LOCUS       NP_001381240             670 aa            linear   PRI 12-JUN-2024
DEFINITION  polycomb protein SCMH1 isoform m [Homo sapiens].
ACCESSION   NP_001381240 XP_006710525
VERSION     NP_001381240.1
DBSOURCE    REFSEQ: accession NM_001394311.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 670)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (residues 1 to 670)
  AUTHORS   Zhao,J., Li,M., Bradfield,J.P., Zhang,H., Mentch,F.D., Wang,K.,
            Sleiman,P.M., Kim,C.E., Glessner,J.T., Hou,C., Keating,B.J.,
            Thomas,K.A., Garris,M.L., Deliard,S., Frackelton,E.C., Otieno,F.G.,
            Chiavacci,R.M., Berkowitz,R.I., Hakonarson,H. and Grant,S.F.
  TITLE     The role of height-associated loci identified in genome wide
            association studies in the determination of pediatric stature
  JOURNAL   BMC Med Genet 11, 96 (2010)
   PUBMED   20546612
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 670)
  AUTHORS   Sovio,U., Bennett,A.J., Millwood,I.Y., Molitor,J., O'Reilly,P.F.,
            Timpson,N.J., Kaakinen,M., Laitinen,J., Haukka,J., Pillas,D.,
            Tzoulaki,I., Molitor,J., Hoggart,C., Coin,L.J., Whittaker,J.,
            Pouta,A., Hartikainen,A.L., Freimer,N.B., Widen,E., Peltonen,L.,
            Elliott,P., McCarthy,M.I. and Jarvelin,M.R.
  TITLE     Genetic determinants of height growth assessed longitudinally from
            infancy to adulthood in the northern Finland birth cohort 1966
  JOURNAL   PLoS Genet 5 (3), e1000409 (2009)
   PUBMED   19266077
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (residues 1 to 670)
  AUTHORS   Weedon,M.N., Lango,H., Lindgren,C.M., Wallace,C., Evans,D.M.,
            Mangino,M., Freathy,R.M., Perry,J.R., Stevens,S., Hall,A.S.,
            Samani,N.J., Shields,B., Prokopenko,I., Farrall,M., Dominiczak,A.,
            Johnson,T., Bergmann,S., Beckmann,J.S., Vollenweider,P.,
            Waterworth,D.M., Mooser,V., Palmer,C.N., Morris,A.D.,
            Ouwehand,W.H., Zhao,J.H., Li,S., Loos,R.J., Barroso,I.,
            Deloukas,P., Sandhu,M.S., Wheeler,E., Soranzo,N., Inouye,M.,
            Wareham,N.J., Caulfield,M., Munroe,P.B., Hattersley,A.T.,
            McCarthy,M.I. and Frayling,T.M.
  CONSRTM   Diabetes Genetics Initiative; Wellcome Trust Case Control
            Consortium; Cambridge GEM Consortium
  TITLE     Genome-wide association analysis identifies 20 loci that influence
            adult height
  JOURNAL   Nat Genet 40 (5), 575-583 (2008)
   PUBMED   18391952
REFERENCE   5  (residues 1 to 670)
  AUTHORS   Luo,L., Yang,X., Takihara,Y., Knoetgen,H. and Kessel,M.
  TITLE     The cell-cycle regulator geminin inhibits Hox function through
            direct and polycomb-mediated interactions
  JOURNAL   Nature 427 (6976), 749-753 (2004)
   PUBMED   14973489
REFERENCE   6  (residues 1 to 670)
  AUTHORS   Levine,S.S., Weiss,A., Erdjument-Bromage,H., Shao,Z., Tempst,P. and
            Kingston,R.E.
  TITLE     The core of the polycomb repressive complex is compositionally and
            functionally conserved in flies and humans
  JOURNAL   Mol Cell Biol 22 (17), 6070-6078 (2002)
   PUBMED   12167701
REFERENCE   7  (residues 1 to 670)
  AUTHORS   Tomotsune,D., Takihara,Y., Berger,J., Duhl,D., Joo,S., Kyba,M.,
            Shirai,M., Ohta,H., Matsuda,Y., Honda,B.M., Simon,J., Shimada,K.,
            Brock,H.W. and Randazzo,F.
