LOCUS       NM_001349253            6793 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens sodium voltage-gated channel alpha subunit 11
            (SCN11A), transcript variant 2, mRNA.
ACCESSION   NM_001349253 XM_017005649
VERSION     NM_001349253.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6793)
  AUTHORS   Noguchi,A., Tezuka,T., Okuda,H., Kobayashi,H., Harada,K.H.,
            Yoshida,T., Akioka,S., Wada,K., Takeya,A., Kabata-Murasawa,R.,
            Kondo,D., Ishikawa,K., Asano,T., Fujiwara,M., Hishikawa,N.,
            Mizukami,T., Hitomi,T., Youssefian,S., Nagai,Y., Tanaka,M., Eto,K.,
            Shiraishi,H., Amaya,F., Koizumi,A. and Takahashi,T.
  TITLE     Genetic Analysis of SCN11A, SCN10A, and SCN9A in Familial Episodic
            Pain Syndrome (FEPS) in Japan and Proposal of Clinical Diagnostic
            Criteria
  JOURNAL   Int J Mol Sci 25 (13), 6832 (2024)
   PUBMED   38999942
  REMARK    GeneRIF: Genetic Analysis of SCN11A, SCN10A, and SCN9A in Familial
            Episodic Pain Syndrome (FEPS) in Japan and Proposal of Clinical
            Diagnostic Criteria.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6793)
  AUTHORS   Xu,K., Zhao,S., Ren,Y., Zhong,Q., Feng,J., Tu,D., Wu,W., Wang,J.,
            Chen,J. and Xie,P.
  TITLE     Elevated SCN11A concentrations associated with lower serum lipid
            levels in patients with major depressive disorder
  JOURNAL   Transl Psychiatry 14 (1), 202 (2024)
   PUBMED   38734669
  REMARK    GeneRIF: Elevated SCN11A concentrations associated with lower serum
            lipid levels in patients with major depressive disorder.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6793)
  AUTHORS   Zhao,C., Zhou,X. and Shi,X.
  TITLE     The influence of Nav1.9 channels on intestinal hyperpathia and
            dysmotility
  JOURNAL   Channels (Austin) 17 (1), 2212350 (2023)
   PUBMED   37186898
  REMARK    GeneRIF: The influence of Nav1.9 channels on intestinal hyperpathia
            and dysmotility.
            Review article
REFERENCE   4  (bases 1 to 6793)
  AUTHORS   Brackx,W., Collaco,R.C., Theys,M., Vander Cruyssen,J. and
            Bosmans,F.
  TITLE     Understanding the physiological role of NaV1.9: Challenges and
            opportunities for pain modulation
  JOURNAL   Pharmacol Ther 245, 108416 (2023)
   PUBMED   37061202
  REMARK    GeneRIF: Understanding the physiological role of NaV1.9: Challenges
            and opportunities for pain modulation.
            Review article
REFERENCE   5  (bases 1 to 6793)
  AUTHORS   Alsaloum,M., Labau,J.I.R., Liu,S., Estacion,M., Zhao,P.,
            Dib-Hajj,F. and Waxman,S.G.
  TITLE     Contributions of NaV1.8 and NaV1.9 to excitability in human induced
            pluripotent stem-cell derived somatosensory neurons
  JOURNAL   Sci Rep 11 (1), 24283 (2021)
   PUBMED   34930944
  REMARK    GeneRIF: Contributions of NaV1.8 and NaV1.9 to excitability in
            human induced pluripotent stem-cell derived somatosensory neurons.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6793)
  AUTHORS   Delmas,P. and Coste,B.
  TITLE     Na+ channel Nav1.9: in search of a gating mechanism
  JOURNAL   Trends Neurosci 26 (2), 55-57 (2003)
   PUBMED   12536125
REFERENCE   7  (bases 1 to 6793)
  AUTHORS   Blum,R., Kafitz,K.W. and Konnerth,A.
