LOCUS       NM_001112706            9682 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens scinderin (SCIN), transcript variant 1, mRNA.
ACCESSION   NM_001112706
VERSION     NM_001112706.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9682)
  AUTHORS   Li,Y., Tang,L., Dang,G., Ma,M. and Tang,X.
  TITLE     Scinderin Promotes Hydrogen Peroxide-induced Lens Epithelial Cell
            Injury in Age-related Cataract
  JOURNAL   Curr Mol Med 24 (11), 1426-1436 (2024)
   PUBMED   37936437
  REMARK    GeneRIF: Scinderin Promotes Hydrogen Peroxide-induced Lens
            Epithelial Cell Injury in Age-related Cataract.
REFERENCE   2  (bases 1 to 9682)
  AUTHORS   Perez-Castro,L., Venkateswaran,N., Garcia,R., Hao,Y.H.,
            Lafita-Navarro,M.C., Kim,J., Segal,D., Saponzik,E., Chang,B.J.,
            Fiolka,R., Danuser,G., Xu,L., Brabletz,T. and Conacci-Sorrell,M.
  TITLE     The AHR target gene scinderin activates the WNT pathway by
            facilitating the nuclear translocation of beta-catenin
  JOURNAL   J Cell Sci 135 (20) (2022)
   PUBMED   36148682
  REMARK    GeneRIF: The AHR target gene scinderin activates the WNT pathway by
            facilitating the nuclear translocation of beta-catenin.
REFERENCE   3  (bases 1 to 9682)
  AUTHORS   Qin,Y., Huttlin,E.L., Winsnes,C.F., Gosztyla,M.L., Wacheul,L.,
            Kelly,M.R., Blue,S.M., Zheng,F., Chen,M., Schaffer,L.V., Licon,K.,
            Backstrom,A., Vaites,L.P., Lee,J.J., Ouyang,W., Liu,S.N., Zhang,T.,
            Silva,E., Park,J., Pitea,A., Kreisberg,J.F., Gygi,S.P., Ma,J.,
            Harper,J.W., Yeo,G.W., Lafontaine,D.L.J., Lundberg,E. and Ideker,T.
  TITLE     A multi-scale map of cell structure fusing protein images and
            interactions
  JOURNAL   Nature 600 (7889), 536-542 (2021)
   PUBMED   34819669
REFERENCE   4  (bases 1 to 9682)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 9682)
  AUTHORS   Zhang,Z.H., Lian,X.Y., Li,X.X., He,P.F., Lin,J. and Qian,J.
  TITLE     [Clinical Study of SCIN Expression and Dromoter Methylation in
            Patients with Chronic Myeloid Leukemia]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 27 (3), 646-651 (2019)
   PUBMED   31204912
  REMARK    GeneRIF: down-regulation of SCIN expression may relate with the
            progression of chronic myeloid leukemia
REFERENCE   6  (bases 1 to 9682)
  AUTHORS   Lejen,T., Pene,T.D., Rose,S.D. and Trifaro,J.M.
  TITLE     The role of different Scinderin domains in the control of F-actin
            cytoskeleton during exocytosis
  JOURNAL   Ann N Y Acad Sci 971, 248-250 (2002)
   PUBMED   12438125
REFERENCE   7  (bases 1 to 9682)
  AUTHORS   Zunino,R., Li,Q., Rose,S.D., Romero-Benitez,M.M., Lejen,T.,
            Brandan,N.C. and Trifaro,J.M.
  TITLE     Expression of scinderin in megakaryoblastic leukemia cells induces
            differentiation, maturation, and apoptosis with release of
            plateletlike particles and inhibits proliferation and tumorigenesis
  JOURNAL   Blood 98 (7), 2210-2219 (2001)
   PUBMED   11568009
REFERENCE   8  (bases 1 to 9682)
  AUTHORS   Lueck,A., Brown,D. and Kwiatkowski,D.J.
