LOCUS       NM_207103               2424 bp    mRNA    linear   PRI 29-JUL-2024
DEFINITION  Homo sapiens SLP adaptor and CSK interacting membrane protein
            (SCIMP), transcript variant 1, mRNA.
ACCESSION   NM_207103 XM_371007
VERSION     NM_207103.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2424)
  AUTHORS   Sun,X., Tian,A., Li,P., Zhao,J., Hou,X., Ma,X. and Yuan,X.
  TITLE     SCIMP: A Novel Targeted Gene for Postmenopausal Osteoporosis
            Progression
  JOURNAL   Orthop Surg 15 (5), 1375-1383 (2023)
   PUBMED   37057624
  REMARK    GeneRIF: SCIMP: A Novel Targeted Gene for Postmenopausal
            Osteoporosis Progression.
REFERENCE   2  (bases 1 to 2424)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2424)
  AUTHORS   Lambert,J.C., Ibrahim-Verbaas,C.A., Harold,D., Naj,A.C., Sims,R.,
            Bellenguez,C., DeStafano,A.L., Bis,J.C., Beecham,G.W.,
            Grenier-Boley,B., Russo,G., Thorton-Wells,T.A., Jones,N.,
            Smith,A.V., Chouraki,V., Thomas,C., Ikram,M.A., Zelenika,D.,
            Vardarajan,B.N., Kamatani,Y., Lin,C.F., Gerrish,A., Schmidt,H.,
            Kunkle,B., Dunstan,M.L., Ruiz,A., Bihoreau,M.T., Choi,S.H.,
            Reitz,C., Pasquier,F., Cruchaga,C., Craig,D., Amin,N., Berr,C.,
            Lopez,O.L., De Jager,P.L., Deramecourt,V., Johnston,J.A., Evans,D.,
            Lovestone,S., Letenneur,L., Moron,F.J., Rubinsztein,D.C.,
            Eiriksdottir,G., Sleegers,K., Goate,A.M., Fievet,N.,
            Huentelman,M.W., Gill,M., Brown,K., Kamboh,M.I., Keller,L.,
            Barberger-Gateau,P., McGuiness,B., Larson,E.B., Green,R.,
            Myers,A.J., Dufouil,C., Todd,S., Wallon,D., Love,S., Rogaeva,E.,
            Gallacher,J., St George-Hyslop,P., Clarimon,J., Lleo,A., Bayer,A.,
            Tsuang,D.W., Yu,L., Tsolaki,M., Bossu,P., Spalletta,G., Proitsi,P.,
            Collinge,J., Sorbi,S., Sanchez-Garcia,F., Fox,N.C., Hardy,J., Deniz
            Naranjo,M.C., Bosco,P., Clarke,R., Brayne,C., Galimberti,D.,
            Mancuso,M., Matthews,F., Moebus,S., Mecocci,P., Del Zompo,M.,
            Maier,W., Hampel,H., Pilotto,A., Bullido,M., Panza,F., Caffarra,P.,
            Nacmias,B., Gilbert,J.R., Mayhaus,M., Lannefelt,L., Hakonarson,H.,
            Pichler,S., Carrasquillo,M.M., Ingelsson,M., Beekly,D., Alvarez,V.,
            Zou,F., Valladares,O., Younkin,S.G., Coto,E., Hamilton-Nelson,K.L.,
            Gu,W., Razquin,C., Pastor,P., Mateo,I., Owen,M.J., Faber,K.M.,
            Jonsson,P.V., Combarros,O., O'Donovan,M.C., Cantwell,L.B.,
            Soininen,H., Blacker,D., Mead,S., Mosley,T.H. Jr., Bennett,D.A.,
            Harris,T.B., Fratiglioni,L., Holmes,C., de Bruijn,R.F.,
            Passmore,P., Montine,T.J., Bettens,K., Rotter,J.I., Brice,A.,
            Morgan,K., Foroud,T.M., Kukull,W.A., Hannequin,D., Powell,J.F.,
            Nalls,M.A., Ritchie,K., Lunetta,K.L., Kauwe,J.S., Boerwinkle,E.,
            Riemenschneider,M., Boada,M., Hiltuenen,M., Martin,E.R.,
            Schmidt,R., Rujescu,D., Wang,L.S., Dartigues,J.F., Mayeux,R.,
            Tzourio,C., Hofman,A., Nothen,M.M., Graff,C., Psaty,B.M., Jones,L.,
            Haines,J.L., Holmans,P.A., Lathrop,M., Pericak-Vance,M.A.,
            Launer,L.J., Farrer,L.A., van Duijn,C.M., Van Broeckhoven,C.,
            Moskvina,V., Seshadri,S., Williams,J., Schellenberg,G.D. and
            Amouyel,P.
