LOCUS       NM_001025591            6763 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens secretoglobin family 2B member 2 (SCGB2B2), transcript
            variant 1, mRNA.
ACCESSION   NM_001025591 XM_378794
VERSION     NM_001025591.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6763)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 6763)
  AUTHORS   Jackson,B.C., Thompson,D.C., Wright,M.W., McAndrews,M., Bernard,A.,
            Nebert,D.W. and Vasiliou,V.
  TITLE     Update of the human secretoglobin (SCGB) gene superfamily and an
            example of 'evolutionary bloom' of androgen-binding protein genes
            within the mouse Scgb gene superfamily
  JOURNAL   Hum Genomics 5 (6), 691-702 (2011)
   PUBMED   22155607
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020910.7, AK093495.1 and AC022143.7.
            
            On Oct 29, 2020 this sequence version replaced NM_001025591.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: AK093495.1, SRR14372079.313075.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1968968, SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            MANE Ensembl match               :: ENST00000601241.6/
                                                ENSP00000469876.1
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1460              AC020910.7         77555-79014         c
            1461-2033           AK093495.1         1-573
            2034-2034           AC022143.7         82580-82580         c
            2035-3421           AK093495.1         575-1961
            3422-3435           AC022143.7         81179-81192         c
            3436-3965           AK093495.1         1962-2491
            3966-6763           AC022143.7         77133-79930         c
FEATURES             Location/Qualifiers
     source          1..6763
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.11"
     gene            1..6763
                     /gene="SCGB2B2"
                     /gene_synonym="SCGB4A2; SCGBL"
                     /note="secretoglobin family 2B member 2"
                     /db_xref="GeneID:284402"
                     /db_xref="HGNC:HGNC:27616"
                     /db_xref="MIM:615063"
     exon            1..1530
                     /gene="SCGB2B2"
                     /gene_synonym="SCGB4A2; SCGBL"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..3622
                     /gene="SCGB2B2"
                     /gene_synonym="SCGB4A2; SCGBL"
                     /inference="alignment:Splign:2.1.0"
     CDS             3562..3852
                     /gene="SCGB2B2"
                     /gene_synonym="SCGB4A2; SCGBL"
                     /note="secretoglobin-like protein"
                     /codon_start=1
                     /product="secretoglobin family 2B member 2 precursor"
                     /protein_id="NP_001020762.1"
                     /db_xref="CCDS:CCDS32989.1"
                     /db_xref="GeneID:284402"
                     /db_xref="HGNC:HGNC:27616"
                     /db_xref="MIM:615063"
                     /translation="MRVTSATCALLLALICSVQLGDACLDIDKLLANVVFDVSQDLLK
                     EELARYNPSPLTEESFLNVQQCFANVSVTERFAHSVVIKKILQSNDCIEAAF"
