LOCUS       NM_003357                443 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens secretoglobin family 1A member 1 (SCGB1A1), mRNA.
ACCESSION   NM_003357
VERSION     NM_003357.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 443)
  AUTHORS   Neumann,S., Casjens,S., Hoffmeyer,F., Ruhle,K., Gamrad-Streubel,L.,
            Haase,L.M., Rudolph,K.K., Giesen,J., Neumann,V., Taeger,D.,
            Pallapies,D., Birk,T., Bruning,T. and Bunger,J.
  TITLE     Club cell protein (CC16) in serum as an effect marker for small
            airway epithelial damage caused by diesel exhaust and blasting
            fumes in potash mining
  JOURNAL   Int Arch Occup Environ Health 97 (2), 121-132 (2024)
   PUBMED   38110551
  REMARK    GeneRIF: Club cell protein (CC16) in serum as an effect marker for
            small airway epithelial damage caused by diesel exhaust and
            blasting fumes in potash mining.
REFERENCE   2  (bases 1 to 443)
  AUTHORS   Iannuzo,N., Welfley,H., Li,N.C., Johnson,M.D.L., Rojas-Quintero,J.,
            Polverino,F., Guerra,S., Li,X., Cusanovich,D.A., Langlais,P.R. and
            Ledford,J.G.
  TITLE     CC16 drives VLA-2-dependent SPLUNC1 expression
  JOURNAL   Front Immunol 14, 1277582 (2023)
   PUBMED   38053993
  REMARK    GeneRIF: CC16 drives VLA-2-dependent SPLUNC1 expression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 443)
  AUTHORS   Voraphani,N., Stern,D.A., Ledford,J.G., Spangenberg,A.L., Zhai,J.,
            Wright,A.L., Morgan,W.J., Kraft,M., Sherrill,D.L., Curtin,J.A.,
            Murray,C.S., Custovic,A., Kull,I., Hallberg,J., Bergstrom,A.,
            Herrera-Luis,E., Halonen,M., Martinez,F.D., Simpson,A., Melen,E.
            and Guerra,S.
  TITLE     Circulating CC16 and Asthma: A Population-based, Multicohort Study
            from Early Childhood through Adult Life
  JOURNAL   Am J Respir Crit Care Med 208 (7), 758-769 (2023)
   PUBMED   37523710
  REMARK    GeneRIF: Circulating CC16 and Asthma: A Population-based,
            Multicohort Study from Early Childhood through Adult Life.
REFERENCE   4  (bases 1 to 443)
  AUTHORS   Gribben,K.C., Wyss,A.B., Poole,J.A., Farazi,P.A., Wichman,C.,
            Richards-Barber,M., Beane Freeman,L.E., Henneberger,P.K.,
            Umbach,D.M., London,S.J. and LeVan,T.D.
  TITLE     CC16 polymorphisms in asthma, asthma subtypes, and asthma control
            in adults from the Agricultural Lung Health Study
  JOURNAL   Respir Res 23 (1), 305 (2022)
   PUBMED   36352422
  REMARK    GeneRIF: CC16 polymorphisms in asthma, asthma subtypes, and asthma
            control in adults from the Agricultural Lung Health Study.
            Erratum:[Respir Res. 2022 Dec 16;23(1):350. doi:
            10.1186/s12931-022-02261-w.. PMID: 36527017]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 443)
  AUTHORS   Jensen,S.M., Jones,J.E., Pass,H., Steinberg,S.M. and Linnoila,R.I.
  TITLE     Clara cell 10 kDa protein mRNA in normal and atypical regions of
            human respiratory epithelium
  JOURNAL   Int J Cancer 58 (5), 629-637 (1994)
   PUBMED   7521325
REFERENCE   6  (bases 1 to 443)
  AUTHORS   Umland,T.C., Swaminathan,S., Singh,G., Warty,V., Furey,W.,
            Pletcher,J. and Sax,M.
  TITLE     Structure of a human Clara cell phospholipid-binding protein-ligand
            complex at 1.9 A resolution
  JOURNAL   Nat Struct Biol 1 (8), 538-545 (1994)
   PUBMED   7664082
REFERENCE   7  (bases 1 to 443)
  AUTHORS   Wolf,M., Klug,J., Hackenberg,R., Gessler,M., Grzeschik,K.H.,
            Beato,M. and Suske,G.
  TITLE     Human CC10, the homologue of rabbit uteroglobin: genomic cloning,
            chromosomal localization and expression in endometrial cell lines
  JOURNAL   Hum Mol Genet 1 (6), 371-378 (1992)
   PUBMED   1284526
REFERENCE   8  (bases 1 to 443)
  AUTHORS   Bernard,A., Roels,H., Lauwerys,R., Witters,R., Gielens,C.,
            Soumillion,A., Van Damme,J. and De Ley,M.
