LOCUS       NM_152540               3162 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens sec1 family domain containing 2 (SCFD2), mRNA.
ACCESSION   NM_152540
VERSION     NM_152540.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3162)
  AUTHORS   Takeiwa,T., Ikeda,K., Suzuki,T., Sato,W., Iino,K., Mitobe,Y.,
            Kawabata,H., Horie,K. and Inoue,S.
  TITLE     PSPC1 is a potential prognostic marker for hormone-dependent breast
            cancer patients and modulates RNA processing of ESR1 and SCFD2
  JOURNAL   Sci Rep 12 (1), 9495 (2022)
   PUBMED   35681031
  REMARK    GeneRIF: PSPC1 is a potential prognostic marker for
            hormone-dependent breast cancer patients and modulates RNA
            processing of ESR1 and SCFD2.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3162)
  AUTHORS   Mitobe,Y., Iino,K., Takayama,K.I., Ikeda,K., Suzuki,T., Aogi,K.,
            Kawabata,H., Suzuki,Y., Horie-Inoue,K. and Inoue,S.
  TITLE     PSF Promotes ER-Positive Breast Cancer Progression via
            Posttranscriptional Regulation of ESR1 and SCFD2
  JOURNAL   Cancer Res 80 (11), 2230-2242 (2020)
   PUBMED   32213542
  REMARK    GeneRIF: PSF Promotes ER-Positive Breast Cancer Progression via
            Posttranscriptional Regulation of ESR1 and SCFD2.
REFERENCE   3  (bases 1 to 3162)
  AUTHORS   Siedlinski,M., Cho,M.H., Bakke,P., Gulsvik,A., Lomas,D.A.,
            Anderson,W., Kong,X., Rennard,S.I., Beaty,T.H., Hokanson,J.E.,
            Crapo,J.D. and Silverman,E.K.
  CONSRTM   COPDGene Investigators; ECLIPSE Investigators
  TITLE     Genome-wide association study of smoking behaviours in patients
            with COPD
  JOURNAL   Thorax 66 (10), 894-902 (2011)
   PUBMED   21685187
REFERENCE   4  (bases 1 to 3162)
  AUTHORS   Macgregor,S., Hewitt,A.W., Hysi,P.G., Ruddle,J.B., Medland,S.E.,
            Henders,A.K., Gordon,S.D., Andrew,T., McEvoy,B., Sanfilippo,P.G.,
            Carbonaro,F., Tah,V., Li,Y.J., Bennett,S.L., Craig,J.E.,
            Montgomery,G.W., Tran-Viet,K.N., Brown,N.L., Spector,T.D.,
            Martin,N.G., Young,T.L., Hammond,C.J. and Mackey,D.A.
  TITLE     Genome-wide association identifies ATOH7 as a major gene
            determining human optic disc size
  JOURNAL   Hum Mol Genet 19 (13), 2716-2724 (2010)
   PUBMED   20395239
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY299407.1.
            
            On Nov 23, 2018 this sequence version replaced NM_152540.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY299407.1, SRR1803612.143169.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000401642.8/ ENSP00000384182.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3162              AY299407.1         15-3176
FEATURES             Location/Qualifiers
     source          1..3162
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q12"
     gene            1..3162
                     /gene="SCFD2"
                     /gene_synonym="STXBP1L1"
                     /note="sec1 family domain containing 2"
                     /db_xref="GeneID:152579"
                     /db_xref="HGNC:HGNC:30676"
     exon            1..958
                     /gene="SCFD2"
                     /gene_synonym="STXBP1L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..2175
                     /gene="SCFD2"
                     /gene_synonym="STXBP1L1"
                     /note="syntaxin binding protein 1-like 1"
                     /codon_start=1