     exon            3623..3807
                     /gene="SCGB2B2"
                     /gene_synonym="SCGB4A2; SCGBL"
                     /inference="alignment:Splign:2.1.0"
     exon            3808..6763
                     /gene="SCGB2B2"
                     /gene_synonym="SCGB4A2; SCGBL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6666..6671
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCGB2B2"
                     /gene_synonym="SCGB4A2; SCGBL"
                     /note="hexamer: ACTAAA"
     polyA_site      6696
                     /gene="SCGB2B2"
                     /gene_synonym="SCGB4A2; SCGBL"
                     /note="major polyA site"
     regulatory      6733..6738
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCGB2B2"
                     /gene_synonym="SCGB4A2; SCGBL"
                     /note="hexamer: ATTATA"
     polyA_site      6763
                     /gene="SCGB2B2"
                     /gene_synonym="SCGB4A2; SCGBL"
                     /note="major polyA site"
ORIGIN      
        1 gcactcattt gcccaagacg ataactcaca aaacgccctg tggcccgact gtcacgactg
       61 tagttcgcca accaagggca tttcctggaa atgcaagggg acacgtatct gtgacactaa
      121 tggccgttct gacgtgcgtt acgcccctgg aaggacttgg aaatactgaa cttgagtgag
      181 cactgggagg atggagaccc tcatcctggg aggagtcact cctcccgcag ccatcacagc
      241 ctgacgcccc ctctccccag aagtgcttct taggcccacc caaaagggca atggacctct
      301 ctgtatgcaa gccagagcag tctactgttt gtgtatattt gggttgttta ctttcttttt
      361 aacacttaaa tgttaattga cttcaatcat ttttaaaatt ataaatagtg tcgctataga
      421 cttttttgta cttattaagt actgacctgc atgatcttcg tgaagcagtg cttctgttac
      481 cagaaagggg tccggatccg accccaagag agagttctta gagctcacgc aagaaaaaat
      541 ccatgggaga gcacagtgca aagccaaagc aagtgtatta agaaagtaaa gaaacaatgg
      601 gtactccatt gttagagcag cagcttgggc tgctggacta gggatacttg tatttattgc
      661 ttgatgatgt gctaaacaag ggtggattat tcatgagttt tccaggaaag aggtgggcaa
      721 tttcaatttc tcggagctga gggcttccca gctttttgaa ccatacaggg taacttctga
      781 accttaccat ggcatttgta aattgccatg gcactgatga gcgtttctct tagcgtgcta
      841 atgcatataa ttagcatata accgagaggt gaagccagct gggcttctgg atcaggtggg
      901 gccttggaga acttttctgt atagctgaag gattgtaaat acaccaatca gtgctctgtg
      961 tctagctaaa ggtttgtaaa tgcaccagtc agcactctgt aaaaacggac caaacagcac
     1021 tctgtaaaat agaccaatca gcgctctgta aaatggacaa atcagcagga tgtgggcggg
     1081 gccaaataag ggaataaaaa cgggccaccc gaacaaccag cggcaaccgc gctggggtct
     1141 acttcccagg tgtgggatgt ttgttctttt gctctttggg tctgcactac ctttatgagc
     1201 tgcaacactc accctgaagg tctgcagctt cactcttgaa gccagcgaga ccacaaaccc
     1261 actgggagga acgaacaact ccagacacgc cgtctttagg agctgtaaca ctcactgtga
     1321 aggtctgcag cttcactcct gaagccagcg aaatcatgaa cccaccggga ggaacaaaca
     1381 actccagcac gactccagac gcaccgcctt tatgagctgt aacacacacc gcgagggtct
     1441 gcagcttcac tcctgaagcc agccagacca ggaacccacc agaaggaacc aattccggac
     1501 acataacaag cagcagtgag gacaccaaag acacagaccc agatgcagag gcagaggcag
     1561 ccacacagcc cctcccagcc acaatcacaa cctcatattc atataatcac agaccctcca
     1621 ccccacatag tgggtggaat cctgccagcg cattccactc acacacacac aaaatcccat
