LOCUS       NM_001394303            3579 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens Scm polycomb group protein homolog 1 (SCMH1),
            transcript variant 15, mRNA.
ACCESSION   NM_001394303 XM_006710464
VERSION     NM_001394303.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3579)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3579)
  AUTHORS   Zhao,J., Li,M., Bradfield,J.P., Zhang,H., Mentch,F.D., Wang,K.,
            Sleiman,P.M., Kim,C.E., Glessner,J.T., Hou,C., Keating,B.J.,
            Thomas,K.A., Garris,M.L., Deliard,S., Frackelton,E.C., Otieno,F.G.,
            Chiavacci,R.M., Berkowitz,R.I., Hakonarson,H. and Grant,S.F.
  TITLE     The role of height-associated loci identified in genome wide
            association studies in the determination of pediatric stature
  JOURNAL   BMC Med Genet 11, 96 (2010)
   PUBMED   20546612
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3579)
  AUTHORS   Sovio,U., Bennett,A.J., Millwood,I.Y., Molitor,J., O'Reilly,P.F.,
            Timpson,N.J., Kaakinen,M., Laitinen,J., Haukka,J., Pillas,D.,
            Tzoulaki,I., Molitor,J., Hoggart,C., Coin,L.J., Whittaker,J.,
            Pouta,A., Hartikainen,A.L., Freimer,N.B., Widen,E., Peltonen,L.,
            Elliott,P., McCarthy,M.I. and Jarvelin,M.R.
  TITLE     Genetic determinants of height growth assessed longitudinally from
            infancy to adulthood in the northern Finland birth cohort 1966
  JOURNAL   PLoS Genet 5 (3), e1000409 (2009)
   PUBMED   19266077
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 3579)
  AUTHORS   Weedon,M.N., Lango,H., Lindgren,C.M., Wallace,C., Evans,D.M.,
            Mangino,M., Freathy,R.M., Perry,J.R., Stevens,S., Hall,A.S.,
            Samani,N.J., Shields,B., Prokopenko,I., Farrall,M., Dominiczak,A.,
            Johnson,T., Bergmann,S., Beckmann,J.S., Vollenweider,P.,
            Waterworth,D.M., Mooser,V., Palmer,C.N., Morris,A.D.,
            Ouwehand,W.H., Zhao,J.H., Li,S., Loos,R.J., Barroso,I.,
            Deloukas,P., Sandhu,M.S., Wheeler,E., Soranzo,N., Inouye,M.,
            Wareham,N.J., Caulfield,M., Munroe,P.B., Hattersley,A.T.,
            McCarthy,M.I. and Frayling,T.M.
  CONSRTM   Diabetes Genetics Initiative; Wellcome Trust Case Control
            Consortium; Cambridge GEM Consortium
  TITLE     Genome-wide association analysis identifies 20 loci that influence
            adult height
  JOURNAL   Nat Genet 40 (5), 575-583 (2008)
   PUBMED   18391952
REFERENCE   5  (bases 1 to 3579)
  AUTHORS   Luo,L., Yang,X., Takihara,Y., Knoetgen,H. and Kessel,M.
  TITLE     The cell-cycle regulator geminin inhibits Hox function through
            direct and polycomb-mediated interactions
  JOURNAL   Nature 427 (6976), 749-753 (2004)
   PUBMED   14973489
REFERENCE   6  (bases 1 to 3579)
  AUTHORS   Levine,S.S., Weiss,A., Erdjument-Bromage,H., Shao,Z., Tempst,P. and
            Kingston,R.E.
  TITLE     The core of the polycomb repressive complex is compositionally and
            functionally conserved in flies and humans
  JOURNAL   Mol Cell Biol 22 (17), 6070-6078 (2002)
   PUBMED   12167701
REFERENCE   7  (bases 1 to 3579)
  AUTHORS   Tomotsune,D., Takihara,Y., Berger,J., Duhl,D., Joo,S., Kyba,M.,
            Shirai,M., Ohta,H., Matsuda,Y., Honda,B.M., Simon,J., Shimada,K.,
            Brock,H.W. and Randazzo,F.
  TITLE     A novel member of murine Polycomb-group proteins, Sex comb on
            midleg homolog protein, is highly conserved, and interacts with
            RAE28/mph1 in vitro
  JOURNAL   Differentiation 65 (4), 229-239 (1999)
   PUBMED   10653359
REFERENCE   8  (bases 1 to 3579)
  AUTHORS   Berger,J., Kurahashi,H., Takihara,Y., Shimada,K., Brock,H.W. and
            Randazzo,F.
  TITLE     The human homolog of Sex comb on midleg (SCMH1) maps to chromosome
            1p34
  JOURNAL   Gene 237 (1), 185-191 (1999)
   PUBMED   10524249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606484.9, AL110502.1 and AL391730.13.
