LOCUS       NM_001394311            3370 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens Scm polycomb group protein homolog 1 (SCMH1),
            transcript variant 22, mRNA.
ACCESSION   NM_001394311 XM_006710462
VERSION     NM_001394311.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3370)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3370)
  AUTHORS   Zhao,J., Li,M., Bradfield,J.P., Zhang,H., Mentch,F.D., Wang,K.,
            Sleiman,P.M., Kim,C.E., Glessner,J.T., Hou,C., Keating,B.J.,
            Thomas,K.A., Garris,M.L., Deliard,S., Frackelton,E.C., Otieno,F.G.,
            Chiavacci,R.M., Berkowitz,R.I., Hakonarson,H. and Grant,S.F.
  TITLE     The role of height-associated loci identified in genome wide
            association studies in the determination of pediatric stature
  JOURNAL   BMC Med Genet 11, 96 (2010)
   PUBMED   20546612
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3370)
  AUTHORS   Sovio,U., Bennett,A.J., Millwood,I.Y., Molitor,J., O'Reilly,P.F.,
            Timpson,N.J., Kaakinen,M., Laitinen,J., Haukka,J., Pillas,D.,
            Tzoulaki,I., Molitor,J., Hoggart,C., Coin,L.J., Whittaker,J.,
            Pouta,A., Hartikainen,A.L., Freimer,N.B., Widen,E., Peltonen,L.,
            Elliott,P., McCarthy,M.I. and Jarvelin,M.R.
  TITLE     Genetic determinants of height growth assessed longitudinally from
            infancy to adulthood in the northern Finland birth cohort 1966
  JOURNAL   PLoS Genet 5 (3), e1000409 (2009)
   PUBMED   19266077
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 3370)
  AUTHORS   Weedon,M.N., Lango,H., Lindgren,C.M., Wallace,C., Evans,D.M.,
            Mangino,M., Freathy,R.M., Perry,J.R., Stevens,S., Hall,A.S.,
            Samani,N.J., Shields,B., Prokopenko,I., Farrall,M., Dominiczak,A.,
            Johnson,T., Bergmann,S., Beckmann,J.S., Vollenweider,P.,
            Waterworth,D.M., Mooser,V., Palmer,C.N., Morris,A.D.,
            Ouwehand,W.H., Zhao,J.H., Li,S., Loos,R.J., Barroso,I.,
            Deloukas,P., Sandhu,M.S., Wheeler,E., Soranzo,N., Inouye,M.,
            Wareham,N.J., Caulfield,M., Munroe,P.B., Hattersley,A.T.,
            McCarthy,M.I. and Frayling,T.M.
  CONSRTM   Diabetes Genetics Initiative; Wellcome Trust Case Control
            Consortium; Cambridge GEM Consortium
  TITLE     Genome-wide association analysis identifies 20 loci that influence
            adult height
  JOURNAL   Nat Genet 40 (5), 575-583 (2008)
   PUBMED   18391952
REFERENCE   5  (bases 1 to 3370)
  AUTHORS   Luo,L., Yang,X., Takihara,Y., Knoetgen,H. and Kessel,M.
  TITLE     The cell-cycle regulator geminin inhibits Hox function through
            direct and polycomb-mediated interactions
  JOURNAL   Nature 427 (6976), 749-753 (2004)
   PUBMED   14973489
REFERENCE   6  (bases 1 to 3370)
  AUTHORS   Levine,S.S., Weiss,A., Erdjument-Bromage,H., Shao,Z., Tempst,P. and
            Kingston,R.E.
  TITLE     The core of the polycomb repressive complex is compositionally and
            functionally conserved in flies and humans
  JOURNAL   Mol Cell Biol 22 (17), 6070-6078 (2002)
   PUBMED   12167701
REFERENCE   7  (bases 1 to 3370)
  AUTHORS   Tomotsune,D., Takihara,Y., Berger,J., Duhl,D., Joo,S., Kyba,M.,
            Shirai,M., Ohta,H., Matsuda,Y., Honda,B.M., Simon,J., Shimada,K.,
            Brock,H.W. and Randazzo,F.
  TITLE     A novel member of murine Polycomb-group proteins, Sex comb on
            midleg homolog protein, is highly conserved, and interacts with
            RAE28/mph1 in vitro
  JOURNAL   Differentiation 65 (4), 229-239 (1999)
   PUBMED   10653359
REFERENCE   8  (bases 1 to 3370)
  AUTHORS   Berger,J., Kurahashi,H., Takihara,Y., Shimada,K., Brock,H.W. and
            Randazzo,F.
  TITLE     The human homolog of Sex comb on midleg (SCMH1) maps to chromosome
            1p34
  JOURNAL   Gene 237 (1), 185-191 (1999)
   PUBMED   10524249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606484.9, AL110502.1 and AL391730.13.
