LOCUS       NM_001037582            3040 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens stearoyl-CoA desaturase 5 (SCD5), transcript variant
            1, mRNA.
ACCESSION   NM_001037582
VERSION     NM_001037582.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3040)
  AUTHORS   Orosz,G., Szabo,L., Bereti,S., Zambo,V., Csala,M. and Kereszturi,E.
  TITLE     Molecular Basis of Unequal Alternative Splicing of Human SCD5 and
            Its Alteration by Natural Genetic Variations
  JOURNAL   Int J Mol Sci 24 (7), 6517 (2023)
   PUBMED   37047490
  REMARK    GeneRIF: Molecular Basis of Unequal Alternative Splicing of Human
            SCD5 and Its Alteration by Natural Genetic Variations.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3040)
  AUTHORS   Zambo,V., Orosz,G., Szabo,L., Tibori,K., Sipeki,S., Molnar,K.,
            Csala,M. and Kereszturi,E.
  TITLE     A Single Nucleotide Polymorphism (rs3811792) Affecting Human SCD5
            Promoter Activity Is Associated with Diabetes Mellitus
  JOURNAL   Genes (Basel) 13 (10), 1784 (2022)
   PUBMED   36292669
  REMARK    GeneRIF: A Single Nucleotide Polymorphism (rs3811792) Affecting
            Human SCD5 Promoter Activity Is Associated with Diabetes Mellitus.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3040)
  AUTHORS   Kanno,T., Miyako,K., Nakajima,T., Yokoyama,S., Sasamoto,S.,
            Asou,H.K., Ohara,O., Nakayama,T. and Endo,Y.
  TITLE     SCD2-mediated cooperative activation of IRF3-IRF9 regulatory
            circuit controls type I interferon transcriptome in CD4+ T cells
  JOURNAL   Front Immunol 13, 904875 (2022)
   PUBMED   36059459
  REMARK    GeneRIF: SCD2-mediated cooperative activation of IRF3-IRF9
            regulatory circuit controls type I interferon transcriptome in
            CD4(+) T cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3040)
  AUTHORS   Zhao,W., Sun,L., Li,X., Wang,J., Zhu,Y., Jia,Y. and Tong,Z.
  TITLE     SCD5 expression correlates with prognosis and response to
            neoadjuvant chemotherapy in breast cancer
  JOURNAL   Sci Rep 11 (1), 8976 (2021)
   PUBMED   33903614
  REMARK    GeneRIF: SCD5 expression correlates with prognosis and response to
            neoadjuvant chemotherapy in breast cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3040)
  AUTHORS   Igal,R.A. and Sinner,D.I.
  TITLE     Stearoyl-CoA desaturase 5 (SCD5), a Delta-9 fatty acyl desaturase
            in search of a function
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1866 (1), 158840 (2021)
   PUBMED   33049404
  REMARK    GeneRIF: Stearoyl-CoA desaturase 5 (SCD5), a Delta-9 fatty acyl
            desaturase in search of a function.
            Review article
REFERENCE   6  (bases 1 to 3040)
  AUTHORS   Ma,J., Dempsey,A.A., Stamatiou,D., Marshall,K.W. and Liew,C.C.
  TITLE     Identifying leukocyte gene expression patterns associated with
            plasma lipid levels in human subjects
  JOURNAL   Atherosclerosis 191 (1), 63-72 (2007)
   PUBMED   16806233
REFERENCE   7  (bases 1 to 3040)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   8  (bases 1 to 3040)
  AUTHORS   Wang,J., Yu,L., Schmidt,R.E., Su,C., Huang,X., Gould,K. and Cao,G.
  TITLE     Characterization of HSCD5, a novel human stearoyl-CoA desaturase
            unique to primates
  JOURNAL   Biochem Biophys Res Commun 332 (3), 735-742 (2005)
   PUBMED   15907797
REFERENCE   9  (bases 1 to 3040)
  AUTHORS   Zhang,S., Yang,Y. and Shi,Y.
  TITLE     Characterization of human SCD2, an oligomeric desaturase with
            improved stability and enzyme activity by cross-linking in intact
            cells
  JOURNAL   Biochem J 388 (Pt 1), 135-142 (2005)
   PUBMED   15610069
  REMARK    GeneRIF: The identification and characterization of SCD2, and its
            relationship to human SCD1 and mouse SCD2, are reported.
REFERENCE   10 (bases 1 to 3040)
  AUTHORS   Beiraghi,S., Zhou,M., Talmadge,C.B., Went-Sumegi,N., Davis,J.R.,
            Huang,D., Saal,H., Seemayer,T.A. and Sumegi,J.
  TITLE     Identification and characterization of a novel gene disrupted by a
            pericentric inversion inv(4)(p13.1q21.1) in a family with cleft lip
  JOURNAL   Gene 309 (1), 11-21 (2003)
   PUBMED   12727354
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB479400.1, AF389338.1, DR763368.1 and BC048971.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001037582.2.