  TITLE     Neurotrophin-evoked depolarization requires the sodium channel
            Na(V)1.9
  JOURNAL   Nature 419 (6908), 687-693 (2002)
   PUBMED   12384689
  REMARK    GeneRIF: we demonstrate that the tetrodotoxin-insensitive sodium
            channel Na(V)1.9 underlies the neurotrophin-evoked excitation
REFERENCE   8  (bases 1 to 6793)
  AUTHORS   Goldin,A.L., Barchi,R.L., Caldwell,J.H., Hofmann,F., Howe,J.R.,
            Hunter,J.C., Kallen,R.G., Mandel,G., Meisler,M.H., Netter,Y.B.,
            Noda,M., Tamkun,M.M., Waxman,S.G., Wood,J.N. and Catterall,W.A.
  TITLE     Nomenclature of voltage-gated sodium channels
  JOURNAL   Neuron 28 (2), 365-368 (2000)
   PUBMED   11144347
REFERENCE   9  (bases 1 to 6793)
  AUTHORS   Dib-Hajj,S.D., Tyrrell,L., Cummins,T.R., Black,J.A., Wood,P.M. and
            Waxman,S.G.
  TITLE     Two tetrodotoxin-resistant sodium channels in human dorsal root
            ganglion neurons
  JOURNAL   FEBS Lett 462 (1-2), 117-120 (1999)
   PUBMED   10580103
REFERENCE   10 (bases 1 to 6793)
  AUTHORS   Dib-Hajj,S.D., Tyrrell,L., Escayg,A., Wood,P.M., Meisler,M.H. and
            Waxman,S.G.
  TITLE     Coding sequence, genomic organization, and conserved chromosomal
            localization of the mouse gene Scn11a encoding the sodium channel
            NaN
  JOURNAL   Genomics 59 (3), 309-318 (1999)
   PUBMED   10444332
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC123903.2 and AC116038.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001349253.1.
            
            Summary: Voltage-gated sodium channels are transmembrane
            glycoprotein complexes composed of a large alpha subunit with 24
            transmembrane domains and one or more regulatory beta subunits.
            They are responsible for the generation and propagation of action
            potentials in neurons and muscle. This gene encodes one member of
            the sodium channel alpha subunit gene family, and is highly
            expressed in nociceptive neurons of dorsal root ganglia and
            trigeminal ganglia. It mediates brain-derived neurotrophic
            factor-evoked membrane depolarization and is a major effector of
            peripheral inflammatory pain hypersensitivity. Mutations in this
            gene have been associated with hereditary sensory and autonomic
            neuropathy type VII and familial episodic pain syndrome-3.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Mar 2017].
            
            Transcript Variant: This variant (2) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF188679.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302328.9/ ENSP00000307599.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                AC123903.2         159605-159688       c
            85-208              AC123903.2         140124-140247       c
            209-349             AC123903.2         68027-68167         c
            350-480             AC123903.2         61373-61503         c
            481-754             AC123903.2         57840-58113         c
            755-873             AC123903.2         54533-54651         c
            874-975             AC123903.2         53155-53256         c
            976-1104            AC116038.3         160701-160829       c
            1105-1199           AC116038.3         159313-159407       c
            1200-1379           AC116038.3         154974-155153       c
            1380-1446           AC116038.3         153833-153899       c
            1447-1588           AC116038.3         143964-144105       c
            1589-1786           AC116038.3         142895-143092       c
            1787-1960           AC116038.3         141847-142020       c
            1961-2090           AC116038.3         139090-139219       c
            2091-2329           AC116038.3         137763-138001       c
            2330-2509           AC116038.3         133792-133971       c
            2510-2890           AC116038.3         130743-131123       c
            2891-3322           AC116038.3         128431-128862       c
            3323-3436           AC116038.3         120023-120136       c