                     /product="sec1 family domain-containing protein 2"
                     /protein_id="NP_689753.2"
                     /db_xref="CCDS:CCDS33984.1"
                     /db_xref="GeneID:152579"
                     /db_xref="HGNC:HGNC:30676"
                     /translation="MSASGVLSFTQQGWEQVLAKVKRAVVYLDAACAESLHWGCGSTR
                     LLEAVGGPDCHLREFEPDAIGGGAKQPKAVFVLSCLLKGRTVEILRDIICRSHFQYCV
                     VVTTVSHAVHLTANHVPAAAAAEMEGQQPVFEQLEEKLCEWMGNMNYTAEVFHVPLLL
                     APVAPHFALTPAFASLFPLLPQDVHLLNSARPDKRKLGSLGDVDSTTLTPELLLQIRC
                     LVSGLSSLCEHLGVREECFAVGSLSQVIAADLANYAPAKNRKKTAAGRASVVFVDRTL
                     DLTGAVGHHGDNLVEKIISALPQLPGHTNDVMVNMIALTALHTEEENYNVVAPGCLSQ
                     SSDTTAKALWEALLNTKHKEAVMEVRRHLVEAASRENLPIKMSMGRVTPGQLMSYIQL
                     FKNNLKALMNHCGLLQLGLATAQTLKHPQTAKWDNFLAFERLLLQSIGESAMSVVLNQ
                     LLPMIKPVTQRTNEDYSPEELLILLIYIYSVTGELTVDKDLCEAEEKVKKALAQVFCE
                     ESGLSPLLQKITDWDSSINLTFHKSKIAVDELFTSLRDIAGARSLLKQFKSVYVPGNH
                     THQASYKPLLKQVVEEIFHPERPDSVDIEHMSSGLTDLLKTGFSMFMKVSRPHPSDYP
                     LLILFVVGGVTVSEVKMVKDLVASLKPGTQVIVLSTRLLKPLNIPELLFATDRLHPDL
                     GF"
     exon            959..1127
                     /gene="SCFD2"
                     /gene_synonym="STXBP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1255
                     /gene="SCFD2"
                     /gene_synonym="STXBP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1431
                     /gene="SCFD2"
                     /gene_synonym="STXBP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1681
                     /gene="SCFD2"
                     /gene_synonym="STXBP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1827
                     /gene="SCFD2"
                     /gene_synonym="STXBP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1962
                     /gene="SCFD2"
                     /gene_synonym="STXBP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2082
                     /gene="SCFD2"
                     /gene_synonym="STXBP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..3162
                     /gene="SCFD2"
                     /gene_synonym="STXBP1L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2498..2503
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCFD2"
                     /gene_synonym="STXBP1L1"
                     /note="hexamer: AATAAA"
     polyA_site      2525
                     /gene="SCFD2"
                     /gene_synonym="STXBP1L1"
                     /note="major polyA site"
     regulatory      3141..3146
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCFD2"
                     /gene_synonym="STXBP1L1"
                     /note="hexamer: AATAAA"
     polyA_site      3162
                     /gene="SCFD2"
                     /gene_synonym="STXBP1L1"
ORIGIN      
        1 agaggccgac cacgtgtact gtggagactg tcaaagtctc ccggagccca atttccggaa
       61 gcggtgagtt ctgaaagaag ttcctgcacc gtagtttccc aagtctgcga atccccaacc
      121 atgagcgcct cgggcgtact gtcctttacc cagcaaggat gggagcaggt gctggccaaa
      181 gtgaaacggg ctgtggttta cctggacgcc gcctgcgccg agagcctgca ctggggctgc
      241 ggatccaccc gtctcctgga ggcggtgggg ggtcctgact gtcacctgcg agagttcgag
      301 cccgacgcaa ttggtggtgg agccaagcag cccaaggcag tgtttgtgct gagctgcctg
      361 ctgaaaggcc ggaccgtgga gatcctacgg gacatcatct gccgcagtca cttccagtat