            
            Summary: Stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is an integral
            membrane protein of the endoplasmic reticulum that catalyzes the
            formation of monounsaturated fatty acids from saturated fatty
            acids. SCD may be a key regulator of energy metabolism with a role
            in obesity and dislipidemia. Four SCD isoforms, Scd1 through Scd4,
            have been identified in mouse. In contrast, only 2 SCD isoforms,
            SCD1 (MIM 604031) and SCD5, have been identified in human. SCD1
            shares about 85% amino acid identity with all 4 mouse SCD isoforms,
            as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited
            homology with the rodent SCDs and appears to be unique to primates
            (Wang et al., 2005 [PubMed 15907797]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encoded the longer isoform (A).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.747918.1,
                                           SRR1660809.146785.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319540.9/ ENSP00000316329.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                DB479400.1         62-85
            25-637              AF389338.1         1-613
            638-1331            DR763368.1         112-805
            1332-1628           AF389338.1         1308-1604
            1629-1707           BC048971.1         785-863
            1708-3040           AF389338.1         1684-3016
FEATURES             Location/Qualifiers
     source          1..3040
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.22"
     gene            1..3040
                     /gene="SCD5"
                     /gene_synonym="ACOD4; DFNA79; FADS4; HSCD5; SCD2; SCD4"
                     /note="stearoyl-CoA desaturase 5"
                     /db_xref="GeneID:79966"
                     /db_xref="HGNC:HGNC:21088"
                     /db_xref="MIM:608370"
     exon            1..491
                     /gene="SCD5"
                     /gene_synonym="ACOD4; DFNA79; FADS4; HSCD5; SCD2; SCD4"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..1252
                     /gene="SCD5"
                     /gene_synonym="ACOD4; DFNA79; FADS4; HSCD5; SCD2; SCD4"
                     /EC_number="1.14.19.1"
                     /note="isoform a is encoded by transcript variant 1;
                     acyl-CoA-desaturase 4; stearoyl-CoA desaturase 4;
                     stearoyl-CoA 9-desaturase; stearoyl-CoA desaturase 2"
                     /codon_start=1
                     /product="stearoyl-CoA desaturase 5 isoform a"
                     /protein_id="NP_001032671.2"
                     /db_xref="CCDS:CCDS34024.1"
                     /db_xref="GeneID:79966"
                     /db_xref="HGNC:HGNC:21088"
                     /db_xref="MIM:608370"
                     /translation="MPGPATDAGKIPFCDAKEEIRAGLESSEGGGGPERPGARGQRQN
                     IVWRNVVLMSLLHLGAVYSLVLIPKAKPLTLLWAYFCFLLAALGVTAGAHRLWSHRSY
                     RAKLPLRIFLAVANSMAFQNDIFEWSRDHRAHHKYSETDADPHNARRGFFFSHIGWLF
                     VRKHRDVIEKGRKLDVTDLLADPVVRIQRKYYKISVVLMCFVVPTLVPWYIWGESLWN
                     SYFLASILRYTISLNISWLVNSAAHMYGNRPYDKHISPRQNPLVALGAIGEGFHNYHH
                     TFPFDYSASEFGLNFNPTTWFIDFMCWLGLATDRKRATKPMIEARKARTGDSSA"
     exon            492..622
                     /gene="SCD5"
                     /gene_synonym="ACOD4; DFNA79; FADS4; HSCD5; SCD2; SCD4"
                     /inference="alignment:Splign:2.1.0"
     exon            623..828
                     /gene="SCD5"
                     /gene_synonym="ACOD4; DFNA79; FADS4; HSCD5; SCD2; SCD4"
                     /inference="alignment:Splign:2.1.0"
     exon            829..1061
                     /gene="SCD5"
                     /gene_synonym="ACOD4; DFNA79; FADS4; HSCD5; SCD2; SCD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..3040
                     /gene="SCD5"
                     /gene_synonym="ACOD4; DFNA79; FADS4; HSCD5; SCD2; SCD4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3021..3026
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCD5"
