LOCUS       NM_006998               1468 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens secretagogin, EF-hand calcium binding protein (SCGN),
            mRNA.
ACCESSION   NM_006998
VERSION     NM_006998.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1468)
  AUTHORS   Liu,Z., Tan,S., Zhou,L., Chen,L., Liu,M., Wang,W., Tang,Y.,
            Yang,Q., Chi,S., Jiang,P., Zhang,Y., Cui,Y., Qin,J., Hu,X., Li,S.,
            Liu,Q., Chen,L., Li,S., Burstein,E., Li,W., Zhang,X., Mo,X. and
            Jia,D.
  TITLE     SCGN deficiency is a risk factor for autism spectrum disorder
  JOURNAL   Signal Transduct Target Ther 8 (1), 3 (2023)
   PUBMED   36588101
  REMARK    GeneRIF: SCGN deficiency is a risk factor for autism spectrum
            disorder.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1468)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1468)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1468)
  AUTHORS   Tapia-Gonzalez,S., Insausti,R. and DeFelipe,J.
  TITLE     Differential expression of secretagogin immunostaining in the
            hippocampal formation and the entorhinal and perirhinal cortices of
            humans, rats, and mice
  JOURNAL   J Comp Neurol 528 (4), 523-541 (2020)
   PUBMED   31512254
  REMARK    GeneRIF: Differential expression of secretagogin immunostaining in
            the hippocampal formation and the entorhinal and perirhinal
            cortices of humans, rats, and mice.
REFERENCE   5  (bases 1 to 1468)
  AUTHORS   Sifuentes-Dominguez,L.F., Li,H., Llano,E., Liu,Z., Singla,A.,
            Patel,A.S., Kathania,M., Khoury,A., Norris,N., Rios,J.J.,
            Starokadomskyy,P., Park,J.Y., Gopal,P., Liu,Q., Tan,S., Chan,L.,
            Ross,T., Harrison,S., Venuprasad,K., Baker,L.A., Jia,D. and
            Burstein,E.
  TITLE     SCGN deficiency results in colitis susceptibility
  JOURNAL   Elife 8, e49910 (2019)
   PUBMED   31663849
  REMARK    GeneRIF: In this study, the authors report the identification of an
            ultrarare missense variant (NM_006998.3:c.230G > A;p.Arg77His) in
            the SCGN gene causing Mendelian early-onset ulcerative colitis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1468)
  AUTHORS   Zierhut,B., Daneva,T., Gartner,W., Brunnmaier,B., Mineva,I.,
            Berggard,T. and Wagner,L.
  TITLE     Setagin and secretagogin-R22: Posttranscriptional modification
            products of the secretagogin gene
  JOURNAL   Biochem Biophys Res Commun 329 (4), 1193-1199 (2005)
   PUBMED   15766553
  REMARK    GeneRIF: two new variants of the recently identified hexa-EF-hand
            calcium binding protein secretagogin
REFERENCE   7  (bases 1 to 1468)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   8  (bases 1 to 1468)
  AUTHORS   Zhan,X., Evans,C.O., Oyesiku,N.M. and Desiderio,D.M.
  TITLE     Proteomics and transcriptomics analyses of secretagogin
            down-regulation in human non-functional pituitary adenomas
  JOURNAL   Pituitary 6 (4), 189-202 (2003)
   PUBMED   15237930
  REMARK    GeneRIF: Secretagogin might play a role in human non-functional
            pituitary adenomas. This novel finding may provide clues to clarify
            the basic molecular mechanisms of pituitary adenoma formation, and
            to identify new tumor-related markers.
REFERENCE   9  (bases 1 to 1468)
  AUTHORS   Gartner,W., Lang,W., Leutmetzer,F., Domanovits,H., Waldhausl,W. and
            Wagner,L.
