LOCUS       NM_001037540            2887 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens Scm polycomb group protein like 1 (SCML1), transcript
            variant 1, mRNA.
ACCESSION   NM_001037540
VERSION     NM_001037540.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2887)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2887)
  AUTHORS   Accogli,A., Traverso,M., Madia,F., Bellini,T., Vari,M.S., Pinto,F.
            and Capra,V.
  TITLE     A novel Xp22.13 microdeletion in Nance-Horan syndrome
  JOURNAL   Birth Defects Res 109 (11), 866-868 (2017)
   PUBMED   28464487
  REMARK    GeneRIF: Here, we report a microdeletion of 170,6 Kb at Xp22.13
            (17.733.948-17.904.576) (GRCh37/hg19).The microdeletion harbors the
            NHS, SCLML1, and RAI2 genes and results in a phenotype consistent
            with Nance-Horan syndromesyndrome and developmental delay
REFERENCE   3  (bases 1 to 2887)
  AUTHORS   Wu,H.H. and Su,B.
  TITLE     Adaptive evolution of SCML1 in primates, a gene involved in male
            reproduction
  JOURNAL   BMC Evol Biol 8, 192 (2008)
   PUBMED   18601738
  REMARK    GeneRIF: the molecular evolutionary pattern of SCML1 in diverse
            primate species showed a strong signature of adaptive evolution
            which is caused by Darwinian positive selection
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2887)
  AUTHORS   van de Vosse,E., Walpole,S.M., Nicolaou,A., van der Bent,P.,
            Cahn,A., Vaudin,M., Ross,M.T., Durham,J., Pavitt,R., Wilkinson,J.,
            Grafham,D., Bergen,A.A., van Ommen,G.J., Yates,J.R., den
            Dunnen,J.T. and Trump,D.
  TITLE     Characterization of SCML1, a new gene in Xp22, with homology to
            developmental polycomb genes
  JOURNAL   Genomics 49 (1), 96-102 (1998)
   PUBMED   9570953
REFERENCE   5  (bases 1 to 2887)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC026159.2, BI461014.1, AF160728.1 and AA382395.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001037540.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.236955.1,
                                           SRR5189667.203827.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145122
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380041.8/ ENSP00000369380.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               BC026159.2         25-212
            189-421             BI461014.1         212-444
            422-1593            BC026159.2         365-1536
            1594-2884           AF160728.1         1345-2635
            2885-2887           AA382395.1         4-6                 c
FEATURES             Location/Qualifiers
     source          1..2887
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.13"
     gene            1..2887
                     /gene="SCML1"
                     /note="Scm polycomb group protein like 1"
                     /db_xref="GeneID:6322"
                     /db_xref="HGNC:HGNC:10580"
                     /db_xref="MIM:300227"
     exon            1..188
                     /gene="SCML1"
                     /inference="alignment:Splign:2.1.0"
     exon            189..337
                     /gene="SCML1"
                     /inference="alignment:Splign:2.1.0"
     CDS             305..1294
                     /gene="SCML1"
                     /note="isoform a is encoded by transcript variant 1; sex
                     comb on midleg-like protein 1; sex comb on midleg like 1"
                     /codon_start=1
                     /product="sex comb on midleg-like protein 1 isoform a"
                     /protein_id="NP_001032629.1"
                     /db_xref="CCDS:CCDS35210.1"
                     /db_xref="GeneID:6322"
                     /db_xref="HGNC:HGNC:10580"
                     /db_xref="MIM:300227"
                     /translation="MMSNSSSEIDVIKTRIPTYDEDDNTILYAYETKPEFVNKEPNIV
                     SDASCNTEEQLKTVDDVLIHCQVIYDALQNLDKKIDVIRRKVSKIQRFHARSLWTNHK
                     RYGYKKHSYRLVKKLKLQKMKKNEVYETFSYPESYSPTLPVSRRENNSPSNLPRPSFC
                     MEEYQRAELEEDPILSRTPSPVHPSDFSEHNCQPYYASDGATYGSSSGLCLGNPRADS
                     IHNTYSTDHASAAPPSVTRSPVENDGYIEEGSITKHPSTWSVEAVVLFLKQTDPLALC
                     PLVDLFRSHEIDGKALLLLTSDVLLKHLGVKLGTAVKLCYYIDRLKQGKCFEN"
     exon            338..421
                     /gene="SCML1"
                     /inference="alignment:Splign:2.1.0"