                     /gene_synonym="ACOD4; DFNA79; FADS4; HSCD5; SCD2; SCD4"
                     /note="hexamer: AATAAA"
     polyA_site      3040
                     /gene="SCD5"
                     /gene_synonym="ACOD4; DFNA79; FADS4; HSCD5; SCD2; SCD4"
                     /note="major polyA site"
ORIGIN      
        1 ctcgcggccg agttcagccc gggcagccat atgggggata cgccagcaac agacgccggc
       61 cgccaagatc tgcatcccta ggccacgcta agaccctggg gaagagcgca ggagcccggg
      121 agaagggctg gaaggagggg actggacgtg cggagaattc ccccctaaaa ggcagaagcc
      181 cccgccccca ccctcgagct ccgctcgggc agagcgcctg cctgcctgcc gctgctgcgg
      241 gcgcccacct cgcccagcca tgccaggccc ggccaccgac gcggggaaga tccctttctg
      301 cgacgccaag gaagaaatcc gtgccgggct cgaaagctct gagggcggcg gcggcccgga
      361 gaggccaggc gcgcgcgggc agcggcagaa catcgtctgg aggaatgtcg tcctgatgag
      421 cttgctccac ttgggggccg tgtactccct ggtgctcatc cccaaagcca agccactcac
      481 tctgctctgg gcctacttct gcttcctcct ggccgctctg ggtgtgacag ctggtgccca
      541 tcgcttgtgg agccacaggt cctaccgggc caagctgcct ctgaggatat ttctggctgt
      601 cgccaactcc atggctttcc agaatgacat cttcgagtgg tccagggacc accgagccca
      661 ccacaagtac tcagagacgg atgctgaccc ccacaatgcc cgccggggct tcttcttctc
      721 ccatattggg tggctgtttg ttcgcaagca tcgagatgtt attgagaagg ggagaaagct
      781 tgacgtcact gacctgcttg ctgatcctgt ggtccggatc cagagaaagt actataagat
      841 ctccgtggtg ctcatgtgct ttgtggtccc cacgctggtg ccctggtaca tctggggaga
      901 gagtctgtgg aattcctact tcttggcctc tattctccgc tataccatct cactcaacat
      961 cagctggctg gtcaacagcg ccgcccacat gtatggaaac cggccctatg acaagcacat
     1021 cagccctcgg cagaacccac tcgtcgctct gggtgccatt ggtgaaggct tccataatta
     1081 ccatcacacc tttccctttg actactctgc gagtgaattt ggcttaaatt ttaacccaac
     1141 cacctggttc attgatttca tgtgctggct ggggctggcc actgaccgca aacgggcaac
     1201 caagccgatg atcgaggccc ggaaggccag gactggagac agcagtgctt gaacttggaa
     1261 cagccatccc acatgtctgc cgttgcaacc tcggttcatg gctttggtta caatagctct
     1321 cttgtacatt ggatcgtggg agggggcaga gggtggggaa ggaacgagtc aatgtggttt
     1381 gggaatgttt ttgtttatct caaaataatg ttgaaataca attatcaatg aaaaaacttt
     1441 cgtttttttt tttgtttgtt ttgtttttga gacagagtct cactctgtca cccaggctgg
     1501 agtgcagtgg cgcagtctcg gctcactgca gcctccacct acctggttca agcaattctc
     1561 ctgcctcagc ctcctgagta gctgagatta caggagcctg ccaccacacc cagctaattt
     1621 ttttgtattt ttagtagaga cagggtttca tcatgttggc cagactggcc tcgaattcct
     1681 gacctcaggc aatccacccg cctcggcctc ccaaagagct gggattacag gcgtgagcca
     1741 ccgcaccctg ccgaaaaaaa cttttttttt tttgagacgg aggctcgctc tgtcccccag
     1801 gctggagtgc agtggcgaga tctcagctca ctgcaagctc cgcctcccgg gttcacgcca
     1861 ttctcctgcc tcagcctccc gagtagctgg gagccagcgc gcccagccta aaaaactttt
     1921 caagtcaata ttactacgat ttaacattag agtgtggaca tgtgatttaa tcgctatagc
     1981 taaaatacgt caaatatacg ttgtcatgtg cttgaacatg atgctaaccc tgacaggatg
     2041 aaggaaagta atattctttc agtgtagttc aggagagcat ttgttttctt ttctaccaat
     2101 taacccatca ttgcttttaa acaaccatct gaaggagcag agaggcaggg tagaagacag
     2161 aagggggatc tatgtggtaa ctaaagaatg tttctgtttt gttaattatt gtgtgtgtgt
     2221 ggttttattg tttgcttaag agaatcaaaa actgaaaaaa atgagaatac aggaaatggc
     2281 tcttgtttat ttttttgctg tgtttacagc ttgttaatgc tctactgtct ttgtttcaag
     2341 agagatttgt tcactgccca gctcgttttg tgtcctgagc cctatggcca gcccacctta
     2401 taaatcatgc ctgtttagat gtttgatttt gttctgtttg ctattgttat cttaaaggtg
     2461 tataactctg acatgccaga catcaaatta agctcaaatt aagctctcgt ttaaatgttt
     2521 aagcacctaa tttatattct aattgatccc agccactgat gcatgtactt tagctacttc
     2581 tgctaaataa gcatattaat tttccacatc agaccatcag atcttgagaa ccaacagtta
     2641 tctagaattc cgtgtctact aatgtttcac ctgcatgcag ccttcattaa ttttgtagca
     2701 aaatataaag tgatcattat gtagcttctg gattaaaaaa atttgtgtgt gaagttgctt
     2761 tgtaaagtgc atgtggaatt aatgggacag tgtgcccttt gtgttagatg ttagagcaaa
     2821 agaaagggct tatagtgtta gtattggagc actttgaaga tagatatttt cagaaaagat
     2881 gtaggattta aaagttaaat tttaaatttt agaaaaagat atgatggcaa ttggaaatag
     2941 tcacaatgaa gttcttcatc cagtaggtgt ttaacagtgt tattttgcca ctggtaatgt
     3001 gtaaactgtg agtgatttac aataaatgat tatgaattca
//
