LOCUS       NM_054023                516 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens secretoglobin family 3A member 2 (SCGB3A2), mRNA.
ACCESSION   NM_054023
VERSION     NM_054023.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 516)
  AUTHORS   Kimura,S., Yokoyama,S., Pilon,A.L. and Kurotani,R.
  TITLE     Emerging role of an immunomodulatory protein secretoglobin 3A2 in
            human diseases
  JOURNAL   Pharmacol Ther 236, 108112 (2022)
   PUBMED   35016921
  REMARK    GeneRIF: Emerging role of an immunomodulatory protein secretoglobin
            3A2 in human diseases.
            Review article
REFERENCE   2  (bases 1 to 516)
  AUTHORS   Zhou,Z., Zuo,C.L., Li,X.S., Ye,X.P., Zhang,Q.Y., Wang,P.,
            Zhang,R.X., Chen,G., Yang,J.L., Chen,Y., Ma,Q.Y. and Song,H.D.
  TITLE     Uterus globulin associated protein 1 (UGRP1) is a potential marker
            of progression of Graves' disease into hypothyroidism
  JOURNAL   Mol Cell Endocrinol 494, 110492 (2019)
   PUBMED   31255731
  REMARK    GeneRIF: UGRP1 may be a novel marker in thyrocytes to predict
            Grave's disease patients who develop hypothyroidism.
REFERENCE   3  (bases 1 to 516)
  AUTHORS   Kim,S.K., Seok,H., Park,H.J., Han,K., Kang,S.W., Ban,J.Y.,
            Jung,H.J., Kim,K.I., Lee,B.J., Kim,J. and Chung,J.H.
  TITLE     Association Between Secretoglobin Family 3A Member 2 (SCGB3A2) Gene
            Polymorphisms and Asthma in a Korean Population
  JOURNAL   Med Sci Monit 23, 1880-1885 (2017)
   PUBMED   28422086
  REMARK    GeneRIF: rs151333009 SNP showed a monomorphic genotype. Two
            promoter SNPs (rs6882292, -659 G/A and rs1368408, -112 G/A) showed
            significant association with asthma. These results suggest that the
            promoter SNPs (rs6882292 and rs1368408) of SCGB3A2 gene may
            contribute to susceptibility to asthma in a Korean population.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 516)
  AUTHORS   Xue,L., Han,B., Pan,C. and Song,H.
  TITLE     The association of SCGB3A2 polymorphisms with the risk of Graves'
            disease: a meta-analysis
  JOURNAL   Endocrine 45 (3), 365-369 (2014)
   PUBMED   23934357
  REMARK    GeneRIF: This meta-analysis suggests that SCGB3A2 polymorphism at
            positions -112G>A was associated with Graves' disease both in
            Chinese and Caucasian population.
REFERENCE   5  (bases 1 to 516)
  AUTHORS   Jackson,B.C., Thompson,D.C., Wright,M.W., McAndrews,M., Bernard,A.,
            Nebert,D.W. and Vasiliou,V.
  TITLE     Update of the human secretoglobin (SCGB) gene superfamily and an
            example of 'evolutionary bloom' of androgen-binding protein genes
            within the mouse Scgb gene superfamily
  JOURNAL   Hum Genomics 5 (6), 691-702 (2011)
   PUBMED   22155607
  REMARK    Review article
REFERENCE   6  (bases 1 to 516)
  AUTHORS   Porter,D., Lahti-Domenici,J., Torres-Arzayus,M., Chin,L. and
            Polyak,K.
  TITLE     Expression of high in normal-1 (HIN-1) and uteroglobin related
            protein-1 (UGRP-1) in adult and developing tissues
  JOURNAL   Mech Dev 114 (1-2), 201-204 (2002)
   PUBMED   12175512
REFERENCE   7  (bases 1 to 516)
  AUTHORS   Niimi,T., Munakata,M., Keck-Waggoner,C.L., Popescu,N.C.,
            Levitt,R.C., Hisada,M. and Kimura,S.
  TITLE     A polymorphism in the human UGRP1 gene promoter that regulates
            transcription is associated with an increased risk of asthma
  JOURNAL   Am J Hum Genet 70 (3), 718-725 (2002)
   PUBMED   11813133
  REMARK    GeneRIF: polymorphism in the human UGRP1 gene promoter that
            regulates transcription is associated with an increased risk of
            asthma
REFERENCE   8  (bases 1 to 516)
  AUTHORS   Niimi,T., Keck-Waggoner,C.L., Popescu,N.C., Zhou,Y., Levitt,R.C.
            and Kimura,S.