            3437-3551           AC116038.3         119186-119300       c
            3552-3706           AC116038.3         117131-117285       c
            3707-3880           AC116038.3         113848-114021       c
            3881-3982           AC116038.3         106091-106192       c
            3983-4246           AC116038.3         105343-105606       c
            4247-4300           AC116038.3         104589-104642       c
            4301-4438           AC116038.3         101219-101356       c
            4439-4543           AC116038.3         97093-97197         c
            4544-4814           AC116038.3         84379-84649         c
            4815-6793           AC116038.3         79662-81640         c
FEATURES             Location/Qualifiers
     source          1..6793
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.2"
     gene            1..6793
                     /gene="SCN11A"
                     /gene_synonym="FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN12A;
                     SNS-2"
                     /note="sodium voltage-gated channel alpha subunit 11"
                     /db_xref="GeneID:11280"
                     /db_xref="HGNC:HGNC:10583"
                     /db_xref="MIM:604385"
     exon            1..84
                     /gene="SCN11A"
                     /gene_synonym="FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN12A;
                     SNS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            85..208
                     /gene="SCN11A"
                     /gene_synonym="FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN12A;
                     SNS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            209..349
                     /gene="SCN11A"
                     /gene_synonym="FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN12A;
                     SNS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            350..480
                     /gene="SCN11A"
                     /gene_synonym="FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN12A;
                     SNS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            481..754
                     /gene="SCN11A"
                     /gene_synonym="FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN12A;
                     SNS-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             488..5863
                     /gene="SCN11A"
                     /gene_synonym="FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN12A;
                     SNS-2"
                     /note="sodium channel, voltage-gated, type XII, alpha
                     polypeptide; sodium channel, voltage-gated, type XI, alpha
                     polypeptide; sodium channel, voltage-gated, type XI, alpha
                     subunit; sensory neuron sodium channel 2; peripheral nerve
                     sodium channel 5; sodium channel protein type XI subunit
                     alpha; voltage-gated sodium channel subunit alpha Nav1.9"
                     /codon_start=1
                     /product="sodium channel protein type 11 subunit alpha"
                     /protein_id="NP_001336182.1"
                     /db_xref="CCDS:CCDS33737.1"
                     /db_xref="GeneID:11280"
                     /db_xref="HGNC:HGNC:10583"
                     /db_xref="MIM:604385"
                     /translation="MDDRCYPVIFPDERNFRPFTSDSLAAIEKRIAIQKEKKKSKDQT
                     GEVPQPRPQLDLKASRKLPKLYGDIPRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYR
                     FSAKHALFIFGPFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTD
                     IAECVFTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIKL
                     LPLRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFM
                     GSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKIN
                     PDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLI
                     NLTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQLLKEEKEALVAMGIDRSSLTSLET
                     SYFTPKKRKLFGNKKRKSFFLRESGKDQPPGSDSDEDCQKKPQLLEQTKRLSQNLSLD