  TITLE     A novel member of murine Polycomb-group proteins, Sex comb on
            midleg homolog protein, is highly conserved, and interacts with
            RAE28/mph1 in vitro
  JOURNAL   Differentiation 65 (4), 229-239 (1999)
   PUBMED   10653359
REFERENCE   8  (residues 1 to 670)
  AUTHORS   Berger,J., Kurahashi,H., Takihara,Y., Shimada,K., Brock,H.W. and
            Randazzo,F.
  TITLE     The human homolog of Sex comb on midleg (SCMH1) maps to chromosome
            1p34
  JOURNAL   Gene 237 (1), 185-191 (1999)
   PUBMED   10524249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606484.9, AL110502.1 and AL391730.13.
            
            On Apr 10, 2021 this sequence version replaced XP_006710525.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074968.4071583.1,
                                           SRR14038196.3328081.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000695335.1/ ENSP00000511813.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..670
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.2"
     Protein         1..670
                     /product="polycomb protein SCMH1 isoform m"
                     /note="polycomb protein SCMH1; sex comb on midleg homolog
                     1"
                     /calculated_mol_wt=74511
     Region          37..167
                     /region_name="MBT_SCMH1_rpt1"
                     /note="first malignant brain tumor (MBT) repeat found in
                     Polycomb protein sex comb on midleg homolog 1; cd20105"
                     /db_xref="CDD:439095"
     Region          172..246
                     /region_name="MBT_SCMH1_rpt2"
                     /note="second malignant brain tumor (MBT) repeat found in
                     Polycomb protein sex comb on midleg homolog 1 (SCMH1) and
                     similar proteins; cd20108"
                     /db_xref="CDD:439098"
     Site            order(187,190,192..193,195,211,214,218,244..246)
                     /site_type="other"
                     /note="methyllysine peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:439098"
     Region          <243..367
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          281..334
                     /region_name="RBR"
                     /note="RNA binding Region; pfam17208"
                     /db_xref="CDD:465382"
     Region          368..476
                     /region_name="SLED"
                     /note="SLED domain; pfam12140"
                     /db_xref="CDD:463469"
     Region          597..667
                     /region_name="SAM_Scm"
                     /note="SAM domain of Scm proteins of Polycomb group;
                     cd09578"
                     /db_xref="CDD:188977"
     Site            order(616,651..654,656..657,660,663)
                     /site_type="other"
                     /note="oligomer interface EH [polypeptide binding]"
                     /db_xref="CDD:188977"
     Site            order(628..632,634..635,638..639,642..643,645..648)
                     /site_type="other"
                     /note="oligomer interface ML [polypeptide binding]"
                     /db_xref="CDD:188977"
     CDS             1..670
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /coded_by="NM_001394311.1:366..2378"
                     /note="isoform m is encoded by transcript variant 22"
                     /db_xref="CCDS:CCDS90928.1"
                     /db_xref="GeneID:22955"
                     /db_xref="HGNC:HGNC:19003"
                     /db_xref="MIM:616396"
ORIGIN      
        1 mqpnvidwsd vrkhkyghls esasqyqeaa dildlghftw dkylketcsv papvhcfkqs
       61 ytppsnefki smkleaqdpr nttstciatv vgltgarlrl rldgsdnknd fwrlvdsaei
      121 qpigncekng gmlqpplgfr lnasswpmfl lktlngaema pirifhkepp spshnffkmg
      181 mkleavdrkn phficpatig evrgsevlvt fdgwrgafdy wcrfdsrdif pvgwcsltgd
      241 nlqppgtkvv ipknpypasd vntekpsihs stktvlehqp gqrgrkpgkk rgrtpktlis
      301 hpisapskta eplkfpkkrg pkpgskrkpr tllnpppasp ttstpepdts tvpqdaatip
      361 ssamqaptvc iylnkngstg phldkkkvqq lpdhfgpara svvlqqavqa cidcayhqkt
      421 vfsflkqghg gevisavfdr eqhtlnlpav nsityvlrfl eklchnlrsd nlfgnqpftq
      481 thlsltaiey shshdrylpg etfvlgnsla rslephsdsm dsasnptnlv stsqrhrpll
      541 sscglppsta savrrlcsrg vlkgsnerrd mesfwklnrs pgsdrylesr dasrlsgrdp
      601 sswtvedvmq fvreadpqlg phadlfrkhe idgkallllr sdmmmkymgl klgpalklsy
      661 hidrlkqgkf
//
