LOCUS       NM_006551                455 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens secretoglobin family 1D member 2 (SCGB1D2), mRNA.
ACCESSION   NM_006551
VERSION     NM_006551.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 455)
  AUTHORS   Strausz,S., Abner,E., Blacker,G., Galloway,S., Hansen,P., Feng,Q.,
            Lee,B.T., Jones,S.E., Haapaniemi,H., Raak,S., Nahass,G.R.,
            Sanders,E., Soodla,P., Vosa,U., Esko,T., Sinnott-Armstrong,N.,
            Weissman,I.L., Daly,M., Aivelo,T., Tal,M.C. and Ollila,H.M.
  CONSRTM   FinnGen; Estonian Genome Centre; Estonian Biobank Research Team
  TITLE     SCGB1D2 inhibits growth of Borrelia burgdorferi and affects
            susceptibility to Lyme disease
  JOURNAL   Nat Commun 15 (1), 2041 (2024)
   PUBMED   38503741
  REMARK    GeneRIF: SCGB1D2 inhibits growth of Borrelia burgdorferi and
            affects susceptibility to Lyme disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 455)
  AUTHORS   Taniuchi,K., Okabayashi,T., Sakaguchi,M. and Iwata,J.
  TITLE     [Measurement of PODXL and SCGB1D2 for detecting intraductal
            papillary mucinous neoplasm]
  JOURNAL   Nihon Shokakibyo Gakkai Zasshi 118 (3), 235-244 (2021)
   PUBMED   33692257
  REMARK    GeneRIF: [Measurement of PODXL and SCGB1D2 for detecting
            intraductal papillary mucinous neoplasm].
REFERENCE   3  (bases 1 to 455)
  AUTHORS   Fischer,K., von Brunneck,A.C., Hornung,D., Denkert,C., Ufer,C.,
            Schiebel,H., Kuhn,H. and Borchert,A.
  TITLE     Differential expression of secretoglobins in normal ovary and in
            ovarian carcinoma--overexpression of mammaglobin-1 is linked to
            tumor progression
  JOURNAL   Arch Biochem Biophys 547, 27-36 (2014)
   PUBMED   24603286
  REMARK    GeneRIF: The data indicate that MGB1, MGB2 and LIPB mRNAs are
            expressed at low levels in human tissues but basal expression is
            upregulated in ovarian cancer.
REFERENCE   4  (bases 1 to 455)
  AUTHORS   Bignotti,E., Tassi,R.A., Calza,S., Ravaggi,A., Rossi,E.,
            Donzelli,C., Todeschini,P., Romani,C., Bandiera,E., Zanotti,L.,
            Carnazza,M., Quadraro,F., Tognon,G., Sartori,E., Pecorelli,S.,
            Roque,D.M. and Santin,A.D.
  TITLE     Secretoglobin expression in ovarian carcinoma: lipophilin B gene
            upregulation as an independent marker of better prognosis
  JOURNAL   J Transl Med 11, 162 (2013)
   PUBMED   23819652
  REMARK    GeneRIF: lipophilin B gene overexpression correlates with a less
            aggressive tumor phenotype and represents a novel ovarian carcinoma
            prognostic factor
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 455)
  AUTHORS   Jackson,B.C., Thompson,D.C., Wright,M.W., McAndrews,M., Bernard,A.,
            Nebert,D.W. and Vasiliou,V.
  TITLE     Update of the human secretoglobin (SCGB) gene superfamily and an
            example of 'evolutionary bloom' of androgen-binding protein genes
            within the mouse Scgb gene superfamily
  JOURNAL   Hum Genomics 5 (6), 691-702 (2011)
   PUBMED   22155607
  REMARK    Review article
REFERENCE   6  (bases 1 to 455)
  AUTHORS   Sjodin,A., Guo,D., Lund-Johansen,M., Krossnes,B.K., Lilleng,P.,
            Henriksson,R. and Hedman,H.
  TITLE     Secretoglobins in the human pituitary: high expression of
            lipophilin B and its down-regulation in pituitary adenomas
  JOURNAL   Acta Neuropathol 109 (4), 381-386 (2005)
   PUBMED   15668787
  REMARK    GeneRIF: The present report demonstrates, for the first time,
            lipophilin B expression in the pituitary and its apparent
            down-regulation in pituitary adenomas.
REFERENCE   7  (bases 1 to 455)
  AUTHORS   Carter,D., Dillon,D.C., Reynolds,L.D., Retter,M.W., Fanger,G.,
            Molesh,D.A., Sleath,P.R., McNeill,P.D., Vedvick,T.S., Reed,S.G.,
            Persing,D.H. and Houghton,R.L.
  TITLE     Serum antibodies to lipophilin B detected in late stage breast
            cancer patients
  JOURNAL   Clin Cancer Res 9 (2), 749-754 (2003)
   PUBMED   12576445
  REMARK    GeneRIF: Serum antibodies to this protein are detected in late
            stage breast cancer patients.