  TITLE     The actin-binding proteins adseverin and gelsolin are both highly
            expressed but differentially localized in kidney and intestine
  JOURNAL   J Cell Sci 111 (Pt 24), 3633-3643 (1998)
   PUBMED   9819354
REFERENCE   9  (bases 1 to 9682)
  AUTHORS   Rodriguez Del Castillo,A., Vitale,M.L. and Trifaro,J.M.
  TITLE     Ca2+ and pH determine the interaction of chromaffin cell scinderin
            with phosphatidylserine and phosphatidylinositol 4,5,-biphosphate
            and its cellular distribution during nicotinic-receptor stimulation
            and protein kinase C activation
  JOURNAL   J Cell Biol 119 (4), 797-810 (1992)
   PUBMED   1331119
REFERENCE   10 (bases 1 to 9682)
  AUTHORS   Rodriguez Del Castillo,A., Vitale,M.L., Tchakarov,L. and
            Trifaro,J.M.
  TITLE     Human platelets contain scinderin, a Ca(2+)-dependent actin
            filament-severing protein
  JOURNAL   Thromb Haemost 67 (2), 248-251 (1992)
   PUBMED   1621245
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK290363.1, BC021090.1, CA447429.1 and AC011891.3.
            
            On Nov 23, 2018 this sequence version replaced NM_001112706.2.
            
            Summary: SCIN is a Ca(2+)-dependent actin-severing and -capping
            protein (Zunino et al., 2001 [PubMed 11568009]).[supplied by OMIM,
            May 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.93047.1,
                                           SRR1660807.32051.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297029.10/ ENSP00000297029.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2347              AK290363.1         37-2383
            2348-2620           BC021090.1         2330-2602
            2621-3103           CA447429.1         16-498              c
            3104-9682           AC011891.3         7462-14040
FEATURES             Location/Qualifiers
     source          1..9682
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p21.3"
     gene            1..9682
                     /gene="SCIN"
                     /note="scinderin"
                     /db_xref="GeneID:85477"
                     /db_xref="HGNC:HGNC:21695"
                     /db_xref="MIM:613416"
     exon            1..266
                     /gene="SCIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..2215
                     /gene="SCIN"
                     /note="isoform 1 is encoded by transcript variant 1;
                     adseverin"
                     /codon_start=1
                     /product="scinderin isoform 1"
                     /protein_id="NP_001106177.1"
                     /db_xref="CCDS:CCDS47545.1"
                     /db_xref="GeneID:85477"
                     /db_xref="HGNC:HGNC:21695"
                     /db_xref="MIM:613416"
                     /translation="MARELYHEEFARAGKQAGLQVWRIEKLELVPVPQSAHGDFYVGD
                     AYLVLHTAKTSRGFTYHLHFWLGKECSQDESTAAAIFTVQMDDYLGGKPVQNRELQGY
                     ESNDFVSYFKGGLKYKAGGVASGLNHVLTNDLTAKRLLHVKGRRVVRATEVPLSWDSF