     1681 tctcacacac gtgcacccaa gcctcgtccc gcacacacaa catgacaggc cacagagccg
     1741 gctgagagtc tcagcacgca tggacgcctg cactgcgcag gttgcagccc aggctgcagg
     1801 accacaggtg gcagggacga cacagcaggt ggccggccag ggagtggcag tggcctccat
     1861 cctccctgct cagccacagc ccctgcttca gcgtctgcca gtccaactgt caactcatcc
     1921 actcaacttt acaactggaa tgtgggggcg ttcagggccc tgccactggt gacggccact
     1981 ctaagtccta cccaatgctg ggtaggtcct ttaagaggcc caagtcctgg gcgctactat
     2041 gaggttctgt acgtgcacag tgatggctca tgcctggccg aggtgagccc actcagtctg
     2101 ggtggcacag cctaatctag gaactgctct gcggttctac atggctctca gcagcccagt
     2161 gagtgtcctc tgcaccgggc gtgtccctca ggtgctccta gccagaccct cccttgacac
     2221 agtagggcac aaaccgctat tggagcggca ctggcacccg agtgtacaag cgtcagcatc
     2281 cctgctgcct tccccacccc cagctgtccc cacctgctga ttctgcccct ggggtcacac
     2341 ttacaattta gggtcctgtc aggagacaaa aatcacgtga gtgacatcag ctccctcata
     2401 tgtaggtgct gggaaaaggg cttgtggggt gcctgtataa actggccata aaaatacggg
     2461 aataagttgt ggaaagccac aaaaggcctc tgaggaggaa agcctcctaa ttgccatcat
     2521 gttcccatgc tcagagcaag acccgctgtc ttctctgtaa acactgtgct cagggagaaa
     2581 gacacttctt tgaaacactg gaatgtggac agacgtgcag gctcccagtc aaggccgctc
     2641 ctactagcta ctctccaaca agttaaagtt atgctgtttg agcacaaagg agactcattt
     2701 aaactgctat tgctatagat tatgcctgtg atgcactgcc accctttcac tgtttctccc
     2761 tgaacatctg cttcttagat cgaagggact gtactcaata aatagtgtgg agaccagagc
     2821 tcggcacctt ttgcagcctc cacattttgc actggccccc tggctcccca cctttcactc
     2881 ttaacttgtc ttttctcaat cctttgtcac caccagactt cgggtaccct acgggtagtg
     2941 ttgaggctgg tccccaacat gtaggatccc ttcactgtgt cacatgtgtc cctaacacac
     3001 ttgctacatc tcatgtcctt taggttctgt gttttactcc agataatgtt ctttgaatct
     3061 aaattacagt ttactgattt ctcaaaagct gcacctaatg tgctatccat tcagacagac
     3121 atactcactt agcaaatgtt tgttgagcca gcactcagtg gcagattctg tgctagggcg
     3181 tgccaagtgc agacacacgt ttgccaagac acagggtcac atgtgcatgc acactcagac
     3241 ttgcaggctt acaccagtgt tcagcctgct cccaatccca gggagctcca gggaggacag
     3301 agagaatgtc acaacaccca acccctccca ctgcatgctg agtccagttc ccgatacgct
     3361 gccaccccaa cagcatggcc cagggccgag ggtctctctg cagacctgcc ctgaccacat
     3421 tcacacacac acacacacac acacacacac acacacacac acacacacac acgaagaggc
     3481 atgtgccttg ttcagatata cataaagctc acccatcgcc aaattccctg cctgtgcctg
     3541 ctgggaccag actccgctgt catgagggtg acatccgcca cctgtgctct tctgctggct
     3601 ctgatctgca gcgtccagct gggggatgcc tgcctggata tcgataaact gcttgcgaat
     3661 gttgtgtttg atgtgtccca agacctcctg aaggaggagc ttgctcgtta caaccccagt
     3721 cccctgacag aggagtcctt cctcaatgtc cagcaatgct ttgccaatgt ctccgtgaca
     3781 gaaagatttg ctcattcagt tgttattaag aagatccttc agagcaacga ttgcatagaa
     3841 gcagccttct gatctgagga cccctgcaga tcagatattg gccctcctgc cttccttggg
     3901 gctccccgcg ttcctggcct ggctctgttc atcactacag agaccccaat gaacacctgc
     3961 agctcagttc tgtgttctgg catctgtgtg gggttggctg tgaccgcata tgcagagtgt
     4021 gaccagggtc ccagtgtgaa aatatgcgac tgaggaaaaa ctctacaggt gtagcataga
     4081 catgcctgtt ttctttttgg cggggaggag ggtggctgga gtgcattggc gcgatcttgg
     4141 ctcactgcag cctccacctt ctgggttcaa gcgattctcc tgcctctgcc tcctgagtag
     4201 cagaatacag ccacacacca ccacgcttgg ctaatttttg tatttttagt ggagacaggg
