LOCUS       NM_002407                520 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens secretoglobin family 2A member 1 (SCGB2A1), mRNA.
ACCESSION   NM_002407
VERSION     NM_002407.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 520)
  AUTHORS   Soleimani,S., Alizadeh Shargh,S., Keramatinia,A., Mehrvar,N.,
            Mansouri,N., Doosti,A., Mortazavi-Tabatabaei,S.A., Hashemi,M. and
            Movafagh,A.
  TITLE     Detection of gene expression in sentinel lymph node of primary
            breast cancer patients
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 64 (5), 118-121 (2018)
   PUBMED   29729704
  REMARK    GeneRIF: The expression of HOXB13, IL17BR, and mammaglobin 1 in
            sentinel lymph nodes predict the outcome of primary breast cancer
            patients.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 520)
  AUTHORS   Sangoi,A.R., Shrestha,B., Yang,G., Mego,O. and Beck,A.H.
  TITLE     The Novel Marker GATA3 is Significantly More Sensitive Than
            Traditional Markers Mammaglobin and GCDFP15 for Identifying Breast
            Cancer in Surgical and Cytology Specimens of Metastatic and Matched
            Primary Tumors
  JOURNAL   Appl Immunohistochem Mol Morphol 24 (4), 229-237 (2016)
   PUBMED   25906123
  REMARK    GeneRIF: novel marker GATA3 stains a significantly higher
            proportion of both primary and metastatic breast carcinomas than
            GCDFP15 or mammaglobin with stronger and more diffuse staining,
            helpful in cases with small tissue samples
            Review article
REFERENCE   3  (bases 1 to 520)
  AUTHORS   Ni,Y.B., Tsang,J.Y., Chan,S.K. and Tse,G.M.
  TITLE     GATA-binding protein 3, gross cystic disease fluid protein-15 and
            mammaglobin have distinct prognostic implications in different
            invasive breast carcinoma subgroups
  JOURNAL   Histopathology 67 (1), 96-105 (2015)
   PUBMED   25425335
  REMARK    GeneRIF: The commonly used breast carcinoma biomarkers vary in
            their prognostic implications. GCDFP-15 independently indicated a
            favourable prognosis. GATA-3 and MGB were not associated with
            outcome.
REFERENCE   4  (bases 1 to 520)
  AUTHORS   Cheng,M., Chen,Y., Zou,D., Shen,G., Bian,G., Shen,G. and Hu,S.
  TITLE     The clinical utility of circulating tumor cells in breast cancer
            patients: detection by a quantitative assay of h-MAM gene
            expression
  JOURNAL   Int J Biol Markers 29 (3), e268-e278 (2014)
   PUBMED   24706379
  REMARK    GeneRIF: Results indicate that the quantitative analysis of h-MAM
            mRNA is a useful tool for detecting CTCs in breast cancer patients.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 520)
  AUTHORS   Guan,W., Steffen,B.T., Lemaitre,R.N., Wu,J.H.Y., Tanaka,T.,
            Manichaikul,A., Foy,M., Rich,S.S., Wang,L., Nettleton,J.A.,
            Tang,W., Gu,X., Bandinelli,S., King,I.B., McKnight,B., Psaty,B.M.,
            Siscovick,D., Djousse,L., Chen,Y.I., Ferrucci,L., Fornage,M.,
            Mozafarrian,D., Tsai,M.Y. and Steffen,L.M.
  TITLE     Genome-wide association study of plasma N6 polyunsaturated fatty
            acids within the cohorts for heart and aging research in genomic
            epidemiology consortium
  JOURNAL   Circ Cardiovasc Genet 7 (3), 321-331 (2014)
   PUBMED   24823311
REFERENCE   6  (bases 1 to 520)
  AUTHORS   Evans,V., Vockler,C., Friedlander,M., Walsh,B. and Willcox,M.D.
  TITLE     Lacryglobin in human tears, a potential marker for cancer
  JOURNAL   Clin Exp Ophthalmol 29 (3), 161-163 (2001)
   PUBMED   11446459
REFERENCE   7  (bases 1 to 520)
  AUTHORS   Zhao,C., Nguyen,T., Yusifov,T., Glasgow,B.J. and Lehrer,R.I.
  TITLE     Lipophilins: human peptides homologous to rat prostatein
  JOURNAL   Biochem Biophys Res Commun 256 (1), 147-155 (1999)
   PUBMED   10066439
REFERENCE   8  (bases 1 to 520)
  AUTHORS   Becker,R.M., Darrow,C., Zimonjic,D.B., Popescu,N.C., Watson,M.A.
            and Fleming,T.P.
