LOCUS       NM_052863                478 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens secretoglobin family 3A member 1 (SCGB3A1), mRNA.
ACCESSION   NM_052863
VERSION     NM_052863.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Costa,A.L., Moreira-Barbosa,C., Lobo,J., Vilela-Salgueiro,B.,
            Cantante,M., Guimaraes,R., Lopes,P., Braga,I., Oliveira,J.,
            Antunes,L., Henrique,R. and Jeronimo,C.
  TITLE     DNA methylation profiling as a tool for testicular germ cell tumors
            subtyping
  JOURNAL   Epigenomics 10 (12), 1511-1523 (2018)
   PUBMED   30418048
  REMARK    GeneRIF: HOXA9, RASSF1A and SCGB3A1 promoter methylation
            significantly associated with testicular germ cell tumor stage.
REFERENCE   3  (bases 1 to 478)
  AUTHORS   Atilla,M.H., Ozdas,S., Ozdas,T., Bastimur,S., Muz,S.E., Oz,I.,
            Kurt,K., Izbirak,A., Babademez,M.A. and Vatandas,N.
  TITLE     Association of Ugrp2 gene polymorphisms with adenoid hypertrophy in
            the pediatric population
  JOURNAL   Braz J Otorhinolaryngol 84 (5), 599-607 (2018)
   PUBMED   28823693
  REMARK    GeneRIF: Some single nucleotide polymorphisms and their
            combinations in the Ugrp2 gene are associated with an increased
            risk of developing adenoid hypertrophy.
REFERENCE   4  (bases 1 to 478)
  AUTHORS   Herranz,M., Padin-Iruegas,M.E., Martinez-Lago,N., Losada,S.A.,
            Rana-Diez,P., Vazquez,E.B., Carrera,J.J., Antunez,J.R., Ruibal,A.
            and Lopez-Lopez,R.
  TITLE     HIN-1: a New Epigenetic Biomarker Crucial for Therapy Selection in
            Glioblastoma Multiforme
  JOURNAL   Mol Neurobiol 53 (3), 1802-1807 (2016)
   PUBMED   25752997
  REMARK    GeneRIF: The role of high in normal-1 (HIN-1) as a potential
            biomarker in combating glioblastoma is being described for the
            first time in this study.
REFERENCE   5  (bases 1 to 478)
  AUTHORS   Spitzwieser,M., Holzweber,E., Pfeiler,G., Hacker,S. and
            Cichna-Markl,M.
  TITLE     Applicability of HIN-1, MGMT and RASSF1A promoter methylation as
            biomarkers for detecting field cancerization in breast cancer
  JOURNAL   Breast Cancer Res 17 (1), 125 (2015)
   PUBMED   26370119
  REMARK    GeneRIF: Tumor-adjacent tissues showed higher methylation status of
            RASSF1A, HIN-1 and MGMT promoters.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 478)
  AUTHORS   Krop,I., Maguire,P., Lahti-Domenici,J., Lodeiro,G., Richardson,A.,
            Johannsdottir,H.K., Nevanlinna,H., Borg,A., Gelman,R.,
            Barkardottir,R.B., Lindblom,A. and Polyak,K.
  TITLE     Lack of HIN-1 methylation in BRCA1-linked and 'BRCA1-like' breast
            tumors
  JOURNAL   Cancer Res 63 (9), 2024-2027 (2003)
   PUBMED   12727813
  REMARK    GeneRIF: Sporadic breast tumors with a 'BRCA1-like'
            histopathological phenotype also demonstrated significantly lower
            frequency of HIN-1 promoter methylation.
REFERENCE   7  (bases 1 to 478)
  AUTHORS   Reynolds,S.D., Reynolds,P.R., Pryhuber,G.S., Finder,J.D. and
            Stripp,B.R.
  TITLE     Secretoglobins SCGB3A1 and SCGB3A2 define secretory cell subsets in
            mouse and human airways
  JOURNAL   Am J Respir Crit Care Med 166 (11), 1498-1509 (2002)
   PUBMED   12406855
REFERENCE   8  (bases 1 to 478)
  AUTHORS   Porter,D., Lahti-Domenici,J., Torres-Arzayus,M., Chin,L. and
            Polyak,K.
  TITLE     Expression of high in normal-1 (HIN-1) and uteroglobin related
            protein-1 (UGRP-1) in adult and developing tissues
  JOURNAL   Mech Dev 114 (1-2), 201-204 (2002)
   PUBMED   12175512
REFERENCE   9  (bases 1 to 478)
  AUTHORS   Niimi,T., Copeland,N.G., Gilbert,D.J., Jenkins,N.A., Srisodsai,A.,
            Zimonjic,D.B., Keck-Waggoner,C.L., Popescu,N.C. and Kimura,S.
