LOCUS       NM_006514               6626 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens sodium voltage-gated channel alpha subunit 10
            (SCN10A), transcript variant 1, mRNA.
ACCESSION   NM_006514
VERSION     NM_006514.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6626)
  AUTHORS   Noguchi,A., Tezuka,T., Okuda,H., Kobayashi,H., Harada,K.H.,
            Yoshida,T., Akioka,S., Wada,K., Takeya,A., Kabata-Murasawa,R.,
            Kondo,D., Ishikawa,K., Asano,T., Fujiwara,M., Hishikawa,N.,
            Mizukami,T., Hitomi,T., Youssefian,S., Nagai,Y., Tanaka,M., Eto,K.,
            Shiraishi,H., Amaya,F., Koizumi,A. and Takahashi,T.
  TITLE     Genetic Analysis of SCN11A, SCN10A, and SCN9A in Familial Episodic
            Pain Syndrome (FEPS) in Japan and Proposal of Clinical Diagnostic
            Criteria
  JOURNAL   Int J Mol Sci 25 (13), 6832 (2024)
   PUBMED   38999942
  REMARK    GeneRIF: Genetic Analysis of SCN11A, SCN10A, and SCN9A in Familial
            Episodic Pain Syndrome (FEPS) in Japan and Proposal of Clinical
            Diagnostic Criteria.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6626)
  AUTHORS   Kapur,M.M., Soliman,M., Blanke,E.N., Herold,P.B., Janicki,P.K.,
            Vrana,K.E., Coates,M.D. and Ruiz-Velasco,V.
  TITLE     Heterologous expression of the human wild-type and variant NaV 1.8
            (A1073V) in rat sensory neurons
  JOURNAL   Neurogastroenterol Motil 36 (3), e14748 (2024)
   PUBMED   38263802
  REMARK    GeneRIF: Heterologous expression of the human wild-type and variant
            NaV 1.8 (A1073V) in rat sensory neurons.
REFERENCE   3  (bases 1 to 6626)
  AUTHORS   Zhou,Y., Huang,W., Liu,L., Li,A., Jiang,C., Zhou,R., Wang,J.,
            Tan,X., Huang,C.L. and Zhang,Y.
  TITLE     Patient-specific induced pluripotent stem cell properties implicate
            Ca2+-homeostasis in clinical arrhythmia associated with combined
            heterozygous RYR2 and SCN10A variants
  JOURNAL   Philos Trans R Soc Lond B Biol Sci 378 (1879), 20220175 (2023)
   PUBMED   37122207
  REMARK    GeneRIF: Patient-specific induced pluripotent stem cell properties
            implicate Ca[2+]-homeostasis in clinical arrhythmia associated with
            combined heterozygous RYR2 and SCN10A variants.
REFERENCE   4  (bases 1 to 6626)
  AUTHORS   Hartmann,N., Knierim,M., Maurer,W., Dybkova,N., Hasenfuss,G.,
            Sossalla,S. and Streckfuss-Bomeke,K.
  TITLE     Molecular and Functional Relevance of NaV1.8-Induced Atrial
            Arrhythmogenic Triggers in a Human SCN10A Knock-Out Stem Cell Model
  JOURNAL   Int J Mol Sci 24 (12), 10189 (2023)
   PUBMED   37373335
  REMARK    GeneRIF: Molecular and Functional Relevance of NaV1.8-Induced
            Atrial Arrhythmogenic Triggers in a Human SCN10A Knock-Out Stem
            Cell Model.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6626)
  AUTHORS   Rabia,A., Harripaul,R., Mikhailov,A., Mahmood,S., Maqbool,S.,
            Vincent,J.B. and Ayub,M.
  TITLE     Biallelic Loss of Function Mutation in Sodium Channel Gene SCN10A
            in an Autism Spectrum Disorder Trio from Pakistan
  JOURNAL   Genes (Basel) 13 (9), 1633 (2022)
   PUBMED   36140801
  REMARK    GeneRIF: Biallelic Loss of Function Mutation in Sodium Channel Gene
            SCN10A in an Autism Spectrum Disorder Trio from Pakistan.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6626)
  AUTHORS   Catterall,W.A., Goldin,A.L. and Waxman,S.G.
  TITLE     International Union of Pharmacology. XLVII. Nomenclature and
            structure-function relationships of voltage-gated sodium channels
  JOURNAL   Pharmacol Rev 57 (4), 397-409 (2005)
   PUBMED   16382098
  REMARK    Review article
REFERENCE   7  (bases 1 to 6626)
  AUTHORS   Malik-Hall,M., Poon,W.Y., Baker,M.D., Wood,J.N. and Okuse,K.