            
            On Apr 10, 2021 this sequence version replaced XM_006710464.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853566.834.1,
                                           SRR18074969.1010194.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-248               AL606484.9         77285-77532         c
            249-378             AL606484.9         21347-21476         c
            379-447             AL110502.1         5343-5411
            448-471             AL110502.1         5877-5900
            472-680             AL110502.1         6842-7050
            681-751             AL110502.1         15091-15161
            752-986             AL110502.1         23663-23897
            987-1075            AL110502.1         49765-49853
            1076-1319           AL110502.1         53249-53492
            1320-1552           AL110502.1         91324-91556
            1553-1679           AL110502.1         96054-96180
            1680-1880           AL110502.1         117885-118085
            1881-2072           AL110502.1         120177-120368
            2073-2252           AL110502.1         129234-129413
            2253-2318           AL110502.1         132727-132792
            2319-2461           AL391730.13        95151-95293         c
            2462-3579           AL391730.13        93769-94886         c
FEATURES             Location/Qualifiers
     source          1..3579
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.2"
     gene            1..3579
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /note="Scm polycomb group protein homolog 1"
                     /db_xref="GeneID:22955"
                     /db_xref="HGNC:HGNC:19003"
                     /db_xref="MIM:616396"
     exon            1..248
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            249..378
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            379..447
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            448..471
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            472..680
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            681..751
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            752..986
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /inference="alignment:Splign:2.1.0"
     CDS             788..2587
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /note="isoform e is encoded by transcript variant 15;
                     polycomb protein SCMH1; sex comb on midleg homolog 1"
                     /codon_start=1
                     /product="polycomb protein SCMH1 isoform e"
                     /protein_id="NP_001381232.1"
                     /db_xref="CCDS:CCDS53302.1"
                     /db_xref="GeneID:22955"
                     /db_xref="HGNC:HGNC:19003"
                     /db_xref="MIM:616396"
                     /translation="MKLEAQDPRNTTSTCIATVVGLTGARLRLRLDGSDNKNDFWRLV
                     DSAEIQPIGNCEKNGGMLQPPLGFRLNASSWPMFLLKTLNGAEMAPIRIFHKEPPSPS
                     HNFFKMGMKLEAVDRKNPHFICPATIGEVRGSEVLVTFDGWRGAFDYWCRFDSRDIFP
                     VGWCSLTGDNLQPPGTKVVIPKNPYPASDVNTEKPSIHSSTKTVLEHQPGQRGRKPGK
                     KRGRTPKTLISHPISAPSKTAEPLKFPKKRGPKPGSKRKPRTLLNPPPASPTTSTPEP
                     DTSTVPQDAATIPSSAMQAPTVCIYLNKNGSTGPHLDKKKVQQLPDHFGPARASVVLQ
                     QAVQACIDCAYHQKTVFSFLKQGHGGEVISAVFDREQHTLNLPAVNSITYVLRFLEKL
                     CHNLRSDNLFGNQPFTQTHLSLTAIEYSHSHDRYLPGETFVLGNSLARSLEPHSDSMD
                     SASNPTNLVSTSQRHRPLLSSCGLPPSTASAVRRLCSRGVLKGSNERRDMESFWKLNR
                     SPGSDRYLESRDASRLSGRDPSSWTVEDVMQFVREADPQLGPHADLFRKHEIDGKALL
                     LLRSDMMMKYMGLKLGPALKLSYHIDRLKQGKF"
     exon            987..1075
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1319
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1552
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1679
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1880
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2072
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2252
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2318
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..2461
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            2462..3579
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3560..3565
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /note="hexamer: AATAAA"
     polyA_site      3579
                     /gene="SCMH1"