                     HFDEHGDPLQRQRALSAVSILTITMKEQEKSQEPCLPCGENLASKYLVWNCCPQWLCV
                     KKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEM
                     CLKIIALDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAK
                     SWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTG
                     PTVSCLRHWHMGDFWHSFLVVFRILCGEWIENMWECMQEANASSSLCVIVFILITVIG
                     KLVVLNLFIALLLNSFSNEERNGNLEGEARKTKVQLALDRFRRAFCFVRHTLEHFCHK
                     WCRKQNLPQQKEVAGGCAAQSKDIIPLVMEMKRGSETQEELGILTSVPKTLGVRHDWT
                     WLAPLAEEEDDVEFSGEDNAQRITQPEPEQQAYELHQENKKPTSQRVQSVEIDMFSED
                     EPHLTIQDPRKKSDVTSILSECSTIDLQDGFGWLPEMVPKKQPERCLPKGFGCCFPCC
                     SVDKRKPPWVIWWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQE
                     LLNCTDIIFTHIFILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLINLMELKSF
                     RTLRALRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKF
                     GKCINGTDSVINYTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDI
                     IYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGG
                     QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIIL
                     NMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALRQYYFTNGWNLFDCVV
                     VLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSL
                     PSLFNIGLLLFLIMFIYAILGMNWFSKVNPESGIDDIFNFKTFASSMLCLFQISTSAG
                     WDSLLSPMLRSKESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTA
                     TEESEDPLGEDDFDIFYEVWEKFDPEATQFIKYSALSDFADALPEPLRVAKPNKYQFL
                     VMDLPMVSEDRLHCMDILFAFTARVLGGSDGLDSMKAMMEEKFMEANPLKKLYEPIVT
                     TTKRKEEERGAAIIQKAFRKYMMKVTKGDQGDQNDLENGPHSPLQTLCNGDLSSFGVA
                     KGKVHCD"
     exon            755..873
                     /gene="SCN11A"
                     /gene_synonym="FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN12A;
                     SNS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            874..975
                     /gene="SCN11A"
                     /gene_synonym="FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN12A;
                     SNS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1104
                     /gene="SCN11A"
                     /gene_synonym="FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN12A;
                     SNS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1199
                     /gene="SCN11A"
                     /gene_synonym="FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN12A;
                     SNS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1379
                     /gene="SCN11A"
                     /gene_synonym="FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN12A;
                     SNS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1446
                     /gene="SCN11A"
                     /gene_synonym="FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN12A;
                     SNS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1588
                     /gene="SCN11A"
                     /gene_synonym="FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN12A;
                     SNS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1786
                     /gene="SCN11A"
                     /gene_synonym="FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN12A;
                     SNS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1960
                     /gene="SCN11A"
                     /gene_synonym="FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN12A;
                     SNS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2090
                     /gene="SCN11A"
                     /gene_synonym="FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN12A;
                     SNS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2329
                     /gene="SCN11A"
                     /gene_synonym="FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN12A;
                     SNS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..2509