  TITLE     Sensory neuron proteins interact with the intracellular domains of
            sodium channel NaV1.8
  JOURNAL   Brain Res Mol Brain Res 110 (2), 298-304 (2003)
   PUBMED   12591166
REFERENCE   8  (bases 1 to 6626)
  AUTHORS   Plummer,N.W. and Meisler,M.H.
  TITLE     Evolution and diversity of mammalian sodium channel genes
  JOURNAL   Genomics 57 (2), 323-331 (1999)
   PUBMED   10198179
  REMARK    Review article
REFERENCE   9  (bases 1 to 6626)
  AUTHORS   Rabert,D.K., Koch,B.D., Ilnicka,M., Obernolte,R.A., Naylor,S.L.,
            Herman,R.C., Eglen,R.M., Hunter,J.C. and Sangameswaran,L.
  TITLE     A tetrodotoxin-resistant voltage-gated sodium channel from human
            dorsal root ganglia, hPN3/SCN10A
  JOURNAL   Pain 78 (2), 107-114 (1998)
   PUBMED   9839820
REFERENCE   10 (bases 1 to 6626)
  AUTHORS   Brugada,R., Campuzano,O., Sarquella-Brugada,G., Brugada,P.,
            Brugada,J. and Hong,K.
  TITLE     Brugada Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301690
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC116038.3 and AC137625.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 4, 2020 this sequence version replaced NM_006514.3.
            
            Summary: The protein encoded by this gene is a
            tetrodotoxin-resistant voltage-gated sodium channel alpha subunit.
            The properties of the channel formed by the encoded transmembrane
            protein can be altered by interaction with different beta subunits.
            This protein may be involved in the onset of pain associated with
            peripheral neuropathy. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Jun 2014].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF117907.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1968968,
                                    SAMEA2144333 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000449082.3/ ENSP00000390600.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               AC116038.3         49935-50115         c
            182-483             AC116038.3         27639-27940         c
            484-602             AC116038.3         25948-26066         c
            603-683             AC116038.3         22854-22934         c
            684-812             AC116038.3         5177-5305           c
            813-904             AC137625.2         98467-98558         c
            905-1096            AC137625.2         96154-96345         c
            1097-1163           AC137625.2         95643-95709         c
            1164-1305           AC137625.2         91980-92121         c
            1306-1503           AC137625.2         91636-91833         c
            1504-1674           AC137625.2         90750-90920         c
            1675-1968           AC137625.2         87181-87474         c
            1969-2080           AC137625.2         85035-85146         c
            2081-2319           AC137625.2         77253-77491         c
            2320-2493           AC137625.2         74477-74650         c
            2494-2853           AC137625.2         63504-63863         c
            2854-3300           AC137625.2         61568-62014         c
            3301-3441           AC137625.2         60136-60276         c
            3442-3565           AC137625.2         58392-58515         c
            3566-3720           AC137625.2         57220-57374         c
            3721-3894           AC137625.2         53615-53788         c
            3895-4017           AC137625.2         48920-49042         c
            4018-4302           AC137625.2         47123-47407         c
            4303-4356           AC137625.2         45806-45859         c
            4357-4494           AC137625.2         44440-44577         c
            4495-4599           AC137625.2         42241-42345         c
            4600-4870           AC137625.2         36801-37071         c
            4871-6626           AC137625.2         31769-33524         c
FEATURES             Location/Qualifiers
     source          1..6626
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.2"
     gene            1..6626