                     /gene_synonym="Scml3"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgagccc aacggccgag gcgcgcgcca cctcgcagcg ggaggcgcgg gggaggggcc
       61 gggggagccc ccgccccgcc ccccgcctca gccgccaccg ccagctcggt ggagcccccc
      121 gccgcccgcc cgccgctctc ccgagccgcc cgcccgcccc cttcccgcgt ctccgctccc
      181 tccctgcgca gcggaaacat ggcggcggga agagagtgag ccgccccgcg cccccgccgc
      241 gccctcagat ggagaaatta gcatacaaag aaactgactt gtcagaagtc agagcaaggt
      301 attggtggat ccagggataa atcccaaact tcttaacccc tagaccggtt tttagtccat
      361 tgactatgca gcctaatgtg atagactgga gtgatgttag aaaacacaaa tatggtcacc
      421 tatcagagtc tgcatcccaa tatcaagaag ctgctgacat cctggatcta gggttgtaaa
      481 gaagattaca tgagctaatg gatgtgaaaa catcttaaaa actctcaaat acttttcaac
      541 tttggaggat tattatgatt ttcattctgt tcagcggcta tactcagact ttactctaaa
      601 agtcaaatct tctgacattc tttgaagtga agcattctat gaatgtgagc tgaagaaatg
      661 aatgaaatga aataatgcag gtcattttac ctgggacaaa tacctaaaag aaacatgttc
      721 agtcccagcg cctgtccatt gcttcaagca gtcctacaca cctccaagca acgagttcaa
      781 gatcagtatg aaattggaag cacaggaccc caggaacacc acatccacct gtattgccac
      841 agtagttgga ctgacaggtg cccgccttcg cctgcgcctt gatgggagcg acaacaaaaa
      901 tgacttctgg cggctggttg actcagctga aatccagcct attgggaact gtgaaaagaa
      961 tgggggtatg ctacagccac ctcttggatt tcggctgaat gcgtcttctt ggcccatgtt
     1021 ccttttgaag acgctaaatg gagcagagat ggctcccatc aggattttcc acaaggagcc
     1081 accatcgcct tcccacaact tcttcaaaat gggaatgaag ctagaagctg tggacaggaa
     1141 gaaccctcat ttcatttgcc cagccactat tggggaggtt cggggctcag aggtgcttgt
     1201 cacttttgat gggtggcgag gggcctttga ctactggtgc cgcttcgact cccgagacat
     1261 cttccctgtg ggctggtgtt ccttgactgg agacaacctg cagcctcctg gcaccaaagt
     1321 tgtgattcca aagaatccct atcctgcctc cgatgtgaat actgagaagc ccagcatcca
     1381 cagcagcacc aaaactgtct tggaacatca accagggcag agggggcgta aaccaggaaa
     1441 gaagcggggc cggacaccca agaccctaat ttcccatccc atctctgccc catccaagac
     1501 agctgaacct ttgaaattcc caaagaagag aggtcccaaa cctggcagca agaggaaacc
     1561 tcggactttg ctgaacccac cacctgcctc accaacaacc agcactcctg aaccggatac
     1621 cagcactgta ccccaggatg ctgccaccat ccccagctca gccatgcagg ccccaacagt
     1681 ttgtatctac ttgaacaaga atggcagcac aggcccccac ttagataaga agaaggtcca
     1741 gcaactccct gaccattttg gaccagcccg tgcctctgtg gtgttgcagc aggctgtcca
     1801 ggcctgtatc gactgtgctt atcaccagaa aaccgtcttc agcttcctca agcaaggcca
     1861 tggtggtgag gttatctcag ccgtgtttga ccgggaacag cataccctca acctcccagc
     1921 agtcaacagc atcacctacg tcctccgctt cctggagaaa ctctgccaca accttcgtag
     1981 tgacaatctg tttggcaacc agccctttac acagactcac ttgtcactca ctgccataga
     2041 gtacagccac agccacgaca ggtacctacc aggtgaaacc tttgtcctgg ggaatagtct
     2101 ggcccgctcc ttggaaccac actcagactc aatggactct gcctcaaatc ccaccaacct
     2161 tgtcagcacc tcccaaaggc accggccctt gctttcatcc tgtggcctcc caccaagcac
     2221 tgcctcagct gtgcgcaggc tatgctccag gggagtgtta aaaggatcaa atgaaagaag
     2281 ggatatggaa tcattttgga aactaaatcg ttccccaggg tcggaccgat acctggagag
     2341 ccgcgatgcc tctcgactga gtggccggga cccctcctca tggacagtcg aggatgtgat
     2401 gcagtttgtc cgggaagctg atcctcagct tggaccccac gctgacctgt ttcgcaaaca
     2461 cgagatcgat ggcaaggccc tgctgctgct gcgcagtgac atgatgatga agtacatggg
     2521 cctgaagctg gggcctgcac tcaagctctc ctaccacatt gaccggctga agcagggcaa
     2581 gttctgaacc aggagaggca gcctagacaa ccaagtggca gcaggtgggg gcattcttct
     2641 aggaatgagg ggcatcagcc caccccaggc acctcagtgg ggttccgggc cacctcagga
     2701 ctccaagagg ctgtgtggag ccaccactcc tagccacagc tgccatgata agtccttcca
     2761 tgaaggactg aggagggaga gtgggggtcc agggctggtg ctgctcttcc ctcagctctg
     2821 ccggggctct aaggtccctc tatttatttc tcaaccctgg ctggcctctc accaggagtt
     2881 taggctgaat gccttccacg tgatggagga aaaggccaac tctgtcctgg tcttgctgtg
     2941 gcaccccatc gccccacagc tcgtaccttc tcaccagatt cccctgaatc caaactcgtg
     3001 gtgcaaacct ctaccttttt tacaaaaaga tcttattgtt aatttattgt ttctggcact
     3061 tgggcaaacc ctgtagttaa tactcctccc acactagaca ctgggtttca ggaggaggga
     3121 gactgccctg ctttggtccc agagaggccc tctgcagata ggcgtggccc ctcttcagag
     3181 gacactaccc tagggcactt tctctttgag gtggagagac ccataaagcc ttgaccacat
     3241 cactccatat ggggaggaga aggatccctg tcaccttctc ctctcttcac ggggcccttt
     3301 tgcagcccta ggcctcatct gtgggaaggg agtccctggc ttatactgcc cccaccacag
     3361 ctccttgccc tggccagaac tgctgtcgaa gaaaatcagg ccggaaggcc aagaaggcgc
     3421 taagggggat gggagggcag gttttccagg ctggagtcgg ttccacccac tcgcctgtcc
     3481 acaggcttcc ttgtaagcaa gtcagcagca cagctactca cgctgccatc tggacttatt
     3541 ttatgtcaat ctgtttataa ataaaaacca atatagata
//