  CONSRTM   European Alzheimer's Disease Initiative (EADI); Genetic and
            Environmental Risk in Alzheimer's Disease; Alzheimer's Disease
            Genetic Consortium; Cohorts for Heart and Aging Research in Genomic
            Epidemiology
  TITLE     Meta-analysis of 74,046 individuals identifies 11 new
            susceptibility loci for Alzheimer's disease
  JOURNAL   Nat Genet 45 (12), 1452-1458 (2013)
   PUBMED   24162737
REFERENCE   4  (bases 1 to 2424)
  AUTHORS   Draber,P., Vonkova,I., Stepanek,O., Hrdinka,M., Kucova,M.,
            Skopcova,T., Otahal,P., Angelisova,P., Horejsi,V., Yeung,M.,
            Weiss,A. and Brdicka,T.
  TITLE     SCIMP, a transmembrane adaptor protein involved in major
            histocompatibility complex class II signaling
  JOURNAL   Mol Cell Biol 31 (22), 4550-4562 (2011)
   PUBMED   21930792
  REMARK    GeneRIF: results suggest that SCIMP is involved in signal
            transduction after MHC-II stimulation and therefore serves as a
            regulator of antigen presentation and other APC functions.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK310145.1, BC130554.1 and
            AC087500.16.
            
            On Dec 4, 2012 this sequence version replaced NM_207103.2.
            
            Summary: This gene encodes a transmembrane adaptor protein that is
            expressed in antigen-presenting cells and is localized in the
            immunologic synapse. The encoded protein is involved in major
            histocompatibility complex class II signal transduction and immune
            synapse formation. Alternatively spliced transcript variants have
            been found for this gene. [provided by RefSeq, Dec 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.127681.1,
                                           SRR1163655.286835.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2153733
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000574081.6/ ENSP00000461269.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                AK310145.1         1-72
            73-738              BC130554.1         1-666
            739-2424            AC087500.16        112055-113740
FEATURES             Location/Qualifiers
     source          1..2424
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..2424
                     /gene="SCIMP"
                     /gene_synonym="C17orf87; UNQ5783"
                     /note="SLP adaptor and CSK interacting membrane protein"
                     /db_xref="GeneID:388325"
                     /db_xref="HGNC:HGNC:33504"
                     /db_xref="MIM:614406"
     exon            1..126
                     /gene="SCIMP"
                     /gene_synonym="C17orf87; UNQ5783"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..543
                     /gene="SCIMP"
                     /gene_synonym="C17orf87; UNQ5783"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transmembrane protein C17orf87; DTFT5783; SLP65/SLP76,
                     Csk-interacting membrane protein"
                     /codon_start=1
                     /product="SLP adapter and CSK-interacting membrane protein
                     isoform 1"
                     /protein_id="NP_996986.1"
                     /db_xref="CCDS:CCDS42242.1"
                     /db_xref="GeneID:388325"
                     /db_xref="HGNC:HGNC:33504"
                     /db_xref="MIM:614406"
                     /translation="MDTFTVQDSTAMSWWRNNFWIILAVAIIVVSVGLGLILYCVCKW
                     QLRRGKKWEIAKPLKHKQVDEEKMYENVLNESPVQLPPLPPRNWPSLEDSSPQEAPSQ
                     PPATYSLVNKVKNKKTVSIPSYIEPEDDYDDVEIPANTEKASF"
     exon            127..250
                     /gene="SCIMP"
                     /gene_synonym="C17orf87; UNQ5783"
                     /inference="alignment:Splign:2.1.0"
     exon            251..314
                     /gene="SCIMP"
                     /gene_synonym="C17orf87; UNQ5783"
                     /inference="alignment:Splign:2.1.0"
     exon            315..388
                     /gene="SCIMP"