                     /gene="SCN10A"
                     /gene_synonym="FEPS2; Nav1.8; PN3; SNS"
                     /note="sodium voltage-gated channel alpha subunit 10"
                     /db_xref="GeneID:6336"
                     /db_xref="HGNC:HGNC:10582"
                     /db_xref="MIM:604427"
     exon            1..181
                     /gene="SCN10A"
                     /gene_synonym="FEPS2; Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            182..483
                     /gene="SCN10A"
                     /gene_synonym="FEPS2; Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..6084
                     /gene="SCN10A"
                     /gene_synonym="FEPS2; Nav1.8; PN3; SNS"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sodium channel, voltage-gated, type X, alpha polypeptide;
                     sodium channel, voltage-gated, type X, alpha subunit;
                     sodium channel protein type 10 subunit alpha; peripheral
                     nerve sodium channel 3; sodium channel protein type X
                     subunit alpha; voltage-gated sodium channel subunit alpha
                     Nav1.8; sensory neuron sodium channel"
                     /codon_start=1
                     /product="sodium channel protein type 10 subunit alpha
                     isoform 1"
                     /protein_id="NP_006505.4"
                     /db_xref="CCDS:CCDS33736.1"
                     /db_xref="GeneID:6336"
                     /db_xref="HGNC:HGNC:10582"
                     /db_xref="MIM:604427"
                     /translation="MEFPIGSLETNNFRRFTPESLVEIEKQIAAKQGTKKAREKHREQ
                     KDQEEKPRPQLDLKACNQLPKFYGELPAELIGEPLEDLDPFYSTHRTFMVLNKGRTIS
                     RFSATRALWLFSPFNLIRRTAIKVSVHSWFSLFITVTILVNCVCMTRTDLPEKIEYVF
                     TVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISGLRTFR
                     VLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKC
                     VKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDF
                     NYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLI
                     LAVVTMAYEEQNQATTDEIEAKEKKFQEALEMLRKEQEVLAALGIDTTSLHSHNGSPL
                     TSKNASERRHRIKPRVSEGSTEDNKSPRSDPYNQRRMSFLGLASGKRRASHGSVFHFR
                     SPGRDISLPEGVTDDGVFPGDHESHRGSLLLGGGAGQQGPLPRSPLPQPSNPDSRHGE
                     DEHQPPPTSELAPGAVDVSAFDAGQKKTFLSAEYLDEPFRAQRAMSVVSIITSVLEEL
                     EESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIFM
                     AMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVS
                     LLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIV
                     FVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGEWIENMWA
                     CMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNLQVAL
                     ARIQVFGHRTKQALCSFFSRSCPFPQPKAEPELVVKLPLSSSKAENHIAANTARGSSG
                     GLQAPRGPRDEHSDFIANPTVWVSVPIAEGESDLDDLEDDGGEDAQSFQQEVIPKGQQ
                     EQLQQVERCGDHLTPRSPGTGTSSEDLAPSLGETWKDESVPQVPAEGVDDTSSSEGST
                     VDCLDPEEILRKIPELADDLEEPDDCFTEGCIRHCPCCKLDTTKSPWDVGWQVRKTCY
                     RIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLLK
                     WVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRALS
                     RFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSL
                     VPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVD
                     SREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMT
                     EEQKKYYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITMM
                     VETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALRQYYFTNGWNVFDFIVVVLSIA
                     SLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNI
                     GLLLFLVMFIYSIFGMSSFPHVRWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLS
                     PILNTGPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTYIIISFLIMVNMYIAVILENFN
                     VATEESTEPLSEDDFDMFYETWEKFDPEATQFITFSALSDFADTLSGPLRIPKPNRNI
