LOCUS       NM_144777               3194 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens sciellin (SCEL), transcript variant 1, mRNA.
ACCESSION   NM_144777
VERSION     NM_144777.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3194)
  AUTHORS   Guo,H., Wang,Z., Yin,K., Ma,R., Zhang,Y., Yin,F., Li,H. and Yin,D.
  TITLE     Sciellin promotes the development and progression of thyroid cancer
            through the JAK2/STAT3 signaling pathway
  JOURNAL   Mol Carcinog 63 (4), 701-713 (2024)
   PUBMED   38411346
  REMARK    GeneRIF: Sciellin promotes the development and progression of
            thyroid cancer through the JAK2/STAT3 signaling pathway.
REFERENCE   2  (bases 1 to 3194)
  AUTHORS   Chen,H., Su,Y., Yang,L., Xi,L., Li,X., Lan,B., Liu,M. and Xuan,C.
  TITLE     CBX8 promotes lung adenocarcinoma growth and metastasis through
            transcriptional repression of CDKN2C and SCEL
  JOURNAL   J Cell Physiol 238 (11), 2710-2723 (2023)
   PUBMED   37733753
  REMARK    GeneRIF: CBX8 promotes lung adenocarcinoma growth and metastasis
            through transcriptional repression of CDKN2C and SCEL.
REFERENCE   3  (bases 1 to 3194)
  AUTHORS   Liang,T., Wu,X., Wang,L., Ni,Z., Fan,Y., Wu,P., Wang,H., Niu,Y. and
            Huang,H.
  TITLE     Clinical significance and diagnostic value of QPCT, SCEL and
            TNFRSF12A in papillary thyroid cancer
  JOURNAL   Pathol Res Pract 245, 154431 (2023)
   PUBMED   37060824
  REMARK    GeneRIF: Clinical significance and diagnostic value of QPCT, SCEL
            and TNFRSF12A in papillary thyroid cancer.
REFERENCE   4  (bases 1 to 3194)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3194)
  AUTHORS   Jiang,B., Tang,Y., Wang,H., Chen,C., Yu,W., Sun,H., Duan,M., Lin,X.
            and Liang,P.
  TITLE     Down-regulation of long non-coding RNA HOTAIR promotes angiogenesis
            via regulating miR-126/SCEL pathways in burn wound healing
  JOURNAL   Cell Death Dis 11 (1), 61 (2020)
   PUBMED   31974341
  REMARK    GeneRIF: Down-regulation of long non-coding RNA HOTAIR promotes
            angiogenesis via regulating miR-126/SCEL pathways in burn wound
            healing.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3194)
  AUTHORS   Corona,W., Karkera,D.J., Patterson,R.H., Saini,N., Trachiotis,G.D.,
            Korman,L.Y., Liu,B., Alexander,E.P., De la Pena,A.S., Marcelo,A.B.
            and Wadleigh,R.
  TITLE     Analysis of Sciellin (SCEL) as a candidate gene in esophageal
            squamous cell carcinoma
  JOURNAL   Anticancer Res 24 (3a), 1417-1419 (2004)
   PUBMED   15274303
  REMARK    GeneRIF: Single nucleotide polymorphisms were detected in both
            matching tumor and normal esophageal tissues but no
            disease-associated mutations suggesting that SCEL is not a major
            factor in esophageal squamous cell carcinogenesis.
REFERENCE   7  (bases 1 to 3194)
  AUTHORS   Champliaud,M.F., Viel,A. and Baden,H.P.
  TITLE     The expression of vitamin D-upregulated protein 1 in skin and its
            interaction with sciellin in cultured keratinocytes
  JOURNAL   J Invest Dermatol 121 (4), 781-785 (2003)
   PUBMED   14632196
  REMARK    GeneRIF: VDUP1 and sciellin were more highly expressed in
            keratinocytes undergoing differentiation and colocalization of the
            proteins could be demonstrated
REFERENCE   8  (bases 1 to 3194)
  AUTHORS   Champliaud,M.F., Baden,H.P., Koch,M., Jin,W., Burgeson,R.E. and
            Viel,A.
