LOCUS       NM_005063               5245 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens stearoyl-CoA desaturase (SCD), mRNA.
ACCESSION   NM_005063 XM_001723785 XM_001725202 XM_001725496
VERSION     NM_005063.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5245)
  AUTHORS   Igal,R.A.
  TITLE     Death and the desaturase: Implication of Stearoyl-CoA desaturase-1
            in the mechanisms of cell stress, apoptosis, and ferroptosis
  JOURNAL   Biochimie 225, 156-167 (2024)
   PUBMED   38823621
  REMARK    GeneRIF: Death and the desaturase: Implication of Stearoyl-CoA
            desaturase-1 in the mechanisms of cell stress, apoptosis, and
            ferroptosis.
            Review article
REFERENCE   2  (bases 1 to 5245)
  AUTHORS   Susan,H.K., Orosz,G., Zambo,V., Csala,M. and Kereszturi,E.
  TITLE     Severity Ranking of Missense and Frameshift Genetic Variants in
            SCD1 by In Silico and In Vitro Functional Analysis
  JOURNAL   Nutrients 16 (19), 3259 (2024)
   PUBMED   39408225
  REMARK    GeneRIF: Severity Ranking of Missense and Frameshift Genetic
            Variants in SCD1 by In Silico and In Vitro Functional Analysis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5245)
  AUTHORS   Fan,Z., Ye,M., Liu,D., Zhou,W., Zeng,T., He,S. and Li,Y.
  TITLE     Lactate drives the ESM1-SCD1 axis to inhibit the antitumor CD8+
            T-cell response by activating the Wnt/beta-catenin pathway in
            ovarian cancer cells and inducing cisplatin resistance
  JOURNAL   Int Immunopharmacol 137, 112461 (2024)
   PUBMED   38897128
  REMARK    GeneRIF: Lactate drives the ESM1-SCD1 axis to inhibit the antitumor
            CD8[+] T-cell response by activating the Wnt/beta-catenin pathway
            in ovarian cancer cells and inducing cisplatin resistance.
REFERENCE   4  (bases 1 to 5245)
  AUTHORS   Ikeda,T., Katoh,Y., Hino,H., Seta,D., Ogawa,T., Iwata,T.,
            Nishio,H., Sugawara,M. and Hirai,S.
  TITLE     FADS2 confers SCD1 inhibition resistance to cancer cells by
            modulating the ER stress response
  JOURNAL   Sci Rep 14 (1), 13116 (2024)
   PUBMED   38849435
  REMARK    GeneRIF: FADS2 confers SCD1 inhibition resistance to cancer cells
            by modulating the ER stress response.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5245)
  AUTHORS   Dong,Y.H., Liuxu,W.T., Chen,Y., Gan,W.D. and Li,D.M.
  TITLE     [Expression of SCD1 in TFE3-rRCC and its effect on proliferation
            and migration]
  JOURNAL   Zhonghua Nan Ke Xue 29 (8), 682-687 (2023)
   PUBMED   38619513
  REMARK    GeneRIF: [Expression of SCD1 in TFE3-rRCC and its effect on
            proliferation and migration].
REFERENCE   6  (bases 1 to 5245)
  AUTHORS   Mziaut,H., Korza,G. and Ozols,J.
  TITLE     The N terminus of microsomal delta 9 stearoyl-CoA desaturase
            contains the sequence determinant for its rapid degradation
  JOURNAL   Proc Natl Acad Sci U S A 97 (16), 8883-8888 (2000)
   PUBMED   10922050
REFERENCE   7  (bases 1 to 5245)
  AUTHORS   Zhang,L., Ge,L., Parimoo,S., Stenn,K. and Prouty,S.M.
  TITLE     Human stearoyl-CoA desaturase: alternative transcripts generated
            from a single gene by usage of tandem polyadenylation sites
  JOURNAL   Biochem J 340 (Pt 1) (Pt 1), 255-264 (1999)
   PUBMED   10229681
REFERENCE   8  (bases 1 to 5245)
  AUTHORS   Ozols,J.
  TITLE     Degradation of hepatic stearyl CoA delta 9-desaturase
  JOURNAL   Mol Biol Cell 8 (11), 2281-2290 (1997)
   PUBMED   9362069
REFERENCE   9  (bases 1 to 5245)
  AUTHORS   Li,J., Ding,S.F., Habib,N.A., Fermor,B.F., Wood,C.B. and
            Gilmour,R.S.
  TITLE     Partial characterization of a cDNA for human stearoyl-CoA
            desaturase and changes in its mRNA expression in some normal and
            malignant tissues
  JOURNAL   Int J Cancer 57 (3), 348-352 (1994)
   PUBMED   7909540
REFERENCE   10 (bases 1 to 5245)
  AUTHORS   Dailey,H.A. and Strittmatter,P.