  TITLE     Human urinary protein 1: evidence for identity with the Clara cell
            protein and occurrence in respiratory tract and urogenital
            secretions
  JOURNAL   Clin Chim Acta 207 (3), 239-249 (1992)
   PUBMED   1395029
REFERENCE   9  (bases 1 to 443)
  AUTHORS   Singh,G., Katyal,S.L., Brown,W.E., Phillips,S., Kennedy,A.L.,
            Anthony,J. and Squeglia,N.
  TITLE     Amino-acid and cDNA nucleotide sequences of human Clara cell 10 kDa
            protein
  JOURNAL   Biochim Biophys Acta 950 (3), 329-337 (1988)
   PUBMED   3167058
  REMARK    Erratum:[Biochim Biophys Acta 1989 Mar 1;1007(2):243]
REFERENCE   10 (bases 1 to 443)
  AUTHORS   Singh,G., Singh,J., Katyal,S.L., Brown,W.E., Kramps,J.A.,
            Paradis,I.L., Dauber,J.H., Macpherson,T.A. and Squeglia,N.
  TITLE     Identification, cellular localization, isolation, and
            characterization of human Clara cell-specific 10 KD protein
  JOURNAL   J Histochem Cytochem 36 (1), 73-80 (1988)
   PUBMED   3275712
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP003064.2, AK312165.1 and
            BC004481.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003357.4.
            
            Summary: This gene encodes a member of the secretoglobin family of
            small secreted proteins. The encoded protein has been implicated in
            numerous functions including anti-inflammation, inhibition of
            phospholipase A2 and the sequestering of hydrophobic ligands.
            Defects in this gene are associated with a susceptibility to
            asthma. [provided by RefSeq, May 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CD684434.1, DB196705.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142363, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000278282.3/ ENSP00000278282.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AP003064.2         122181-122182
            3-37                AK312165.1         1-35
            38-38               AP003064.2         122218-122218
            39-339              AK312165.1         37-337
            340-443             BC004481.2         322-425
FEATURES             Location/Qualifiers
     source          1..443
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.3"
     gene            1..443
                     /gene="SCGB1A1"
                     /gene_synonym="CC10; CC16; CCPBP; CCSP; UGB; UP-1; UP1"
                     /note="secretoglobin family 1A member 1"
                     /db_xref="GeneID:7356"
                     /db_xref="HGNC:HGNC:12523"
                     /db_xref="MIM:192020"
     exon            1..118
                     /gene="SCGB1A1"
                     /gene_synonym="CC10; CC16; CCPBP; CCSP; UGB; UP-1; UP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..339
                     /gene="SCGB1A1"
                     /gene_synonym="CC10; CC16; CCPBP; CCSP; UGB; UP-1; UP1"
                     /note="blastokinin; club cells 10 kDa secretory protein;
                     urine protein 1; urinary protein 1; secretoglobin, family
                     1A, member 1 (uteroglobin); Uteroglobin (club-cell
                     specific 10-kD protein); club cell 10 kDa secretory
                     protein; club cell phospholipid-binding protein; club cell
                     protein 16; club secretory protein 16"
                     /codon_start=1
                     /product="uteroglobin precursor"
                     /protein_id="NP_003348.1"
                     /db_xref="CCDS:CCDS8020.1"
                     /db_xref="GeneID:7356"
                     /db_xref="HGNC:HGNC:12523"
                     /db_xref="MIM:192020"
                     /translation="MKLAVTLTLVTLALCCSSASAEICPSFQRVIETLLMDTPSSYEA
                     AMELFSPDQDMREAGAQLKKLVDTLPQKPRESIIKLMEKIAQSSLCN"
     exon            119..306
                     /gene="SCGB1A1"
                     /gene_synonym="CC10; CC16; CCPBP; CCSP; UGB; UP-1; UP1"
                     /inference="alignment:Splign:2.1.0"
     exon            307..443
                     /gene="SCGB1A1"
                     /gene_synonym="CC10; CC16; CCPBP; CCSP; UGB; UP-1; UP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      424..429
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCGB1A1"
                     /gene_synonym="CC10; CC16; CCPBP; CCSP; UGB; UP-1; UP1"
                     /note="hexamer: AATAAA"
     polyA_site      443
                     /gene="SCGB1A1"
                     /gene_synonym="CC10; CC16; CCPBP; CCSP; UGB; UP-1; UP1"
                     /note="major polyA site"
ORIGIN      
        1 atactagccc accagactca gagacggaac cagagacggg ccagagcatc cccctcctcc
       61 accatgaaac tcgctgtcac cctcaccctg gtcacactgg ctctctgctg cagctccgct
      121 tctgcagaga tctgcccgag ctttcagcgt gtcatcgaaa ccctcctcat ggacacaccc
      181 tccagttatg aggctgccat ggaacttttc agccctgatc aagacatgag ggaggcaggg
      241 gctcagctga agaagctggt ggacaccctc ccccaaaagc ccagagaaag catcattaag
      301 ctcatggaaa aaatagccca aagctcactg tgtaattagc atttagaagc tgaagatccc
      361 caactgctcc agcctctgcc gctgccatgc tttgagtcca cgcccaccag ccttgctctc
      421 ttcaataaac cacaagcatc tca
//