                     /gene_synonym="C17orf87; UNQ5783"
                     /inference="alignment:Splign:2.1.0"
     exon            389..2424
                     /gene="SCIMP"
                     /gene_synonym="C17orf87; UNQ5783"
                     /inference="alignment:Splign:2.1.0"
     regulatory      909..914
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCIMP"
                     /gene_synonym="C17orf87; UNQ5783"
                     /note="hexamer: ATTAAA"
     polyA_site      934
                     /gene="SCIMP"
                     /gene_synonym="C17orf87; UNQ5783"
                     /note="major polyA site"
     regulatory      2408..2413
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCIMP"
                     /gene_synonym="C17orf87; UNQ5783"
                     /note="hexamer: AACAAA"
     polyA_site      2424
                     /gene="SCIMP"
                     /gene_synonym="C17orf87; UNQ5783"
                     /note="major polyA site"
ORIGIN      
        1 actgtctcta gcagtgggtg aaggcctgtg agtgaggaat gcctctcacc agctgtgcct
       61 gagctgcagc actccagcca ctgctgtctc cttagctgct cacatatgga tactttcaca
      121 gttcaggatt ccactgcaat gagctggtgg aggaataatt tctggatcat cttagctgtg
      181 gccatcatcg ttgtctctgt gggtctgggc ctcatcctgt actgtgtctg taagtggcag
      241 cttagacgag gcaagaaatg ggaaattgcc aagcccctga aacacaagca agtagatgaa
      301 gaaaagatgt atgagaatgt tcttaatgag tcgccagttc aattaccgcc tctgccaccg
      361 aggaattggc cttctctaga agactcttcc ccacaggaag ccccaagtca gccgcccgct
      421 acatactcac tggtaaataa agttaaaaat aagaagactg tttccatccc aagctacatt
      481 gagcctgaag atgactatga cgatgttgaa atccctgcaa atactgaaaa agcatcattt
      541 tgaaacagcc atttcttctt tttggcaaaa ctgaagaggg ttcacacaac ttattttaaa
      601 acaatcaaga atggttgaac ttcagtaggt ctctgggccc tgaaagccag tggtgatttt
      661 atgaagctct ataagataaa gcacttccca aaccttagat gaagacaccc ctgcgatcgg
      721 atgactgcag ccagaggaga cacatgggtg ctcggctctg aggacttaga ggggtcagcc
      781 ttgtgctgtt gaggaaactt tccatgggaa ggaccacggg gctccatggc tcccacctgt
      841 gggaaactac tcatttcttg gcattctttc ccccttcatt ccctttggtt tgcatggttc
      901 tgagtgatat taaatctcag catttggttg tgcagaccct cccaggctcc catccccagc
      961 aaggccctca ccaagcatgc tggtctttac cctctcaccc cacccacctc ctgcactgtg
     1021 aggctgtggg tgagttacag ctgagtgctc tcgtgcccag gttcccacac cacatctcgc
     1081 gagtttgcaa gggcagggag taccttttgt tctcgtgaac cctccccacc tagacaccct
     1141 gcaaacccca gtgcctttat atgatgtagg ccaaattgac catagagatt tgagttttca
     1201 cctaggtttt ctccccgtgc ttgcaagttg tactgtaaca atggacaaag gacaaaagtt
     1261 accttctgat ttacacctag aagcatcatt ttgcaatagg tgtgttgggg gtgctacagg
     1321 aaaaatacat ttcccccagg acaaatcatg gggaacagga aagaaaaggg gcatgtaaca
     1381 atggcatata caagatgaga gttcaggggg cttaatatcc cctgtccatc attttcatca
     1441 gtacttactc gagttctagg aaaacagcct caagcccctt ccttccagat cactgtccct
     1501 gggcatctgg gaggaggcag aaggtccact gtgatgtgct gcagccaatg agatgggcca
     1561 gggacatggg cagatgtctt gttaaacaag tgtcctaatg gggtcaacaa ggcccgagtc
     1621 agctttatag gctcttagac ctcatcaatt ccttctagct gatcgccaga gccctaggac
     1681 ttgactcatt ctaactatac tcacaagatg ctggtttcta agtgacctct gggaaatctg
     1741 gcaaatgaac agccttgcag agagagcact gtgaacctgg aaaggcctga gagtgactca
     1801 gatttccctc aagagatggg aaaatgtgtt cctcccattt tcaagctttc tccctcaatc
     1861 aacgctggag cactggggac ctgggcttcc tccctggttc tctctttcca gactctatga
     1921 aggcttccac cttgctatta atacctcctt gggaggccaa ggtgggcgga tcacctgagg
     1981 tcgggagttc gagaccagcc tgaccaacat ggagaaaccc catttctact aaaaatacaa
     2041 aattagtcag gcatggtcgc gcatgcctgt aatcccagct acttgggagg ctgaggcaga
     2101 agaatcgctt gaaactggga ggcggaggtt gcggtgagcc gagaacatgc cattgcactc
     2161 cagcctggac aacaagagtg aaactccatc taaaaataaa taaataaata aataaataaa
     2221 ccctccttat gttaggccag tagttatcta actatggcct tatgggactc tggtatccca
     2281 ccagccaaag agaggactct tcccaaatta tagaacaaaa ataagccaaa ggattggagt
     2341 gtttcaaaca catgctttcg tcttataaat gttctgtaaa ccctccatga ctatgacaaa
     2401 agttaaaaac aaatgccaga caaa
//
