LOCUS       NM_002411                506 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens secretoglobin family 2A member 2 (SCGB2A2), mRNA.
ACCESSION   NM_002411
VERSION     NM_002411.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Kusumastuti,R., Kumagai,Y., Ishihara,S., Enomoto,A., Murakami,T.,
            Yasuda,M. and Haga,H.
  TITLE     Mammaglobin 1 mediates progression of trastuzumab-resistant breast
            cancer cells through regulation of cyclins and NF-kappaB
  JOURNAL   FEBS Open Bio 12 (10), 1797-1813 (2022)
   PUBMED   35945910
  REMARK    GeneRIF: Mammaglobin 1 mediates progression of
            trastuzumab-resistant breast cancer cells through regulation of
            cyclins and NF-kappaB.
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Talaat,I.M., Hachim,M.Y., Hachim,I.Y., Ibrahim,R.A.E.,
            Ahmed,M.A.E.R. and Tayel,H.Y.
  TITLE     Bone marrow mammaglobin-1 (SCGB2A2) immunohistochemistry expression
            as a breast cancer specific marker for early detection of bone
            marrow micrometastases
  JOURNAL   Sci Rep 10 (1), 13061 (2020)
   PUBMED   32747636
  REMARK    GeneRIF: Bone marrow mammaglobin-1 (SCGB2A2) immunohistochemistry
            expression as a breast cancer specific marker for early detection
            of bone marrow micrometastases.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 506)
  AUTHORS   Soares,C.D., de Lima Morais,T.M., Carlos,R., Martins,M.D., de
            Almeida,O.P., Mariano,F.V. and Altemani,A.
  TITLE     Immunohistochemical expression of mammaglobin in salivary duct
            carcinomas de novo and salivary duct carcinoma ex pleomorphic
            adenoma
  JOURNAL   Hum Pathol 92, 59-66 (2019)
   PUBMED   31400353
  REMARK    GeneRIF: This study has confirmed that the mammaglobin is commonly
            expressed in salivary duct carcinoma de novo and secretory
            carcinomas.
REFERENCE   4  (bases 1 to 506)
  AUTHORS   Ni,Y.B., Tsang,J.Y.S., Shao,M.M., Chan,S.K., Cheung,S.Y., Tong,J.,
            To,K.F. and Tse,G.M.
  TITLE     GATA-3 is superior to GCDFP-15 and mammaglobin to identify primary
            and metastatic breast cancer
  JOURNAL   Breast Cancer Res Treat 169 (1), 25-32 (2018)
   PUBMED   29340880
  REMARK    GeneRIF: GATA-3 expression was the highest in luminal breast
            carcinomas, and showed higher sensitivity than GCDFP-15 and MGB.
            However, in the poorly differentiated IBC, its utility was still
            limited. One should be aware of the possible GATA-3 expression in
            lung carcinomas.
REFERENCE   5  (bases 1 to 506)
  AUTHORS   Yang,Y., Lu,S., Zeng,W., Xie,S. and Xiao,S.
  TITLE     GATA3 expression in clinically useful groups of breast carcinoma: a
            comparison with GCDFP15 and mammaglobin for identifying paired
            primary and metastatic tumors
  JOURNAL   Ann Diagn Pathol 26, 1-5 (2017)
   PUBMED   28038704
  REMARK    GeneRIF: good coincidence was observed between primary and
            metastatic tumor GATA3 expression (kappa value = 0.826 >0.75) as
            compared with the coincidence of GCDFP15 (kappa value =0.492 <0.75)
            and mammaglobin (kappa value =0.593 <0.75)
REFERENCE   6  (bases 1 to 506)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
REFERENCE   7  (bases 1 to 506)
  AUTHORS   Fischer,M. and Kuppers,R.
  TITLE     Human IgA- and IgM-secreting intestinal plasma cells carry heavily
            mutated VH region genes
  JOURNAL   Eur J Immunol 28 (9), 2971-2977 (1998)
   PUBMED   9754584
REFERENCE   8  (bases 1 to 506)
  AUTHORS   Watson,M.A., Darrow,C., Zimonjic,D.B., Popescu,N.C. and
            Fleming,T.P.