                     NKGDCFIIDLGTEIYQWCGSSCNKYERLKANQVATGIRYNERKGRSELIVVEEGSEPS
                     ELIKVLGEKPELPDGGDDDDIIADISNRKMAKLYMVSDASGSMRVTVVAEENPFSMAM
                     LLSEECFILDHGAAKQIFVWKGKDANPQERKAAMKTAEEFLQQMNYSKNTQIQVLPEG
                     GETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQIKQIPFDASKLHSSPQMAAQHNMVD
                     DGSGKVEIWRVENNGRIQVDQNSYGEFYGGDCYIILYTYPRGQIIYTWQGANATRDEL
                     TTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPLIIYKNGTSKKGGQAPAP
                     PTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKLPQNSGYIWVGKGASQEEEKGA
                     EYVASVLKCKTLRIQEGEEPEEFWNSLGGKKDYQTSPLLETQAEDHPPRLYGCSNKTG
                     RFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVEKKESLKSAKMYLETDP
                     SGRDKRTPIVIIKQGHEPPTFTGWFLGWDSSKW"
     exon            267..421
                     /gene="SCIN"
                     /inference="alignment:Splign:2.1.0"
     exon            422..583
                     /gene="SCIN"
                     /inference="alignment:Splign:2.1.0"
     exon            584..733
                     /gene="SCIN"
                     /inference="alignment:Splign:2.1.0"
     exon            734..826
                     /gene="SCIN"
                     /inference="alignment:Splign:2.1.0"
     exon            827..959
                     /gene="SCIN"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1048
                     /gene="SCIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1264
                     /gene="SCIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1386
                     /gene="SCIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1477
                     /gene="SCIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1648
                     /gene="SCIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1826
                     /gene="SCIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1948
                     /gene="SCIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2026
                     /gene="SCIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2087
                     /gene="SCIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..9682
                     /gene="SCIN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3082..3087
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCIN"
                     /note="hexamer: ATTAAA"
     polyA_site      3103
                     /gene="SCIN"
                     /note="major polyA site"
     regulatory      7492..7497
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCIN"
                     /note="hexamer: AATAAA"
     polyA_site      7517
                     /gene="SCIN"
     regulatory      9656..9661
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCIN"
                     /note="hexamer: AATAAA"
     polyA_site      9682
                     /gene="SCIN"
ORIGIN      
        1 tgctgctctc ggtttagtcc aagatcagcg atatcacgcg tcccccggag catcgcgtgc