  TITLE     UGRP1, a uteroglobin/Clara cell secretory protein-related protein,
            is a novel lung-enriched downstream target gene for the
            T/EBP/NKX2.1 homeodomain transcription factor
  JOURNAL   Mol Endocrinol 15 (11), 2021-2036 (2001)
   PUBMED   11682631
REFERENCE   9  (bases 1 to 516)
  AUTHORS   Wattiez,R., Hermans,C., Cruyt,C., Bernard,A. and Falmagne,P.
  TITLE     Human bronchoalveolar lavage fluid protein two-dimensional
            database: study of interstitial lung diseases
  JOURNAL   Electrophoresis 21 (13), 2703-2712 (2000)
   PUBMED   10949149
REFERENCE   10 (bases 1 to 516)
  AUTHORS   Kimura,S., Hara,Y., Pineau,T., Fernandez-Salguero,P., Fox,C.H.,
            Ward,J.M. and Gonzalez,F.J.
  TITLE     The T/ebp null mouse: thyroid-specific enhancer-binding protein is
            essential for the organogenesis of the thyroid, lung, ventral
            forebrain, and pituitary
  JOURNAL   Genes Dev 10 (1), 60-69 (1996)
   PUBMED   8557195
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC024232.1 and AA988559.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_054023.4.
            
            Summary: The protein encoded by this gene is a secreted lung
            surfactant protein and a downstream target of thyroid transcription
            factor. A single nucleotide polymorphism in the promoter of this
            gene results in susceptibility to asthma.[provided by RefSeq, Mar
            2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BF433853.1, BC024232.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2142363
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296694.5/ ENSP00000296694.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-515               BC024232.1         5-519
            516-516             AA988559.1         5-5                 c
FEATURES             Location/Qualifiers
     source          1..516
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q32"
     gene            1..516
                     /gene="SCGB3A2"
                     /gene_synonym="LU103; pnSP-1; PNSP1; UGRP1"
                     /note="secretoglobin family 3A member 2"
                     /db_xref="GeneID:117156"
                     /db_xref="HGNC:HGNC:18391"
                     /db_xref="MIM:606531"
     exon            1..148
                     /gene="SCGB3A2"
                     /gene_synonym="LU103; pnSP-1; PNSP1; UGRP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..375
                     /gene="SCGB3A2"
                     /gene_synonym="LU103; pnSP-1; PNSP1; UGRP1"
                     /note="uteroglobin-related protein 1; pneumo secretory
                     protein 1"
                     /codon_start=1
                     /product="secretoglobin family 3A member 2 precursor"
                     /protein_id="NP_473364.1"
                     /db_xref="CCDS:CCDS4287.1"
                     /db_xref="GeneID:117156"
                     /db_xref="HGNC:HGNC:18391"
                     /db_xref="MIM:606531"
                     /translation="MKLVTIFLLVTISLCSYSATAFLINKVPLPVDKLAPLPLDNILP
                     FMDPLKLLLKTLGISVEHLVEGLRKCVNELGPEASEAVKKLLEALSHLV"
     exon            149..351
                     /gene="SCGB3A2"
                     /gene_synonym="LU103; pnSP-1; PNSP1; UGRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            352..516
                     /gene="SCGB3A2"
                     /gene_synonym="LU103; pnSP-1; PNSP1; UGRP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      499..504
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCGB3A2"
                     /gene_synonym="LU103; pnSP-1; PNSP1; UGRP1"
                     /note="hexamer: AATAAA"
     polyA_site      516
                     /gene="SCGB3A2"
                     /gene_synonym="LU103; pnSP-1; PNSP1; UGRP1"
                     /note="major polyA site"
ORIGIN      
        1 acactttgta tggcaagtgg aaccactggc ttggtggatt ttgctagatt tttctgattt
       61 ttaaactcct gaaaaatatc ccagataact gtcatgaagc tggtaactat cttcctgctg
      121 gtgaccatca gcctttgtag ttactctgct actgccttcc tcatcaacaa agtgcccctt
      181 cctgttgaca agttggcacc tttacctctg gacaacattc ttccctttat ggatccatta
      241 aagcttcttc tgaaaactct gggcatttct gttgagcacc ttgtggaggg gctaaggaag
      301 tgtgtaaatg agctgggacc agaggcttct gaagctgtga agaaactgct ggaggcgcta
      361 tcacacttgg tgtgacatca agataaagag cggaggtgga tggggatgga agatgatgct
      421 cctatcctcc ctgcctgaaa cctgttctac caattataga tcaaatgccc taaaatgtag
      481 tgacccgtga aaaggacaaa taaagcaatg aataca
//