  TITLE     Characterization of the interaction of amphipathic cytochrome b5
            with stearyl coenzyme A desaturase and NADPH:cytochrome P-450
            reductase
  JOURNAL   J Biol Chem 255 (11), 5184-5189 (1980)
   PUBMED   6102994
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC062303.1, AK312312.1,
            AL139819.8 and AI761929.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005063.4.
            
            Summary: This gene encodes an enzyme involved in fatty acid
            biosynthesis, primarily the synthesis of oleic acid. The protein
            belongs to the fatty acid desaturase family and is an integral
            membrane protein located in the endoplasmic reticulum. Transcripts
            of approximately 3.9 and 5.2 kb, differing only by alternative
            polyadenlyation signals, have been detected. A gene encoding a
            similar enzyme is located on chromosome 4 and a pseudogene of this
            gene is located on chromosome 17. [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.188810.1,
                                           SRR1803611.46536.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370355.3/ ENSP00000359380.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-261               BC062303.1         105-365
            262-1339            AK312312.1         262-1339
            1340-5242           AL139819.8         82107-86009
            5243-5245           AI761929.1         11-13               c
FEATURES             Location/Qualifiers
     source          1..5245
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.31"
     gene            1..5245
                     /gene="SCD"
                     /gene_synonym="FADS5; hSCD1; MSTP008; SCD1; SCDOS"
                     /note="stearoyl-CoA desaturase"
                     /db_xref="GeneID:6319"
                     /db_xref="HGNC:HGNC:10571"
                     /db_xref="MIM:604031"
     exon            1..299
                     /gene="SCD"
                     /gene_synonym="FADS5; hSCD1; MSTP008; SCD1; SCDOS"
                     /inference="alignment:Splign:2.1.0"
     CDS             273..1352
                     /gene="SCD"
                     /gene_synonym="FADS5; hSCD1; MSTP008; SCD1; SCDOS"
                     /EC_number="1.14.19.1"
                     /note="stearoyl-CoA desaturase opposite strand; acyl-CoA
                     desaturase; fatty acid desaturase; predicted protein of
                     HQ0998; delta(9)-desaturase; stearoyl-CoA desaturase
                     (delta-9-desaturase)"
                     /codon_start=1
                     /product="stearoyl-CoA desaturase"
                     /protein_id="NP_005054.3"
                     /db_xref="CCDS:CCDS7493.1"
                     /db_xref="GeneID:6319"
                     /db_xref="HGNC:HGNC:10571"
                     /db_xref="MIM:604031"
                     /translation="MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLED
                     DIRPDIKDDIYDPTYKDKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWL
                     WGVFYYFVSALGITAGAHRLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAH
                     HKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYY
                     KPGLLMMCFILPTLVPWYFWGETFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPY
                     DKNISPRENILVSLGAVGEGFHNYHHSFPYDYSASEYRWHINFTTFFIDCMAALGLAY
                     DRKKVSKAAILARIKRTGDGNYKSG"
     exon            300..582
                     /gene="SCD"
                     /gene_synonym="FADS5; hSCD1; MSTP008; SCD1; SCDOS"
                     /inference="alignment:Splign:2.1.0"
     exon            583..713
                     /gene="SCD"
                     /gene_synonym="FADS5; hSCD1; MSTP008; SCD1; SCDOS"
