LOCUS       NM_001144757            1198 bp    mRNA    linear   PRI 02-JUN-2024
DEFINITION  Homo sapiens secretogranin V (SCG5), transcript variant 1, mRNA.
ACCESSION   NM_001144757
VERSION     NM_001144757.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1198)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1198)
  AUTHORS   Plesec,T., Brown,K., Allen,C., A Burke,C., Church,J., Kalady,M.,
            LaGuardia,L., O'Malley,M. and Heald,B.
  TITLE     Clinicopathological features of a kindred with
            SCG5-GREM1-associated hereditary mixed polyposis syndrome
  JOURNAL   Hum Pathol 60, 75-81 (2017)
   PUBMED   27984123
  REMARK    GeneRIF: Describe a hereditary mixed polyposis syndrome in which is
            characterized by SCG5-GREM1 duplication.
REFERENCE   3  (bases 1 to 1198)
  AUTHORS   Ramos-Molina,B. and Lindberg,I.
  TITLE     Phosphorylation and Alternative Splicing of 7B2 Reduce Prohormone
            Convertase 2 Activation
  JOURNAL   Mol Endocrinol 29 (5), 756-764 (2015)
   PUBMED   25811241
  REMARK    GeneRIF: FAM20C plays a role in 7B2-mediated proPC2 activation by
            phosphorylating residue Thr111; and that 7B2 function is regulated
            by alternative splicing.
REFERENCE   4  (bases 1 to 1198)
  AUTHORS   Peinado,J.R., Sami,F., Rajpurohit,N. and Lindberg,I.
  TITLE     Blockade of islet amyloid polypeptide fibrillation and cytotoxicity
            by the secretory chaperones 7B2 and proSAAS
  JOURNAL   FEBS Lett 587 (21), 3406-3411 (2013)
   PUBMED   24042052
  REMARK    GeneRIF: 7B2 chaperones blocked the cytotoxic effects of exogenous
            hIAPP
REFERENCE   5  (bases 1 to 1198)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   6  (bases 1 to 1198)
  AUTHORS   Paquet,L., Lazure,C., Seidah,N.G., Chretien,M. and Mbikay,M.
  TITLE     The production by alternate splicing of two mRNAs differing by one
            codon could be an intrinsic property of neuroendocrine protein 7B2
            gene expression in man
  JOURNAL   Biochem Biophys Res Commun 174 (1), 156-162 (1991)
   PUBMED   1989596
REFERENCE   7  (bases 1 to 1198)
  AUTHORS   Roebroek,A.J., Dehaen,M.R., van Bokhoven,A., Martens,G.J.,
            Marynen,P., van den Berghe,H. and Van de Ven,W.J.
  TITLE     Regional mapping of the human gene encoding the novel pituitary
            polypeptide 7B2 to chromosome 15q13----q14 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 50 (2-3), 158-160 (1989)
   PUBMED   2776483
REFERENCE   8  (bases 1 to 1198)
  AUTHORS   Brayton,K.A., Aimi,J., Qiu,H., Yazdanparast,R., Ghatei,M.A.,
            Polak,J.M., Bloom,S.R. and Dixon,J.E.
  TITLE     Cloning, characterization, and sequence of a porcine cDNA encoding
            a secreted neuronal and endocrine protein
  JOURNAL   DNA 7 (10), 713-719 (1988)
   PUBMED   3234177
REFERENCE   9  (bases 1 to 1198)
  AUTHORS   Benjannet,S., Marcinkiewicz,M., Falgueyret,J.P., Johnson,D.E.,
            Seidah,N.G. and Chretien,M.
  TITLE     Secretory protein 7B2 is associated with pancreatic hormones within
            normal islets and some experimentally induced tumors
  JOURNAL   Endocrinology 123 (2), 874-884 (1988)
   PUBMED   2840270
REFERENCE   10 (bases 1 to 1198)
  AUTHORS   Martens,G.J.
  TITLE     Cloning and sequence analysis of human pituitary cDNA encoding the
            novel polypeptide 7B2
  JOURNAL   FEBS Lett 234 (1), 160-164 (1988)
   PUBMED   3134253
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP308267.1, BC005349.1 and
            Y00757.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 13, 2020 this sequence version replaced NM_001144757.2.
