LOCUS       NM_013243               3160 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens secretogranin III (SCG3), transcript variant 1, mRNA.
ACCESSION   NM_013243
VERSION     NM_013243.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3160)
  AUTHORS   Dai,C., Webster,K.A., Bhatt,A., Tian,H., Su,G. and Li,W.
  TITLE     Concurrent Physiological and Pathological Angiogenesis in
            Retinopathy of Prematurity and Emerging Therapies
  JOURNAL   Int J Mol Sci 22 (9), 4809 (2021)
   PUBMED   34062733
  REMARK    GeneRIF: Concurrent Physiological and Pathological Angiogenesis in
            Retinopathy of Prematurity and Emerging Therapies.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3160)
  AUTHORS   Wang,Y., Ji,N., Wang,J., Cao,J., Li,D., Zhang,Y. and Zhang,L.
  TITLE     SCG3 Protein Expression in Glioma Associates With less Malignancy
            and Favorable Clinical Outcomes
  JOURNAL   Pathol Oncol Res 27, 594931 (2021)
   PUBMED   34257545
  REMARK    GeneRIF: SCG3 Protein Expression in Glioma Associates With less
            Malignancy and Favorable Clinical Outcomes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3160)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3160)
  AUTHORS   Zhan,X., Li,F., Chu,Q. and Pang,H.
  TITLE     Secretogranin III may be an indicator of paraquat-induced astrocyte
            activation and affects the recruitment of BDNF during this process
  JOURNAL   Int J Mol Med 42 (6), 3622-3630 (2018)
   PUBMED   30280190
  REMARK    GeneRIF: SCG3 may be involved in PQinduced astrocyte activation via
            regulation of the expression and selective recruitment of cellular
            factors, thus suggesting that SCG3 may represent an indicator of
            astrocyte activation.
REFERENCE   5  (bases 1 to 3160)
  AUTHORS   Togayachi,A., Iwaki,J., Kaji,H., Matsuzaki,H., Kuno,A., Hirao,Y.,
            Nomura,M., Noguchi,M., Ikehara,Y. and Narimatsu,H.
  TITLE     Glycobiomarker, Fucosylated Short-Form Secretogranin III Levels Are
            Increased in Serum of Patients with Small Cell Lung Carcinoma
  JOURNAL   J Proteome Res 16 (12), 4495-4505 (2017)
   PUBMED   28949141
  REMARK    GeneRIF: results suggested an association between the fucosylated
            glycoform of short-form SgIII and Small Cell Lung Carcinoma
REFERENCE   6  (bases 1 to 3160)
  AUTHORS   Hosaka,M., Watanabe,T., Sakai,Y., Uchiyama,Y. and Takeuchi,T.
  TITLE     Identification of a chromogranin A domain that mediates binding to
            secretogranin III and targeting to secretory granules in pituitary
            cells and pancreatic beta-cells
  JOURNAL   Mol Biol Cell 13 (10), 3388-3399 (2002)
   PUBMED   12388744
REFERENCE   7  (bases 1 to 3160)
  AUTHORS   Rong,Y.P., Liu,F., Zeng,L.C., Ma,W.J., Wei,D.Z. and Han,Z.G.
  TITLE     Cloning and characterization of a novel human secretory protein:
            secretogranin III
  JOURNAL   Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 34 (4),
            411-417 (2002)
   PUBMED   12098761
REFERENCE   8  (bases 1 to 3160)
  AUTHORS   Ozawa,H. and Takata,K.
  TITLE     The granin family--its role in sorting and secretory granule
            formation
  JOURNAL   Cell Struct Funct 20 (6), 415-420 (1995)
   PUBMED   8825061
  REMARK    Review article
REFERENCE   9  (bases 1 to 3160)
  AUTHORS   Dopazo,A., Lovenberg,T.W., Danielson,P.E., Ottiger,H.P. and
            Sutcliffe,J.G.
  TITLE     Primary structure of mouse secretogranin III and its absence from
            deficient mice
  JOURNAL   J Mol Neurosci 4 (4), 225-233 (1993)
   PUBMED   7917832
REFERENCE   10 (bases 1 to 3160)
  AUTHORS   Huttner,W.B., Gerdes,H.H. and Rosa,P.
  TITLE     The granin (chromogranin/secretogranin) family
  JOURNAL   Trends Biochem Sci 16 (1), 27-30 (1991)
   PUBMED   2053134
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF453583.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_013243.3.