     4261 ttttgccatg ttggccaggc tggtctcaaa ctcctgaccg caaatgatcc acctacctca
     4321 acctccaacg tgctagggtt agaggcatga gccactgtgt ccagtcgata tgcctgtttt
     4381 cggaacccag gaaatcaacc ttaacacact tctccatccc tacctaccca agctgtcctt
     4441 ttttctcccc ctacctctac cccacaaccc ctcaatgcag aacctccagg gctccccagg
     4501 actcgggatg ctggaggctg ggaaatcaca ccctcctggc taagtcacaa gcctcagcgt
     4561 ccccataaat acctgcagct cagctctgct cctggggctg gtgggaccag gcaatctgca
     4621 tgaggccatg ggtctgtgtg gccatgtcac catgacaggg gacattgaca ttgaggtcac
     4681 agggaacgag tgccaccctc aaacacggcc cctctctccc acctcacccc tcagttgatt
     4741 tcatcctcga tggaggtctc agtggccttc aatacactga tgaggctcca tcaactcctt
     4801 ctgggggagg tccctcccca aacctcaagc cctttccgca ggctccttgg acctcccagg
     4861 cggtggtcgc ctacccctat cagctcacac cgccctagac tcctccctct ccctcccacc
     4921 caggtgtctc tcagatgaca ccctccaaac cctgtccctc cctcctgctc aggtcagcga
     4981 gacctccatc cctctgagtc tccctgcctc cagcctcact ccccttccat gggaatacca
     5041 gcctggatct tctttctccc tggatctttg agagctcatt tccctacaag tgcagaccca
     5101 ccttcagcag ggcacacacg gctggccagg acaaggctcc actgctgacc accctatctt
     5161 tgcactccca gatttccttt caacattctt ctcctccctc actcccactg cccaaaatgc
     5221 cctttctccc ttccacccat tctccttgtc atccctcagc cgtcatctcc tccaggtcac
     5281 acgtttcagt cccccatctc aggacacatc atctcccctc tgtccccaga attggcctca
     5341 tttaatgcac tttccatccc agtcatcacc catccactca gccagggaag aagtgtcccc
     5401 tgccacacat caggcccttt cccagagccg ggcacccagt ggaaaacaag gcaggtgacg
     5461 gccctgcttc cctgaagttc acatccaagg tgaagagggg gttgcaaagc tcaagaaaat
     5521 tgtaatagtg atgagaacca caaggaccac ccaacaggga aatgtgatca ggcgggactg
     5581 gcttgaggtg ccacattggt caggtggtcc cagaaggcat ctgaggagac aacatctccc
     5641 ctgagtcctg aagaacctga ggcagccacc aggtgaaggt ctggggcagg gaatgcggca
     5701 tgatgagaaa ggatttgttg tgttggagaa atggccagtg cagctggaac aaggggcagc
     5761 agggaaggag gtcacgtcag aaaacgaggc aagtgccagg tcacgcagga ccttgcagaa
     5821 aggtggatcc tttccatgtg cagtgaaaaa tcctgggagg ggatgagcag gacttacgag
     5881 gtcacacttt ccctgttgga atagagcaac gggggcggca gtagaggcag gaagaccaac
     5941 tgggagtccc tgtggccgtc caggtagaca ccgtggcctt gtcacagtgc agccctggag
     6001 agacacgagg gagacagagg ctggggcagc actgacagca cctgctgttg aattgaatat
     6061 ggggagagga tgtggagaga aggggaatca aaatgatctc atcacatttg ggctggagca
     6121 gctggctgga tgtgatgcca ctgctgagaa ggtgaagcct ggggaggagc aggtttaggg
     6181 caaagatcca gagtcccatg ctggcctgga taagtttccc acatccaaga catccattag
     6241 ctatccagga ggacgggaca cagggggtgt gagacgctct agtttggagc tcatggaata
     6301 gttgggcctg gagacaaaaa catgtaaatt tcagcatttc aatggaattt aaatctgtgg
     6361 agctaaagaa aataatgcag atcatgctac ttattcagtc tcaattaaaa ctcagcttgt
     6421 agcaatcaaa gatggagagt ttcaaccaga agtaaatgaa aagaattaga aatgccctga
     6481 gaaatttgga caaacatgtt attgatataa atactttgag atgcaaaagc atttcacatg
     6541 tgtttgaaag aataaggaaa atgttagaaa ataattgtca ctgaagatga gtctacccat
     6601 gatctgtcag ttgtcctgaa attgagtaat ttcttaaaat gacaatgtcc tgtgagttta
     6661 ctttaactaa aatgcttacg actctgttat tcttaatgat atgtgatgat ctctgtattg
     6721 ttggtataag gaattatatt ccctacttgt atgtttcata gaa
//
