LOCUS       NM_005505               3405 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens scavenger receptor class B member 1 (SCARB1),
            transcript variant 1, mRNA.
ACCESSION   NM_005505
VERSION     NM_005505.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3405)
  AUTHORS   Capellmann,S., Kauffmann,M., Arock,M. and Huber,M.
  TITLE     SR-BI regulates the synergistic mast cell response by modulating
            the plasma membrane-associated cholesterol pool
  JOURNAL   Eur J Immunol 54 (8), e2350788 (2024)
   PUBMED   38708681
  REMARK    GeneRIF: SR-BI regulates the synergistic mast cell response by
            modulating the plasma membrane-associated cholesterol pool.
REFERENCE   2  (bases 1 to 3405)
  AUTHORS   Ashkar,R., Khattib,A., Musa,S., Goldberg,D. and Khatib,S.
  TITLE     PON1 has palmitoyl-protein thioesterase (PPT) activity, and can
            affect the presence of SR-B1 on the endothelial cell membrane
  JOURNAL   Biofactors 50 (3), 608-618 (2024)
   PUBMED   38135490
  REMARK    GeneRIF: PON1 has palmitoyl-protein thioesterase (PPT) activity,
            and can affect the presence of SR-B1 on the endothelial cell
            membrane.
REFERENCE   3  (bases 1 to 3405)
  AUTHORS   Li,Y., Xiong,Z., Jiang,W.L., Tian,D., Zhou,H., Hou,Q., Xiao,L.,
            Zhang,M., Huang,L., Zhong,L., Zhou,L. and Zeng,G.G.
  TITLE     An innovative viewpoint on the existing and prospectiveness of
            SR-B1
  JOURNAL   Curr Probl Cardiol 49 (2), 102226 (2024)
   PUBMED   38040207
  REMARK    GeneRIF: An innovative viewpoint on the existing and
            prospectiveness of SR-B1.
            Review article
REFERENCE   4  (bases 1 to 3405)
  AUTHORS   Song,L., Wang,S., Zhang,X., Song,N., Lu,Y. and Qin,C.
  TITLE     Bridging the gap between clear cell renal cell carcinoma and
            cutaneous melanoma: the role of SCARB1 in dysregulated cholesterol
            metabolism
  JOURNAL   Aging (Albany NY) 15 (19), 10370-10388 (2023)
   PUBMED   37801479
  REMARK    GeneRIF: Bridging the gap between clear cell renal cell carcinoma
            and cutaneous melanoma: the role of SCARB1 in dysregulated
            cholesterol metabolism.
REFERENCE   5  (bases 1 to 3405)
  AUTHORS   Li,W., Wang,Z.H., Shi,P. and Xue,S.
  TITLE     [Association Analysis Between Methylation of SCARB1 Gene Promoter
            and Coronary Heart Disease]
  JOURNAL   Zhongguo Yi Xue Ke Xue Yuan Xue Bao 45 (3), 405-409 (2023)
   PUBMED   37407526
  REMARK    GeneRIF: [Association Analysis Between Methylation of SCARB1 Gene
            Promoter and Coronary Heart Disease].
REFERENCE   6  (bases 1 to 3405)
  AUTHORS   Murao,K., Terpstra,V., Green,S.R., Kondratenko,N., Steinberg,D. and
            Quehenberger,O.
  TITLE     Characterization of CLA-1, a human homologue of rodent scavenger
            receptor BI, as a receptor for high density lipoprotein and
            apoptotic thymocytes
  JOURNAL   J Biol Chem 272 (28), 17551-17557 (1997)
   PUBMED   9211901
REFERENCE   7  (bases 1 to 3405)
  AUTHORS   Calvo,D., Dopazo,J. and Vega,M.A.
  TITLE     The CD36, CLA-1 (CD36L1), and LIMPII (CD36L2) gene family: cellular
            distribution, chromosomal location, and genetic evolution
  JOURNAL   Genomics 25 (1), 100-106 (1995)
   PUBMED   7539776
REFERENCE   8  (bases 1 to 3405)
  AUTHORS   Calvo,D. and Vega,M.A.
  TITLE     Identification, primary structure, and distribution of CLA-1, a
            novel member of the CD36/LIMPII gene family
  JOURNAL   J Biol Chem 268 (25), 18929-18935 (1993)
   PUBMED   7689561
REFERENCE   9  (bases 1 to 3405)
  AUTHORS   Phillips,R.W.
  TITLE     The new era in restorative dental materials
  JOURNAL   Oper Dent 1 (1), 29-35 (1976)
   PUBMED   1076467
  REMARK    Review article
REFERENCE   10 (bases 1 to 3405)
  AUTHORS   Skre,H. and Berg,K.