       61 aggagccatg gcgcgggagc tataccacga agagttcgcc cgggcgggca agcaggcggg
      121 gctgcaggtc tggaggattg agaagctgga gctggtgccc gtgccccaga gcgctcacgg
      181 cgacttctac gtcggggatg cctacctggt gctgcacacg gccaagacga gccgaggctt
      241 cacctaccac ctgcacttct ggctcggaaa ggagtgttcc caggatgaaa gcacagctgc
      301 tgccatcttc actgttcaga tggatgacta tttgggtggc aagccagtgc agaatagaga
      361 acttcaagga tatgagtcta atgactttgt tagctatttc aaaggcggtc tgaaatacaa
      421 ggctggaggc gtggcatctg gattaaatca tgttcttacg aacgacctga cagccaagag
      481 gctcctacat gtgaagggtc gtagagtggt gagagccaca gaagttcccc ttagctggga
      541 cagtttcaac aagggtgact gcttcatcat tgaccttggc accgaaattt atcagtggtg
      601 tggttcctcg tgcaacaaat atgaacgtct gaaggcaaac caggtagcta ctggcattcg
      661 gtacaatgaa aggaaaggaa ggtctgaact aattgtcgtg gaagaaggaa gtgaaccctc
      721 agaacttata aaggtcttag gggaaaagcc agagcttcca gatggaggtg atgatgatga
      781 cattatagca gacataagta acaggaaaat ggctaaacta tacatggttt cagatgcaag
      841 tggctccatg agagtgactg tggtggcaga agaaaacccc ttctcaatgg caatgctgct
      901 gtctgaagaa tgctttattt tggaccacgg ggctgccaaa caaattttcg tatggaaagg
      961 taaagatgct aatccccaag agaggaaggc tgcaatgaag acagctgaag aatttctaca
     1021 gcaaatgaat tattccaaga atacccaaat tcaagttctt ccagaaggag gtgaaacacc
     1081 aatcttcaaa cagtttttta aggactggag agataaagat cagagtgatg gcttcgggaa
     1141 agtttatgtc acagagaaag tggctcaaat aaaacaaatt ccctttgatg cctcaaaatt
     1201 acacagttct ccgcagatgg cagcccagca caatatggtg gatgatggtt ctggcaaagt
     1261 ggagatttgg cgtgtagaaa acaatggtag gatccaagtt gaccaaaact catatggtga
     1321 attctatggt ggtgactgct acatcatact ctacacctat cccagaggac agattatcta
     1381 cacgtggcaa ggagcaaatg ccacacgaga tgagctgaca acatctgcgt tcctgactgt
     1441 tcagttggat cggtcccttg gaggacaggc tgtgcagatc cgagtctccc aaggcaaaga
     1501 gcctgttcac ctactgagtt tgttcaaaga caaaccgctc attatttaca agaatggaac
     1561 atcaaagaaa ggaggtcagg cacctgctcc ccctacacgc ctctttcaag tccggagaaa
     1621 cctggcatct atcaccagaa ttgtggaggt tgatgttgat gcaaattcac tgaattctaa
     1681 cgatgttttt gtcctgaaac tgccacaaaa tagtggctac atctgggtag gaaaaggtgc
     1741 tagccaggag gaggagaaag gagcagagta tgtagcaagt gtcctaaagt gcaaaacctt
     1801 aaggatccaa gaaggcgagg agccagagga gttctggaat tcccttggag ggaaaaaaga
     1861 ctaccagacc tcaccactac tggaaaccca ggctgaagac catccacctc ggctttacgg
     1921 ctgctctaac aaaactggaa gatttgttat tgaagagatt ccaggagagt tcacccagga
     1981 tgatttagct gaagatgatg tcatgttact agatgcttgg gaacagatat ttatttggat
     2041 tggcaaagat gctaatgaag ttgagaaaaa agaatctctg aagtctgcca aaatgtacct
     2101 tgagacagac ccttctggaa gagacaagag gacaccaatt gtcatcataa aacagggcca
     2161 tgagccaccc acattcacag gctggttcct gggctgggat tccagcaagt ggtaaattgg
     2221 tatttgtaaa aagcaaacaa acattacaag gcagttatct cattgctgtt ttgggagagg
     2281 aacgggaaaa gctttttgct tatttgtctt ttgaaaatta aggctgggcg cggtggctca
     2341 cacctgtaat cccagcactt tgagaggatg aggtaggcgg atcactgggg tcaggatttc
     2401 gagaccagcc tggccaacat ggcgaaacct cgcctctact aaaaatacaa aaaaattagc
