaaaactt gtttaaatat aaataatgta
     7861 aaaatataat caactttatt tgtcagcatt ttgtacataa gaaaattatt ttcaggttga
     7921 tgacatcaca atttatttta ctttatgctt ttgcttttga tttttaatca caattccaaa
     7981 cttttgaatc cataagattt ttcaatggat aatttcctaa aataaaagtt agataatggg
     8041 ttttatggat ttctttgtta taatatattt tctaccattc caataggaga tacattggtc
     8101 aaacactcaa acctagatca ttttctacca actatggttg cctcaatata accttttatt
     8161 catagatgtt tttttttatt caacttttgt agtatttacg tatgcagact agtcttattt
     8221 ttttaattcc tgctgcacta aagctattac aaatataaca tggactttgt tctttttagc
     8281 catgaacaaa gtggcaaagt tgtgcaatta cctaacatga tataaatttt tgttttttgc
     8341 acaaaccaaa agtttaatgt taattctttt tacaaaacta tttactgtag tgtattgaag
     8401 aactgcatgc agggaattgc tattgctaaa aagaatggtg agctacgtca ttattgagcc
     8461 aaaagaataa atttcatttt ttattgcatt tcacttattg gcctctgggg ttttttgttt
     8521 ttgttttttg ctgttggcag tttaaaatat atataattaa taaaacctgt gcttgatctg
     8581 acatttgtat acataaaagt ttacatgaat tttacaacaa actagtgcat gattcaccaa
     8641 gcagtactac agaacaaagg caaattaaaa gcagctttgt gaacttttat gtgtgcaaag
     8701 gatcaagttc acatgttcca actttcaggt ttgataataa tagtagtaac cacctacaat
     8761 agctttcaat ttcaattaac tcccttggct ataagcatct aaactcatct tctttcaata
     8821 taattgatgc tatctcctaa ttacttggtg gctaataaat gttacattct ttgttactta
     8881 aatgcattat ataaactcct atgtatacat aaggtattaa tgatatagtt attgagaatt
     8941 tatattaact tttttttcaa gaacccttgg atttatgtga ggtcaaaacc aaactcttat
     9001 tctcagtgga aaactccagt tgtaatgcat atttttaaag acaatttgga tctaaatatg
     9061 tatttcataa ttctcccata ataaattata taaggtggct aa
//