  TITLE     Cerebellar ataxia and total albinism: a kindred suggesting
            pleitotropism or linkage
  JOURNAL   Clin Genet 5 (3), 196-204 (1974)
   PUBMED   4838888
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG770204.1, BC080647.1,
            AC073593.13 and CA428516.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005505.4.
            
            Summary: The protein encoded by this gene is a plasma membrane
            receptor for high density lipoprotein cholesterol (HDL). The
            encoded protein mediates cholesterol transfer to and from HDL. In
            addition, this protein is a receptor for hepatitis C virus
            glycoprotein E2 and facilitates cell entry by the virus, SARS-CoV2.
            [provided by RefSeq, Oct 2021].
            
            Transcript Variant: This variant (1) encodes isoform 1. Variants 1
            and 13 both encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.159570.1,
                                           SRR3476690.975742.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in SARS-CoV-2 infection
            MANE Ensembl match     :: ENST00000261693.11/ ENSP00000261693.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BG770204.1         111-127
            18-1193             BC080647.1         1-1176
            1194-1194           AC073593.13        9463-9463
            1195-2628           BC080647.1         1178-2611
            2629-2633           CA428516.1         18-22               c
            2634-3405           AC073593.13        32038-32809
FEATURES             Location/Qualifiers
     source          1..3405
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     gene            1..3405
                     /gene="SCARB1"
                     /gene_synonym="CD36L1; CLA-1; CLA1; HDLCQ6; HDLQTL6;
                     SR-BI; SRB1"
                     /note="scavenger receptor class B member 1"
                     /db_xref="GeneID:949"
                     /db_xref="HGNC:HGNC:1664"
                     /db_xref="MIM:601040"
     exon            1..270
                     /gene="SCARB1"
                     /gene_synonym="CD36L1; CLA-1; CLA1; HDLCQ6; HDLQTL6;
                     SR-BI; SRB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..1674
                     /gene="SCARB1"
                     /gene_synonym="CD36L1; CLA-1; CLA1; HDLCQ6; HDLQTL6;
                     SR-BI; SRB1"
                     /note="isoform 1 is encoded by transcript variant 1; CD36
                     antigen (collagen type I receptor, thrombospondin
                     receptor)-like 1; scavenger receptor class B type III;
                     CD36 and LIMPII analogous 1"
                     /codon_start=1
                     /product="scavenger receptor class B member 1 isoform 1"
                     /protein_id="NP_005496.4"
                     /db_xref="CCDS:CCDS9259.1"
                     /db_xref="GeneID:949"
                     /db_xref="HGNC:HGNC:1664"
                     /db_xref="MIM:601040"
                     /translation="MGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKNV
                     RIDPSSLSFNMWKEIPIPFYLSVYFFDVMNPSEILKGEKPQVRERGPYVYREFRHKSN
                     ITFNNNDTVSFLEYRTFQFQPSKSHGSESDYIVMPNILVLGAAVMMENKPMTLKLIMT
                     LAFTTLGERAFMNRTVGEIMWGYKDPLVNLINKYFPGMFPFKDKFGLFAELNNSDSGL
                     FTVFTGVQNISRIHLVDKWNGLSKVDFWHSDQCNMINGTSGQMWPPFMTPESSLEFYS
                     PEACRSMKLMYKESGVFEGIPTYRFVAPKTLFANGSIYPPNEGFCPCLESGIQNVSTC
                     RFSAPLFLSHPHFLNADPVLAEAVTGLHPNQEAHSLFLDIHPVTGIPMNCSVKLQLSL
                     YMKSVAGIGQTGKIEPVVLPLLWFAESGAMEGETLHTFYTQLVLMPKVMHYAQYVLLA
                     LGCVLLLVPVICQIRSQEKCYLFWSSSKKGSKDKEAIQAYSESLMTSAPKGSVLQEAK
                     L"