            
            Summary: This gene encodes a secreted chaperone protein that
            prevents the aggregation of other secreted proteins, including
            proteins that are associated with neurodegenerative and metabolic
            disease. The encoded protein may be best known for its role in the
            trafficking and activation of prohormone convertase PC2 (encoded by
            Gene ID: 5126). Phosphorylation of the encoded protein has been
            shown to have an inhibitory effect on its chaperone function. This
            gene also produces a ARHGAP11A-SCG5 readthrough transcript and
            ARHGAP11A-SCG5 protein. [provided by RefSeq, Feb 2019].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005349.1, BI668719.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300175.9/ ENSP00000300175.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                BP308267.1         98-117
            21-527              BC005349.1         1-507
            528-1198            Y00757.1           477-1147
FEATURES             Location/Qualifiers
     source          1..1198
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q13.3"
     gene            1..1198
                     /gene="SCG5"
                     /gene_synonym="7B2; P7B2; SGNE1; SgV"
                     /note="secretogranin V"
                     /db_xref="GeneID:6447"
                     /db_xref="HGNC:HGNC:10816"
                     /db_xref="MIM:173120"
     exon            1..69
                     /gene="SCG5"
                     /gene_synonym="7B2; P7B2; SGNE1; SgV"
                     /inference="alignment:Splign:2.1.0"
     exon            70..302
                     /gene="SCG5"
                     /gene_synonym="7B2; P7B2; SGNE1; SgV"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..715
                     /gene="SCG5"
                     /gene_synonym="7B2; P7B2; SGNE1; SgV"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; prohormone convertase chaperone; secretory
                     granule, neuroendocrine protein 1 (7B2 protein);
                     neuroendocrine protein 7B2; secretogranin-5; pituitary
                     polypeptide; secretory granule endocrine protein I"
                     /codon_start=1
                     /product="neuroendocrine protein 7B2 isoform 1 precursor"
                     /protein_id="NP_001138229.1"
                     /db_xref="CCDS:CCDS45207.1"
                     /db_xref="GeneID:6447"
                     /db_xref="HGNC:HGNC:10816"
                     /db_xref="MIM:173120"
                     /translation="MVSRMVSTMLSGLLFWLASGWTPAFAYSPRTPDRVSEADIQRLL
                     HGVMEQLGIARPRVEYPAHQAMNLVGPQSIEGGAHEGLQHLGPFGNIPNIVAELTGDN
                     IPKDFSEDQGYPDPPNPCPVGKTADDGCLENTPDTAEFSREFQLHQHLFDPEHDYPGL
                     GKWNKKLLYEKMKGGERRKRRSVNPYLQGQRLDNVVAKKSVPHFSDEDKDPE"
     exon            303..452
                     /gene="SCG5"
                     /gene_synonym="7B2; P7B2; SGNE1; SgV"
                     /inference="alignment:Splign:2.1.0"
     exon            453..565
                     /gene="SCG5"
                     /gene_synonym="7B2; P7B2; SGNE1; SgV"
                     /inference="alignment:Splign:2.1.0"
     exon            566..619
                     /gene="SCG5"
                     /gene_synonym="7B2; P7B2; SGNE1; SgV"
                     /inference="alignment:Splign:2.1.0"
     exon            620..1198
                     /gene="SCG5"
                     /gene_synonym="7B2; P7B2; SGNE1; SgV"
                     /inference="alignment:Splign:2.1.0"
     regulatory      977..982
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCG5"
                     /gene_synonym="7B2; P7B2; SGNE1; SgV"
                     /note="hexamer: AATAAA"
     polyA_site      998
                     /gene="SCG5"
                     /gene_synonym="7B2; P7B2; SGNE1; SgV"
     regulatory      1179..1184
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCG5"
                     /gene_synonym="7B2; P7B2; SGNE1; SgV"
                     /note="hexamer: AATAAA"
     polyA_site      1198
                     /gene="SCG5"
                     /gene_synonym="7B2; P7B2; SGNE1; SgV"
                     /note="major polyA site"
ORIGIN      
        1 agttcgcccg ttcctggcct gacccccacc aaggcccata ccgcagtagg ctcctcgggc
       61 tgcccctcgg ttgacaatgg tctccaggat ggtctctacc atgctatctg gcctactgtt
      121 ttggctggca tctggatgga ctccagcatt tgcttacagc ccccggaccc ctgaccgggt
      181 ctcagaagca gatatccaga ggctgcttca tggtgttatg gagcaattgg gcattgccag
      241 gccccgagtg gaatatccag ctcaccaggc catgaatctt gtgggccccc agagcattga
      301 aggtggagct catgaaggac ttcagcattt gggtcctttt ggcaacatcc ccaacatcgt
      361 ggcagagttg actggagaca acattcctaa ggactttagt gaggatcagg ggtacccaga
      421 ccctccaaat ccctgtcctg ttggaaaaac agcagatgat ggatgtctag aaaacacccc
      481 tgacactgca gagttcagtc gagagttcca gttgcaccag catctctttg atccggaaca
      541 tgactatcca ggcttgggca agtggaacaa gaaactcctt tacgagaaga tgaagggagg
      601 agagagacga aagcggagga gtgtcaatcc atatctacaa ggacagagac tggataatgt
      661 tgttgcaaag aagtctgtcc cccatttttc agatgaggat aaggatccag agtaaagaga
      721 agatgctaga cgaaaaccca cattacctgt taggcctcag catggcttat gtgcacgtgt
      781 aaatggagtc cctgtgaatg acagcatgtt tcttacatag ataattatgg atacaaagca
      841 gctgtatgta gatagtgtat tgtcttcaca ccgatgattc tgctttttgc taaattagaa
      901 taagagcttt tttgtttctt gggtttttaa aatgtgaatc tgcaatgatc ataaaaatta
      961 aaatgtgaat gtcaacaata aaaagcaaga ctatgaaagg ctcagatttc ttgcagttta
     1021 aaatggtgtc tgaggttgta ctattttggc caagtctgta gaaagctgtc atttgatttt
     1081 gattatgtag ttcatccagc ccttgggcat tgttatacac cagtaaagaa ggctgtactc
     1141 aagaggagga gctgacacat ttcacttggc tgcgtcttaa taaacatgaa tgcaagca
//