            
            On Apr 10, 2021 this sequence version replaced XM_006710462.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074968.4071583.1,
                                           SRR14038196.3328081.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000695335.1/ ENSP00000511813.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-248               AL606484.9         77285-77532         c
            249-378             AL606484.9         21347-21476         c
            379-447             AL110502.1         5343-5411
            448-471             AL110502.1         5877-5900
            472-542             AL110502.1         15091-15161
            543-777             AL110502.1         23663-23897
            778-866             AL110502.1         49765-49853
            867-1110            AL110502.1         53249-53492
            1111-1343           AL110502.1         91324-91556
            1344-1470           AL110502.1         96054-96180
            1471-1671           AL110502.1         117885-118085
            1672-1863           AL110502.1         120177-120368
            1864-2043           AL110502.1         129234-129413
            2044-2109           AL110502.1         132727-132792
            2110-2252           AL391730.13        95151-95293         c
            2253-3370           AL391730.13        93769-94886         c
FEATURES             Location/Qualifiers
     source          1..3370
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.2"
     gene            1..3370
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /note="Scm polycomb group protein homolog 1"
                     /db_xref="GeneID:22955"
                     /db_xref="HGNC:HGNC:19003"
                     /db_xref="MIM:616396"
     exon            1..248
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            249..378
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /inference="alignment:Splign:2.1.0"
     CDS             366..2378
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /note="isoform m is encoded by transcript variant 22;
                     polycomb protein SCMH1; sex comb on midleg homolog 1"
                     /codon_start=1
                     /product="polycomb protein SCMH1 isoform m"
                     /protein_id="NP_001381240.1"
                     /db_xref="CCDS:CCDS90928.1"
                     /db_xref="GeneID:22955"
                     /db_xref="HGNC:HGNC:19003"
                     /db_xref="MIM:616396"
                     /translation="MQPNVIDWSDVRKHKYGHLSESASQYQEAADILDLGHFTWDKYL
                     KETCSVPAPVHCFKQSYTPPSNEFKISMKLEAQDPRNTTSTCIATVVGLTGARLRLRL
                     DGSDNKNDFWRLVDSAEIQPIGNCEKNGGMLQPPLGFRLNASSWPMFLLKTLNGAEMA
                     PIRIFHKEPPSPSHNFFKMGMKLEAVDRKNPHFICPATIGEVRGSEVLVTFDGWRGAF
                     DYWCRFDSRDIFPVGWCSLTGDNLQPPGTKVVIPKNPYPASDVNTEKPSIHSSTKTVL
                     EHQPGQRGRKPGKKRGRTPKTLISHPISAPSKTAEPLKFPKKRGPKPGSKRKPRTLLN
                     PPPASPTTSTPEPDTSTVPQDAATIPSSAMQAPTVCIYLNKNGSTGPHLDKKKVQQLP
                     DHFGPARASVVLQQAVQACIDCAYHQKTVFSFLKQGHGGEVISAVFDREQHTLNLPAV
                     NSITYVLRFLEKLCHNLRSDNLFGNQPFTQTHLSLTAIEYSHSHDRYLPGETFVLGNS
                     LARSLEPHSDSMDSASNPTNLVSTSQRHRPLLSSCGLPPSTASAVRRLCSRGVLKGSN
                     ERRDMESFWKLNRSPGSDRYLESRDASRLSGRDPSSWTVEDVMQFVREADPQLGPHAD
                     LFRKHEIDGKALLLLRSDMMMKYMGLKLGPALKLSYHIDRLKQGKF"
     exon            379..447
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            448..471
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            472..542
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            543..777
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            778..866
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1110
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1343
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1470
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1671
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1863
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..2043
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2109
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2252
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..3370
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3351..3356