     exon            271..428
                     /gene="SCARB1"
                     /gene_synonym="CD36L1; CLA-1; CLA1; HDLCQ6; HDLQTL6;
                     SR-BI; SRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            429..570
                     /gene="SCARB1"
                     /gene_synonym="CD36L1; CLA-1; CLA1; HDLCQ6; HDLQTL6;
                     SR-BI; SRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            571..774
                     /gene="SCARB1"
                     /gene_synonym="CD36L1; CLA-1; CLA1; HDLCQ6; HDLQTL6;
                     SR-BI; SRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            775..870
                     /gene="SCARB1"
                     /gene_synonym="CD36L1; CLA-1; CLA1; HDLCQ6; HDLQTL6;
                     SR-BI; SRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            871..986
                     /gene="SCARB1"
                     /gene_synonym="CD36L1; CLA-1; CLA1; HDLCQ6; HDLQTL6;
                     SR-BI; SRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1153
                     /gene="SCARB1"
                     /gene_synonym="CD36L1; CLA-1; CLA1; HDLCQ6; HDLQTL6;
                     SR-BI; SRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1272
                     /gene="SCARB1"
                     /gene_synonym="CD36L1; CLA-1; CLA1; HDLCQ6; HDLQTL6;
                     SR-BI; SRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1346
                     /gene="SCARB1"
                     /gene_synonym="CD36L1; CLA-1; CLA1; HDLCQ6; HDLQTL6;
                     SR-BI; SRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1398
                     /gene="SCARB1"
                     /gene_synonym="CD36L1; CLA-1; CLA1; HDLCQ6; HDLQTL6;
                     SR-BI; SRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1545
                     /gene="SCARB1"
                     /gene_synonym="CD36L1; CLA-1; CLA1; HDLCQ6; HDLQTL6;
                     SR-BI; SRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1674
                     /gene="SCARB1"
                     /gene_synonym="CD36L1; CLA-1; CLA1; HDLCQ6; HDLQTL6;
                     SR-BI; SRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..3405
                     /gene="SCARB1"
                     /gene_synonym="CD36L1; CLA-1; CLA1; HDLCQ6; HDLQTL6;
                     SR-BI; SRB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2611..2616
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCARB1"
                     /gene_synonym="CD36L1; CLA-1; CLA1; HDLCQ6; HDLQTL6;
                     SR-BI; SRB1"
                     /note="hexamer: AATAAA"
     polyA_site      2633
                     /gene="SCARB1"
                     /gene_synonym="CD36L1; CLA-1; CLA1; HDLCQ6; HDLQTL6;
                     SR-BI; SRB1"
                     /note="major polyA site"
     regulatory      3386..3391
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCARB1"
                     /gene_synonym="CD36L1; CLA-1; CLA1; HDLCQ6; HDLQTL6;
                     SR-BI; SRB1"
                     /note="hexamer: AATATA"
     polyA_site      3405
                     /gene="SCARB1"
                     /gene_synonym="CD36L1; CLA-1; CLA1; HDLCQ6; HDLQTL6;
                     SR-BI; SRB1"
ORIGIN      
        1 cctgcgtgcg ctgccgtccc ggatccaccg tgcctctgcg gcctgcgtgc ccggagtccc
       61 cgcctgtgtc gtctctgtcg ccgtccccgt ctcctgccag gcgcggagcc ctgcgagccg
      121 cgggtgggcc ccaggcgcgc agacatgggc tgctccgcca aagcgcgctg ggctgccggg
      181 gcgctgggcg tcgcggggct actgtgcgct gtgctgggcg ctgtcatgat cgtgatggtg
      241 ccgtcgctca tcaagcagca ggtccttaag aacgtgcgca tcgaccccag tagcctgtcc
      301 ttcaacatgt ggaaggagat ccctatcccc ttctatctct ccgtctactt ctttgacgtc
      361 atgaacccca gcgagatcct gaagggcgag aagccgcagg tgcgggagcg cgggccctac