            
            Summary: The protein encoded by this gene is a member of the
            chromogranin/secretogranin family of neuroendocrine secretory
            proteins. Granins may serve as precursors for biologically active
            peptides. Some granins have been shown to function as helper
            proteins in sorting and proteolytic processing of prohormones;
            however, the function of this protein is unknown. Two transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Sep 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF453583.1, SRR1660807.120976.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000220478.8/ ENSP00000220478.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3160              AF453583.1         156-3315
FEATURES             Location/Qualifiers
     source          1..3160
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.2"
     gene            1..3160
                     /gene="SCG3"
                     /gene_synonym="SGIII"
                     /note="secretogranin III"
                     /db_xref="GeneID:29106"
                     /db_xref="HGNC:HGNC:13707"
                     /db_xref="MIM:611796"
     exon            1..335
                     /gene="SCG3"
                     /gene_synonym="SGIII"
                     /inference="alignment:Splign:2.1.0"
     CDS             254..1660
                     /gene="SCG3"
                     /gene_synonym="SGIII"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; secretogranin-3"
                     /codon_start=1
                     /product="secretogranin-3 isoform 1 precursor"
                     /protein_id="NP_037375.2"
                     /db_xref="CCDS:CCDS10142.1"
                     /db_xref="GeneID:29106"
                     /db_xref="HGNC:HGNC:13707"
                     /db_xref="MIM:611796"
                     /translation="MGFLGTGTWILVLVLPIQAFPKPGGSQDKSLHNRELSAERPLNE
                     QIAEAEEDKIKKTYPPENKPGQSNYSFVDNLNLLKAITEKEKIEKERQSIRSSPLDNK
                     LNVEDVDSTKNRKLIDDYDSTKSGLDHKFQDDPDGLHQLDGTPLTAEDIVHKIAARIY
                     EENDRAVFDKIVSKLLNLGLITESQAHTLEDEVAEVLQKLISKEANNYEEDPNKPTSW
                     TENQAGKIPEKVTPMAAIQDGLAKGENDETVSNTLTLTNGLERRTKTYSEDNFEELQY
                     FPNFYALLKSIDSEKEAKEKETLITIMKTLIDFVKMMVKYGTISPEEGVSYLENLDEM
                     IALQTKNKLEKNATDNISKLFPAPSEKSHEETDSTKEEAAKMEKEYGSLKDSTKDDNS
                     NPGGKTDEPKGKTEAYLEAIRKNIEWLKKHDKKGNKEDYDLSKMRDFINKQADAYVEK
                     GILDKEEAEAIKRIYSSL"
     exon            336..388
                     /gene="SCG3"
                     /gene_synonym="SGIII"
                     /inference="alignment:Splign:2.1.0"
     exon            389..434
                     /gene="SCG3"
                     /gene_synonym="SGIII"
                     /inference="alignment:Splign:2.1.0"
     exon            435..650
                     /gene="SCG3"
                     /gene_synonym="SGIII"
                     /inference="alignment:Splign:2.1.0"
     exon            651..793
                     /gene="SCG3"
                     /gene_synonym="SGIII"
                     /inference="alignment:Splign:2.1.0"
     exon            794..943
                     /gene="SCG3"
                     /gene_synonym="SGIII"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1121
                     /gene="SCG3"
                     /gene_synonym="SGIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1238
                     /gene="SCG3"
                     /gene_synonym="SGIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1322
                     /gene="SCG3"
                     /gene_synonym="SGIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1460
                     /gene="SCG3"
                     /gene_synonym="SGIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1541
                     /gene="SCG3"
                     /gene_synonym="SGIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..3160
                     /gene="SCG3"
                     /gene_synonym="SGIII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1842..1847
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCG3"
                     /gene_synonym="SGIII"
                     /note="hexamer: AGTAAA"
     polyA_site      1863
                     /gene="SCG3"
                     /gene_synonym="SGIII"