  TITLE     Cloning, expression, and chromosomal localization of the mouse gene
            (Scgb3a1, alias Ugrp2) that encodes a member of the novel
            uteroglobin-related protein gene family
  JOURNAL   Cytogenet Genome Res 97 (1-2), 120-127 (2002)
   PUBMED   12438750
REFERENCE   10 (bases 1 to 478)
  AUTHORS   Krop,I.E., Sgroi,D., Porter,D.A., Lunetta,K.L., LeVangie,R.,
            Seth,P., Kaelin,C.M., Rhei,E., Bosenberg,M., Schnitt,S.,
            Marks,J.R., Pagon,Z., Belina,D., Razumovic,J. and Polyak,K.
  TITLE     HIN-1, a putative cytokine highly expressed in normal but not
            cancerous mammary epithelial cells
  JOURNAL   Proc Natl Acad Sci U S A 98 (17), 9796-9801 (2001)
   PUBMED   11481438
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122714.2 and AY359064.1.
            
            On Nov 22, 2018 this sequence version replaced NM_052863.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY359064.1, AF436839.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144333, SAMEA2147920
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000292641.4/ ENSP00000292641.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC122714.2         80963-80974         c
            13-478              AY359064.1         54-519
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..478
                     /gene="SCGB3A1"
                     /gene_synonym="HIN-1; HIN1; LU105; PnSP-2; UGRP2"
                     /note="secretoglobin family 3A member 1"
                     /db_xref="GeneID:92304"
                     /db_xref="HGNC:HGNC:18384"
                     /db_xref="MIM:606500"
     exon            1..89
                     /gene="SCGB3A1"
                     /gene_synonym="HIN-1; HIN1; LU105; PnSP-2; UGRP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..352
                     /gene="SCGB3A1"
                     /gene_synonym="HIN-1; HIN1; LU105; PnSP-2; UGRP2"
                     /note="pneumo secretory protein 2; cytokine high in
                     normal-1; cytokine HIN-1; high in normal 1;
                     uteroglobin-related protein 2"
                     /codon_start=1
                     /product="secretoglobin family 3A member 1 precursor"
                     /protein_id="NP_443095.2"
                     /db_xref="CCDS:CCDS4456.1"
                     /db_xref="GeneID:92304"
                     /db_xref="HGNC:HGNC:18384"
                     /db_xref="MIM:606500"
                     /translation="MKLAALLGLCVALSCSSAAAFLVGSAKPVAQPVAALESAAEAGA
                     GTLANPLGTLNPLKLLLSSLGIPVNHLIEGSQKCVAELGPQAVGAVKALKALLGALTV
                     FG"
     exon            90..328
                     /gene="SCGB3A1"
                     /gene_synonym="HIN-1; HIN1; LU105; PnSP-2; UGRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            329..478
                     /gene="SCGB3A1"
                     /gene_synonym="HIN-1; HIN1; LU105; PnSP-2; UGRP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      459..464
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCGB3A1"
                     /gene_synonym="HIN-1; HIN1; LU105; PnSP-2; UGRP2"
                     /note="hexamer: AATAAA"
     polyA_site      478
                     /gene="SCGB3A1"
                     /gene_synonym="HIN-1; HIN1; LU105; PnSP-2; UGRP2"
                     /note="major polyA site"
ORIGIN      
        1 agccgcaggt tccccgcgcg ccccgagccc ccgcgccatg aagctcgccg ccctcctggg
       61 gctctgcgtg gccctgtcct gcagctccgc tgctgctttc ttagtgggct cggccaagcc
      121 tgtggcccag cctgtcgctg cgctggagtc ggcggcggag gccggggccg ggaccctggc
      181 caaccccctc ggcaccctca acccgctgaa gctcctgctg agcagcctgg gcatccccgt
      241 gaaccacctc atagagggct cccagaagtg tgtggctgag ctgggtcccc aggccgtggg
      301 ggccgtgaag gccctgaagg ccctgctggg ggccctgaca gtgtttggct gagccgagac
      361 tggagcatct acacctgagg acaagacgct gcccacccgc gagggctgaa aaccccgccg
      421 cggggaggac cgtccatccc cttcccccgg cccctctcaa taaacgtggt taagagca
//