     exon            422..502
                     /gene="SCML1"
                     /inference="alignment:Splign:2.1.0"
     exon            503..607
                     /gene="SCML1"
                     /inference="alignment:Splign:2.1.0"
     exon            608..1007
                     /gene="SCML1"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1159
                     /gene="SCML1"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..2887
                     /gene="SCML1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2863..2868
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCML1"
                     /note="hexamer: AATAAA"
     polyA_site      2887
                     /gene="SCML1"
                     /note="major polyA site"
ORIGIN      
        1 actcaggggt cagggcatca ctggtctcgc gtgcgcgtga ccaggcccgg tttccggtgc
       61 caggaccttt ccgaagcgtc gagtggccta acggtcacag ctgtcgccca tcggagaggc
      121 aggactactg cgagcagttt taccgcgacc tccggaggcc ggcgtgacag gctctgtcac
      181 taaaatagga gtagaggttt accactctta ggtgactaag cagtatcaca aataaaccct
      241 ccagcaagtt taaaaataat taggtccaac tcagaggaag tggagtttct cctgttgcac
      301 aaaaatgatg tctaacagct ccagtgaaat cgatgtgata aaaacaagaa tacctactta
      361 cgatgaagat gacaacacta ttctttatgc gtatgaaaca aaacctgaat ttgtcaataa
      421 agaaccgaat attgtatctg acgcatcctg taatactgaa gagcaactga agacagttga
      481 tgatgtcctt attcattgcc aggttatata tgatgctctg caaaacctgg ataagaagat
      541 tgatgtgatt cgtagaaagg tttcaaaaat ccaacgtttc catgcgagat ccctgtggac
      601 aaatcataag cgatatggat ataaaaagca ttcttaccgg cttgttaaaa agcttaaact
      661 ccagaaaatg aagaaaaatg aggtttacga gacattctcc taccctgaaa gttacagccc
      721 cactttacca gtgtcaaggc gtgagaataa ttccccgagc aaccttccaa ggccatcctt
      781 ttgcatggaa gaataccagc gagctgagct ggaggaggac ccgatcctca gccgcactcc
      841 gagtccagtg catccctcag atttctctga gcataattgt cagccgtatt atgcatctga
      901 tggtgcaacg tatggttctt cttcagggct ctgccttggc aaccctcggg ctgacagcat
      961 ccacaacact tactcaactg accatgcttc tgcagcacca ccttcagtta caaggtcacc
     1021 agttgaaaat gacggttaca tagaggaagg aagcatcact aagcaccctt caacctggtc
     1081 ggtggaagca gtggtcctat ttctaaaaca aacagatcct cttgcattat gccctcttgt
     1141 cgacctcttc agaagccatg aaattgacgg gaaggctctg ctcctactca cgagtgacgt
     1201 gttgctgaag cacttggggg tgaagctggg aacggctgtg aagctatgct actacattga
     1261 ccgacttaaa caaggaaaat gctttgaaaa ttgaaaaaat ccttgtgcaa atttagattg
     1321 ggccaacttc tagaggcacc aatgccttct tagtgtggaa tcatttttct gccctttagt
     1381 cgtttttgtt ttgtagaaag tatctctcaa aatatattat agctagaatt gtagaactat
     1441 gttatagtcc agtctacttc tttaaaaacc atttaaactg ctagatagta ttagaatagt
     1501 ccaatagaaa attcattctt tataggtctt taaaaattac ttttattata ttgtttacaa
     1561 atatatttca tgcaagaaac agaaaaaaaa aaaaaccctt tgattctggt tcatctcgat
     1621 acagagaacc aaaacagcta agagaggtat tatcagggtt gacaactcct atgattgaat
     1681 ctatgggaat tattcctcag aagagaattt aaaggtgtac ccatatatat ctctttctgg
     1741 agtattttat ctgtctgatg ttgcagtatt ctacaagttt ccagaaagag aatagccata
     1801 taaattattt tcctttctgc tattatttct ctatatgttt tatttattca gatttagagt
     1861 aaaaaataag catataaact tttattatgt gctcttaaca gttttaagat aaactatagg
     1921 atagatagaa tggttatttt atgcaagaaa tattgtaccg caagggtggt ttggatgaag
     1981 tctgactact ttttttcaaa caaactatta tattaaaact gtcatatttt ggctaagttt
     2041 ggacctataa ctacactttc attgtttgca tctctctatg aagatacgtc tgtccaaact
     2101 tttaaaaggc ataactgtat tttatgtgtt tattctttat atagatagta ttttatattt
     2161 tattctcacc cgaagtattc acacaatctt tttaaaaaaa atttgaaatg gcattttgta
     2221 ttgccacaga ggtaggatga gccatatatt agtgaaatgt tttattttgt aaaatataaa
     2281 tggattattt gccatcatta gtacctctca acttactttt tagaggacaa gaaacaatct
     2341 gtagattggt ttccatacag ggaagttctc cgtcctatgc aatgtttcta attaatttgc
     2401 ttaattctga gccattaatc ctgctacact ttgaatgata cattaattca gactaatctt
     2461 tgggggcttt attttgtaag ttagaacttt caagggaaac atgttcaaca ctattatttt
     2521 gttataaatt tataactttg ttattacatt gtgtaacaaa tataaggttt acgagctatg
     2581 agaattggtg ctatcaccat tagctatttg ctgtaatgtc aagaaaatgt tcaccagatg
     2641 caagaatgta ccttttcttt ttagaaagcc aaatgtactt tagacatgaa tgcaactatt
     2701 taaagaatag cttcatcaat gttattcctt acatgtcata agattcttac ttaaacttgg
     2761 tcttctttca aattgtttgt atgaagatgc tgtacccact tgaacagtcc tcaggtgttt
     2821 acataaatac tatgttttac agttttcata ttttaaaata ttaataaagt taaatcacaa
     2881 tagttca
//