                     /gene="SCN11A"
                     /gene_synonym="FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN12A;
                     SNS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2510..2890
                     /gene="SCN11A"
                     /gene_synonym="FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN12A;
                     SNS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2891..3322
                     /gene="SCN11A"
                     /gene_synonym="FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN12A;
                     SNS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3323..3436
                     /gene="SCN11A"
                     /gene_synonym="FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN12A;
                     SNS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3437..3551
                     /gene="SCN11A"
                     /gene_synonym="FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN12A;
                     SNS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3552..3706
                     /gene="SCN11A"
                     /gene_synonym="FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN12A;
                     SNS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3707..3880
                     /gene="SCN11A"
                     /gene_synonym="FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN12A;
                     SNS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3881..3982
                     /gene="SCN11A"
                     /gene_synonym="FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN12A;
                     SNS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3983..4246
                     /gene="SCN11A"
                     /gene_synonym="FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN12A;
                     SNS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4247..4300
                     /gene="SCN11A"
                     /gene_synonym="FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN12A;
                     SNS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4301..4438
                     /gene="SCN11A"
                     /gene_synonym="FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN12A;
                     SNS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4439..4543
                     /gene="SCN11A"
                     /gene_synonym="FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN12A;
                     SNS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4544..4814
                     /gene="SCN11A"
                     /gene_synonym="FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN12A;
                     SNS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4815..6793
                     /gene="SCN11A"
                     /gene_synonym="FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN12A;
                     SNS-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6626..6631
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCN11A"
                     /gene_synonym="FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN12A;
                     SNS-2"
                     /note="hexamer: AATGAA"
     polyA_site      6645
                     /gene="SCN11A"
                     /gene_synonym="FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN12A;
                     SNS-2"
                     /note="major polyA site"
     regulatory      6765..6770
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCN11A"
                     /gene_synonym="FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN12A;
                     SNS-2"
                     /note="hexamer: AATAAA"
     polyA_site      6793
                     /gene="SCN11A"
                     /gene_synonym="FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN12A;
                     SNS-2"
ORIGIN      
        1 gttagtggcg gggctgaagg taaacaggct gttgtgtttc ctcggtgctg ttagttgctg
       61 tgtggccggt agccatgtga tgagattgtc ccagtgcttc gcatgttttt ggctccatgt
      121 tcaatccatt tgctgaacac agtgaaagta tccagtatgt ctttccaccg taccctagag