  TITLE     Gene characterization of sciellin (SCEL) and protein localization
            in vertebrate epithelia displaying barrier properties
  JOURNAL   Genomics 70 (2), 264-268 (2000)
   PUBMED   11112355
REFERENCE   9  (bases 1 to 3194)
  AUTHORS   Champliaud,M.F., Burgeson,R.E., Jin,W., Baden,H.P. and Olson,P.F.
  TITLE     cDNA cloning and characterization of sciellin, a LIM domain protein
            of the keratinocyte cornified envelope
  JOURNAL   J Biol Chem 273 (47), 31547-31554 (1998)
   PUBMED   9813070
REFERENCE   10 (bases 1 to 3194)
  AUTHORS   Kvedar,J.C., Manabe,M., Phillips,S.B., Ross,B.S. and Baden,H.P.
  TITLE     Characterization of sciellin, a precursor to the cornified envelope
            of human keratinocytes
  JOURNAL   Differentiation 49 (3), 195-204 (1992)
   PUBMED   1377656
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC372982.1, AK222720.1, AL137140.12, BC047536.1 and BM973059.1.
            
            On Nov 23, 2018 this sequence version replaced NM_144777.2.
            
            Summary: The protein encoded by this gene is a precursor to the
            cornified envelope of terminally differentiated keratinocytes. This
            protein localizes to the periphery of cells and may function in the
            assembly or regulation of proteins in the cornified envelope.
            Transcript variants encoding different isoforms exist. A transcript
            variant utilizing an alternative polyA signal has been described in
            the literature, but its full-length nature has not been determined.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK025320.1, AK222720.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000349847.4/ ENSP00000302579.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-333               DC372982.1         33-365
            334-659             AK222720.1         280-605
            660-660             AL137140.12        113299-113299
            661-2117            AK222720.1         607-2063
            2118-2176           AL137140.12        183871-183929
            2177-3021           BC047536.1         2224-3068
            3022-3194           BM973059.1         15-187              c
FEATURES             Location/Qualifiers
     source          1..3194
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q22.3"
     gene            1..3194
                     /gene="SCEL"
                     /note="sciellin"
                     /db_xref="GeneID:8796"
                     /db_xref="HGNC:HGNC:10573"
                     /db_xref="MIM:604112"
     exon            1..119
                     /gene="SCEL"
                     /inference="alignment:Splign:2.1.0"
     exon            120..181
                     /gene="SCEL"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..2205
                     /gene="SCEL"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="sciellin isoform 1"
                     /protein_id="NP_659001.2"
                     /db_xref="CCDS:CCDS9459.1"
                     /db_xref="GeneID:8796"
                     /db_xref="HGNC:HGNC:10573"
                     /db_xref="MIM:604112"
                     /translation="MSNVTLRKMSPTGNEMKSTTQGTTRKQQDFHEVNKRRTFLQDNS
                     WIKKRPEEEKDENYGRVVLNRHNSHDALDRKVNERDVPKATISRYSSDDTLDRISDRN
                     DAAKTYKANTLDNQLTNRSMSMFRSLEVTKLQPGGSLNANTSNTIASTSATTPVKKKR
                     QSWFPPPPPGYNASSSTGTRRREPGVHPPIPPKPSSPVSSPNQLRQDNRQIHPPKPGV
                     YTETNRSAERNIRSQDLDNIVKVATSLQRSDKGEELDNLIKMNKSLNRNQGLDSLFRA
                     NPKVEEREKRAKSLESLIYMSTRTDKDGKGIQSLGSPIKVNQRTDKNEKGRQNLESVA
                     KVNARMNKTSRRSEDLDNATEVNPKGHENTTGKKDLDGLIKVDPETNKNITRGQSLDN
                     LIKVTPEVKRSNQGSKDLNNFIKVYPGTEKSTEGGQSLDSLIKVTPERNRTNQGNQDL
                     ENLIKVIPSANKSSEQGLDEHINVSPKAVKNTDGKQDLDKLIKVNPEIFTNNQRNQDL
                     ANLIKVNPAVIRNNQSQDLDNLIKVKPSALRNTNRDQNLENLIEVNSHVSENKNGSSN