      421 gtgtacaggg agttcaggca caaaagcaac atcaccttca acaacaacga caccgtgtcc
      481 ttcctcgagt accgcacctt ccagttccag ccctccaagt cccacggctc ggagagcgac
      541 tacatcgtca tgcccaacat cctggtcttg ggtgcggcgg tgatgatgga gaataagccc
      601 atgaccctga agctcatcat gaccttggca ttcaccaccc tcggcgaacg tgccttcatg
      661 aaccgcactg tgggtgagat catgtggggc tacaaggacc cccttgtgaa tctcatcaac
      721 aagtactttc caggcatgtt ccccttcaag gacaagttcg gattatttgc tgagctcaac
      781 aactccgact ctgggctctt cacggtgttc acgggggtcc agaacatcag caggatccac
      841 ctcgtggaca agtggaacgg gctgagcaag gttgacttct ggcattccga tcagtgcaac
      901 atgatcaatg gaacttctgg gcaaatgtgg ccgcccttca tgactcctga gtcctcgctg
      961 gagttctaca gcccggaggc ctgccgatcc atgaagctaa tgtacaagga gtcaggggtg
     1021 tttgaaggca tccccaccta tcgcttcgtg gctcccaaaa ccctgtttgc caacgggtcc
     1081 atctacccac ccaacgaagg cttctgcccg tgcctggagt ctggaattca gaacgtcagc
     1141 acctgcaggt tcagtgcccc cttgtttctc tcccatcctc acttcctcaa cgctgacccg
     1201 gttctggcag aagcggtgac tggcctgcac cctaaccagg aggcacactc cttgttcctg
     1261 gacatccacc cggtcacggg aatccccatg aactgctctg tgaaactgca gctgagcctc
     1321 tacatgaaat ctgtcgcagg cattggacaa actgggaaga ttgagcctgt ggtcctgccg
     1381 ctgctctggt ttgcagagag cggggccatg gagggggaga ctcttcacac attctacact
     1441 cagctggtgt tgatgcccaa ggtgatgcac tatgcccagt acgtcctcct ggcgctgggc
     1501 tgcgtcctgc tgctggtccc tgtcatctgc caaatccgga gccaagagaa atgctattta
     1561 ttttggagta gtagtaaaaa gggctcaaag gataaggagg ccattcaggc ctattctgaa
     1621 tccctgatga catcagctcc caagggctct gtgctgcagg aagcaaaact gtagggtcct
     1681 gaggacaccg tgagccagcc aggcctggcc gctgggcctg accggccccc cagcccctac
     1741 accccgcttc tcccggactc tcccagcgga cagcccccca gccccacagc ctgagcctcc
     1801 cagctgccat gtgcctgttg cacacctgca cacacgccct ggcacacata cacacatgcg
     1861 tgcaggcttg tgcagacact cagggatgga gctgctgctg aagggacttg tagggagagg
     1921 ctcgtcaaca agcactgttc tggaaccttc tctccacgtg gcccacaggc ctgaccacag
     1981 gggctgtggg tcctgcgtcc ccttcctcgg gtgagcctgg cctgtcccgt tcagccgttg
     2041 ggcccaggct tcctcccctc caaggtgaaa cactgcagtc ccggtgtggt ggctccccat
     2101 gcaggacggg ccaggctggg agtgccgcct tcctgtgcca aattcagtgg ggactcagtg
     2161 cccaggccct ggccacgagc tttggccttg gtctacctgc caggccaggc aaagcgcctt
     2221 tacacaggcc tcggaaaaca atggagtgag cacaagatgc cctgtgcagc tgcccgaggg
     2281 tctccgccca ccccggccgg actttgatcc ccccgaagtc ttcacaggca ctgcatcggg
     2341 ttgtctggcg cccttttcct ccagcctaaa ctgacatcat cctatggact gagccggcca
     2401 ctctctggcc gaagtggccg caggctgtgc ccccgagctg cccccacccc ctcacagggt
     2461 ccctcagatt ataggtgccc aggctgaggt gaagaggcct gggggccctg ccttccgggc
     2521 gctcctggac cctggggcaa acctgtgacc cttttctact ggaatagaaa tgagttttat
     2581 catctttgaa aaataattca ctcttgaagt aataaacgtt taaaaaaatg ggatgcctgc
     2641 ctctgtgaca gccttgtttg ctgaggtcgt gggggtgggg gcctctggga agttccgggc
     2701 tcctcttctc ttggtcaata gctcctttct ggtggctgcc aagagcgtct ctcccagggc
     2761 cgggctgctg gcttaccttc ctgttgtttt caaatttcaa ccttgtgcaa tgttgagttt
     2821 catagaaata ctgcatgagt acgcccttgt ttagaagcag cagggtctga gtcccatccc
     2881 acagccccca gtgcagacgc ttttgccact tttgcatggg gccccctgga tgtgtttctg
     2941 tgcatttatc tacaaatcct ggtgcccata ggacatgccc cgtgttgttc taggcctttg
     3001 ctttctgctc gttacataaa tggtgaagaa gagaagcggg taagagaaca gattggagcc
     3061 atctaaaagt tctcatctta agtgtagatc attgcaaagg atggaatttt ctccgattgt
     3121 catcatcgtt gatgtttgaa tatgagacca tttcatcagt atttaagtgt gcccgctggg
     3181 atctaactag gagaggagag ggtattcact gccgaacatt tcaaagaata tacgaacaag
     3241 ctcttttatg gtcagaaatg ttagcccttt tccccttaaa cttgtatttc ctttcttctt
     3301 ccctcctaaa attttatcta aatgatattt atatttgatg cttttaagcc ttttattaat
     3361 cactcctata cttgcctgca acataaatat ataagttgaa gcaaa
//