     2461 tgcgcgtggt ggtgcacgcc tgtagtccct gctacttgga aggctgagac aggaaaattg
     2521 cttgaaccca ggaggctgag gttgcagtga gccaggattg cgccaccaca ctccagcctg
     2581 ggcaacagag actctgtctc aaaaaaaaaa aaaaaaaaaa ttaacctcaa ccaaacgcct
     2641 attttttaat gcttagtttt ggcttgaaat tcttcttcac ctggagtttt cttacgttaa
     2701 tacattaaaa taacctgaag gaaactttcg ttatgggcca atattagctc ttatggaaac
     2761 tgatttatat cttttttatg acctttcaaa agtaaaatac tatgcataat ctagaaagat
     2821 ttgtcagata ggaaatttta taatgcatta gccattagtc agagttgttt tttaacatgc
     2881 cagagaaaaa gttgtaatgc cttggaagtt attctctttt ctatagattg tgttcaaaag
     2941 atgtgtatac ttgcaataag gtttatgtta aggtggcttt aacaattggt tgctattttc
     3001 cttctttagt caatatgact ttgatgtcat taactgctaa gtgttatttt ctaagaggaa
     3061 ttttatcttt tttttaacct tattaaaagc ctttgaaaac acagctcttt catgacaaaa
     3121 tgaattgtat tgttatccac ttagatacat gtacatgtac agtacatgtt taatatcaca
     3181 ggagatcaaa aagacaatgc acaggggagt atcccaggga gcagagccaa gttcaagtaa
     3241 gttaacgata tcaagttact tactggcagg tagccactag agaatcttag caatttttgt
     3301 cctgcaagat ttcagcaaag ctacagaaaa gtgagttttt atgttttcca ttcttccctt
     3361 ttctaagtaa taatttttat cgcagttacc ctgattctat tccattccat tctattctat
     3421 tctattattt cattctattt tatttccaat ataccattgt atatcagtat atactgatac
     3481 actgagtggc agttgcatta tctactaatc tatataggtc attgaaaaag aagaagctac
     3541 gttagaaccc atggaaagaa ctttgcctca tgtagagatt ctagattctt agccaaaagc
     3601 tcagaattgt tgggccctaa aggatgaaca atgtagggtc caacaattca tcccacatga
     3661 atttttctca tccttcatgt ggaatgaaaa aactaaagag acaactgact taccacacaa
     3721 atggactatg gtagaagctg ctgtccctta gtattgaata tctctatttt cttttaatca
     3781 tagaattcac tgatatttta gcagataatg tggccgtcca ggcaggcatg agatttctca
     3841 gccttacttc aacttgatta tgaccatgtg acccaattct gacatttgcc taaaggaaaa
     3901 tttacctaaa aaggcgtttt cttgctatgg cagtgtaacc tgtactaata aatatagtgc
     3961 tagtcctgca tgcaacaaaa atgatgtaag tagacattta acatttctag gaatgtaatt
     4021 gagtgaaaaa taatttttaa aaatatttat aaatatcttc tgggtcaagc tgaatatttt
     4081 ttgaaggatg atgagaataa aatgatttaa taagtagtac tttttcacaa aattagtaaa
     4141 ggtcaaggtg agtggcttag ggtacactgt attttacgat gtttctctag tttagccagt
     4201 ggtttttctc atctccaatt tatagcacag gccgaggcat atagtagggt ctcagttaat
     4261 atttattgaa tggcaatatc aaaaatgaga tcagcagcaa gatgataagg cagaataaaa
     4321 gttgctgaga gcctaaaatg attattcagt tctgttgcag ggttttaacc tgcccaaagg
     4381 atggaaaaag aagaacataa gcataatttc tgaatgcatc acggcaaaga tgcatgtact
     4441 catgaagcat aaaattaaaa atatgataca ttcactacat gaaaatatga tatacggttt
     4501 ttcttcagta tccgcgggag attggctcga ggaaccccat ggataccaac atccttgaat
     4561 gctcaagtcc cttatataaa acggcatagt atttgcataa aacctatacc attctcctgt
     4621 atactctaag tcatctctgc gttacttata atacctaata cagtgtaaac gctgtgtaaa
     4681 cagttgttat actatattgg ttttttaatt tgcattactt ttgtattgtt gtattatttt
     4741 attgtttttc cccaaatagt tttgatccgc agatgtagaa cccacagata tgataaatca
     4801 actgtatcta gtacccaaaa cagatgagta acttagaaat taatatgtaa tacatacagc