                     /note="major polyA site"
     regulatory      3140..3145
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCG3"
                     /gene_synonym="SGIII"
                     /note="hexamer: AATAAA"
     polyA_site      3160
                     /gene="SCG3"
                     /gene_synonym="SGIII"
                     /note="major polyA site"
ORIGIN      
        1 acaggaactt cagcacccac agggcggaca gcgctcccct ctacctggag acttgactcc
       61 cgcgcgcccc aaccctgctt atcccttgac cgtcgagtgt cagagatcct gcagccgccc
      121 agtcccggcc cctctcccgc cccacaccca ccctcctggc tcttcctgtt tttactcctc
      181 cttttcattc ataacaaaag ctacagctcc aggagcccag cgccgggctg tgacccaagc
      241 cgagcgtgga agaatggggt tcctcgggac cggcacttgg attctggtgt tagtgctccc
      301 gattcaagct ttccccaaac ctggaggaag ccaagacaaa tctctacata atagagaatt
      361 aagtgcagaa agacctttga atgaacagat tgctgaagca gaagaagaca agattaaaaa
      421 aacatatcct ccagaaaaca agccaggtca gagcaactat tcttttgttg ataacttgaa
      481 cctgctaaag gcaataacag aaaaggaaaa aattgagaaa gaaagacaat ctataagaag
      541 ctccccactt gataataagt tgaatgtgga agatgttgat tcaaccaaga atcgaaaact
      601 gatcgatgat tatgactcta ctaagagtgg attggatcat aaatttcaag atgatccaga
      661 tggtcttcat caactagacg ggactccttt aaccgctgaa gacattgtcc ataaaatcgc
      721 tgccaggatt tatgaagaaa atgacagagc cgtgtttgac aagattgttt ctaaactact
      781 taatctcggc cttatcacag aaagccaagc acatacactg gaagatgaag tagcagaggt
      841 tttacaaaaa ttaatctcaa aggaagccaa caattatgag gaggatccca ataagcccac
      901 aagctggact gagaatcagg ctggaaaaat accagagaaa gtgactccaa tggcagcaat
      961 tcaagatggt cttgctaagg gagaaaacga tgaaacagta tctaacacat taaccttgac
     1021 aaatggcttg gaaaggagaa ctaaaaccta cagtgaagac aactttgagg aactccaata
     1081 tttcccaaat ttctatgcgc tactgaaaag tattgattca gaaaaagaag caaaagagaa
     1141 agaaacactg attactatca tgaaaacact gattgacttt gtgaagatga tggtgaaata
     1201 tggaacaata tctccagaag aaggtgtttc ctaccttgaa aacttggatg aaatgattgc
     1261 tcttcagacc aaaaacaagc tagaaaaaaa tgctactgac aatataagca agcttttccc
     1321 agcaccatca gagaagagtc atgaagaaac agacagtacc aaggaagaag cagctaagat
     1381 ggaaaaggaa tatggaagct tgaaggattc cacaaaagat gataactcca acccaggagg
     1441 aaagacagat gaacccaaag gaaaaacaga agcctatttg gaagccatca gaaaaaatat
     1501 tgaatggttg aagaaacatg acaaaaaggg aaataaagaa gattatgacc tttcaaagat
     1561 gagagacttc atcaataaac aagctgatgc ttatgtggag aaaggcatcc ttgacaagga
     1621 agaagccgag gccatcaagc gcatttatag cagcctgtaa aaatggcaaa agatccagga
     1681 gtctttcaac tgtttcagaa aacataatat agcttaaaac acttctaatt ctgtgattaa
     1741 aattttttga cccaagggtt attagaaagt gctgaattta cagtagttaa ccttttacaa
     1801 gtggttaaaa catagctttc ttcccgtaaa aactatctga aagtaaagtt gtatgtaagc
     1861 tgagattttg tatacagaat ccttatttcc tcatagactt atattttata atcagaatat
     1921 gttgctttga aaaagcctct aatggactga ccttaaaact catccttctt ccactgtctc
     1981 atccacataa gcactccccg aagaattaag ggggttctgt tttcaaggca tgccaagtac
     2041 taaagcacct tgcagagcgt gtctattaca agatgtcatt tccaccagca gttcccttag
     2101 gggagctgaa ataaattcac attttctcaa agtctcatag ctttggagga gccatctgct
     2161 tttttggctg ctctttttag ctggcttttt attaggctca gtgacataaa aaggatccag
     2221 gtaaatgggt ataggatttg ctggatttac taacaatttc cccctgttct taacacttcc
     2281 tattagtgac ttttcagaca ttgagtttac ttataaagag agatatttat gtactctcta
     2341 agaagacaaa tgaggtcata aacactgcat aaagcaaggc aaaaatgtat gccacatctc
     2401 agttatctaa actagattag atccaagcca agttttctca acagagagca aagggccagg
     2461 cagtaaggta gaaatagaga taaaaatcat tccttccttg tgatccaaag ctggtcgagc
     2521 agctttcctg gaggaaaagg ttaatgaact tcaggtccct gcaactcagc ccccaccaca
     2581 aacacagccc tggaaacata cagtggcgca aggtcctctt gaaatgttaa tggttaatgt
     2641 tcccaaacca gagaatgctt tgaaaatgta tcattcagtg taaattaatt acatacatat
     2701 ttttctatat atttgtttca aactgtaaaa ataacataat atgtaatttg tgtattagtg
     2761 agaggtgaag ccagctggac ttcctgggtc gagtggggcc ttggagaact tttctgtctt
     2821 acaagaggat tgtaaaatgc acccatcagt gctctgtaaa acacaccaat cagcgctctg
     2881 tagctagcaa taggtttgta aaatgcaccc atcagcactc tgtaaaacgc accaatcagc
     2941 actctgtaaa atgcaccaat cagcaggatt ctaaaagtag acaatcacag ggaggattga
     3001 aaaaaagggc actctgatag ggcaaaaacg gaacatggga ggggacaaat aagggaataa
     3061 aatctggcca ccccagccag cagcagcaac ctgttcaggt cgcctgccgc tgtggaagct
     3121 ttgtcctttt gctcttcata ataaaccttg ctactgttca
//