                     LIQMDLPLVPGDKIHCLDILFAFTKNVLGESGELDSLKANMEEKFMATNLSKSSYEPI
                     ATTLRWKQEDISATVIQKAYRSYVLHRSMALSNTPCVPRAEEEAASLPDEGFVAFTAN
                     ENCVLPDKSETASATSFPPSYESVTRGLSDRVNMRTSSSIQNEDEATSMELIAPGP"
     exon            484..602
                     /gene="SCN10A"
                     /gene_synonym="FEPS2; Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            603..683
                     /gene="SCN10A"
                     /gene_synonym="FEPS2; Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            684..812
                     /gene="SCN10A"
                     /gene_synonym="FEPS2; Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            813..904
                     /gene="SCN10A"
                     /gene_synonym="FEPS2; Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1096
                     /gene="SCN10A"
                     /gene_synonym="FEPS2; Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1163
                     /gene="SCN10A"
                     /gene_synonym="FEPS2; Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1305
                     /gene="SCN10A"
                     /gene_synonym="FEPS2; Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1503
                     /gene="SCN10A"
                     /gene_synonym="FEPS2; Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1674
                     /gene="SCN10A"
                     /gene_synonym="FEPS2; Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1968
                     /gene="SCN10A"
                     /gene_synonym="FEPS2; Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2080
                     /gene="SCN10A"
                     /gene_synonym="FEPS2; Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2319
                     /gene="SCN10A"
                     /gene_synonym="FEPS2; Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2493
                     /gene="SCN10A"
                     /gene_synonym="FEPS2; Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            2494..2853
                     /gene="SCN10A"
                     /gene_synonym="FEPS2; Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            2854..3300
                     /gene="SCN10A"
                     /gene_synonym="FEPS2; Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            3301..3441
                     /gene="SCN10A"
                     /gene_synonym="FEPS2; Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            3442..3565
                     /gene="SCN10A"
                     /gene_synonym="FEPS2; Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            3566..3720
                     /gene="SCN10A"
                     /gene_synonym="FEPS2; Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            3721..3894
                     /gene="SCN10A"
                     /gene_synonym="FEPS2; Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            3895..4017
                     /gene="SCN10A"
                     /gene_synonym="FEPS2; Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            4018..4302
                     /gene="SCN10A"
                     /gene_synonym="FEPS2; Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            4303..4356
                     /gene="SCN10A"
                     /gene_synonym="FEPS2; Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            4357..4494
                     /gene="SCN10A"
                     /gene_synonym="FEPS2; Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            4495..4599
                     /gene="SCN10A"
                     /gene_synonym="FEPS2; Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            4600..4870
                     /gene="SCN10A"
                     /gene_synonym="FEPS2; Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            4871..6626
                     /gene="SCN10A"
                     /gene_synonym="FEPS2; Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttcttgcttc acacactagc ctcttggcta gagaacagac atcagatgga gtttcttctg