  TITLE     Cerebral expression and serum detectability of secretagogin, a
            recently cloned EF-hand Ca(2+)-binding protein
  JOURNAL   Cereb Cortex 11 (12), 1161-1169 (2001)
   PUBMED   11709487
REFERENCE   10 (bases 1 to 1468)
  AUTHORS   Wagner,L., Oliyarnyk,O., Gartner,W., Nowotny,P., Groeger,M.,
            Kaserer,K., Waldhausl,W. and Pasternack,M.S.
  TITLE     Cloning and expression of secretagogin, a novel neuroendocrine- and
            pancreatic islet of Langerhans-specific Ca2+-binding protein
  JOURNAL   J Biol Chem 275 (32), 24740-24751 (2000)
   PUBMED   10811645
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM511122.1, Y16752.1,
            BC000336.2 and BQ477463.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006998.3.
            
            Summary: The encoded protein is a secreted calcium-binding protein
            which is found in the cytoplasm. It is related to calbindin D-28K
            and calretinin. This protein is thought to be involved in
            KCL-stimulated calcium flux and cell proliferation. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1051261.1,
                                           SRR3476690.287500.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377961.3/ ENSP00000367197.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                BM511122.1         22-57
            37-253              Y16752.1           4-220
            254-1147            BC000336.2         235-1128
            1148-1468           BQ477463.1         11-331              c
FEATURES             Location/Qualifiers
     source          1..1468
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.2"
     gene            1..1468
                     /gene="SCGN"
                     /gene_synonym="CALBL; DJ501N12.8; SECRET; SEGN; setagin"
                     /note="secretagogin, EF-hand calcium binding protein"
                     /db_xref="GeneID:10590"
                     /db_xref="HGNC:HGNC:16941"
                     /db_xref="MIM:609202"
     exon            1..271
                     /gene="SCGN"
                     /gene_synonym="CALBL; DJ501N12.8; SECRET; SEGN; setagin"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..1020
                     /gene="SCGN"
                     /gene_synonym="CALBL; DJ501N12.8; SECRET; SEGN; setagin"
                     /codon_start=1
                     /product="secretagogin"
                     /protein_id="NP_008929.2"
                     /db_xref="CCDS:CCDS4561.1"
                     /db_xref="GeneID:10590"
                     /db_xref="HGNC:HGNC:16941"
                     /db_xref="MIM:609202"
                     /translation="MDSSREPTLGRLDAAGFWQVWQRFDADEKGYIEEKELDAFFLHM
                     LMKLGTDDTVMKANLHKVKQQFMTTQDASKDGRIRMKELAGMFLSEDENFLLLFRREN
                     PLDSSVEFMQIWRKYDADSSGFISAAELRNFLRDLFLHHKKAISEAKLEEYTGTMMKI
                     FDRNKDGRLDLNDLARILALQENFLLQFKMDACSTEERKRDFEKIFAYYDVSKTGALE
                     GPEVDGFVKDMMELVQPSISGVDLDKFREILLRHCDVNKDGKIQKSELALCLGLKINP
                     "
     exon            272..342
                     /gene="SCGN"
                     /gene_synonym="CALBL; DJ501N12.8; SECRET; SEGN; setagin"
                     /inference="alignment:Splign:2.1.0"
     exon            343..435
                     /gene="SCGN"
                     /gene_synonym="CALBL; DJ501N12.8; SECRET; SEGN; setagin"
                     /inference="alignment:Splign:2.1.0"
     exon            436..525
                     /gene="SCGN"
                     /gene_synonym="CALBL; DJ501N12.8; SECRET; SEGN; setagin"