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /note="hexamer: AATAAA"
     polyA_site      3370
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgagccc aacggccgag gcgcgcgcca cctcgcagcg ggaggcgcgg gggaggggcc
       61 gggggagccc ccgccccgcc ccccgcctca gccgccaccg ccagctcggt ggagcccccc
      121 gccgcccgcc cgccgctctc ccgagccgcc cgcccgcccc cttcccgcgt ctccgctccc
      181 tccctgcgca gcggaaacat ggcggcggga agagagtgag ccgccccgcg cccccgccgc
      241 gccctcagat ggagaaatta gcatacaaag aaactgactt gtcagaagtc agagcaaggt
      301 attggtggat ccagggataa atcccaaact tcttaacccc tagaccggtt tttagtccat
      361 tgactatgca gcctaatgtg atagactgga gtgatgttag aaaacacaaa tatggtcacc
      421 tatcagagtc tgcatcccaa tatcaagaag ctgctgacat cctggatcta ggtcatttta
      481 cctgggacaa atacctaaaa gaaacatgtt cagtcccagc gcctgtccat tgcttcaagc
      541 agtcctacac acctccaagc aacgagttca agatcagtat gaaattggaa gcacaggacc
      601 ccaggaacac cacatccacc tgtattgcca cagtagttgg actgacaggt gcccgccttc
      661 gcctgcgcct tgatgggagc gacaacaaaa atgacttctg gcggctggtt gactcagctg
      721 aaatccagcc tattgggaac tgtgaaaaga atgggggtat gctacagcca cctcttggat
      781 ttcggctgaa tgcgtcttct tggcccatgt tccttttgaa gacgctaaat ggagcagaga
      841 tggctcccat caggattttc cacaaggagc caccatcgcc ttcccacaac ttcttcaaaa
      901 tgggaatgaa gctagaagct gtggacagga agaaccctca tttcatttgc ccagccacta
      961 ttggggaggt tcggggctca gaggtgcttg tcacttttga tgggtggcga ggggcctttg
     1021 actactggtg ccgcttcgac tcccgagaca tcttccctgt gggctggtgt tccttgactg
     1081 gagacaacct gcagcctcct ggcaccaaag ttgtgattcc aaagaatccc tatcctgcct
     1141 ccgatgtgaa tactgagaag cccagcatcc acagcagcac caaaactgtc ttggaacatc
     1201 aaccagggca gagggggcgt aaaccaggaa agaagcgggg ccggacaccc aagaccctaa
     1261 tttcccatcc catctctgcc ccatccaaga cagctgaacc tttgaaattc ccaaagaaga
     1321 gaggtcccaa acctggcagc aagaggaaac ctcggacttt gctgaaccca ccacctgcct
     1381 caccaacaac cagcactcct gaaccggata ccagcactgt accccaggat gctgccacca
     1441 tccccagctc agccatgcag gccccaacag tttgtatcta cttgaacaag aatggcagca
     1501 caggccccca cttagataag aagaaggtcc agcaactccc tgaccatttt ggaccagccc
     1561 gtgcctctgt ggtgttgcag caggctgtcc aggcctgtat cgactgtgct tatcaccaga
     1621 aaaccgtctt cagcttcctc aagcaaggcc atggtggtga ggttatctca gccgtgtttg
     1681 accgggaaca gcataccctc aacctcccag cagtcaacag catcacctac gtcctccgct
     1741 tcctggagaa actctgccac aaccttcgta gtgacaatct gtttggcaac cagcccttta
     1801 cacagactca cttgtcactc actgccatag agtacagcca cagccacgac aggtacctac
     1861 caggtgaaac ctttgtcctg gggaatagtc tggcccgctc cttggaacca cactcagact
     1921 caatggactc tgcctcaaat cccaccaacc ttgtcagcac ctcccaaagg caccggccct
     1981 tgctttcatc ctgtggcctc ccaccaagca ctgcctcagc tgtgcgcagg ctatgctcca
     2041 ggggagtgtt aaaaggatca aatgaaagaa gggatatgga atcattttgg aaactaaatc
     2101 gttccccagg gtcggaccga tacctggaga gccgcgatgc ctctcgactg agtggccggg
     2161 acccctcctc atggacagtc gaggatgtga tgcagtttgt ccgggaagct gatcctcagc
     2221 ttggacccca cgctgacctg tttcgcaaac acgagatcga tggcaaggcc ctgctgctgc
     2281 tgcgcagtga catgatgatg aagtacatgg gcctgaagct ggggcctgca ctcaagctct
     2341 cctaccacat tgaccggctg aagcagggca agttctgaac caggagaggc agcctagaca
     2401 accaagtggc agcaggtggg ggcattcttc taggaatgag gggcatcagc ccaccccagg
     2461 cacctcagtg gggttccggg ccacctcagg actccaagag gctgtgtgga gccaccactc
     2521 ctagccacag ctgccatgat aagtccttcc atgaaggact gaggagggag agtgggggtc
     2581 cagggctggt gctgctcttc cctcagctct gccggggctc taaggtccct ctatttattt
     2641 ctcaaccctg gctggcctct caccaggagt ttaggctgaa tgccttccac gtgatggagg
     2701 aaaaggccaa ctctgtcctg gtcttgctgt ggcaccccat cgccccacag ctcgtacctt
     2761 ctcaccagat tcccctgaat ccaaactcgt ggtgcaaacc tctacctttt ttacaaaaag
     2821 atcttattgt taatttattg tttctggcac ttgggcaaac cctgtagtta atactcctcc
     2881 cacactagac actgggtttc aggaggaggg agactgccct gctttggtcc cagagaggcc
     2941 ctctgcagat aggcgtggcc cctcttcaga ggacactacc ctagggcact ttctctttga
     3001 ggtggagaga cccataaagc cttgaccaca tcactccata tggggaggag aaggatccct
     3061 gtcaccttct cctctcttca cggggccctt ttgcagccct aggcctcatc tgtgggaagg
     3121 gagtccctgg cttatactgc ccccaccaca gctccttgcc ctggccagaa ctgctgtcga
     3181 agaaaatcag gccggaaggc caagaaggcg ctaaggggga tgggagggca ggttttccag
     3241 gctggagtcg gttccaccca ctcgcctgtc cacaggcttc cttgtaagca agtcagcagc
     3301 acagctactc acgctgccat ctggacttat tttatgtcaa tctgtttata aataaaaacc
     3361 aatatagata
//