      421 tgtgtggtgg tcacaaccgt gagccacgct gtccacctca cagctaatca tgtcccagcg
      481 gcggcagcgg ccgagatgga ggggcagcag ccggtgttcg agcagctgga ggagaagctg
      541 tgtgaatgga tgggcaacat gaactacacg gccgaggtgt tccatgtccc gttattgctt
      601 gcccctgttg ctccccactt tgccttgact ccagcttttg catccctttt cccactgcta
      661 ccccaggatg tgcacctcct taatagcgcc cgaccggaca agaggaagct gggaagcctg
      721 ggtgatgtgg actccactac gctaacccca gagctgctgc tgcagatcag atgcctagtg
      781 tcaggcctca gttctctgtg tgaacattta ggagtacggg aggagtgttt tgctgtaggt
      841 tccttaagtc aggtcatcgc tgcggatctg gccaattatg cccctgcaaa gaacaggaag
      901 aagactgctg caggcagggc atcagtggtt tttgtggaca gaaccctgga tctcacagga
      961 gcagttggac atcatggaga caacttagta gagaagatca tttcagcact tccccagctc
     1021 ccaggccaca caaatgatgt gatggttaac atgatagcgc tcactgcact ccatactgag
     1081 gaggaaaatt ataatgtggt tgcaccaggc tgtctttcac aatccagtga caccacagcc
     1141 aaagccctat gggaagcttt actgaacact aagcacaaag aggcagtgat ggaagttcgg
     1201 agacatctag tggaagcggc aagcagagaa aacctgccaa tcaagatgag tatggggaga
     1261 gtcacaccgg gacagctcat gtcctatatt cagctcttca agaacaacct caaagctcta
     1321 atgaatcatt gtggcctcct ccagcttgga ctggccacag ctcaaacgtt gaaacaccca
     1381 cagactgcca agtgggacaa ctttctggct tttgaaaggc tccttcttca gagcattggg
     1441 gagtcagcaa tgtccgttgt gttaaatcag ctgctgccca tgattaagcc tgtaacccag
     1501 agaaccaacg aggactacag ccctgaggaa ctgctgatcc ttctcatata tatttattct
     1561 gtcactggag agctcacggt agacaaagac ctgtgtgaag cagaagaaaa agtcaagaaa
     1621 gcattggctc aggtcttctg tgaggaatct ggattgtcac ctttgctgca aaaaattacg
     1681 gactgggact cttcaattaa tctgacattt cacaaatcca aaattgccgt ggatgaactc
     1741 tttacttcac ttcgggatat tgctggagct cggagtctcc tgaaacagtt taagtctgta
     1801 tatgttcctg gaaatcatac ccaccaggca tcttataagc cattgttgaa gcaagttgtg
     1861 gaggaaatat ttcatcccga gaggccagat tccgttgata ttgaacacat gtcttcaggc
     1921 ctcactgatc tccttaaaac tggatttagc atgttcatga aggtgagccg gcctcatcct
     1981 agtgactacc ccctcctgat cctctttgtg gtaggtgggg tcacagtctc tgaagtgaaa
     2041 atggtcaaag atcttgtggc atcgttgaag ccaggaaccc aggtaatcgt gctgtccaca
     2101 cgactcctga agccacttaa cattcctgag ctgttatttg caactgaccg actgcatcca
     2161 gaccttggct tctgagcatc cgctaagaag ataagaccta ctcaagctgg aaatgccgat
     2221 gcaattttct gccaccactc caaatactcc tccacaacca gcgtccctgt cactaattgc
     2281 gagaatgatg gaattctgcc tgaagggtct tgatacctac tcagtgaggt actttgcttg
     2341 gattgctgtg attcttaaaa aaaaaaaaaa aaagtttttt tattttcctg aaggcgacag
     2401 tctgtctttt ggcgagtcca attagtgatc gtttccattt atccttaacc ctctgtttgt
     2461 gatcttcctg attccaccta caagttcatt agttctaaat aaaagcctgt tggcaagtgt
     2521 tggtagatta caactctttt tatttgaagt tgctcgagaa gttagacatg ctttagaatt
     2581 atgagtgtgg ggaaaatttg atgttcctta ggattatata actgaggagg gaacattgca
     2641 aatagggtct gaggctttgt ttctctcttg ctctgaaaca tttctgaaaa ggcaaggaag
     2701 ggaggggtag tgtctggggc agtgctggta gcctgcatgt gttgtaaatc atcctgccat
     2761 aacaaaggac tgcattgttc tagctggccc actgggcagg tctgccaggc tacttggaac
     2821 tgtagtggga aggtggttga ttggagggtt atctgtatat aaaaggtttt ctcccctcca
     2881 aagaaagact ccagtacaag atacctggtc ccagggagtc taaattgtaa cagcaacccc
     2941 tgtggacttt gtgggtatga gttttgattg aaatataaag ctttcttttc tgtaagttta
     3001 agttttccat ctgaccatag cagaaaaacc tagacccacc tagtgaaact ttgtaagaac
     3061 tccagggcaa aaacgaacca cttgcaaccc acatgtttgt aggtgtatgg tcgatggaag
     3121 tttctggcat ccatgttggt aataaagaga taaaactgaa aa
//