       61 gctatgcctg aatgttaagc tgaacgtatg ttccaggagc tcgtggtctc cagtagaggc
      121 aatctgggat agaagagaag atatttctta cgtagaagac aagcaagatt gagcagcaaa
      181 gagtataaat acttcctgaa gaagaatgag aagatggaat tccccattgg atccctcgaa
      241 actaacaact tccgtcgctt tactccggag tcactggtgg agatagagaa gcaaattgct
      301 gccaagcagg gaacaaagaa agccagagag aagcataggg agcagaagga ccaagaagag
      361 aagcctcggc cccagctgga cttgaaagcc tgcaaccagc tgcccaagtt ctatggtgag
      421 ctcccagcag aactgatcgg ggagcccctg gaggatctag atccgttcta cagcacacac
      481 cggacattta tggtgctgaa caaagggagg accatttccc ggtttagtgc cactcgggcc
      541 ctgtggctat tcagtccttt caacctgatc agaagaacgg ccatcaaagt gtctgtccac
      601 tcgtggttca gtttatttat tacggtcact attttggtta attgtgtgtg catgacccga
      661 actgaccttc cagagaaaat tgaatatgtc ttcactgtca tttacacctt tgaagccttg
      721 ataaagatac tggcaagagg attttgtcta aatgagttca cgtacctgag agatccttgg
      781 aactggctgg attttagcgt cattaccctg gcatatgttg gcacagcaat agatctccgt
      841 gggatctcag gcctgcggac attcagagtt cttagagcat taaaaacagt ttctgtgatc
      901 ccaggcctga aggtcattgt gggggccctg attcactcag tgaagaaact ggctgatgtg
      961 accatcctca ccatcttctg cctaagtgtt tttgccttgg tggggctgca actcttcaag
     1021 ggcaacctca aaaataaatg tgtcaagaat gacatggctg tcaatgagac aaccaactac
     1081 tcatctcaca gaaaaccaga tatctacata aataagcgag gcacttctga ccccttactg
     1141 tgtggcaatg gatctgactc aggccactgc cctgatggtt atatctgcct taaaacttct
     1201 gacaacccgg attttaacta caccagcttt gattcctttg cttgggcttt cctctcactg
     1261 ttccgcctca tgacacagga ttcctgggaa cgcctctacc agcagaccct gaggacttct
     1321 gggaaaatct atatgatctt ttttgtgctc gtaatcttcc tgggatcttt ctacctggtc
     1381 aacttgatct tggctgtagt caccatggcg tatgaggagc agaaccaggc aaccactgat
     1441 gaaattgaag caaaggagaa gaagttccag gaggccctcg agatgctccg gaaggagcag
     1501 gaggtgctag cagcactagg gattgacaca acctctctcc actcccacaa tggatcacct
     1561 ttaacctcca aaaatgccag tgagagaagg catagaataa agccaagagt gtcagagggc
     1621 tccacagaag acaacaaatc accccgctct gatccttaca accagcgcag gatgtctttt
     1681 ctaggcctcg cctctggaaa acgccgggct agtcatggca gtgtgttcca tttccggtcc
     1741 cctggccgag atatctcact ccctgaggga gtcacagatg atggagtctt tcctggagac
     1801 cacgaaagcc atcggggctc tctgctgctg ggtgggggtg ctggccagca aggccccctc
     1861 cctagaagcc ctcttcctca acccagcaac cctgactcca ggcatggaga agatgaacac
     1921 caaccgccgc ccactagtga gcttgcccct ggagctgtcg atgtctcggc attcgatgca
     1981 ggacaaaaga agactttctt gtcagcagaa tacttagatg aacctttccg ggcccaaagg
     2041 gcaatgagtg ttgtcagtat cataacctcc gtccttgagg aactcgagga gtctgaacag
     2101 aagtgcccac cctgcttgac cagcttgtct cagaagtatc tgatctggga ttgctgcccc
     2161 atgtgggtga agctcaagac aattctcttt gggcttgtga cggatccctt tgcagagctc
     2221 accatcacct tgtgcatcgt ggtgaacacc atcttcatgg ccatggagca ccatggcatg
     2281 agccctacct tcgaagccat gctccagata ggcaacatcg tctttaccat attttttact
     2341 gctgaaatgg tcttcaaaat cattgccttc gacccatact attatttcca gaagaagtgg
     2401 aatatctttg actgcatcat cgtcactgtg agtctgctag agctgggcgt ggccaagaag
     2461 ggaagcctgt ctgtgctgcg gagcttccgc ttgctgcgcg tattcaagct ggccaaatcc
     2521 tggcccacct taaacacact catcaagatc atcggaaact cagtgggggc actggggaac
     2581 ctcaccatca tcctggccat cattgtcttt gtctttgctc tggttggcaa gcagctccta
     2641 ggggaaaact accgtaacaa ccgaaaaaat atctccgcgc cccatgaaga ctggccccgc
     2701 tggcacatgc acgacttctt ccactctttc ctcattgtct tccgtatcct ctgtggagag
     2761 tggattgaga acatgtgggc ctgcatggaa gttggccaaa aatccatatg cctcatcctt
     2821 ttcttgacgg tgatggtgct agggaacctg gtggtgctta acctgttcat cgccctgcta
     2881 ttgaactctt tcagtgctga caacctcaca gccccggagg acgatgggga ggtgaacaac
     2941 ctgcaggtgg ccctggcacg gatccaggtc tttggccatc gtaccaaaca ggctctttgc
     3001 agcttcttca gcaggtcctg cccattcccc cagcccaagg cagagcctga gctggtggtg
     3061 aaactcccac tctccagctc caaggctgag aaccacattg ctgccaacac tgccaggggg
     3121 agctctggag ggctccaagc tcccagaggc cccagggatg agcacagtga cttcatcgct
     3181 aatccgactg tgtgggtctc tgtgcccatt gctgagggtg aatctgatct tgatgacttg
     3241 gaggatgatg gtggggaaga tgctcagagc ttccagcagg aagtgatccc caaaggacag
     3301 caggagcagc tgcagcaagt cgagaggtgt ggggaccacc tgacacccag gagcccaggc
