LOCUS       NM_206998                446 bp    mRNA    linear   PRI 10-OCT-2024
DEFINITION  Homo sapiens secretoglobin family 1D member 4 (SCGB1D4), mRNA.
ACCESSION   NM_206998
VERSION     NM_206998.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 446)
  AUTHORS   Ozdas,T., Ozdas,S., Babademez,M.A., Muz,S.E., M Atilla,H.,
            Bastimur,S., Izbirak,A., Kurt,K. and Oz,I.
  TITLE     Significant association between SCGB1D4 gene polymorphisms and
            susceptibility to adenoid hypertrophy in a pediatric population
  JOURNAL   Turk J Med Sci 47 (1), 201-210 (2017)
   PUBMED   28263490
  REMARK    GeneRIF: Studied three single nucleotide polymorphisms (SNPs) in
            SCGB1D4 (secretoglobin family 1D member 4) . Found the SNPs to be
            associated with an increased risk of adenoid hypertrophy, as well
            as asthma, allergy, sleep-disordered breathing.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 446)
  AUTHORS   Jackson,B.C., Thompson,D.C., Wright,M.W., McAndrews,M., Bernard,A.,
            Nebert,D.W. and Vasiliou,V.
  TITLE     Update of the human secretoglobin (SCGB) gene superfamily and an
            example of 'evolutionary bloom' of androgen-binding protein genes
            within the mouse Scgb gene superfamily
  JOURNAL   Hum Genomics 5 (6), 691-702 (2011)
   PUBMED   22155607
  REMARK    Review article
REFERENCE   3  (bases 1 to 446)
  AUTHORS   Choi,M.S., Ray,R., Zhang,Z. and Mukherjee,A.B.
  TITLE     IFN-gamma stimulates the expression of a novel secretoglobin that
            regulates chemotactic cell migration and invasion
  JOURNAL   J Immunol 172 (7), 4245-4252 (2004)
   PUBMED   15034037
  REMARK    GeneRIF: This interferon-gamma-inducible secretoglobin gene,
            SCGB1D4, is expressed in virtually all tissues, and the highest
            level of expression is detectable in lymph nodes, tonsil, cultured
            lymphoblasts, and the ovary.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP003306.2 and AY359052.1.
            
            On May 17, 2019 this sequence version replaced NM_206998.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY359052.1, AY236538.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358585.3/ ENSP00000351395.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AP003306.2         106649-106659       c
            12-445              AY359052.1         1-434
            446-446             AP003306.2         103865-103865       c
FEATURES             Location/Qualifiers
     source          1..446
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.3"
     gene            1..446
                     /gene="SCGB1D4"
                     /gene_synonym="IIS"
                     /note="secretoglobin family 1D member 4"
                     /db_xref="GeneID:404552"
                     /db_xref="HGNC:HGNC:31748"
                     /db_xref="MIM:615062"
     exon            1..120
                     /gene="SCGB1D4"
                     /gene_synonym="IIS"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..317
                     /gene="SCGB1D4"
                     /gene_synonym="IIS"
                     /note="IFN-gamma inducible SCGB (IIS); IFN-gamma-inducible
                     secretoglobin"
                     /codon_start=1
                     /product="secretoglobin family 1D member 4 precursor"
                     /protein_id="NP_996881.1"
                     /db_xref="CCDS:CCDS31583.1"
                     /db_xref="GeneID:404552"
                     /db_xref="HGNC:HGNC:31748"
                     /db_xref="MIM:615062"
                     /translation="MRLSVCLLMVSLALCCYQAHALVCPAVASEITVFLFLSDAAVNL
                     QVAKLNPPPEALAAKLEVKHCTDQISFKKRLSLKKSWWK"
     exon            121..307
                     /gene="SCGB1D4"
                     /gene_synonym="IIS"
                     /inference="alignment:Splign:2.1.0"
     exon            308..446
                     /gene="SCGB1D4"
                     /gene_synonym="IIS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      427..432
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCGB1D4"
                     /gene_synonym="IIS"
                     /note="hexamer: AATAAA"
     polyA_site      446
                     /gene="SCGB1D4"
                     /gene_synonym="IIS"
                     /note="major polyA site"
ORIGIN      
        1 aggctcctgg agtcgaatcc aaatcactca ttgtgaaagc tgagctcaca gccgaataag
       61 ccaccatgag gctgtcagtg tgtctcctga tggtctcgct ggccctttgc tgctaccagg
      121 cccatgctct tgtctgccca gctgttgctt ctgagatcac agtcttctta ttcttaagtg
      181 acgctgcggt aaacctccaa gttgccaaac ttaatccacc tccagaagct cttgcagcca
      241 agttggaagt gaagcactgc accgatcaga tatcttttaa gaaacgactc tcattgaaaa
      301 agtcctggtg gaaatagtga aaaaatgtgg tgtgtgacat gtaaaaatgc tcaacctggt
      361 ttccaaagtc tttcaacgac accctgatct tcactaaaaa ttgtaaaggt ttcaacacgt
      421 tgctttaata aatcacttgc cctgca
//