      181 ttggcatctt gtttaccaga ggggagcgcc tccaagccgc tcctcccaga agggctccag
      241 gcagctgcca ggagcagaag ctcgaactct gctgagagac ttgctctgtg gagagcttca
      301 agaagtatcg ctgggattgc tgtctggagc caccttacca agaagtcagg ttccccaggc
      361 agcttcagct tcgtgtgttg caaaccaaat ttattccctc gcagtgccct ccttttcttg
      421 cactctctgt ctcagtgagt ggccacactg tcctctcatc tgctcaagcc aggaatctcg
      481 ggtgaagatg gatgacagat gctacccagt aatctttcca gatgagcgga atttccgccc
      541 cttcacttcc gactctctgg ctgcaattga gaagcggatt gccatccaaa aggagaaaaa
      601 gaagtctaaa gaccagacag gagaagtacc ccagcctcgg cctcagcttg acctaaaggc
      661 ctccaggaag ttgcccaagc tctatggcga cattcctcgt gagctcatag gaaagcctct
      721 ggaagacttg gacccattct accgaaatca taagacattt atggtgttaa acagaaagag
      781 gacaatctac cgcttcagtg ccaagcatgc cttgttcatt tttgggcctt tcaattcaat
      841 cagaagttta gccattagag tctcagtcca ttcattgttc agcatgttca ttatcggcac
      901 cgttatcatc aactgcgtgt tcatggctac agggcctgct aaaaacagca acagtaacaa
      961 tactgacatt gcagagtgtg tcttcactgg gatttatatt tttgaagctt tgattaaaat
     1021 attggcaaga ggtttcattc tggatgagtt ttctttcctt cgagatccat ggaactggct
     1081 ggactccatt gtcattggaa tagcgattgt gtcatatatt ccaggaatca ccatcaaact
     1141 attgcccctg cgtaccttcc gtgtgttcag agctttgaaa gcaatttcag tagtttcacg
     1201 tctgaaggtc atcgtggggg ccttgctacg ctctgtgaag aagctggtca acgtgattat
     1261 cctcaccttc ttttgcctca gcatctttgc cctggtaggt cagcagctct tcatgggaag
     1321 tctgaacctg aaatgcatct cgagggactg taaaaatatc agtaacccgg aagcttatga
     1381 ccattgcttt gaaaagaaag aaaattcacc tgaattcaaa atgtgtggca tctggatggg
     1441 taacagtgcc tgttccatac aatatgaatg taagcacacc aaaattaatc ctgactataa
     1501 ttatacgaat tttgacaact ttggctggtc ttttcttgcc atgttccggc tgatgaccca
     1561 agattcctgg gagaagcttt atcaacagac cctgcgtact actgggctct actcagtctt
     1621 cttcttcatt gtggtcattt tcctgggctc cttctacctg attaacttaa ccctggctgt
     1681 tgttaccatg gcatatgagg agcagaacaa gaatgtagct gcagagatag aggccaagga
     1741 aaagatgttt caggaagccc agcagctgtt aaaggaggaa aaggaggctc tggttgccat
     1801 gggaattgac agaagttcac ttacttccct tgaaacatca tattttaccc caaaaaagag
     1861 aaagctcttt ggtaataaga aaaggaagtc cttctttttg agagagtctg ggaaagacca
     1921 gcctcctggg tcagattctg atgaagattg ccaaaaaaag ccacagctcc tagagcaaac
     1981 caaacgactg tcccagaatc tatcactgga ccactttgat gagcatggag atcctctcca
     2041 aaggcagaga gcactgagtg ctgtcagcat cctcaccatc accatgaagg aacaagaaaa
     2101 atcacaagag ccttgtctcc cttgtggaga aaacctggca tccaagtacc tcgtgtggaa
     2161 ctgttgcccc cagtggctgt gcgttaagaa ggtcctgaga actgtgatga ctgacccgtt
     2221 tactgagctg gccatcacca tctgcatcat catcaacact gtcttcttgg ccatggagca
     2281 tcacaagatg gaggccagtt ttgagaagat gttgaatata gggaatttgg ttttcactag
     2341 catttttata gcagaaatgt gcctaaaaat cattgcgctc gatccctacc actactttcg
     2401 ccgaggctgg aacatttttg acagcattgt tgctcttctg agttttgcag atgtaatgaa
     2461 ctgtgtactt caaaagagaa gctggccatt cttgcgttcc ttcagagtgc tcagggtctt
     2521 caagttagcc aaatcctggc caactttgaa cacactaatt aagataatcg gcaactctgt
     2581 cggagccctt ggaagcctga ctgtggtcct ggtcattgtg atctttattt tctcagtagt
     2641 tggcatgcag ctttttggcc gtagcttcaa ttcccaaaag agtccaaaac tctgtaaccc
     2701 gacaggcccg acagtctcat gtttacggca ctggcacatg ggggatttct ggcactcctt
     2761 cctagtggta ttccgcatcc tctgcgggga atggatcgaa aatatgtggg aatgtatgca
     2821 agaagcgaat gcatcatcat cattgtgtgt tattgtcttc atattgatca cggtgatagg
     2881 aaaacttgtg gtgctcaacc tcttcattgc cttactgctc aattccttta gcaatgagga
     2941 aagaaatgga aacttagaag gagaggccag gaaaactaaa gtccagttag cactggatcg
     3001 attccgccgg gctttttgtt ttgtgagaca cactcttgag catttctgtc acaagtggtg
     3061 caggaagcaa aacttaccac agcaaaaaga ggtggcagga ggctgtgctg cacaaagcaa
     3121 agacatcatt cccctggtca tggagatgaa aaggggctca gagacccagg aggagcttgg
     3181 tatactaacc tctgtaccaa agaccctggg cgtcaggcat gattggactt ggttggcacc
     3241 acttgcggag gaggaagatg acgttgaatt ttctggtgaa gataatgcac agcgcatcac
     3301 acaacctgag cctgaacaac aggcctatga gctccatcag gagaacaaga agcccacgag
     3361 ccagagagtt caaagtgtgg aaattgacat gttctctgaa gatgagcctc atctgaccat
     3421 acaggatccc cgaaagaagt ctgatgttac cagtatacta tcagaatgta gcaccattga