     3361 actggaacat cttctgagga cctggctcca tccctgggtg agacgtggaa agatgagtct
     3421 gttcctcagg tccctgctga gggagtggac gacacaagct cctctgaggg cagcacggtg
     3481 gactgcctag atcctgagga aatcctgagg aagatccctg agctggcaga tgacctggaa
     3541 gaaccagatg actgcttcac agaaggatgc attcgccact gtccctgctg caaactggat
     3601 accaccaaga gtccatggga tgtgggctgg caggtgcgca agacttgcta ccgtatcgtg
     3661 gagcacagct ggtttgagag cttcatcatc ttcatgatcc tgctcagcag tggatctctg
     3721 gcctttgaag actattacct ggaccagaag cccacggtga aagctttgct ggagtacact
     3781 gacagggtct tcacctttat ctttgtgttc gagatgctgc ttaagtgggt ggcctatggc
     3841 ttcaaaaagt acttcaccaa tgcctggtgc tggctggact tcctcattgt gaatatctca
     3901 ctgataagtc tcacagcgaa gattctggaa tattctgaag tggctcccat caaagccctt
     3961 cgaacccttc gcgctctgcg gccactgcgg gctctttctc gatttgaagg catgcgggtg
     4021 gtggtggatg ccctggtggg cgccatccca tccatcatga atgtcctcct cgtctgcctc
     4081 atcttctggc tcatcttcag catcatgggt gtgaacctct tcgcagggaa gttttggagg
     4141 tgcatcaact ataccgatgg agagttttcc cttgtacctt tgtcgattgt gaataacaag
     4201 tctgactgca agattcaaaa ctccactggc agcttcttct gggtcaatgt gaaagtcaac
     4261 tttgataatg ttgcaatggg ttaccttgca cttctgcagg tggcaacctt taaaggctgg
     4321 atggacatta tgtatgcagc tgttgattcc cgggaggtca acatgcaacc caagtgggag
     4381 gacaacgtgt acatgtattt gtactttgtc atcttcatca tttttggagg cttcttcaca
     4441 ctgaatctct ttgttggggt cataattgac aacttcaatc aacagaaaaa aaagttaggg
     4501 ggccaggaca tcttcatgac agaggagcag aagaaatact acaatgccat gaagaagttg
     4561 ggctccaaga agccccagaa gcccatccca cggcccctga acaagttcca gggttttgtc
     4621 tttgacatcg tgaccagaca agcttttgac atcaccatca tggtcctcat ctgcctcaac
     4681 atgatcacca tgatggtgga gactgatgac caaagtgaag aaaagacgaa aattctgggc
     4741 aaaatcaacc agttctttgt ggccgtcttc acaggcgaat gtgtcatgaa gatgttcgct
     4801 ttgaggcagt actacttcac aaatggctgg aatgtgtttg acttcattgt ggtggttctc
     4861 tccattgcga gcctgatttt ttctgcaatt cttaagtcac ttcaaagtta cttctcccca
     4921 acgctcttca gagtcatccg cctggcccga attggccgca tcctcagact gatccgagcg
     4981 gccaagggga tccgcacact gctctttgcc ctcatgatgt ccctgcctgc cctcttcaac
     5041 atcgggctgt tgctattcct tgtcatgttc atctactcta tcttcggtat gtccagcttt
     5101 ccccatgtga ggtgggaggc tggcatcgac gacatgttca acttccagac cttcgccaac
     5161 agcatgctgt gcctcttcca gattaccacg tcggccggct gggatggcct cctcagcccc
     5221 atcctcaaca cagggccccc ctactgtgac cccaatctgc ccaacagcaa tggcaccaga
     5281 ggggactgtg ggagcccagc cgtaggcatc atcttcttca ccacctacat catcatctcc
     5341 ttcctcatca tggtcaacat gtacattgca gtgattctgg agaacttcaa tgtggccacg
     5401 gaggagagca ctgagcccct gagtgaggac gactttgaca tgttctatga gacctgggag
     5461 aagtttgacc cagaggccac tcagtttatt accttttctg ctctctcgga ctttgcagac
     5521 actctctctg gtcccctgag aatcccaaaa cccaatcgaa atatactgat ccagatggac
     5581 ctgcctttgg tccctggaga taagatccac tgcttggaca tcctttttgc tttcaccaag
     5641 aatgtcctag gagaatccgg ggagttggat tctctgaagg caaatatgga ggagaagttt
     5701 atggcaacta atctttcaaa atcatcctat gaaccaatag caaccactct ccgatggaag
     5761 caagaagaca tttcagccac tgtcattcaa aaggcctatc ggagctatgt gctgcaccgc
     5821 tccatggcac tctctaacac cccatgtgtg cccagagctg aggaggaggc tgcatcactc
     5881 ccagatgaag gttttgttgc attcacagca aatgaaaatt gtgtactccc agacaaatct
     5941 gaaactgctt ctgccacatc attcccaccg tcctatgaga gtgtcactag aggccttagt
     6001 gatagagtca acatgaggac atctagctca atacaaaatg aagatgaagc caccagtatg
     6061 gagctgattg cccctgggcc ctagtgagaa cactccagcc tggatatgtt cagttatgat
     6121 gcgtccttct gctctgtgtt aactctttcc cattgcagat cacacccagc tacagcctca
     6181 ccaatgcatg ccactggtca caatgtcaga actgggcagg gaatgcaact ggtaaccacc
     6241 tttgaaaaaa ccatcataca caaataggag tcagaagcta agagcacttc cactgtgatt
     6301 tcccttctga atttcaatat cagatcatgg gttctcttac tctccagaaa atatcccttg
     6361 tccttttatt tttgttgtaa tcagattata tttactgaga caaacttctc aggaccagaa
     6421 cttccaaaga tatagaacaa gaacattact gaaggtccaa ggtagtcctc tgtggagcac
     6481 catacagaga ttggcaatat tatttaggat tttgcatgac tgcatgtgag agctgtcgga
     6541 caactgctct gacccagggt aacacctgtg gcctatgtca tgaaaagcct ttgagatatc
     6601 cattaaaatt aatattttta aatgta
//