                     /inference="alignment:Splign:2.1.0"
     exon            714..919
                     /gene="SCD"
                     /gene_synonym="FADS5; hSCD1; MSTP008; SCD1; SCDOS"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1152
                     /gene="SCD"
                     /gene_synonym="FADS5; hSCD1; MSTP008; SCD1; SCDOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..5245
                     /gene="SCD"
                     /gene_synonym="FADS5; hSCD1; MSTP008; SCD1; SCDOS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5224..5229
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCD"
                     /gene_synonym="FADS5; hSCD1; MSTP008; SCD1; SCDOS"
                     /note="hexamer: AATAAA"
     polyA_site      5245
                     /gene="SCD"
                     /gene_synonym="FADS5; hSCD1; MSTP008; SCD1; SCDOS"
                     /note="major polyA site"
ORIGIN      
        1 agtcaactcc tcgcactttg cccctgcttg gcagcggata aaagggggct gaggaaatac
       61 cggacacggt cacccgttgc cagctctagc ctttaaattc ccggctcggg gacctccacg
      121 caccgcggct agcgccgaca accagctagc gtgcaaggcg ccgcggctca gcgcgtaccg
      181 gcgggcttcg aaaccgcagt cctccggcga ccccgaactc cgctccggag cctcagcccc
      241 ctggaaagtg atcccggcat ccgagagcca agatgccggc ccacttgctg caggacgata
      301 tctctagctc ctataccacc accaccacca ttacagcgcc tccctccagg gtcctgcaga
      361 atggaggaga taagttggag acgatgcccc tctacttgga agacgacatt cgccctgata
      421 taaaagatga tatatatgac cccacctaca aggataagga aggcccaagc cccaaggttg
      481 aatatgtctg gagaaacatc atccttatgt ctctgctaca cttgggagcc ctgtatggga
      541 tcactttgat tcctacctgc aagttctaca cctggctttg gggggtattc tactattttg
      601 tcagtgccct gggcataaca gcaggagctc atcgtctgtg gagccaccgc tcttacaaag
      661 ctcggctgcc cctacggctc tttctgatca ttgccaacac aatggcattc cagaatgatg
      721 tctatgaatg ggctcgtgac caccgtgccc accacaagtt ttcagaaaca catgctgatc
      781 ctcataattc ccgacgtggc tttttcttct ctcacgtggg ttggctgctt gtgcgcaaac
      841 acccagctgt caaagagaag gggagtacgc tagacttgtc tgacctagaa gctgagaaac
      901 tggtgatgtt ccagaggagg tactacaaac ctggcttgct gatgatgtgc ttcatcctgc
      961 ccacgcttgt gccctggtat ttctggggtg aaacttttca aaacagtgtg ttcgttgcca
     1021 ctttcttgcg atatgctgtg gtgcttaatg ccacctggct ggtgaacagt gctgcccacc
     1081 tcttcggata tcgtccttat gacaagaaca ttagcccccg ggagaatatc ctggtttcac
     1141 ttggagctgt gggtgagggc ttccacaact accaccactc ctttccctat gactactctg
     1201 ccagtgagta ccgctggcac atcaacttca ccacattctt cattgattgc atggccgccc
     1261 tcggtctggc ctatgaccgg aagaaagtct ccaaggccgc catcttggcc aggattaaaa
     1321 gaaccggaga tggaaactac aagagtggct gagtttgggg tccctcaggt tcctttttca
     1381 aaaaccagcc aggcagaggt tttaatgtct gtttattaac tactgaataa tgctaccagg
     1441 atgctaaaga tgatgatgtt aacccattcc agtacagtat tcttttaaaa ttcaaaagta
     1501 ttgaaagcca acaactctgc ctttatgatg ctaagctgat attatttctt ctcttatcct
     1561 ctctctcttc taggcccatt gtcctccttt tcactttatt gctatcgccc tcctttccct
     1621 tattgcctcc caggcaagca gctggtcagt ctttgctcag tgtccagctt ccaaagccta
     1681 gacaaccttt ctgtagccta aaacgaatgg tctttgctcc agataactct ctttccttga
     1741 gctgttgtga gctttgaagt aggtggcttg agctagagat aaaacagaat cttctgggta
     1801 gtcccctgtt gattatcttc agcccaggct tttgctagat ggaatggaaa agcaacttca
     1861 tttgacacaa agcttctaaa gcaggtaaat tgtcggggga gagagttagc atgtatgaat
     1921 gtaaggatga gggaagcgaa gcaagaggaa cctctcgcca tgatcagaca tacagctgcc
     1981 tacctaatga ggacttcaag ccccaccaca tagcatgctt cctttctctc ctggctcggg
     2041 gtaaaaagtg gctgcggtgt ttggcaatgc taattcaatg ccgcaacata tagttgaggc
     2101 cgaggataaa gaaaagacat tttaagtttg tagtaaaagt ggtctctgct ggggaagggt
     2161 tttcttttct ttttttcttt aataacaagg agatttctta gttcatatat caagaagtct