                     /inference="alignment:Splign:2.1.0"
     exon            526..582
                     /gene="SCGN"
                     /gene_synonym="CALBL; DJ501N12.8; SECRET; SEGN; setagin"
                     /inference="alignment:Splign:2.1.0"
     exon            583..660
                     /gene="SCGN"
                     /gene_synonym="CALBL; DJ501N12.8; SECRET; SEGN; setagin"
                     /inference="alignment:Splign:2.1.0"
     exon            661..716
                     /gene="SCGN"
                     /gene_synonym="CALBL; DJ501N12.8; SECRET; SEGN; setagin"
                     /inference="alignment:Splign:2.1.0"
     exon            717..762
                     /gene="SCGN"
                     /gene_synonym="CALBL; DJ501N12.8; SECRET; SEGN; setagin"
                     /inference="alignment:Splign:2.1.0"
     exon            763..822
                     /gene="SCGN"
                     /gene_synonym="CALBL; DJ501N12.8; SECRET; SEGN; setagin"
                     /inference="alignment:Splign:2.1.0"
     exon            823..891
                     /gene="SCGN"
                     /gene_synonym="CALBL; DJ501N12.8; SECRET; SEGN; setagin"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1468
                     /gene="SCGN"
                     /gene_synonym="CALBL; DJ501N12.8; SECRET; SEGN; setagin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1443..1448
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCGN"
                     /gene_synonym="CALBL; DJ501N12.8; SECRET; SEGN; setagin"
                     /note="hexamer: AATAAA"
     polyA_site      1468
                     /gene="SCGN"
                     /gene_synonym="CALBL; DJ501N12.8; SECRET; SEGN; setagin"
                     /note="major polyA site"
ORIGIN      
        1 gctgagggct gagggacggc tcagcgacgc cacggccagc agcgctcgcg tcctccccag
       61 caacagttac tcaaagctaa tcagatagcg aaagaagcag gagagcaagt caagaaatac
      121 ggtgaaggag tccttcccaa agttgtctag gtccttccgc gccggtgcct ggtcttcgtc
      181 gtcaacacca tggacagctc ccgggaaccg actctggggc gcttggacgc cgctggcttc
      241 tggcaggtct ggcagcgctt tgatgcggat gaaaaaggtt acatagaaga gaaggaactc
      301 gatgctttct ttctccacat gttgatgaaa ctgggtactg atgacacggt catgaaagca
      361 aatttgcaca aggtgaaaca gcagtttatg actacccaag atgcctctaa agatggtcgc
      421 attcggatga aagagcttgc tggtatgttc ttatctgagg atgaaaactt tcttctgctc
      481 tttcgccggg aaaacccact ggacagcagc gtggagttta tgcagatttg gcgcaaatat
      541 gacgctgaca gcagtggctt tatatcagct gctgagctcc gcaacttcct ccgagacctc
      601 tttcttcacc acaaaaaggc catttctgag gctaaactgg aagaatacac tggcaccatg
      661 atgaagattt ttgacagaaa taaagatggt cggttggatc taaatgactt agcaaggatt
      721 ctggctcttc aggaaaactt ccttctccaa tttaaaatgg atgcttgttc tactgaagaa
      781 aggaaaaggg actttgagaa aatctttgcc tactatgatg ttagtaaaac aggagccctg
      841 gaaggcccag aagtggatgg gtttgtcaaa gacatgatgg agcttgtcca gcccagcatc
      901 agcggggtgg accttgataa gttccgcgag attctcctgc gtcactgcga cgtgaacaag
      961 gatggaaaaa ttcagaagtc tgagctggct ttgtgtcttg ggctgaaaat caacccataa
     1021 tcccagactg ctttgccttt tgctcttact atgtttctgt gatcttgctg gtagaattgt
     1081 atctgtgcat tgatgttggg aacacagtgg gcaaactcac aaatggtgtg ctattcttgg
     1141 gcaagaacag ggacgctagg gccttccttc caccggcgtg atctatccct gtctcactga
     1201 aagcccctgt gtagtgtctg tgttgttttc ccttgaccct gggctttcct atcctcccaa
     1261 agactcagct cccctgttag atggctctgc ctgtccttcc ccagtcacca gggtgggggg
     1321 gacaggggca gctgagtgca ttcattttgt gcttttcttg tgggctttct gcttagtctg
     1381 aaaggtgtgt ggcattcatg gcaatcctgt aacttcaaca tagatttttt tgtgtgtgtg
     1441 gaaataaatc tgcaattgga aacaaaaa
//