     3481 tcttcaggat ggctttggat ggttacctga gatggttccc aaaaagcaac cagagagatg
     3541 tttgcccaaa ggctttggtt gctgctttcc atgctgtagc gtggacaaga gaaagcctcc
     3601 ctgggtcatt tggtggaacc tgcggaaaac ctgctaccaa atagtgaaac acagctggtt
     3661 tgagagcttt attatctttg tgattctgct gagcagtggg gcactgatat ttgaagatgt
     3721 tcaccttgag aaccaaccca aaatccaaga attactaaat tgtactgaca ttatttttac
     3781 acatattttt atcctggaga tggtactaaa atgggtagcc ttcggatttg gaaagtattt
     3841 caccagtgcc tggtgctgcc ttgatttcat cattgtgatt gtctctgtga ccaccctcat
     3901 taacttaatg gaattgaagt ccttccggac tctacgagca ctgaggcctc ttcgtgcgct
     3961 gtcccagttt gaaggaatga aggtggtggt caatgctctc ataggtgcca tacctgccat
     4021 tctgaatgtt ttgcttgtct gcctcatttt ctggctcgta ttttgtattc tgggagtata
     4081 cttcttttct ggaaaatttg ggaaatgcat taatggaaca gactcagtta taaattatac
     4141 catcattaca aataaaagtc aatgtgaaag tggcaatttc tcttggatca accagaaagt
     4201 caactttgac aatgtgggaa atgcttacct cgctctgctg caagtggcaa catttaaggg
     4261 ctggatggat attatatatg cagctgttga ttccacagag aaagaacaac agccagagtt
     4321 tgagagcaat tcactcggtt acatttactt cgtagtcttt atcatctttg gctcattctt
     4381 cactctgaat ctcttcattg gcgttatcat tgacaacttc aaccaacagc agaaaaagtt
     4441 aggtggccaa gacattttta tgacagaaga acagaagaaa tactataatg caatgaaaaa
     4501 attaggatcc aaaaaacctc aaaaacccat tccacggcct ctgaacaaat gtcaaggtct
     4561 cgtgttcgac atagtcacaa gccagatctt tgacatcatc atcataagtc tcattatcct
     4621 aaacatgatt agcatgatgg ctgaatcata caaccaaccc aaagccatga aatccatcct
     4681 tgaccatctc aactgggtct ttgtggtcat ctttacgtta gaatgtctca tcaaaatctt
     4741 tgctttgagg caatactact tcaccaatgg ctggaattta tttgactgtg tggtcgtgct
     4801 tctttccatt gttagtacaa tgatttctac cttggaaaat caggagcaca ttcctttccc
     4861 tccgacgctc ttcagaattg tccgcttggc tcggattggc cgaatcctga ggcttgtccg
     4921 ggctgcacga ggaatcagga ctctcctctt tgctctgatg atgtcgcttc cttctctgtt
     4981 caacattggt cttctactct ttctgattat gtttatctat gccattctgg gtatgaactg
     5041 gttttccaaa gtgaatccag agtctggaat cgatgacata ttcaacttca agacttttgc
     5101 cagcagcatg ctctgtctct tccagataag cacatcagca ggttgggatt ccctgctcag
     5161 ccccatgctg cgatcaaaag aatcatgtaa ctcttcctca gaaaactgcc acctccctgg
     5221 catagccaca tcctactttg tcagttacat tatcatctcc tttctcattg ttgtcaacat
     5281 gtacattgct gtgattttag agaacttcaa tacagccact gaagaaagtg aggacccttt
     5341 gggtgaagat gactttgaca tattttatga agtgtgggaa aagtttgacc cagaagcaac
     5401 acaatttatc aaatattctg ccctttctga ctttgctgat gccttgcctg agcctttgcg
     5461 tgtcgcaaag ccaaataaat atcaatttct agtaatggac ttgcccatgg tgagtgaaga
     5521 tcgcctccac tgcatggata ttcttttcgc cttcaccgct agggtactcg gtggctctga
     5581 tggcctagat agtatgaaag caatgatgga agagaagttc atggaagcca atcctctcaa
     5641 gaagttgtat gaacccatag tcaccaccac caagagaaag gaagaggaaa gaggtgctgc
     5701 tattattcaa aaggcctttc gaaagtacat gatgaaggtg accaagggtg accaaggtga
     5761 ccaaaatgac ttggaaaacg ggcctcattc accactccag actctttgca atggagactt
     5821 gtctagcttt ggggtggcca agggcaaggt ccactgtgac tgagccctca cctccacgcc
     5881 tacctcatag cttcacagcc ttgccttcag cctctgagct ccaggggtca gcagcttagt
     5941 gtatcaacag ggagtggatt caccaaatta gccattccat tttcttttct ggctaaaata
     6001 aatgatattt caatttcatt ttaaataata cttacagaga tataagataa ggctacttga
     6061 caaccagtgg tactattata ataaggaaga agacaccagg aaggactgta aaaggacata
     6121 ccaattttag gattgaaata gttcaggccg ggcgcagtgg ctcatgcctg taatcccagc
     6181 actttgagag gccaaggcag gtggatcacg aggtcaagag atcgagacca tcctggccaa
     6241 catgatgaaa ctccgtctct actaaaaata caaaaattag ctgggcatgg tggcgtgcgc
     6301 ctgtagtccc agctacttgg gaggctgagg caggagaatc gcttaaacct gggagacgga
     6361 ggttgcagtg agccaagatc gtgccactgc actccagcct ggtgacagag tgagactctg
     6421 tttcaaaaaa gaaaagaaaa gaaacatggt tcaaattata tctaaacaaa aaagaataag
     6481 aaacaaaaaa cacattaaaa ttttaagttg tattttctat gtttctagat acatcatttt
     6541 tgtttgatat tttcctgatg caagtatgtg gtttatcaca tgtagctctt ttgcatgcta
     6601 aatgaaaatt caaaacttgc caataaatga atagcttatt gcagacattt tttaccaaca
     6661 ttaattattt tgggtttgtt taaaacctag aggcacaatc ttgacttgtc aattactacc
     6721 ctttcacaag ctaccatctc agatatatat atatatataa attcaataaa gctttctgtt
     6781 tgtgttcctt tca
//