     2221 tgaagttggg tgtttccaga attggtaaaa acagcagctc atagaatttt gagtattcca
     2281 tgagctgctc attacagttc tttcctcttt ctgctctgcc atcttcagga tattggttct
     2341 tcccctcata gtaataagat ggctgtggca tttccaaaca tccaaaaaaa gggaaggatt
     2401 taaggaggtg aagtcgggtc aaaaataaaa tatatataca tatatacatt gcttagaacg
     2461 ttaaactatt agagtatttc ccttccaaag agggatgttt ggaaaaaact ctgaaggaga
     2521 ggaggaatta gttgggatgc caatttcctc tccactgctg gacatgagat ggagaggctg
     2581 agggacagga tctataggca gcttctaaga gcgaacttca cataggaagg gatctgagaa
     2641 cacgttgcca ggggcttgag aaggttactg agtgagttat tgggagtctt aataaaataa
     2701 actagatatt aggtccattc attaattagt tccagtttct ccttgaaatg agtaaaaact
     2761 agaaggcttc tctccacagt gttgtgcccc ttcactcatt tttttttgag gagaaggggg
     2821 tctctgttaa catctagcct aaagtataca actgcctggg gggcagggtt aggaatctct
     2881 tcactaccct gattcttgat tcctggctct accctgtctg tcccttttct ttgaccagat
     2941 ctttctcttc cctgaacgtt ttcttctttc cctggacagg cagcctcctt tgtgtgtatt
     3001 cagaggcagt gatgacttgc tgtccaggca gctccctcct gcacacagaa tgctcagggt
     3061 cactgaacca ctgcttctct tttgaaagta gagctagctg ccactttcac gtggcctccg
     3121 cagtgtctcc acctacaccc ctgtgctccc ctgccacact gatggctcaa gacaaggctg
     3181 gcaaaccctc ccagaaacat ctctggccca gaaagcctct ctctccctcc ctctctcatg
     3241 aggcacagcc aagccaagcg ctcatgttga gccagtgggc cagccacaga gcaaaagagg
     3301 gtttattttc agtcccctct ctctgggtca gaaccagagg gcatgctgaa tgccccctgc
     3361 ttacttggtg agggtgcccc gcctgagtca gtgctctcag ctggcagtgc aatgcttgta
     3421 gaagtaggag gaaacagttc tcactgggaa gaagcaaggg caagaaccca agtgcctcac
     3481 ctcgaaagga ggccctgttc cctggagtca gggtgaactg caaagctttg gctgagacct
     3541 gggatttgag ataccacaaa ccctgctgaa cacagtgtct gttcagcaaa ctaaccagca
     3601 ttccctacag cctagggcag acaatagtat agaagtctgg aaaaaaacaa aaacagaatt
     3661 tgagaacctt ggaccactcc tgtccctgta gctcagtcat caaagcagaa gtctggcttt
     3721 gctctattaa gattggaaat gtacactacc aaacactcag tccactgttg agccccagtg
     3781 ctggaaggga ggaaggcctt tcttctgtgt taattgcgta gaggctacag gggttagcct
     3841 ggactaaagg catccttgtc ttttgagcta ttcacctcag tagaaaagga tctaagggaa
     3901 gatcactgta gtttagttct gttgacctgt gcacctaccc cttggaaatg tctgctggta
     3961 tttctaattc cacaggtcat cagatgcctg cttgataata tataaacaat aaaaacaact
     4021 ttcacttctt cctattgtaa tcgtgtgcca tggatctgat ctgtaccatg accctacata
     4081 aggctggatg gcacctcagg ctgagggccc caatgtatgt gtggctgtgg gtgtgggtgg
     4141 gagtgtgtct gctgagtaag gaacacgatt ttcaagattc taaagctcaa ttcaagtgac
     4201 acattaatga taaactcaga tctgatcaag agtccggatt tctaacagtc cttgctttgg
     4261 ggggtgtgct gacaacttag ctcaggtgcc ttacatcttt tctaatcaca gtgttgcata
     4321 tgagcctgcc ctcactccct ctgcagaatc cctttgcacc tgagacccta ctgaagtggc
     4381 tggtagaaaa aggggcctga gtggaggatt atcagtatca cgatttgcag gattcccttc
     4441 tgggcttcat tctggaaact tttgttaggg ctgcttttct taagtgccca catttgatgg
     4501 agggtggaaa taatttgaat gtatttgatt tataagtttt tttttttttt ttgggttaaa
     4561 agatggttgt agcatttaaa atggaaaatt ttctccttgg tttgctagta tcttgggtgt
     4621 attctctgta agtgtagctc aaataggtca tcatgaaagg ttaaaaaagc gaggtggcca
     4681 tgttatgctg gtggttaagg ccagggcctc tccaaccact gtgccactga cttgctgtgt
     4741 gaccctgggc aagtcactta actataaggt gcctcagttt tccttctgtt aaaatgggga
     4801 taataatact gacctacctc aaagggcagt tttgaggcat gactaatgct ttttagaaag
     4861 cattttggga tccttcagca caggaattct caagacctga gtatttttta taataggaat
     4921 gtccaccatg aacttgatac gtccgtgtgt cccagatgct gtcattagtc tatatggttc
     4981 tccaagaaac tgaatgaatc cattggagaa gcggtggata actagccaga caaaatttga
     5041 gaatacataa acaacgcatt gccacggaaa catacagagg atgccttttc tgtgattggg
     5101 tgggattttt tcccttttta tgtgggatat agtagttact tgtgacaaga ataattttgg
     5161 aataatttct attaatatca actctgaagc taattgtact aatctgagat tgtgtttgtt
     5221 cataataaaa gtgaagtgaa tctga
//