     4861 taatgttata gctacttaag gaattccttt cactgaaaag aaactcttac aaatcaatga
     4921 gtcaacaacc caatggaaaa atggccaaaa gacatgaata gaagttcaca gaaaagaatg
     4981 aaaatgacca gtaaataatg aaaagatgtt ctaagacact cttaattaaa taaattcaca
     5041 ataaaataat catactttta tctatctacc agattagcaa atgttaaaat attaaaatgt
     5101 tagtggtcat caaaatgtag ggttacaggt tcacccatac actgttaata gatgtataaa
     5161 ctggtcaaaa ctttttgatc catagcacag tattactttt gtaaacatac acaaaaaata
     5221 ttatatattt gccaaacgta tgtactaatc taaaaccaaa cacattagac taggtacatg
     5281 tggagaaaga gatacaggtg ttccctagca agttaatatg cttgtgtctc ttcaaaccaa
     5341 tatattggca tatttatcta atatttaatc agaagaaaga aagaacagaa agacccagga
     5401 agcctactgt tagtagaggt cagcctcatc ttttctctct gattcaagaa attcatactc
     5461 aactcagtca aacagaggtc ctgcatttac ctcttggtgc cggagagcct tggtgagcca
     5521 tttagatcct ctgtatcttc tcaagcacaa tcctcagtgt tctcttctcg tcttagatag
     5581 ctcatcaaat aatatttccc accacttatt tctagcagtt ctggtaaaga gaatggcctt
     5641 cacattgtat tttgaacaat gttttggcct ccagtaatga ttaggaacac actataaaca
     5701 taaaacatca gtccacttaa ctcattattc agtcatcaag caattcttgt cccaatcatt
     5761 ctccaaagct atatactgtg aatttatact gttgtgtagt gacacaagcc cttctgctga
     5821 aaaagtaggt agataattac tttgaactga aagaaaacac ttattttatt ttcttttaaa
     5881 cctaatttat tttaaaccta atttatttat tttaaaccta atttatttta aacctaattt
     5941 atttatttta aacatttatt ttaaacctaa ttcatttgaa ctgaacttga atttaaaagc
     6001 ctacaaatgc cccgcatatg tagaattatc attcattccg tgttcttgct cttggataaa
     6061 acggacaact cagagaaaaa actggcttat aaatgcactt cacaaaaact gttagaaaag
     6121 tagccattaa acctgtaaaa aggccgggcg cagtggctga cgcctgtaat cccagcactt
     6181 tgaaaggcca aggcggttgg atcacgaggc caggagtccg agaccagcct gaccaacata
     6241 gtgaaacccc gtctctacta aaaatacaaa aaattagctg ggcgtagtgg cgggcgcctg
     6301 taatcctagc tactcgggag gctgaggcag gagaatcgct tgaacccggg aggcggaggt
     6361 tggagcgaaa gtacgcgcca ctgtactcca gcctgcgtga cgatgagagt ctccgtctcg
     6421 ggggaagaaa aaaaaaacct gtaaaaagtg gctcaacttt aatattcatt aggaaatgac
     6481 taaaatcaaa tattttactt ggtaatgcca agtaaaaata caggagagga tatagtgaaa
     6541 ctggagctta catccactac ttgggaagta taaattgata caatgggttt gaacagtttt
     6601 tgtattttct actaaaatga acatacacat atcctataat ccagaaatcc cactccatgg
     6661 tgtgtaccca acaaaaatgc atacatgtgt gtactaaagg atataatatg attttttttt
     6721 tttttttttt ttttttgaga taggttctca ctctgttgcc caggctggag tacagtagcg
     6781 atctctgctc actgcaatct ctgcctcctg ggttcaagca atcctcccac ctcagtctcc
     6841 ccaggagctg ggactctagg tgcgtgccac cacgcccagc taattctttg tagagatggg
     6901 gttttgccat gttgtccagg ctggtcttga actcctagac tcaggaaatc cacctgcctt
     6961 ggcctcccaa tatgctggga ttacaggcat gagccaccgc atctggacac gaatttttaa
     7021 gttttatata tgtgtgtgta tatatatata tatatatata tatatatata tatttttttt
     7081 tttttttttt ttttttttgc attggcaaaa aaacaaagat attgtttagc aatttccttg
     7141 tataatgcaa tcagtggaag acaaatcaga ggtattattt tcccttgggc ctttgcagcc
     7201 tgtgttgttt ttctcttttt catattgatg tgaaaagcag ccaagtatta tttgacaaca