                     TGAKQAGPQDTVVYTRTYVENSKSPKDGYQENISGKYIQTVYSTSDRSVIERDMCTYC
                     RKPLGVETKMILDELQICCHSTCFKCEICKQPLENLQAGDSIWIYRQTIHCEPCYSKI
                     MAKWIP"
     exon            182..299
                     /gene="SCEL"
                     /inference="alignment:Splign:2.1.0"
     exon            300..359
                     /gene="SCEL"
                     /inference="alignment:Splign:2.1.0"
     exon            360..428
                     /gene="SCEL"
                     /inference="alignment:Splign:2.1.0"
     exon            429..497
                     /gene="SCEL"
                     /inference="alignment:Splign:2.1.0"
     exon            498..536
                     /gene="SCEL"
                     /inference="alignment:Splign:2.1.0"
     exon            537..617
                     /gene="SCEL"
                     /inference="alignment:Splign:2.1.0"
     exon            618..683
                     /gene="SCEL"
                     /inference="alignment:Splign:2.1.0"
     exon            684..764
                     /gene="SCEL"
                     /inference="alignment:Splign:2.1.0"
     exon            765..830
                     /gene="SCEL"
                     /inference="alignment:Splign:2.1.0"
     exon            831..890
                     /gene="SCEL"
                     /inference="alignment:Splign:2.1.0"
     exon            891..935
                     /gene="SCEL"
                     /inference="alignment:Splign:2.1.0"
     exon            936..995
                     /gene="SCEL"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1055
                     /gene="SCEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1115
                     /gene="SCEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1175
                     /gene="SCEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1235
                     /gene="SCEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1295
                     /gene="SCEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1355
                     /gene="SCEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1415
                     /gene="SCEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1475
                     /gene="SCEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1526
                     /gene="SCEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1589
                     /gene="SCEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1649
                     /gene="SCEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1709
                     /gene="SCEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1766
                     /gene="SCEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1829
                     /gene="SCEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..1901
                     /gene="SCEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..1976
                     /gene="SCEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2085
                     /gene="SCEL"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2188
                     /gene="SCEL"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..3194
                     /gene="SCEL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2416..2421
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCEL"
                     /note="hexamer: AATAAA"
     polyA_site      2440
                     /gene="SCEL"
                     /note="major polyA site"
     regulatory      3167..3172
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCEL"
                     /note="hexamer: AATAAA"
     regulatory      3172..3177
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCEL"
                     /note="hexamer: AATGAA"
     polyA_site      3187
                     /gene="SCEL"
     polyA_site      3194
                     /gene="SCEL"
ORIGIN      
        1 aggtagaggt tgagactcca ctgaataaac tctaggttcc catttctttc agccagatcc