REFERENCE   8  (bases 1 to 455)
  AUTHORS   Carter,D., Douglass,J.F., Cornellison,C.D., Retter,M.W.,
            Johnson,J.C., Bennington,A.A., Fleming,T.P., Reed,S.G.,
            Houghton,R.L., Diamond,D.L. and Vedvick,T.S.
  TITLE     Purification and characterization of the mammaglobin/lipophilin B
            complex, a promising diagnostic marker for breast cancer
  JOURNAL   Biochemistry 41 (21), 6714-6722 (2002)
   PUBMED   12022875
REFERENCE   9  (bases 1 to 455)
  AUTHORS   Zhao,C., Nguyen,T., Yusifov,T., Glasgow,B.J. and Lehrer,R.I.
  TITLE     Lipophilins: human peptides homologous to rat prostatein
  JOURNAL   Biochem Biophys Res Commun 256 (1), 147-155 (1999)
   PUBMED   10066439
REFERENCE   10 (bases 1 to 455)
  AUTHORS   Lehrer,R.I., Xu,G., Abduragimov,A., Dinh,N.N., Qu,X.D., Martin,D.
            and Glasgow,B.J.
  TITLE     Lipophilin, a novel heterodimeric protein of human tears
  JOURNAL   FEBS Lett 432 (3), 163-167 (1998)
   PUBMED   9720917
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP003306.2, AL708956.1 and
            AJ224172.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006551.3.
            
            Summary: The protein encoded by this gene is a member of the
            lipophilin subfamily, part of the uteroglobin superfamily, and is
            an ortholog of prostatein, the major secretory glycoprotein of the
            rat ventral prostate gland. Lipophilin gene products are widely
            expressed in normal tissues, especially in endocrine-responsive
            organs. Assuming that human lipophilins are the functional
            counterparts of prostatein, they may be transcriptionally regulated
            by steroid hormones, with the ability to bind androgens, other
            steroids and possibly bind and concentrate estramustine, a
            chemotherapeutic agent widely used for prostate cancer. Although
            the gene has been reported to be on chromosome 10, this sequence
            appears to be from a cluster of genes on chromosome 11 that
            includes mammaglobin 2. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL708956.1, BP314377.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000244926.4/ ENSP00000244926.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AP003306.2         49823-49835
            14-17               AL708956.1         26-29
            18-448              AJ224172.1         31-461
            449-451             AL708956.1         461-463
            452-455             AP003306.2         52393-52396
FEATURES             Location/Qualifiers
     source          1..455
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.3"
     gene            1..455
                     /gene="SCGB1D2"
                     /gene_synonym="LIPB; LPHB; LPNB"
                     /note="secretoglobin family 1D member 2"
                     /db_xref="GeneID:10647"
                     /db_xref="HGNC:HGNC:18396"
                     /db_xref="MIM:615061"
     exon            1..124
                     /gene="SCGB1D2"
                     /gene_synonym="LIPB; LPHB; LPNB"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..342
                     /gene="SCGB1D2"
                     /gene_synonym="LIPB; LPHB; LPNB"
                     /note="prostatein-like lipophilin B; lipophilin-B"
                     /codon_start=1
                     /product="secretoglobin family 1D member 2 precursor"
                     /protein_id="NP_006542.1"
                     /db_xref="CCDS:CCDS8017.1"
                     /db_xref="GeneID:10647"
                     /db_xref="HGNC:HGNC:18396"
                     /db_xref="MIM:615061"
                     /translation="MKLSVCLLLVTLALCCYQANAEFCPALVSELLDFFFISEPLFKL
                     SLAKFDAPPEAVAAKLGVKRCTDQMSLQKRSLIAEVLVKILKKCSV"
     exon            125..312
                     /gene="SCGB1D2"
                     /gene_synonym="LIPB; LPHB; LPNB"
                     /inference="alignment:Splign:2.1.0"
     exon            313..455
                     /gene="SCGB1D2"
                     /gene_synonym="LIPB; LPHB; LPNB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      432..437
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCGB1D2"
                     /gene_synonym="LIPB; LPHB; LPNB"
                     /note="hexamer: AATAAA"
     polyA_site      455
                     /gene="SCGB1D2"
                     /gene_synonym="LIPB; LPHB; LPNB"
                     /note="major polyA site"
ORIGIN      
        1 aggctcctgg ggtggagtcc aaatcactca ttgtttgtga aagctgagct cacagcaaaa
       61 caagccacca tgaagctgtc ggtgtgtctc ctgctggtca cgctggccct ctgctgctac
      121 caggccaatg ccgagttctg cccagctctt gtttctgagc tgttagactt cttcttcatt
      181 agtgaacctc tgttcaagtt aagtcttgcc aaatttgatg cccctccgga agctgttgca
      241 gccaagttag gagtgaagag atgcacggat cagatgtccc ttcagaaacg aagcctcatt
      301 gcggaagtcc tggtgaaaat attgaagaaa tgtagtgtgt gacatgtaaa aactttcatc
      361 ctggtttcca ctgtctttca atgacaccct gatcttcact gcagaatgta aaggtttcaa
      421 cgtcttgctt taataaatca cttgctctcc acgtc
//