     7261 tcagtccctt attaagatgt tatttctagt ttataattga ctatggcatt tgcatgcatt
     7321 tcatcatgtc tccatttctt cggaatgata atttctaata tacttttctt ctattatagg
     7381 aataagaatt cagtagtcat atttcctgtt gcctataaaa aattgatgct ttaatttagt
     7441 taacatgaca aactccatct tatttagaga gattattttt gatgttatta taataaaaat
     7501 gacaccttta ctaaaaatgt ctcatcataa attgttttcc attatttctg tgctgattgc
     7561 aaacaatact gaattaaaat atccctgcaa gttcactgtg actcaatcta aggttttaat
     7621 aattcatgaa ataaaactaa tgttgatgtt atccaaatca ttctaacgcc aacttctagg
     7681 taaacagtaa acaagaataa gcaaatttga gttttcctaa ttatttgaca ttgtcattag
     7741 cttgtgatcc ttagatggaa tatattttgc cagatctcac ctcccaggga actgatgagc
     7801 tttaactgga atagtagtga gaatgataga gcagggccct taactcctta gaaaggtcaa
     7861 aggaagaggt gaatgtgggc agggtttcac tggagtattg acacaccaaa gatgctatgt
     7921 aggtgaaaat ctctcctaat gcattccctt tccaacgaac ctgagcctgg attcttcagt
     7981 aacacaatgc cttctgagaa acaatgttgt tccacatttt agagttttgg catgcataat
     8041 ggagtttatg gcagagttca gaggatacaa tgaaacaaga aagggaggca actgatgttg
     8101 tttgattatc tccattattt tgaaggagcc aggtgcttgg ggaacctggt tgtacagaaa
     8161 ggtgatgcca agactctctt gtatgatttt cctctctagc ttggggctgc accctctgct
     8221 gtgggaagga gtcctcaagg tattaatata catcctatca tttattttag atacagatag
     8281 cattagagtt tatcagtaaa gttgggcaac tcatggaata ttacgagtag aaattgtaat
     8341 tactgtagaa tgtatagtgt tttgaatggc tattgtattt ttcagcatac aaattcagag
     8401 gggtgaaagt aggcaatgac accactattt atgttttttg ttgttgttgt ttgtttttgt
     8461 tttgttttgt tttgagatgg agtcttgcac tgtcacccag gctggaggac agtggcatga
     8521 tctctgctca ctgcaacctc tgcctcccgt gttcaagcga ttctcctgcc tcagcctcct
     8581 gagtagctgg gattacaggc acccgccacc acacctgact aattttttgt atttttaagt
     8641 agagacggag ttttgccatg ttggccaggc tggtcttgaa ctcctgaact tgtgatccac
     8701 cctcctctgc cttccaaagt gctgggatta caggcatgag ccaccgcacc cagccctatt
     8761 tatgtttttt aaaagcacca tttaccaccc atttgtctat ggacttaatc tatgtctcta
     8821 tgagctggta aacaatagac aggtaaatac agacttggct gtatttgaac agcaccttca
     8881 aaaaccagaa gccagaaatc aggtagctag atttgtccat gaaagcagga gattccctta
     8941 actggtgatg cctgaagttg ggataaagag tcttccaaac atgtgccatt ttggcatgga
     9001 tatctaaagc caccatgatg gctttatatt aatgaaggaa ataagttgca ggataagtat
     9061 atccatggtc atccagggga agaaaatggc gtacataact tatataccat atttaaccca
     9121 gagacagata tcacaggtaa acagtgcaaa tcactgtccc tagtctgagc catatttagt
     9181 gtcttgaaag agccacagtg gctggctaaa atggcacagt ggcaaatcct gaccatggac
     9241 tgccctatgc aaaataacta gctccccact ttacacagag tacaccatgt caggcctctg
     9301 agcccaagct aagccatcat atcccctgtg acctgcacat atacatccag atggcctgaa
     9361 gcaattgaag atctacaaaa gaagtgaaaa ttaccttaac tgatgacatt ccaccattgt
     9421 gatgtgtttc tgccccatcc taactgatca gtgtactttg taatctcccc cacccttaag
     9481 aaggttcttt gtaattcttc ccacccttga gaatgtactt tgtgagatcc accccctgcc
     9541 agcaaaacat tgctcctgac tccaccgcct atcccaaaac ctataagaac taatgataat
     9601 cccaccaccc tttgctgact ctcttttcgg actcagcccg cctgcaccca ggtgaaataa
     9661 acagccttgt tgctaaccca aa
//
