LOCUS       NM_016002               2141 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens saccharopine dehydrogenase (putative) (SCCPDH), mRNA.
ACCESSION   NM_016002
VERSION     NM_016002.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2141)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2141)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   3  (bases 1 to 2141)
  AUTHORS   Zhao,X., Leon,I.R., Bak,S., Mogensen,M., Wrzesinski,K., Hojlund,K.
            and Jensen,O.N.
  TITLE     Phosphoproteome analysis of functional mitochondria isolated from
            resting human muscle reveals extensive phosphorylation of inner
            membrane protein complexes and enzymes
  JOURNAL   Mol Cell Proteomics 10 (1), M110.000299 (2011)
   PUBMED   20833797
REFERENCE   4  (bases 1 to 2141)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2141)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 2141)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   7  (bases 1 to 2141)
  AUTHORS   Skop,A.R., Liu,H., Yates,J. 3rd, Meyer,B.J. and Heald,R.
  TITLE     Dissection of the mammalian midbody proteome reveals conserved
            cytokinesis mechanisms
  JOURNAL   Science 305 (5680), 61-66 (2004)
   PUBMED   15166316
REFERENCE   8  (bases 1 to 2141)
  AUTHORS   Fujimoto,Y., Itabe,H., Sakai,J., Makita,M., Noda,J., Mori,M.,
            Higashi,Y., Kojima,S. and Takano,T.
  TITLE     Identification of major proteins in the lipid droplet-enriched
            fraction isolated from the human hepatocyte cell line HuH7
  JOURNAL   Biochim Biophys Acta 1644 (1), 47-59 (2004)
   PUBMED   14741744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG258610.1, AF151807.1, BM786495.1 and AW515488.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016002.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF151807.1, BC026185.2 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366510.4/ ENSP00000355467.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-204               BG258610.1         334-537
            205-1758            AF151807.1         188-1741
            1759-2021           BM786495.1         338-600
            2022-2141           AW515488.1         9-128               c
FEATURES             Location/Qualifiers
     source          1..2141
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q44"
     gene            1..2141
                     /gene="SCCPDH"
                     /gene_synonym="CGI-49; CGI49; NET11"
                     /note="saccharopine dehydrogenase (putative)"
                     /db_xref="GeneID:51097"
                     /db_xref="HGNC:HGNC:24275"
                     /db_xref="MIM:620831"
     exon            1..204
                     /gene="SCCPDH"
                     /gene_synonym="CGI-49; CGI49; NET11"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1304
                     /gene="SCCPDH"
                     /gene_synonym="CGI-49; CGI49; NET11"
                     /EC_number="1.5.1.9"
                     /note="probable saccharopine dehydrogenase; epididymis
                     secretory sperm binding protein"
                     /codon_start=1
                     /product="saccharopine dehydrogenase-like oxidoreductase"
                     /protein_id="NP_057086.2"
                     /db_xref="CCDS:CCDS31084.1"
                     /db_xref="GeneID:51097"
                     /db_xref="HGNC:HGNC:24275"
                     /db_xref="MIM:620831"
                     /translation="MATEQRPFHLVVFGASGFTGQFVTEEVAREQVDPERSSRLPWAV
                     AGRSREKLQRVLEKAALKLGRPTLSSEVGIIICDIANPASLDEMAKQATVVLNCVGPY
                     RFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIPAD
                     LGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSN
                     LKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAA
                     YVTVGGITSVIKLMFAGLFFLFFVRFGIGRQLLIKFPWFFSFGYFSKQGPTQKQIDAA
                     SFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHL
                     PKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV"
     exon            205..317
                     /gene="SCCPDH"
                     /gene_synonym="CGI-49; CGI49; NET11"
                     /inference="alignment:Splign:2.1.0"
     exon            318..398
                     /gene="SCCPDH"
                     /gene_synonym="CGI-49; CGI49; NET11"
                     /inference="alignment:Splign:2.1.0"
     exon            399..528
                     /gene="SCCPDH"
                     /gene_synonym="CGI-49; CGI49; NET11"
                     /inference="alignment:Splign:2.1.0"
     exon            529..578
                     /gene="SCCPDH"
                     /gene_synonym="CGI-49; CGI49; NET11"
                     /inference="alignment:Splign:2.1.0"
     exon            579..709
