LOCUS       NM_006552                453 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens secretoglobin family 1D member 1 (SCGB1D1), mRNA.
ACCESSION   NM_006552
VERSION     NM_006552.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 453)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 453)
  AUTHORS   Guan,W., Steffen,B.T., Lemaitre,R.N., Wu,J.H.Y., Tanaka,T.,
            Manichaikul,A., Foy,M., Rich,S.S., Wang,L., Nettleton,J.A.,
            Tang,W., Gu,X., Bandinelli,S., King,I.B., McKnight,B., Psaty,B.M.,
            Siscovick,D., Djousse,L., Chen,Y.I., Ferrucci,L., Fornage,M.,
            Mozafarrian,D., Tsai,M.Y. and Steffen,L.M.
  TITLE     Genome-wide association study of plasma N6 polyunsaturated fatty
            acids within the cohorts for heart and aging research in genomic
            epidemiology consortium
  JOURNAL   Circ Cardiovasc Genet 7 (3), 321-331 (2014)
   PUBMED   24823311
REFERENCE   3  (bases 1 to 453)
  AUTHORS   Pieragostino,D., Agnifili,L., Fasanella,V., D'Aguanno,S.,
            Mastropasqua,R., Di Ilio,C., Sacchetta,P., Urbani,A. and Del
            Boccio,P.
  TITLE     Shotgun proteomics reveals specific modulated protein patterns in
            tears of patients with primary open angle glaucoma naive to therapy
  JOURNAL   Mol Biosyst 9 (6), 1108-1116 (2013)
   PUBMED   23580065
REFERENCE   4  (bases 1 to 453)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   5  (bases 1 to 453)
  AUTHORS   Jackson,B.C., Thompson,D.C., Wright,M.W., McAndrews,M., Bernard,A.,
            Nebert,D.W. and Vasiliou,V.
  TITLE     Update of the human secretoglobin (SCGB) gene superfamily and an
            example of 'evolutionary bloom' of androgen-binding protein genes
            within the mouse Scgb gene superfamily
  JOURNAL   Hum Genomics 5 (6), 691-702 (2011)
   PUBMED   22155607
  REMARK    Review article
REFERENCE   6  (bases 1 to 453)
  AUTHORS   Zhao,C., Nguyen,T., Yusifov,T., Glasgow,B.J. and Lehrer,R.I.
  TITLE     Lipophilins: human peptides homologous to rat prostatein
  JOURNAL   Biochem Biophys Res Commun 256 (1), 147-155 (1999)
   PUBMED   10066439
REFERENCE   7  (bases 1 to 453)
  AUTHORS   Lehrer,R.I., Xu,G., Abduragimov,A., Dinh,N.N., Qu,X.D., Martin,D.
            and Glasgow,B.J.
  TITLE     Lipophilin, a novel heterodimeric protein of human tears
  JOURNAL   FEBS Lett 432 (3), 163-167 (1998)
   PUBMED   9720917
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP002793.4, AJ224171.1 and
            AP003306.2.
            
            On May 17, 2019 this sequence version replaced NM_006552.1.
            
            Summary: The protein encoded by this gene is a member of the
            lipophilin subfamily, part of the uteroglobin superfamily, and is
            an ortholog of prostatein, the major secretory glycoprotein of the
            rat ventral prostate gland. This gene product represents one
            component of a heterodimeric molecule present in human tears whose
            elution profile is consistent with prostatein, a tetrameric
            molecule composed of three peptide components in heterodimers.
            Assuming that human lipophilins are the functional counterparts of
            prostatein, they may be transcriptionally regulated by steroid
            hormones, with the ability to bind androgens, other steroids and
            possibly bind and concentrate estramustine, a chemotherapeutic
            agent widely used for prostate cancer. Although the gene has been
            reported to be on chromosome 15, this sequence appears to be from a
            cluster of genes on chromosome 11 that includes mammaglobin 2.
            [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062693.1, CB984908.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03465412 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306238.3/ ENSP00000303070.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AP002793.4         110666-110687
            23-451              AJ224171.1         1-429
            452-453             AP003306.2         1122-1123
FEATURES             Location/Qualifiers
     source          1..453
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.3"
     gene            1..453
                     /gene="SCGB1D1"
                     /gene_synonym="LIPA; LPHA; LPNA"
                     /note="secretoglobin family 1D member 1"
                     /db_xref="GeneID:10648"
                     /db_xref="HGNC:HGNC:18395"
                     /db_xref="MIM:615060"
     exon            1..124
                     /gene="SCGB1D1"
                     /gene_synonym="LIPA; LPHA; LPNA"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..342
                     /gene="SCGB1D1"
                     /gene_synonym="LIPA; LPHA; LPNA"
                     /note="prostatein-like lipophilin A; lipophilin A
                     (uteroglobin family member); lipophilin-A"
                     /codon_start=1
                     /product="secretoglobin family 1D member 1 precursor"
                     /protein_id="NP_006543.1"
                     /db_xref="CCDS:CCDS8015.1"
                     /db_xref="GeneID:10648"
                     /db_xref="HGNC:HGNC:18395"
                     /db_xref="MIM:615060"
                     /translation="MRLSVCLLLLTLALCCYRANAVVCQALGSEITGFLLAGKPVFKF
                     QLAKFKAPLEAVAAKMEVKKCVDTMAYEKRVLITKTLGKIAEKCDR"
     exon            125..312
                     /gene="SCGB1D1"
                     /gene_synonym="LIPA; LPHA; LPNA"
                     /inference="alignment:Splign:2.1.0"
     exon            313..453
                     /gene="SCGB1D1"
                     /gene_synonym="LIPA; LPHA; LPNA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggctcccgg ggctgagtct aaatcactca tcattggtta aagccgagct cacagcagaa
       61 taagccacca tgaggctgtc ggtgtgtctc ctgctgctca cgctggccct ttgctgctac
      121 cgggcaaatg cagtggtctg ccaagctctt ggttctgaaa tcacaggctt cttattagct
      181 ggaaaacctg tgttcaagtt ccaacttgcc aaatttaagg cacctctgga agctgttgca
      241 gccaagatgg aagtgaagaa atgcgtggat acgatggcct atgagaaaag agtgctaatt
      301 acaaaaacat tgggaaaaat agcagagaaa tgtgatcgct gagatgtaaa aagtttttaa
      361 tgctagtttc caccatcttt caatgatacc ctgatcttca ctgcagaatg taaaggtttc
      421 aacgtcttgc tctaataaat cacttgccct gaa
//
