LOCUS       NM_198081               4538 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens Scm polycomb group protein like 4 (SCML4), transcript
            variant 1, mRNA.
ACCESSION   NM_198081 XM_171128
VERSION     NM_198081.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4538)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4538)
  AUTHORS   Li,Y., Wang,D.W., Chen,Y., Chen,C., Guo,J., Zhang,S., Sun,Z.,
            Ding,H., Yao,Y., Zhou,L., Xu,K., Song,C., Yang,F., Zhao,B., Yan,H.,
            Wang,W.J., Wu,C., Lu,X., Yang,X., Dong,J., Zheng,G., Tian,S.,
            Cui,Y., Jin,L., Liu,G., Cui,H., Wang,S., Jiang,F., Wang,C.,
            Erdmann,J., Zeng,L., Huang,S., Zhong,J., Ma,Y., Chen,W., Sun,J.,
            Lei,W., Chen,S., Rao,S., Gu,D., Schunkert,H. and Tian,X.L.
  TITLE     Genome-Wide Association and Functional Studies Identify SCML4 and
            THSD7A as Novel Susceptibility Genes for Coronary Artery Disease
  JOURNAL   Arterioscler Thromb Vasc Biol 38 (4), 964-975 (2018)
   PUBMED   29472232
  REMARK    GeneRIF: SCML4 and THSD7A are identified as novel susceptibility
            genes for coronary artery disease.
REFERENCE   3  (bases 1 to 4538)
  AUTHORS   Vieira,A.R., McHenry,T.G., Daack-Hirsch,S., Murray,J.C. and
            Marazita,M.L.
  TITLE     Candidate gene/loci studies in cleft lip/palate and dental
            anomalies finds novel susceptibility genes for clefts
  JOURNAL   Genet Med 10 (9), 668-674 (2008)
   PUBMED   18978678
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK093571.1, AK303562.1, BC033286.1, BC021582.1, AL096816.12 and
            BE349472.1.
            
            On Nov 23, 2018 this sequence version replaced NM_198081.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2152474,
                              SAMEA2155628 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000369020.8/ ENSP00000358016.3
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AK093571.1         5-13
            10-623              AK303562.1         1-614
            624-1220            BC033286.1         395-991
            1221-1440           BC021582.1         714-933
            1441-4301           AL096816.12        21079-23939
            4302-4535           BE349472.1         16-249              c
            4536-4538           AL096816.12        24174-24176
FEATURES             Location/Qualifiers
     source          1..4538
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     gene            1..4538
                     /gene="SCML4"
                     /gene_synonym="dJ47M23.1"
                     /note="Scm polycomb group protein like 4"
                     /db_xref="GeneID:256380"
                     /db_xref="HGNC:HGNC:21397"
     exon            1..188
                     /gene="SCML4"
                     /gene_synonym="dJ47M23.1"
                     /inference="alignment:Splign:2.1.0"
     exon            189..403
                     /gene="SCML4"
                     /gene_synonym="dJ47M23.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..1492
                     /gene="SCML4"
                     /gene_synonym="dJ47M23.1"
                     /note="isoform a is encoded by transcript variant 1; sex
                     comb on midleg-like protein 4; sex comb on midleg like 4"
                     /codon_start=1
                     /product="sex comb on midleg-like protein 4 isoform a"
                     /protein_id="NP_932347.2"
                     /db_xref="CCDS:CCDS5060.2"
                     /db_xref="GeneID:256380"
                     /db_xref="HGNC:HGNC:21397"
                     /translation="MQSQRIPGRKRGRPSLHSTPMKMAVHNLYSASAGSLPAVKIPKK
                     RGRKPGYKIKSRVLMTPLALSPPRSTPEPDLSSIPQDAATVPSLAAPQALTVCLYINK
                     QANAGPYLERKKVQQLPEHFGPERPSAVLQQAVQACIDCAHQQKLVFSLVKQGYGGEM
                     VSVSASFDGKQHLRSLPVVNSIGYVLRFLAKLCRSLLCDDLFSHQPFPRGCSASEKVQ