  TITLE     Identification of mammaglobin B, a novel member of the uteroglobin
            gene family
  JOURNAL   Genomics 54 (1), 70-78 (1998)
   PUBMED   9806831
REFERENCE   9  (bases 1 to 520)
  AUTHORS   Lehrer,R.I., Xu,G., Abduragimov,A., Dinh,N.N., Qu,X.D., Martin,D.
            and Glasgow,B.J.
  TITLE     Lipophilin, a novel heterodimeric protein of human tears
  JOURNAL   FEBS Lett 432 (3), 163-167 (1998)
   PUBMED   9720917
REFERENCE   10 (bases 1 to 520)
  AUTHORS   Molloy,M.P., Bolis,S., Herbert,B.R., Ou,K., Tyler,M.I., van
            Dyk,D.D., Willcox,M.D., Gooley,A.A., Williams,K.L., Morris,C.A. and
            Walsh,B.J.
  TITLE     Establishment of the human reflex tear two-dimensional
            polyacrylamide gel electrophoresis reference map: new proteins of
            potential diagnostic value
  JOURNAL   Electrophoresis 18 (15), 2811-2815 (1997)
   PUBMED   9504814
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF071219.1, BC062218.1, AJ224173.1 and AP003306.2.
            
            On Nov 22, 2018 this sequence version replaced NM_002407.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CD723581.1, BC062218.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000244930.6/ ENSP00000244930.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AF071219.1         6-9
            5-513               BC062218.1         9-517
            514-516             AJ224173.1         494-496
            517-520             AP003306.2         21524-21527
FEATURES             Location/Qualifiers
     source          1..520
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.3"
     gene            1..520
                     /gene="SCGB2A1"
                     /gene_synonym="LPHC; LPNC; MGB2; UGB3"
                     /note="secretoglobin family 2A member 1"
                     /db_xref="GeneID:4246"
                     /db_xref="HGNC:HGNC:7051"
                     /db_xref="MIM:604398"
     exon            1..114
                     /gene="SCGB2A1"
                     /gene_synonym="LPHC; LPNC; MGB2; UGB3"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..347
                     /gene="SCGB2A1"
                     /gene_synonym="LPHC; LPNC; MGB2; UGB3"
                     /note="lipophilin C; mammaglobin-B; lacryglobin;
                     mammaglobin-2"
                     /codon_start=1
                     /product="mammaglobin-B precursor"
                     /protein_id="NP_002398.1"
                     /db_xref="CCDS:CCDS8016.1"
                     /db_xref="GeneID:4246"
                     /db_xref="HGNC:HGNC:7051"
                     /db_xref="MIM:604398"
                     /translation="MKLLMVLMLAALLLHCYADSGCKLLEDMVEKTINSDISIPEYKE
                     LLQEFIDSDAAAEAMGKFKQCFLNQSHRTLKNFGLMMHTVYDSIWCNMKSN"
     exon            115..302
                     /gene="SCGB2A1"
                     /gene_synonym="LPHC; LPNC; MGB2; UGB3"
                     /inference="alignment:Splign:2.1.0"
     exon            303..520
                     /gene="SCGB2A1"
                     /gene_synonym="LPHC; LPNC; MGB2; UGB3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      495..500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCGB2A1"
                     /gene_synonym="LPHC; LPNC; MGB2; UGB3"
                     /note="hexamer: AATAAA"
     polyA_site      520
                     /gene="SCGB2A1"
                     /gene_synonym="LPHC; LPNC; MGB2; UGB3"
                     /note="major polyA site"
ORIGIN      
        1 acagcaactt ccttgatccc tgccacgcac gactgaacac agacagcagc cgcctcgcca
       61 tgaagctgct gatggtcctc atgctggcgg ccctcctcct gcactgctat gcagattctg
      121 gctgcaaact cctggaggac atggttgaaa agaccatcaa ttccgacata tctatacctg
      181 aatacaaaga gcttcttcaa gagttcatag acagtgatgc cgctgcagag gctatgggga
      241 aattcaagca gtgtttcctc aaccagtcac atagaactct gaaaaacttt ggactgatga
      301 tgcatacagt gtacgacagc atttggtgta atatgaagag taattaactt tacccaaggc
      361 gtttggctca gagggctaca gactatggcc agaactcatc tgttgattgc tagaaaccac
      421 ttttctttct tgtgttgtct ttttatgtgg aaactgctag acaactgttg aaacctcaaa
      481 ttcatttcca tttcaataaa ctaactgcaa atcactaaaa
//