  TITLE     Structure and transcriptional regulation of the human mammaglobin
            gene, a breast cancer associated member of the uteroglobin gene
            family localized to chromosome 11q13
  JOURNAL   Oncogene 16 (6), 817-824 (1998)
   PUBMED   9488047
REFERENCE   9  (bases 1 to 506)
  AUTHORS   Wilson,P.C., de Bouteiller,O., Liu,Y.J., Potter,K., Banchereau,J.,
            Capra,J.D. and Pascual,V.
  TITLE     Somatic hypermutation introduces insertions and deletions into
            immunoglobulin V genes
  JOURNAL   J Exp Med 187 (1), 59-70 (1998)
   PUBMED   9419211
REFERENCE   10 (bases 1 to 506)
  AUTHORS   Watson,M.A. and Fleming,T.P.
  TITLE     Mammaglobin, a mammary-specific member of the uteroglobin gene
            family, is overexpressed in human breast cancer
  JOURNAL   Cancer Res 56 (4), 860-865 (1996)
   PUBMED   8631025
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U33147.1 and BG207094.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002411.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AW972474.1, U33147.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000227918.3/ ENSP00000227918.2
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-502               U33147.1           2-503
            503-506             BG207094.1         205-208
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.3"
     gene            1..506
                     /gene="SCGB2A2"
                     /gene_synonym="MGB1; PSBP1; UGB2"
                     /note="secretoglobin family 2A member 2"
                     /db_xref="GeneID:4250"
                     /db_xref="HGNC:HGNC:7050"
                     /db_xref="MIM:605562"
     exon            1..114
                     /gene="SCGB2A2"
                     /gene_synonym="MGB1; PSBP1; UGB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..341
                     /gene="SCGB2A2"
                     /gene_synonym="MGB1; PSBP1; UGB2"
                     /note="mammaglobin 1; mammaglobin-A; prostatic steroid
                     binding protein 1"
                     /codon_start=1
                     /product="mammaglobin-A precursor"
                     /protein_id="NP_002402.1"
                     /db_xref="CCDS:CCDS8018.1"
                     /db_xref="GeneID:4250"
                     /db_xref="HGNC:HGNC:7050"
                     /db_xref="MIM:605562"
                     /translation="MKLLMVLMLAALSQHCYAGSGCPLLENVISKTINPQVSKTEYKE
                     LLQEFIDDNATTNAIDELKECFLNQTDETLSNVEVFMQLIYDSSLCDLF"
     exon            115..302
                     /gene="SCGB2A2"
                     /gene_synonym="MGB1; PSBP1; UGB2"
                     /inference="alignment:Splign:2.1.0"
     exon            303..506
                     /gene="SCGB2A2"
                     /gene_synonym="MGB1; PSBP1; UGB2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      488..493
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCGB2A2"
                     /gene_synonym="MGB1; PSBP1; UGB2"
                     /note="hexamer: AATAAA"
     polyA_site      506
                     /gene="SCGB2A2"
                     /gene_synonym="MGB1; PSBP1; UGB2"
                     /note="major polyA site"
ORIGIN      
        1 acagcggctt ccttgatcct tgccacccgc gactgaacac cgacagcagc agcctcacca
       61 tgaagttgct gatggtcctc atgctggcgg ccctctccca gcactgctac gcaggctctg
      121 gctgcccctt attggagaat gtgatttcca agacaatcaa tccacaagtg tctaagactg
      181 aatacaaaga acttcttcaa gagttcatag acgacaatgc cactacaaat gccatagatg
      241 aattgaagga atgttttctt aaccaaacgg atgaaactct gagcaatgtt gaggtgttta
      301 tgcaattaat atatgacagc agtctttgtg atttatttta actttctgca agacctttgg
      361 ctcacagaac tgcagggtat ggtgagaaac caactacgga ttgctgcaaa ccacaccttc
      421 tctttcttat gtctttttac tacaaactac aagacaattg ttgaaacctg ctatacatgt
      481 ttattttaat aaattgatgg caaaaa
//