       61 tcccagggaa tcactacagg ctggttagcc aaaaagtcct gattttctgc tcaatagagg
      121 tccttactgg aaggcagcat gtccaatgtt accttgagaa aaatgtctcc cacaggaaat
      181 gagatgaaga gcaccactca gggaaccaca cggaagcagc aggattttca cgaggtgaac
      241 aaaagaagaa ctttcttaca ggataacagt tggataaaga aacgccctga agaagaaaaa
      301 gatgaaaatt acggtagggt ggtgctcaac cgacataatt cccatgatgc attggacagg
      361 aaagtaaatg agagagatgt gccaaaagct acaattagtc ggtacagttc tgatgacact
      421 ttggacagga tctcagacag aaatgatgct gctaaaacat ataaggccaa taccttggat
      481 aaccaactaa ccaataggag catgtccatg tttagatcac tggaagtaac aaagttgcaa
      541 cctggcggtt cattgaatgc caacacctcc aacaccatag catccacttc tgctactact
      601 cctgtaaaga agaagaggca gtcctggttt ccaccgcccc ctccaggtta caatgcctcc
      661 tcgagcacag gaaccaggag acgggaacca ggtgttcacc ctccaatacc tccaaagccc
      721 agttctcctg tttcttctcc taaccagctg agacaggata ataggcagat acatccacct
      781 aaaccaggtg tatatacaga aaccaacaga tctgctgaaa gaaatataag gagtcaggat
      841 cttgataaca tcgtcaaagt ggccacttca cttcagagaa gtgacaaagg tgaagaattg
      901 gataatctca tcaaaatgaa caaaagcttg aataggaatc aaggtcttga tagtctcttc
      961 agagcaaatc caaaggtaga agaaagagag aaaagagcca aaagccttga aagtctcatc
     1021 tatatgagta cccggacaga taaagatggc aaaggaatcc aaagccttgg aagtccgatt
     1081 aaagttaatc aaaggactga caaaaatgag aaaggaagac aaaatctcga atctgttgct
     1141 aaagtgaatg ccaggatgaa taaaacgagc agaagaagtg aagaccttga taatgctact
     1201 gaagtaaatc ccaaaggaca tgaaaatacc actggaaaaa aagaccttga tgggcttatt
     1261 aaagtggatc ctgaaacaaa taaaaatatt acgaggggcc agagccttga taatctcatc
     1321 aaagtgaccc ctgaagtaaa gagaagtaac caaggttcca aagaccttaa taacttcatc
     1381 aaagtgtatc caggaacaga aaaaagtact gaagggggcc aaagtctcga cagcctcatt
     1441 aaagtgactc ctgaaagaaa cagaactaac caagggaacc aagacttgga aaatcttatc
     1501 aaagtgatcc cttcagcaaa caaaagcagt gaacaaggtc ttgatgaaca tattaatgtc
     1561 agccccaaag ctgtcaaaaa cactgatgga aaacaagatc ttgataaact catcaaggtg
     1621 aatcctgaaa ttttcacaaa caaccaaaga aaccaagatc ttgctaacct catcaaagta
     1681 aatcctgcag taatcagaaa caatcagagc caagacttgg acaatcttat taaagtgaaa
     1741 ccttcagctc ttagaaacac taatcgagac cagaacctgg aaaatttaat tgaagtaaat
     1801 tctcatgtgt ctgaaaacaa gaatggaagc tctaacactg gagccaagca ggcaggacca
     1861 caggatactg ttgtgtacac aaggacatat gtggagaata gtaaatcacc caaggatgga
     1921 tatcaggaga atatctctgg aaaatacata caaactgttt attcaacttc tgataggtct
     1981 gtcattgaaa gagatatgtg cacttactgc cgaaaaccct tgggtgtaga aactaaaatg
     2041 attttagatg aattacaaat ttgctgccat tctacttgct ttaagtgtga aatatgcaag
     2101 cagcctttgg aaaatctaca agcgggtgat agtatttgga tttatagaca gacaatacac
     2161 tgtgaacctt gctactctaa aattatggca aagtggattc cataactctg gcacaaggaa
     2221 atcaagatga aaagcactca ttaaggaatt aaagttacaa gttttatctt aataatatgt
     2281 aatctagaaa agctttcaca ttgaagatca actcttgtac aaaattaaca attctgttat
     2341 tgcataagta atctaattgt cttcaataag gtcacacaca taaaaagagc catctggtct
     2401 ctggctagag ttagcaataa aaagttcaaa tggttccaga ttccagtgtc aaaggagtga
     2461 tgcattacac tccagccagg tccatccctg ctccgtatgt tggctgtgag tggtggtttc
     2521 catttaaacc aagtttctca tttcttcacc tttttttctc taagaatttg gattcgtaga
     2581 cattgacatc ccgaagaact gtcaaggaag caagatatgc tttcttcatc tgcaaaagaa
     2641 atactaacaa caattttctt atacagtttg gcagaaagat gttaacataa aaagtttata
     2701 tacctcaaaa atcactaaac tttccagatc tctgtcctat tatttgtaac acaaggggca
     2761 ttggataaaa tgatttctag ggttcctttt gcttcccaaa ttctctgatt ctaaagcagt
     2821 ttttagaatc attagctctt tggaaacata tatgcataca tgtttgttaa gcctattgaa
     2881 ctaggtagga catataaaca atttaatttt agtgtcattg tttaatcaca gacttagtgt
     2941 ttgaaaactg tgttttaaaa acagaaacag attgatgggt aacaggtaaa atatgacatg
     3001 tatagcttac atgttattat ttgttaaatt ttctttgtat acatttcaaa atctgggtat
     3061 acttataatc cattagaagt aatggttatg gactaaaaag atatgttctt tagtatgtta
     3121 tatatactca tattacatag cagtatgttt acaaaaggct tataaaaata aaatgaacta
     3181 tcagttacat agaa
//