                     EKEEGRMESVKTVTTEEYLVNPVGMNRYSVDTSASTFNHRGSLHPSSSLYCKRQNSGD
                     SHLGGGPAATAGGPRTSPMSSGGPSAPGLRPPASSPKRNTTSLEGNRCASSPSQDAQD
                     ARRPRSRNPSAWTVEDVVWFVKDADPQALGPHVELFRKHEIDGNALLLLKSDMVMKYL
                     GLKLGPALKLCYHIDKLKQAKF"
     exon            404..533
                     /gene="SCML4"
                     /gene_synonym="dJ47M23.1"
                     /inference="alignment:Splign:2.1.0"
     exon            534..734
                     /gene="SCML4"
                     /gene_synonym="dJ47M23.1"
                     /inference="alignment:Splign:2.1.0"
     exon            735..929
                     /gene="SCML4"
                     /gene_synonym="dJ47M23.1"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1220
                     /gene="SCML4"
                     /gene_synonym="dJ47M23.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1366
                     /gene="SCML4"
                     /gene_synonym="dJ47M23.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..4538
                     /gene="SCML4"
                     /gene_synonym="dJ47M23.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2465..2470
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCML4"
                     /gene_synonym="dJ47M23.1"
                     /note="hexamer: AAGAAA"
     polyA_site      2497
                     /gene="SCML4"
                     /gene_synonym="dJ47M23.1"
                     /note="major polyA site"
     regulatory      2569..2574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCML4"
                     /gene_synonym="dJ47M23.1"
                     /note="hexamer: AATACA"
     polyA_site      2598
                     /gene="SCML4"
                     /gene_synonym="dJ47M23.1"
     regulatory      4512..4517
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCML4"
                     /gene_synonym="dJ47M23.1"
                     /note="hexamer: AATAAA"
     polyA_site      4538
                     /gene="SCML4"
                     /gene_synonym="dJ47M23.1"
ORIGIN      
        1 gcattagtct aatgagatgt ttgcagctgg agcgcagggc tgctggagac taactgtgag
       61 ctactaacac gggtggaaga tagcttttgc aatactcggt ttgcatgtgc tgaaagtcat
      121 ctgtcttctg agtcaacact cccgacctgg taaacaacct gctcagggct ctggtgaaca
      181 agctgtagca cctcttctgc ctgtgagcga tttgtcacct cattctgtaa gactggcacc
      241 agcagaaatg cagtctcaaa ggatcccggg gagaaagcga ggccgaccct cacttcactc
      301 cacgcctatg aagatggcag ttcataacct ttattctgct tcagctggct ctttaccagc
      361 agtgaagatc ccaaagaaaa gagggcggaa acccgggtac aagatcaagt ctcgggttct
      421 catgactccc ttagccctct cacctccgcg gagtacccca gagcccgacc tcagctccat
      481 ccctcaggac gcagccacgg tccccagctt ggcggcccca caggctctca cagtctgcct
      541 ctacatcaac aagcaggcca atgcggggcc ctatctggag aggaagaagg tgcagcagct
      601 cccggagcat tttgggcccg agcggccatc ggcggtgctg cagcaggccg tccaagcctg
      661 catcgactgc gcccaccagc agaagctggt cttctccctg gtcaagcagg gctatggtgg
      721 tgagatggtg tcagtctcgg cttcctttga tggcaaacag cacctgcgga gcctgcctgt
      781 ggtgaacagc atcggctatg tcctccgctt cctcgccaag ctgtgccgaa gcctcctgtg
      841 cgatgacctc ttcagccacc agcccttccc caggggctgc agtgcctctg agaaagtcca
      901 ggagaaagag gaagggagga tggaatcagt caagacagtc accaccgaag agtacctggt
      961 gaaccctgtg ggcatgaacc gctacagcgt ggacacctcc gcctccacct ttaaccacag
     1021 gggctccttg cacccctcct cctcgctgta ctgcaagagg cagaactctg gagacagcca
     1081 ccttgggggt ggtcctgctg ccaccgctgg tggtccccgc actagcccca tgtcttctgg
     1141 tggcccctcg gcacctgggc tgaggcctcc agcctccagc cccaagagaa acacgacctc
     1201 tcttgaagga aacagatgtg cctcaagccc ttctcaggat gcgcaggatg ccaggcggcc
     1261 acggagcagg aacccctccg cctggactgt ggaggacgtg gtgtggtttg tgaaggacgc
     1321 cgacccacag gctctggggc ctcacgtgga gctcttcaga aagcacgaga ttgatggcaa
     1381 cgctctgctg ttgctgaaga gtgacatggt catgaagtac ctgggcctga agctgggacc