                     /gene="SCCPDH"
                     /gene_synonym="CGI-49; CGI49; NET11"
                     /inference="alignment:Splign:2.1.0"
     exon            710..827
                     /gene="SCCPDH"
                     /gene_synonym="CGI-49; CGI49; NET11"
                     /inference="alignment:Splign:2.1.0"
     exon            828..947
                     /gene="SCCPDH"
                     /gene_synonym="CGI-49; CGI49; NET11"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1004
                     /gene="SCCPDH"
                     /gene_synonym="CGI-49; CGI49; NET11"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1116
                     /gene="SCCPDH"
                     /gene_synonym="CGI-49; CGI49; NET11"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1198
                     /gene="SCCPDH"
                     /gene_synonym="CGI-49; CGI49; NET11"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..2141
                     /gene="SCCPDH"
                     /gene_synonym="CGI-49; CGI49; NET11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1433..1438
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCCPDH"
                     /gene_synonym="CGI-49; CGI49; NET11"
                     /note="hexamer: ATTAAA"
     polyA_site      1475
                     /gene="SCCPDH"
                     /gene_synonym="CGI-49; CGI49; NET11"
                     /note="major polyA site"
     regulatory      1817..1822
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCCPDH"
                     /gene_synonym="CGI-49; CGI49; NET11"
                     /note="hexamer: AATAAA"
     polyA_site      1837
                     /gene="SCCPDH"
                     /gene_synonym="CGI-49; CGI49; NET11"
                     /note="major polyA site"
     regulatory      2118..2123
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCCPDH"
                     /gene_synonym="CGI-49; CGI49; NET11"
                     /note="hexamer: AATAAA"
     polyA_site      2141
                     /gene="SCCPDH"
                     /gene_synonym="CGI-49; CGI49; NET11"
ORIGIN      
        1 gctgtggact cgtcatggcg accgagcaga ggcctttcca cctggtggtg ttcggcgcgt
       61 ctggcttcac cggccagttc gtgaccgagg aggtggcccg ggagcaggtg gacccggagc
      121 ggagctcccg cctgccctgg gccgtggcgg gccgctcccg ggagaagctg cagcgggtgc
      181 tggagaaggc ggccctgaag ctgggaagac caacactgtc atctgaagtt ggaatcatca
      241 tctgtgatat tgctaatcca gcctcgcttg atgaaatggc taaacaggca acagttgtcc
      301 tcaattgcgt aggaccatat cggttttatg gagaacctgt aataaaagca tgtattgaaa
      361 atggagccag ttgtatcgac atcagtggag aacctcagtt tctggaacta atgcaactga
      421 agtatcatga gaaagctgca gacaaagggg tttatatcat tggaagcagc ggctttgact
      481 ccattccagc agatctggga gtaatatata ccagaaataa aatgaatggt actttgactg
      541 ctgtggaaag tttcctgact atacattcag gacctgaggg gttgagcatt catgatggta
      601 cctggaagtc agcaatttat ggttttggag atcagagtaa tttgagaaaa ctaagaaatg
      661 tatcaaatct gaaacctgtc ccgctcattg gtccaaaatt gaagagaagg tggccaattt
      721 cttattgtcg ggaactcaaa ggttattcca ttccttttat gggatctgat gtgtctgttg
      781 taaggaggac tcaacgttac ttgtatgaaa atttagagga atcaccagtt cagtatgctg
      841 cgtatgtaac tgtgggaggc atcacctctg ttattaagct gatgtttgca ggacttttct
      901 ttttgttctt tgtgaggttt ggaattggaa ggcaacttct cataaaattc ccatggttct
      961 tctcctttgg ctatttttca aaacaaggcc caacacaaaa acagattgat gctgcctcat
     1021 tcacgctgac attctttggt caaggataca gccaaggcac tggtacagat aagaacaaac
     1081 caaatatcaa aatttgtact caggtgaaag gaccagaggc tggctatgtg gctaccccca
     1141 tagctatggt tcaggcagcc atgactcttc taagtgatgc ttctcatctg cctaaggcgg
     1201 gcggggtctt cacacctgga gcagcttttt ccaaaacaaa gttgattgac agactcaaca
     1261 aacacggtat tgagtttagt gttattagca gctctgaagt ctaaacactg gaagaattaa
     1321 ctgaagtcat aacgtgcgtg aattaacagc ttctctattt gatatttgaa attcttctgt
     1381 aagcctgtct gagtgtatgt ggaaacgatt gtcaaatcta aaatatctat atattaaaaa
     1441 gtaggaaatt gtcctagctt accctaaatt tcaaatctga gttgattttg tgattttatt
     1501 gcttataaca gagaactcat atttgacata tttttttcat tgatgtgttc ctggtagatt
     1561 ttcacgaatg agctggcagg tctaatgggg gaggcggcgt cccagtctgt gttgcagcag
     1621 cattctcatc gggggtgcgc acaccatcgt tactgtcggg cagtaactgc cgcttgcctt
     1681 gccgcagtag gagggaaatc tcaccttcct tccacatact gtcttgagcc tttgctaaat
     1741 taaactgcac tttttgctat ttttgcctag tttttcgcca atctacactg attttggact
     1801 gttacctaag ttgaaaaata aaaggttgtc aatcgaatgg tggtttaatg tttggacctg
     1861 ccgatgtatt tgtatagtgg tagaaacatg ctgcttaagt ggcctaacct gtttcttgcc
     1921 aataagtagg cttatcattt tatctttacg taattctata tctgtgacta ggtttttaag
     1981 gatacagctt ataagttgct atcaattttc actacctaag cagaattttt ctctaattta
     2041 ctttttgtat tttaactagg ttttacatgg aagccctaaa ataaggcaaa agactttttc
     2101 ttttgtaata agcatataat aaacacgtat atacatagca a
//