     1441 tgcactgaaa ctctgctacc acattgacaa actgaagcaa gccaagttct gactttttta
     1501 aaaagacaga agcgaaaccc aaaacaacag atcccaagat tatcttctgc cttaccaata
     1561 tcccgccaac atcacaaact agactctcct cttaaaatta acagccacag agacgtggtc
     1621 tttttataaa acttgtgaat ctttgccttt tgaagaattt aacatggacc ttttcgagag
     1681 gctcctctgt gttcataatt tgccaaaaaa ttacaaaagc ctgtgatttt taacatccct
     1741 gttatgctgg tttctcttaa agtgggtcct atttgcataa cgagagagtg gggaactgaa
     1801 tgcttatgcc caaggagagt tctggagggt tcaaaggatg aaagaaggac ctttgtccct
     1861 gcggtctctg cagggacaac cccctcagca ccatctgcct ctaactctga cctggggacc
     1921 tatccatgtg agccttgttt gcctcagctc tggaagctga cttctgaaga tgactgcctc
     1981 accttgcact gtctggaaaa cttgaattat tttacgccgt gaaagaaaaa ggaaaaaaaa
     2041 aaaaatcttt tctgttccta gaaaatctga agtactgtgt ttctccgcta gagggcagac
     2101 tgctaatgaa atttcaggac cctcactgac tgcagtagca ggattgttca gtactgagtg
     2161 gatgggttag ggtgtctgtg aacaagatct agcccacaca gaaacagggg atttattcca
     2221 cagttagcac cacagattgc gacttgggaa gaaaccatca gctagagggg tctagttcgt
     2281 atccaatcat tattgactga ctgactgata ctcaactagc aaaggcaaga atttggaagc
     2341 acgctctacc cagatgggac tttggagttc cttcccttcc agagtcctta ttgaggtgtt
     2401 gaagtgttgg catgccgaag aatcttagtg acatttagcc atgggtgttt ctttaaaaaa
     2461 ggaaaagaaa atgtctcaac gaagctttga aatgggagag tgttgatttc tagttacatt
     2521 gctgggttat gtagttgtat ctgtggctaa tttttctagt cctcaacaaa tacacagaca
     2581 tgctattatg gggtttaatt caatttacaa ataggttttc cttcctcaca gtggagtaat
     2641 agaaaaaatt gattttctgc tcctttgcag ctgtgtccag agacggacaa tgaatccaca
     2701 atttattagg cagaggcaca acttctccac cattcgtttt atccttctct tttctctgtt
     2761 tccctccacc tctcttcttc ttctttcaca ctgagcagaa aacatatctt caaaatgaat
     2821 tcgcctttgc catgtgcata ttctcttcct taaaaggaca tcaacagtgt tggagatgag
     2881 gagatgaaca ttagattttg gaatttctgg gagggagagg gttagggatg actcagggcc
     2941 tcccttcgcc caaaggtgaa tcagaaaagg cacccctttc tctgggatac aacctgagca
     3001 ggggtctcag ctggcaagtg gagcagggtg ggggctcaac ctcctcaccg cttgatcagc
     3061 tgccgttgta cagagcatga cctgtataac cttgagggca gccctgggta gatctgcaga
     3121 gtgaccctct atatagttag aatccagatg aaggccataa gaaatagtcc atgccatgcc
     3181 gttaggccca ctttcatgtg cagtacttga gaaagcacat cgtagcctcc ttttcagaca
     3241 cacaaatggc ggctggactg agagcatggc agagaagggg aggaggagaa tgtactaaac
     3301 ttgctcactg aattgagctt gagttattag attgtagaag agcttgatgt ctggtgattt
     3361 tgttacagga agggggtccc gatccagacc ccaagagagg gctcttggat ctcatgcaag
     3421 aaagaattca gggtgagtcc ataaagtaaa gtgaaagcaa gtttattaag aaagtaaagg
     3481 aaggaaagaa tggctacccc atagtcaaag cagctctgag ggctgctggt tgcccatttt
     3541 tatgtttatt tcttgatatg ctaaacaagg ggtggattat tcatgcctcc cccttttaga
     3601 tcatataggg taacttcctg atgttgccat ggcatttgta aaccgtcatg gcactggtgg
     3661 tagtatagca gcgaggacaa ccagaggtca ctctcgttgc catcttggtt ttggtgggtt
     3721 ttagccaact tctttactgc aacctgtttt atcagaaggt ctttatgacc tatatcttgt
     3781 gctgacctcc tgtctcatcc tgtgactcag aatgctttag ccatctggga atgcagccca
     3841 gtaggtctca gcctcatttt acccagctcc cattcaagat ggagttgctc tggttcaaat
     3901 gcctctgaca ggttcagcac ctgagaaaag taccttgaat caggccttgg ggcagagtct
     3961 tcaagatttt aaggtgatag ggcctgtctc ttaagaattt attaatcgta agtgctcact
     4021 gctggtttag agttagatac atttccctca aaacagccat gggcaggtta tgtactcaga
     4081 actgccaggg tgaaaacaat gagatccaga aaaatcccac aacaatccag gtttttcact
     4141 cctctttttt ttctcaatct tccgatactt gtggtacctc ttccatcaac agatacctca
     4201 tgtagtgact tccagtatca agttttcaaa acttcctacc caccctcatc agtgcctcct
     4261 tcactacaga gtcacaaaca ttggtgctct caaataaaaa tcagccccaa acaatgtcaa
     4321 agagatccct tgagtagttt tcaggcgaga gatatgttct catttcaagt cttggagaaa
     4381 actggatcca tgttcacgtg gaacttctct cgcggaggtg ctatctcatt ttgcattaaa
     4441 ctttaagcag gacagattgc tgaagccatg atatttaagg tttgactttt taaaaatctc
     4501 attactctta aaataaatgc tgccacatca gagaataa
//
